{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:27:12Z","timestamp":1716942432818},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Women's Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>To demonstrate and analyze the <jats:sup>18<\/jats:sup>F-FDG positron emission tomography\/computed tomography (PET\/CT) findings in this rare nevoid basal cell carcinoma syndrome (NBCCS).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 71-year-old woman with the left invasive breast cancer was treated with hormone therapy for six months and underwent the <jats:sup>18<\/jats:sup>F-FDG PET\/CT examination for efficacy evaluation. <jats:sup>18<\/jats:sup>F-FDG PET\/CT revealed the improvement after treatment and other unexpected findings, including multiple nodules on the skin with <jats:sup>18<\/jats:sup>F-FDG uptake, bone expansion of cystic lesions in the bilateral ribs, ectopic calcifications and dilated right ureter. She had no known family history. Then, the patient underwent surgical excision of the all skin nodules and the postoperative pathology were multiple basal cell carcinomas. Finally, the comprehensive diagnosis of NBCCS was made. The patient was still in follow-up. Additionally, we have summarized the reported cases (<jats:italic>n<\/jats:italic>\u2009=\u20093) with <jats:sup>18<\/jats:sup>F-FDG PET\/CT from the literature.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>It is important to recognize this syndrome on <jats:sup>18<\/jats:sup>F-FDG PET\/CT because of different diagnoses and therapeutic consequences.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12905-024-03145-5","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T02:01:28Z","timestamp":1716861688000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["18F-FDG PET\/CT findings in nevoid basal cell carcinoma syndrome: a systematic review and a new case report"],"prefix":"10.1186","volume":"24","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aodi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"issue":"3","key":"3145_CR1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1177\/205016841800700306","volume":"7","author":"A Hasan","year":"2018","unstructured":"Hasan A, Akintola D. An Update of Gorlin-Goltz Syndrome. Prim Dent J. 2018;7(3):38\u201341.","journal-title":"Prim Dent J"},{"issue":"2","key":"3145_CR2","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/bjd.20700","volume":"186","author":"BJA Verkouteren","year":"2022","unstructured":"Verkouteren BJA, Cosgun B, Reinders MGHC, Kessler PAWK, Vermeulen RJ, Klaassens M, Lambrechts S, van Rheenen JR, van Geel M, Vreeburg M, Mosterd K. A guideline for the clinical management of basal cell naevus syndrome (Gorlin-Goltz syndrome). Br J Dermatol. 2022;186(2):215\u201326.","journal-title":"Br J Dermatol"},{"issue":"9","key":"3145_CR3","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1111\/ijd.15884","volume":"61","author":"LT Fern\u00e1ndez","year":"2022","unstructured":"Fern\u00e1ndez LT, Ocampo-Garza SS, Elizondo-Riojas G, Ocampo-Candiani J. Basal cell nevus syndrome: an update on clinical findings. Int J Dermatol. 2022;61(9):1047\u201355.","journal-title":"Int J Dermatol"},{"issue":"4","key":"3145_CR4","doi-asserted-by":"publisher","first-page":"e869","DOI":"10.1097\/MPH.0000000000002436","volume":"44","author":"D Katayama","year":"2022","unstructured":"Katayama D, Inoue A, Kayatani R, Urabe K, Suzuki R, Takitani K, Yoshida M, Kato M, Ashida A. A Case of Gorlin-Goltz Syndrome Without the Characteristic Physical Features That Was Diagnosed After the Development of a Fifth Cancer. J Pediatr Hematol Oncol. 