{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:12:20Z","timestamp":1791868340521,"version":"4.3.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81960273"],"award-info":[{"award-number":["81960273"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Women's Health"],"DOI":"10.1186\/s12905-024-03405-4","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T12:03:34Z","timestamp":1729166614000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Correlation and predictive value of systemic immune-inflammation index for dyslipidemia in patients with polycystic ovary syndrome"],"prefix":"10.1186","volume":"24","author":[{"given":"Xinyue","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiao","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"issue":"9","key":"3405_CR1","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1093\/humrep\/det262","volume":"28","author":"R Li","year":"2013","unstructured":"Li R, et al. Prevalence of polycystic ovary syndrome in women in China: a large community-based study. Hum Reprod. 2013;28(9):2562\u20139.","journal-title":"Hum Reprod"},{"issue":"11","key":"3405_CR2","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1111\/j.1471-0528.2000.tb11644.x","volume":"107","author":"CJG Kelly","year":"2000","unstructured":"Kelly CJG, et al. The long term health consequences of polycystic ovary syndrome. Bjog An International Journal of Obstetrics & Gynaecology. 2000;107(11):1327.","journal-title":"Bjog An International Journal of Obstetrics & Gynaecology"},{"issue":"3","key":"3405_CR3","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00404-020-05951-2","volume":"303","author":"S Abraham Gnanadass","year":"2021","unstructured":"Abraham Gnanadass S, et al. Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): an update. Arch Gynecol Obstet. 2021;303(3):631\u201343.","journal-title":"Arch Gynecol Obstet"},{"issue":"8","key":"3405_CR4","doi-asserted-by":"publisher","first-page":"3923","DOI":"10.3390\/ijms22083923","volume":"22","author":"SA Dabravoiski","year":"2021","unstructured":"Dabravoiski SA, et al. Mitochondrial dysfunction and chronic inflammation in polycystic ovary syndrome. Int J Mol Sci. 2021;22(8):3923.","journal-title":"Int J Mol Sci"},{"issue":"7","key":"3405_CR5","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.3390\/ijms22073789","volume":"22","author":"E Rudnicka","year":"2021","unstructured":"Rudnicka E, Suchta K, Grymowicz M, Calik-Ksepka A, Smolarczyk K, Duszewska AM, Smolarczyk R, Meczekalski B. Chronic Low Grade Inflammation in Pathogenesis of PCOS. Int J Mol Sci. 2021;22(7):3789.","journal-title":"Int J Mol Sci"},{"issue":"18","key":"3405_CR6","doi-asserted-by":"publisher","first-page":"5611","DOI":"10.1158\/1078-0432.CCR-16-3272","volume":"23","author":"Q Hu","year":"2017","unstructured":"Hu Q, et al. Role of platelet-derived Tgf\u03b21 in the progression of ovarian cancer. Clin Cancer Res. 2017;23(18):5611\u201321.","journal-title":"Clin Cancer Res"},{"issue":"1","key":"3405_CR7","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/s13048-023-01321-z","volume":"16","author":"X Li","year":"2023","unstructured":"Li X, et al. The association between systemic immune-inflammation index and in vitro fertilization outcomes in women with polycystic ovary syndrome: a cohort study. J Ovarian Res. 2023;16(1):236.","journal-title":"J Ovarian Res"},{"issue":"1","key":"3405_CR8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","volume":"81","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","unstructured":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19\u201325.","journal-title":"Fertil Steril"},{"issue":"11","key":"3405_CR9","doi-asserted-by":"publisher","first-page":"ITC81-ITC96","DOI":"10.7326\/AITC201712050","volume":"167","author":"L Kopin","year":"2017","unstructured":"Kopin L, et al. Dyslipidemia. Ann Intern Med. 2017;167(11):ITC81\u201396.","journal-title":"Ann Intern Med."},{"key":"3405_CR10","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.atherosclerosis.2021.02.012","volume":"323","author":"M Xu","year":"2021","unstructured":"Xu M, Chen R, Liu L, et al. Systemic immune-inflammation index and incident cardiovascular diseases among middle-aged and elderly Chinese adults: The Dongfeng-Tongji cohort study. Atherosclerosis. 2021;323:20\u20139. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2021.02.012.","journal-title":"Atherosclerosis"},{"issue":"4","key":"3405_CR11","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.fertnstert.2023.07.025","volume":"120","author":"HJ Teede","year":"2023","unstructured":"Teede HJ, et al. International PCOS Network . Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Fertil Steril. 