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They were divided into HPV16+, 18\/45\u2009+\u2009and other HR-HPV\u2009+\u2009groups premenopausal and postmenopausal groups. The pathological results of the biopsy were divided into the LSIL- group (including normal and low-grade squamous intraepithelial lesions) and the HSIL\u2009+\u2009group (including high-grade squamous intraepithelial lesions and higher lesions). SPSS was used for the analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The age group 31\u201340 years had the highest level of HPV16+, and HPV18\/45\u2009+\u2009was the highest in the 41\u201350 years group. The detection rates of HSIL\u2009+\u2009in the HPV16+, HPV18\/45+, HPV 16\/18\/45\u2009+\u2009and Other HR-HPV\u2009+\u2009groups were 48.4%, 18.8%, 43.9% and 15.0%, respectively. The infection rates of HPV16\/18\/45 in postmenopausal and premenopausal women were 42.4% and 34.3%, respectively. In the HPV18\/45 group, the incidence of HSIL\u2009+\u2009was 30.0% in postmenopausal women and 15.0% in premenopausal women (P\u2009&lt;\u20090.01). In the HPV 16\u2009+\u2009and Other HR-HPV\u2009+\u2009groups, the incidence of HSIL\u2009+\u2009in postmenopausal patients was not significantly different from that in premenopausal patients. The incidence of cervical cancer in postmenopausal patients is significantly higher than that in premenopausal patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Colposcopy referral or further biopsy is recommended for all ASCUS patients with HPV16\/18\/45E6\/E7 mRNA positivity and postmenopausal patients with HR-HPVE6\/E7 mRNA positivity. For premenopausal ASCUS patients with other HR-HPV E6\/E7 mRNA positivity, colposcopy should be performed if possible, depending on the specific situation, to achieve early detection and diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12905-023-02599-3","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T12:02:50Z","timestamp":1694692970000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic value of high-risk HPV E6\/E7 mRNA in patients with ASCUS"],"prefix":"10.1186","volume":"23","author":[{"given":"Xiu","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"2599_CR1","doi-asserted-by":"publisher","first-page":"4000","DOI":"10.7150\/jca.41472","volume":"11","author":"Z Wang","year":"2020","unstructured":"Wang Z, Wang T, Yang J, Wang W, Zhang L, Su X, et al. 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