{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:18:41Z","timestamp":1790702321245,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Women's Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute abdomen comprises several emergencies. Hemoperitoneum associated with uterine fibroids, which can present as acute abdominal pain, is rare and difficult to diagnose. Especially, spontaneous hemorrhage from the rupture of the superficial vessels overlying a uterine fibroid is extremely rare, and its diagnosis and management have not been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We report a case of a 55-year-old woman who presented at our hospital with acute abdomen. After performing a computed tomography scan, we conducted a laparoscopic examination and diagnosed hemoperitoneum of ambiguous origin. We treated the patient surgically, performing a laparoscopic myomectomy to remove the origin of the hemorrhage. The patient recovered well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report a case of hemoperitoneum of ambiguous origin that was diagnosed laparoscopically and treated by laparoscopic myomectomy to remove the origin of the hemorrhage. Surgeons should rapidly diagnose and manage acute abdominal pain in women with a history of uterine fibroids to prevent severe morbidity or even mortality. Therefore, laparoscopic surgery is recommended in patients with stable hemodynamics.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12905-022-01970-0","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T23:03:41Z","timestamp":1663887821000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Successful laparoscopic management of acute abdominal pain due to spontaneous rupture of subserosal vessels overlying a uterine fibroid: a case report and surgical video"],"prefix":"10.1186","volume":"22","author":[{"given":"Toshimitsu","family":"Maemura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Furusawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayo","family":"Mitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nishizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3984-975X","authenticated-orcid":false,"given":"Kuniaki","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"issue":"1","key":"1970_CR1","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1067\/mob.2003.99","volume":"188","author":"DD Baird","year":"2003","unstructured":"Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol. 2003;188(1):100\u20137.","journal-title":"Am J Obstet Gynecol"},{"issue":"17","key":"1970_CR2","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1056\/NEJMcp1411029","volume":"372","author":"EA Stewart","year":"2015","unstructured":"Stewart EA. Clinical practice Uterine fibroids. N Engl J Med. 2015;372(17):1646\u201355.","journal-title":"N Engl J Med"},{"issue":"2","key":"1970_CR3","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S1701-2163(15)30338-8","volume":"37","author":"GA Vilos","year":"2015","unstructured":"Vilos GA, Allaire C, Laberge PY, Leyland N. The management of uterine leiomyomas. J Obstet Gynaecol Can. 2015;37(2):157\u201378.","journal-title":"J Obstet Gynaecol Can"},{"issue":"9","key":"1970_CR4","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1080\/13543784.2021.1957830","volume":"30","author":"S Dababou","year":"2021","unstructured":"Dababou S, Garzon S, Lagan\u00e0 AS, Ferrero S, Evangelisti G, Noventa M, et al. Linzagolix: a new GnRH-antagonist under investigation for the treatment of endometriosis and uterine myomas. Expert Opin Investig Drugs. 2021;30(9):903\u201311.","journal-title":"Expert Opin Investig Drugs"},{"issue":"36","key":"1970_CR5","doi-asserted-by":"publisher","first-page":"3821","DOI":"10.2174\/1381612826666210101152820","volume":"27","author":"S Angioni","year":"2021","unstructured":"Angioni S, D\u2019Alterio MN, Daniilidis A. Highlights on medical treatment of uterine fibroids. Curr Pharm Des. 2021;27(36):3821\u201332.","journal-title":"Curr Pharm Des"},{"issue":"1","key":"1970_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/0002-9378(84)90282-5","volume":"149","author":"JG Hallatt","year":"1984","unstructured":"Hallatt JG, Steele CH Jr, Snyder M. Ruptured corpus luteum with hemoperitoneum: a study of 173 surgical cases. Am J Obstet Gynecol. 1984;149(1):5\u20139.","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"1970_CR7","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1447-0756.2007.00540.x","volume":"33","author":"N Gupta","year":"2007","unstructured":"Gupta N, Dadhwal V, Deka D, Jain SK, Mittal S. Corpus luteum hemorrhage: rare complication of congenital and acquired coagulation abnormalities. J Obst Gynaecol Res. 2007;33(3):376\u201380.","journal-title":"J Obst Gynaecol Res"},{"issue":"1","key":"1970_CR8","first-page":"48","volume":"111","author":"M Beuran","year":"2016","unstructured":"Beuran M, Negoi I, Hostiuc S, Catena F, Sartelli M, Negoi RI, et al. Laparoscopic approach has benefits in gynecological emergencies-even for massive hemoperitoneum. Chirurgia (Bucur). 2016;111(1):48\u201353.","journal-title":"Chirurgia (Bucur)"},{"issue":"1","key":"1970_CR9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.11152\/mu-1784","volume":"21","author":"AM Levai","year":"2019","unstructured":"Levai AM, Rotar IC, Muresan D. Torsion of a uterine leiomyoma\u2013a rare cause of hemoperitoneum; a case report and review of the literature. Med Ultrason. 2019;21(1):77\u201382.","journal-title":"Med Ultrason"},{"key":"1970_CR10","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ijsu.2018.10.028","volume":"60","author":"RA Agha","year":"2018","unstructured":"Agha RA, Borrelli MR, Farwana R, Koshy K, Fowler AJ, Orgill DP, et al. The SCARE 2018 statement: updating consensus Surgical CAse REport (SCARE) guidelines. Int J Surg. 2018;60:132\u20136.","journal-title":"Int J Surg"},{"key":"1970_CR11","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ijscr.2019.07.004","volume":"61","author":"A Elkbuli","year":"2019","unstructured":"Elkbuli A, Shaikh S, McKenney M, Boneva D. Life-threatening hemoperitoneum secondary to rupture of a uterine leiomyoma: A case report and review of the literature. Int J Surg Case Rep. 2019;61:51\u20135.","journal-title":"Int J Surg Case Rep"},{"issue":"1","key":"1970_CR12","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12893-020-00736-5","volume":"20","author":"WH Lim","year":"2020","unstructured":"Lim WH, Cohen SC, Lamaro VP. Intra-abdominal haemorrhage from uterine fibroids: a systematic review of the literature. BMC Surg. 2020;20(1):70.","journal-title":"BMC Surg"},{"issue":"6","key":"1970_CR13","first-page":"553","volume":"55","author":"P Dasari","year":"2005","unstructured":"Dasari P, Maurya D. Hemoperitoneum associated with fibroid uterus. J Obstet Gynecol India. 2005;55(6):553\u20134.","journal-title":"J Obstet Gynecol India"},{"issue":"12","key":"1970_CR14","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1177\/000313489906501219","volume":"65","author":"D Danikas","year":"1999","unstructured":"Danikas D, Theodorou SJ, Kotrotsios J, Sills C, Cordero PE. Hemoperitoneum from spontaneous bleeding of a uterine leiomyoma: a case report. Am Surg. 1999;65(12):1180.","journal-title":"Am Surg"},{"issue":"9","key":"1970_CR15","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.diii.2013.01.021","volume":"94","author":"M Fontarensky","year":"2013","unstructured":"Fontarensky M, Cassagnes L, Bouchet P, Azuar AS, Boyer L, Chabrot P. Acute complications of benign uterine leiomyomas: treatment of intraperitoneal haemorrhage by embolisation of the uterine arteries. Diagn Interv Imaging. 2013;94(9):885\u201390.","journal-title":"Diagn Interv Imaging"},{"issue":"1","key":"1970_CR16","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.tjog.2013.01.018","volume":"52","author":"CH Chen","year":"2013","unstructured":"Chen CH, Lin JY, Tzeng CR, Chiu LH, Liu WM. Hemoperitoneum secondary to rupture of a superficial uterine artery overlying a subserous myoma with no predisposing factors in a young woman. Taiwan J Obstet Gynecol. 2013;52(1):133\u20134.","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"3","key":"1970_CR17","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/S1028-4559(08)60142-4","volume":"47","author":"WH Su","year":"2008","unstructured":"Su WH, Cheung SM, Chang SP, Lee WL. Internal bleeding from a ruptured serosal vein covering the myoma surface mimicking upper gastrointestinal bleeding. Taiwan J Obstet Gynecol. 2008;47(3):352\u20134.","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"4","key":"1970_CR18","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1111\/j.0001-6349.2005.0475d.x","volume":"84","author":"E Horowitz","year":"2005","unstructured":"Horowitz E, Dekel A, Feldberg D, Rabinerson D. Massive hemoperitoneum due to rupture of an artery overlying a uterine leiomyoma: a case report. Acta Obstet Gynecol Scand. 2005;84(4):408\u20139.","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"3","key":"1970_CR19","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1210\/en.2013-1763","volume":"155","author":"W Qiang","year":"2014","unstructured":"Qiang W, Liu Z, Serna VA, Druschitz SA, Liu Y, Espona-Fiedler M, et al. Down-regulation of miR-29b is essential for pathogenesis of uterine leiomyoma. Endocrinology. 2014;155(3):663\u20139.","journal-title":"Endocrinology"},{"issue":"2","key":"1970_CR20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/1933719115584449","volume":"23","author":"Q Yang","year":"2016","unstructured":"Yang Q, Mas A, Diamond MP, Al-Hendy A. The mechanism and function of epigenetics in uterine leiomyoma development. Reprod Sci. 2016;23(2):163\u201375.","journal-title":"Reprod Sci"},{"issue":"10","key":"1970_CR21","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000024024","volume":"100","author":"A Daimon","year":"2021","unstructured":"Daimon A, Tanaka T, Kogata Y, Tanaka Y, Fujita D, Ohmichi M. Hemoperitoneum associated with uterine fibroids: A case report. Medicine. 2021;100(10): e24024.","journal-title":"Medicine"},{"issue":"3","key":"1970_CR22","first-page":"260","volume":"14","author":"AS Lagan\u00e0","year":"2020","unstructured":"Lagan\u00e0 AS, Scioscia M. Endometrial cancer in women with adenomyosis: an underestimated risk? Int J Fertil Steril. 2020;14(3):260\u20131.","journal-title":"Int J Fertil Steril"},{"issue":"4","key":"1970_CR23","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.ajog.2020.05.049","volume":"223","author":"M Scioscia","year":"2020","unstructured":"Scioscia M, Noventa M, Lagan\u00e0 AS. Abnormal uterine bleeding and the risk of endometrial cancer: can subendometrial vascular ultrasound be of help to discriminate cancer from adenomyosis? Am J Obstet Gynecol. 2020;223(4):605\u20136.","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"1970_CR24","first-page":"103","volume":"20","author":"G Stabile","year":"2021","unstructured":"Stabile G, Zinicola G, Romano F, Lagan\u00e0 AS, Pozzolo CD, Ricci G. Pelvic mass, ascites, hydrothorax: a malignant or benign condition? Meigs syndrome with high levels of CA 125. Prz Menopauzalny. 2021;20(2):103\u20137.","journal-title":"Prz Menopauzalny"},{"issue":"4","key":"1970_CR25","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S1028-4559(09)60254-0","volume":"45","author":"YJ Tsai","year":"2006","unstructured":"Tsai YJ, Yeat SK, Jeng CJ, Chen SC. Torsion of a uterine leiomyoma. Taiwan J Obstet Gynecol. 2006;45(4):333\u20135.","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"4","key":"1970_CR26","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1097\/AOG.0b013e3182888478","volume":"121","author":"T Falcone","year":"2013","unstructured":"Falcone T, Parker WH. Surgical management of leiomyomas for fertility or uterine preservation. Obstet Gynecol. 2013;121(4):856\u201368.","journal-title":"Obstet Gynecol"},{"issue":"1","key":"1970_CR27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s13256-020-02383-z","volume":"14","author":"S Rokhgireh","year":"2020","unstructured":"Rokhgireh S, Kashi AM, Kermansaravi M, Tajbakhsh B, Allahqoli L, Alkatout I, et al. Hemoperitoneum due to bleeding from a vein overlying a subserous uterine myoma: a case report. J Med Case Reports. 2020;14(1):55.","journal-title":"J Med Case Reports"}],"container-title":["BMC Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-022-01970-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12905-022-01970-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-022-01970-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T04:14:31Z","timestamp":1676866471000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcwomenshealth.biomedcentral.com\/articles\/10.1186\/s12905-022-01970-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,23]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1970"],"URL":"https:\/\/doi.org\/10.1186\/s12905-022-01970-0","relation":{},"ISSN":["1472-6874"],"issn-type":[{"value":"1472-6874","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,23]]},"assertion":[{"value":"27 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted according to the guidelines of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent with opt-out method was individually obtained from our patient for publication of her case and accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"388"}}