2023;120(4):767\u201393.","journal-title":"Fertil Steril."},{"issue":"5","key":"3405_CR12","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3003","volume":"34","author":"G Li","year":"2018","unstructured":"Li G, et al. A prospective cohort study of early-pregnancy risk factors for gestational diabetes in polycystic ovarian syndrome. Diabetes Metab Res Rev. 2018;34(5): e3003.","journal-title":"Diabetes Metab Res Rev"},{"issue":"2","key":"3405_CR13","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3390\/jcm12020557","volume":"12","author":"A Giannouli","year":"2023","unstructured":"Giannouli A, et al. The Burden of Non-Alcoholic Fatty Liver Disease in Adolescents with Polycystic Ovary Syndrome: A Case-Control Study. J Clin Med. 2023;12(2):557.","journal-title":"J Clin Med"},{"issue":"2","key":"3405_CR14","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1080\/13813455.2018.1499120","volume":"126","author":"DM Bannigida","year":"2020","unstructured":"Bannigida DM, et al. Insulin resistance and oxidative marker in women with PCOS. Arch Physiol Biochem. 2020;126(2):183\u20136.","journal-title":"Arch Physiol Biochem"},{"issue":"6","key":"3405_CR15","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1210\/jcem.86.6.7580","volume":"86","author":"CC Kelly","year":"2001","unstructured":"Kelly CC, et al. Low grade chronic inflammation in women with polyeystic ovarian syndrome. Clin Endocrinol Metab. 2001;86(6):2453\u20135.","journal-title":"Clin Endocrinol Metab"},{"issue":"11","key":"3405_CR16","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3390\/metabo10110439","volume":"10","author":"R Herman","year":"2020","unstructured":"Herman R, et al. Genetic variability in antioxidative and inflammatory pathways modifies the risk for PCOS and influences metabolic profile of the syndrome. Metabolites. 2020;10(11):439.","journal-title":"Metabolites"},{"issue":"29","key":"3405_CR17","doi-asserted-by":"publisher","first-page":"e29678","DOI":"10.1097\/MD.0000000000029678","volume":"101","author":"WH Liu","year":"2022","unstructured":"Liu WH, et al. Assessment of neutrophil to lymphocyte ratio, C-reactive protein, mean platelet volume in obese, and nonobese patients with polycystic ovary syndrome. Medicine (Baltimore). 2022;101(29):e29678.","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"3405_CR18","doi-asserted-by":"publisher","first-page":"417","DOI":"10.4183\/aeb.2022.417","volume":"18","author":"P Tsenkova","year":"2022","unstructured":"Tsenkova P, et al. Prevalence and characteristics of the polycystic ovarian syndrome in overweight and obese premenopausal women. Acta Endocrinol (Buchar). 2022;18(4):417\u201323.","journal-title":"Acta Endocrinol (Buchar)"},{"key":"3405_CR19","first-page":"265A","volume":"17","author":"F Gonz\u00e1lez","year":"2010","unstructured":"Gonz\u00e1lez F, et al. Androgen administration stimulates reactive oxygen species generation from leukocytes of normal reproductive-age women. Reprod Sci. 2010;17:265A.","journal-title":"Reprod Sci"},{"key":"3405_CR20","doi-asserted-by":"publisher","first-page":"E297","DOI":"10.1152\/ajpendo.00416.2011","volume":"302","author":"F Gonzalez","year":"2012","unstructured":"Gonzalez F, et al. Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women. Am J Physiol Endocrinol Metab. 2012;302:E297-306.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"3405_CR21","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1055\/a-0806-8281","volume":"51","author":"M Amiri","year":"2019","unstructured":"Amiri M, et al. Relationships between biochemical markers of hyperandrogenism and metabolic parameters in women with polycystic ovary syndrome: a systematic review and meta-analysis. Horm Metab Res. 2019;51(1):22\u201334.","journal-title":"Horm Metab Res"},{"key":"3405_CR22","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.cca.2019.11.003","volume":"502","author":"X Zeng","year":"2019","unstructured":"Zeng X, et al. Polycystic ovarian syndrome: correlation between hyperandrogenism, insulin resistance and obesity. Clin Chim Acta. 2019;502:214\u201321.","journal-title":"Clin Chim Acta"},{"issue":"2023","key":"3405_CR23","first-page":"3924018","volume":"9","author":"M Hafizi Moori","year":"2023","unstructured":"Hafizi Moori M, et al. The Effect of Exercise on Inflammatory Markers in PCOS Women: A Systematic Review and Meta-Analysis of Randomized Trials. Int J Clin Pract. 2023;9(2023):3924018.","journal-title":"Int J Clin Pract"},{"issue":"1","key":"3405_CR24","first-page":"70","volume":"12","author":"F Rezayat","year":"2023","unstructured":"Rezayat F, et al. Inflammatory Responses of Women with Polycystic Ovary Syndrome in Vitro Differ from Healthy Women. