{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:16:59Z","timestamp":1785842219488,"version":"3.56.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Women's Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Ovarian metastasis or recurrence of cervical microinvasive squamous cell carcinoma (SCC) is very rare. We report a case of unilateral ovarian recurrence 5\u00a0years after hysterectomy for the SCC stage IA1 without lymph vascular space invasion (LVSI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 49-year-old female patient suffered from a dull pain in the left lower abdomen for 3\u00a0months. And five years ago, she received a laparoscopic hysterectomy for the treatment of stage IA1 (without LVSI) SCC of the cervix. The level of squamous cell carcinoma antigen (SCC-Ag) in serum was significantly elevated (10.60\u00a0ng\/mL). Pelvic magnetic resonance imaging (MRI) revealed a left ovarian solid tumor measuring 5.5\u2009\u00d7\u20093.9\u2009\u00d7\u20095.6\u00a0cm with heterogeneous enhancement. During laparotomy, the left ovarian tumor was measured about 5.0\u2009\u00d7\u20094.5\u2009\u00d7\u20093.0\u00a0cm and seemed densely adherent to the posterior peritoneal wall, including the left ureter. The tumor and pelvic lymph node were carefully removed. Postoperative anatomy revealed a solid mass with a greyish-white section. Postoperative pathology showed recurrent moderately differentiated ovarian SCC with negative pelvic lymph nodes. Immunohistochemistry showed that the tumor cells were positive for P16, P63, P40, and CK5\/6 markers, and the positive rate of Ki67 was about 80%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Ovary preservation is reasonable and appropriate in young patients with microinvasive SCC. Ovarian recurrence is rare, but gynecological oncologists should not overlook its possibility. The serum SCC-Ag is an important indicator for monitoring postoperative disease progression.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12905-023-02496-9","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T19:01:48Z","timestamp":1688238108000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unilateral ovarian recurrence 5\u00a0years after hysterectomy for microinvasive squamous cervical cancer stage IA1: a rare case report"],"prefix":"10.1186","volume":"23","author":[{"given":"Longxia","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-8418","authenticated-orcid":false,"given":"Lin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,1]]},"reference":[{"issue":"2","key":"2496_CR1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1097\/IGC.0000000000000887","volume":"27","author":"CA Hartman","year":"2017","unstructured":"Hartman CA, Teixeira JC, Barbosa SB, Figueiredo SM, Andrade LA, Bastos JF. Analysis of Conservative Surgical Treatment and Prognosis of Microinvasive Squamous Cell Carcinoma of the Cervix Stage IA1: Results of Follow-Up to 20 Years. Int J Gynecol Cancer. 2017;27(2):357\u201363.","journal-title":"Int J Gynecol Cancer"},{"key":"2496_CR2","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1056\/NEJMoa1309748","volume":"370","author":"KS Tewari","year":"2014","unstructured":"Tewari KS, Sill MW, Long HJ III, et al. Improved survival with bevacizumab in advanced cervical cancer. N Engl J Med. 2014;370:734\u201343.","journal-title":"N Engl J Med"},{"issue":"6","key":"2496_CR3","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1093\/jjco\/hyr041","volume":"41","author":"T Hidaka","year":"2011","unstructured":"Hidaka T, Nakashima A, Hasegawa T, Nomoto K, Ishizawa S, Tsuneyama K, Takano Y, Saito S. Ovarian Squamous Cell Carcinoma Which Metastasized 8 Years After Cervical Conization for Early Microinvasive Cervical Cancer: A Case Report. Jpn J Clin Oncol. 2011;41(6):807\u201310.","journal-title":"Jpn J Clin Oncol"},{"issue":"31","key":"2496_CR4","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021146","volume":"99","author":"Yu Fan","year":"2020","unstructured":"Fan Yu, Wang M-Y, Yi Mu, Mo S-P, Zheng Ai, Li J-K. Ovarian metastasis in women with cervical carcinoma in stages IA to IIB A systematic review and meta-analysis. Medicine (Baltimore). 