2022;44(4):e869\u201371.","journal-title":"J Pediatr Hematol Oncol"},{"issue":"1","key":"3145_CR5","doi-asserted-by":"publisher","first-page":"64","DOI":"10.5603\/NMR.2017.0007","volume":"20","author":"M Pachowicz","year":"2017","unstructured":"Pachowicz M, Staskiewicz G, Opielak G, Scibisz-Dziedzic K, Chrapko B. Complex rib anomalies in patient undergoing PET\/CT study - a case report. Nucl Med Rev Cent East Eur. 2017;20(1):64\u20135.","journal-title":"Nucl Med Rev Cent East Eur"},{"issue":"2","key":"3145_CR6","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1148\/radiol.2021204508","volume":"300","author":"H Yin","year":"2021","unstructured":"Yin H, Shi H. Fluorine 18 Fluorodeoxyglucose PET\/CT Findings in Gorlin-Goltz Syndrome. Radiology. 2021;300(2):288.","journal-title":"Radiology"},{"issue":"7","key":"3145_CR7","doi-asserted-by":"publisher","first-page":"561","DOI":"10.2217\/fca-2022-0013","volume":"18","author":"S Reaz","year":"2022","unstructured":"Reaz S, Sammi S, Gholkar G. A rare case of cardiac fibroma diagnosis in Gorlin-Goltz syndrome with information on management. Future Cardiol. 2022;18(7):561\u20137.","journal-title":"Future Cardiol"},{"key":"3145_CR8","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1750-1172-3-32","volume":"3","author":"ML Lo","year":"2008","unstructured":"Lo ML. Nevoid basal cell carcinoma syndrome (Gorlin syndrome). Orphanet J Rare Dis. 2008;3:32.","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"3145_CR9","doi-asserted-by":"publisher","first-page":"e987","DOI":"10.1002\/mgg3.987","volume":"8","author":"B Beltrami","year":"2020","unstructured":"Beltrami B, Prada E, Tolva G, Scuvera G, Silipigni R, Graziani D, Bulfamante G, Gervasini C, Marchisio P, Milani D. Unexpected phenotype in a frameshift mutation of PTCH1. Mol Genet Genomic Med. 2020;8(1):e987.","journal-title":"Mol Genet Genomic Med"},{"issue":"1","key":"3145_CR10","doi-asserted-by":"publisher","first-page":"112","DOI":"10.5507\/bp.2020.063","volume":"166","author":"J Pazdera","year":"2022","unstructured":"Pazdera J, Santava A, Kolar Z. Gorlin-Goltz syndrome with familial manifestation. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022;166(1):112\u20136.","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"issue":"6","key":"3145_CR11","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1136\/jmg.30.6.460","volume":"30","author":"DG Evans","year":"1993","unstructured":"Evans DG, Ladusans EJ, Rimmer S, Burnell LD, Thakker N, Farndon PA. Complications of the naevoid basal cell carcinoma syndrome: results of a population based study. J Med Genet. 1993;30(6):460\u20134.","journal-title":"J Med Genet"},{"issue":"3","key":"3145_CR12","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1002\/(SICI)1096-8628(19970331)69:3<299::AID-AJMG16>3.0.CO;2-M","volume":"69","author":"VE Kimonis","year":"1997","unstructured":"Kimonis VE, Goldstein AM, Pastakia B, Yang ML, Kase R, DiGiovanna JJ, Bale AE, Bale SJ. Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome. Am J Med Genet. 1997;69(3):299\u2013308.","journal-title":"Am J Med Genet"},{"issue":"6","key":"3145_CR13","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1097\/01.GIM.0000145045.17711.1C","volume":"6","author":"VE Kimonis","year":"2004","unstructured":"Kimonis VE, Mehta SG, Digiovanna JJ, Bale SJ, Pastakia B. Radiological features in 82 patients with nevoid basal cell carcinoma (NBCC or Gorlin) syndrome. Genet Med. 2004;6(6):495\u2013502.","journal-title":"Genet Med"},{"issue":"9","key":"3145_CR14","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1002\/ajmg.a.34128","volume":"155A","author":"AF Bree","year":"2011","unstructured":"Bree AF, Shah MR, BCNS Colloquium Gr. Consensus statement from the first international colloquium on basal cell nevus syndrome (BCNS). Am J Med Genet A. 2011;155A(9):2091\u20137.","journal-title":"Am J Med Genet A."