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The secondary outcome measures the odds of primary dysmenorrhea in Asian adolescents with vitamin D receptor TaqI (rs731236) polymorphism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The serum 25(OH)D was significantly lower in the studied-dysmenorrhea group compared to controls (16.17\u2009\u00b1\u20097.36 versus 17.65\u2009\u00b1\u20096.36 ng\/ml, respectively), (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01). The correlation analysis showed a significant negative correlation between the serum 25(OH)D and visual analogue scale of dysmenorrhea (r\u2009=\u2009-0.9003,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                    <jats:p>\n                      The studied-dysmenorrhea cases with vitamin D receptor T\/t and t\/t genotypes had significantly lower serum 25(OH)D (16.7\u2009\u00b1\u20098.05 and 14.4\u2009\u00b1\u20094.1 ng\/ml, respectively) compared to controls (18.97\u2009\u00b1\u20096.7 and 21.4\u2009\u00b1\u20092.45 ng\/ml, respectively), (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02 and 0.004, respectively).\n                    <\/jats:p>\n                    <jats:p>\n                      The VDR T\/t and t\/t polymorphisms significantly increase the odds of primary dysmenorrhea\u00a0(OR 1367.2,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001 and OR 106.2,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The serum 25(OH)D was significantly lower in the studied-dysmenorrhea group compared to controls. The studied-dysmenorrhea cases with VDR T\/t and t\/t TaqI genotypes had significantly lower serum 25(OH)D compared to controls. The VDR T\/t and t\/t polymorphisms significantly increase the odds of primary dysmenorrhea.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12905-023-02569-9","type":"journal-article","created":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T04:01:49Z","timestamp":1691208109000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Vitamin D and vitamin D receptor polymorphism in Asian adolescents with primary dysmenorrhea"],"prefix":"10.1186","volume":"23","author":[{"given":"Ainur","family":"Donayeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainur","family":"Amanzholkyzy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza","family":"Nurgaliyeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulnara","family":"Gubasheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samat","family":"Saparbayev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinmukhamed","family":"Ayaganov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiman","family":"Kaldybayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim A.","family":"Abdelazim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2245-4903","authenticated-orcid":false,"given":"Mohamed M.","family":"Farghali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,5]]},"reference":[{"issue":"6","key":"2569_CR1","doi-asserted-by":"publisher","first-page":"e249","DOI":"10.1097\/AOG.0000000000002978.[PubMed]","volume":"132","author":"ACOG Committee Opinion No","year":"2018","unstructured":"ACOG Committee Opinion No. 760: Dysmenorrhea and Endometriosis in the Adolescent. 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