2020;99(31): e21146.","journal-title":"Medicine (Baltimore)"},{"key":"2496_CR5","doi-asserted-by":"crossref","unstructured":"Perez CA, Grigsby PW, Nene SM, Camel HM, Galakatos A, Kao MS, et al. Effect of tumor size on the prognosis of carcinoma of the uterine cervix treated with irradiation alone. Cancer. 1992;69:2796e806.","DOI":"10.1002\/1097-0142(19920601)69:11<2796::AID-CNCR2820691127>3.0.CO;2-O"},{"key":"2496_CR6","doi-asserted-by":"crossref","unstructured":"Marchiol\u00e9 P, Bu\u00e9nerd A, Benchaib M, Nezhat K, Dargent D, Mathevet P. Clinical significance of lympho vascular space involvement and lymph node micrometastases in early-stage cervical cancer: a retrospective case-control surgicopathological study. Gynecol Oncol. 2005;97(3):727e32.","DOI":"10.1016\/j.ygyno.2005.01.004"},{"key":"2496_CR7","doi-asserted-by":"crossref","unstructured":"Grisaru DA, Covens A, Franssen E, Chapman W, Shaw P, Colgan T, et al. Histopathologic score predicts recurrence free survival after radical surgery in patients with stage IA2-IB1\u20132 cervical carcinoma. Cancer. 2003;97(8):1904e8.","DOI":"10.1002\/cncr.11269"},{"issue":"5","key":"2496_CR8","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.ijrobp.2017.03.029","volume":"98","author":"TH Kim","year":"2017","unstructured":"Kim TH, Kim MH, Kim BJ, Park SI, Ryu SY, Cho CK. Prognostic Importance of the Site of Recurrence in Patients With Metastatic Recurrent Cervical Cancer. Int J Radiat Oncol Biol Phys. 2017;98(5):1124\u201331.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2496_CR9","doi-asserted-by":"crossref","unstructured":"Should ovaries be removed or not in early-stage cervical adenocarcinoma: a multicenter retrospective study of 105 patients. Hu J, Jiao X, Yang Z, Cui H, Guo H, Wu Y, Zhu L. J Obstet Gynaecol. 2017;37(8):1065\u20131069.","DOI":"10.1080\/01443615.2017.1323198"},{"issue":"1","key":"2496_CR10","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.ygyno.2018.03.056","volume":"150","author":"C Charakorn","year":"2018","unstructured":"Charakorn C, Thadanipon K, Chaijindaratana S, Rattanasiri S, Numthavaj P, Thakkinstian A. The association between serum squamous cell carcinoma antigen and recurrence and survival of patients with cervical squamous cell carcinoma: A systematic review and meta-analysis. Gynecol Oncol. 2018;150(1):190\u2013200.","journal-title":"Gynecol Oncol"},{"key":"2496_CR11","doi-asserted-by":"crossref","unstructured":"Chung Chang,Jiabin Chen,Chi-Hsiang Huang,Wen-Ying Lee,Li-Chuan Hsu,An Jen Chiang.Time-Dependent Squamous Cell Carcinoma Antigen in Prediction of Relapse and Death of Patients With Cervical Cancer. J Low Genit Tract Dis. 2020;24(1):38\u201342.","DOI":"10.1097\/LGT.0000000000000499"}],"container-title":["BMC Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-023-02496-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12905-023-02496-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-023-02496-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T19:01:52Z","timestamp":1688238112000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcwomenshealth.biomedcentral.com\/articles\/10.1186\/s12905-023-02496-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,1]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["2496"],"URL":"https:\/\/doi.org\/10.1186\/s12905-023-02496-9","relation":{},"ISSN":["1472-6874"],"issn-type":[{"value":"1472-6874","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,1]]},"assertion":[{"value":"26 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Research Committee of the West China Second University Hospital, Sichuan University. Ethical Lot Number: 20220129.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report. A copy of the written consent is available for review.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"350"}}