},{"key":"3145_CR15","doi-asserted-by":"publisher","first-page":"bcr2017219344","DOI":"10.1136\/bcr-2017-219344","volume":"2017","author":"S Hino","year":"2017","unstructured":"Hino S, Tanaka H, Hamakawa H. Multiple jaw cysts and ectopic calcification. BMJ Case Rep. 2017;2017:bcr2017219344.","journal-title":"BMJ Case Rep"},{"issue":"5","key":"3145_CR16","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s13244-018-0644-z","volume":"9","author":"A Borghesi","year":"2018","unstructured":"Borghesi A, Nardi C, Giannitto C, Tironi A, Maroldi R, Di Bartolomeo F, Preda L. Odontogenic keratocyst: imaging features of a benign lesion with an aggressive behaviour. Insights Imaging. 2018;9(5):883\u201397.","journal-title":"Insights Imaging"},{"issue":"3","key":"3145_CR17","doi-asserted-by":"publisher","first-page":"847","DOI":"10.4103\/0028-3886.232340","volume":"66","author":"S Kumar","year":"2018","unstructured":"Kumar S, Eshanth R, Indiran V, Mariappan K, Maduraimuthu P. A rare association of Gorlin-Goltz syndrome. Neurol India. 2018;66(3):847\u20139.","journal-title":"Neurol India"},{"issue":"1","key":"3145_CR18","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s13023-019-1190-6","volume":"14","author":"A Moramarco","year":"2019","unstructured":"Moramarco A, Himmelblau E, Miraglia E, Mallone F, Roberti V, Franzone F, Iacovino C, Giustini S, Lambiase A. Ocular manifestations in Gorlin-Goltz syndrome. Orphanet J Rare Dis. 2019;14(1):218.","journal-title":"Orphanet J Rare Dis"},{"key":"3145_CR19","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.wneu.2019.09.156","volume":"133","author":"A Narang","year":"2020","unstructured":"Narang A, Maheshwari C, Aggarwal V, Bansal P, Singh P. Gorlin-Goltz Syndrome with Intracranial Meningioma: Case Report and Review of Literature. World Neurosurg. 2020;133:324\u201330.","journal-title":"World Neurosurg"},{"key":"3145_CR20","first-page":"239","volume":"39","author":"RK Singh","year":"2021","unstructured":"Singh RK, Mishra GV. Gorlin-Goltz syndrome without cutaneous manifestations. Pan Afr Med J. 2021;39:239.","journal-title":"Pan Afr Med J"},{"issue":"6","key":"3145_CR21","doi-asserted-by":"publisher","first-page":"e530","DOI":"10.1097\/SCS.0000000000004438","volume":"29","author":"JA Figueira","year":"2018","unstructured":"Figueira JA, Batista FRS, Rosso K, Veltrini VC, Pavan AJ. Delayed Diagnosis of Gorlin-Goltz Syndrome: The Importance of the Multidisciplinary Approach. J Craniofac Surg. 2018;29(6):e530\u20131.","journal-title":"J Craniofac Surg"},{"issue":"2","key":"3145_CR22","doi-asserted-by":"publisher","first-page":"W132","DOI":"10.2214\/AJR.14.13160","volume":"204","author":"AD Baheti","year":"2015","unstructured":"Baheti AD, Tirumani SH, Giardino A, Rosenthal MH, Tirumani H, Krajewski K, Ramaiya NH. Basal cell carcinoma: a comprehensive review for the radiologist. AJR Am J Roentgenol. 2015;204(2):W132\u201340.","journal-title":"AJR Am J Roentgenol"},{"issue":"2","key":"3145_CR23","first-page":"124","volume":"35","author":"S Ayala","year":"2016","unstructured":"Ayala S, Perlaza P, Puig S, Prats E, Vidal-Sicart S. Usefulness of (18)F-FDG PET\/CT in recurrent basal cell carcinoma: Report of a case. Rev Esp Med Nucl Imagen Mol. 2016;35(2):124\u20136.","journal-title":"Rev Esp Med Nucl Imagen Mol"},{"issue":"1","key":"3145_CR24","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.bjoms.2018.10.286","volume":"57","author":"A Pabst","year":"2019","unstructured":"Pabst A, Klinghuber M, M\u00fcller G, Vandersee S, Werkmeister R. Extensive bony metastases from facial metatypical basal cell carcinoma: a case report. Br J Oral Maxillofac Surg. 2019;57(1):82\u20134.","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"2","key":"3145_CR25","doi-asserted-by":"publisher","first-page":"124","DOI":"10.14735\/amko2019124","volume":"32","author":"V Barto\u0161","year":"2019","unstructured":"Barto\u0161 V, Kullov\u00e1 M, Adamicov\u00e1 K, Pau\u010dinov\u00e1 I. Gorlin-Goltz syndrome. Klin Onkol. 2019;32(2):124\u20138.","journal-title":"Klin Onkol"},{"issue":"7","key":"3145_CR26","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1097\/RLU.0b013e318177934e","volume":"33","author":"S Borkar","year":"2008","unstructured":"Borkar S, Pandit-Taskar N. F-18 FDG uptake in cutaneous metastases from breast cancer. Clin Nucl Med. 2008;33(7):488\u20139.","journal-title":"Clin Nucl Med"},{"issue":"1","key":"3145_CR27","doi-asserted-by":"publisher","first-page":"e63","DOI":"10.1097\/RLU.0000000000000553","volume":"40","author":"SR Dave","year":"2015","unstructured":"Dave SR, Samuel TA, Pucar D, Savage N, Williams HT. FDG PET\/CT in evaluation of unusual cutaneous manifestations of breast cancer. Clin Nucl Med. 2015;40(1):e63\u20137.","journal-title":"Clin Nucl Med"},{"issue":"1","key":"3145_CR28","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0190-9622(90)70002-Y","volume":"22","author":"DP Lookingbill","year":"1990","unstructured":"Lookingbill DP, Spangler N, Sexton FM. Skin involvement as the presenting sign of internal carcinoma. A retrospective study of 7316 cancer patients. J Am Acad Dermatol. 1990;22(1):19\u201326.","journal-title":"J Am Acad Dermatol."},{"issue":"1","key":"3145_CR29","doi-asserted-by":"publisher","first-page":"307","DOI":"10.37029\/jcas.v6i1.307","volume":"6","author":"S Rehman","year":"2020","unstructured":"Rehman S, Naveed MA. Skin Metastasis in Breast Cancer Patients; a Case Series. J Cancer Allied Spec. 2020;6(1):307.","journal-title":"J Cancer Allied Spec"},{"issue":"(1(B))","key":"3145_CR30","first-page":"433","volume":"73","author":"M Muzaffar","year":"2023","unstructured":"Muzaffar M, Hassan A. 18F-FDG PET-CT in Cutaneous Metastases in Breast Carcinoma: An unusual presentation. J Pak Med Assoc. 2023;73((1(B))):433\u20134.","journal-title":"J Pak Med Assoc"},{"issue":"7","key":"3145_CR31","doi-asserted-by":"publisher","first-page":"e513","DOI":"10.1097\/RLU.0000000000004224","volume":"47","author":"T T","year":"2022","unstructured":"T T, Goyal H, Singh H, Das CK, Sekar A, Kumar R. Nivolumab Immunotherapy-Related Skin Reactions Detected on 18F-FDG PET\/CT in Renal Cell Cancer. Clin Nucl Med. 2022;47(7):e513\u20134.","journal-title":"Clin Nucl Med"}],"container-title":["BMC Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-024-03145-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12905-024-03145-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-024-03145-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T02:04:15Z","timestamp":1716861855000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcwomenshealth.biomedcentral.com\/articles\/10.1186\/s12905-024-03145-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,28]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3145"],"URL":"https:\/\/doi.org\/10.1186\/s12905-024-03145-5","relation":{},"ISSN":["1472-6874"],"issn-type":[{"value":"1472-6874","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,28]]},"assertion":[{"value":"17 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. And this was an observational study. The Medical Ethics Committee of the Affiliated Qingdao Central Hospital of Qingdao University has confirmed that no ethical approval is required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient gave her written informed consent for the publication of any identifying information\/images in this case report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"310"}}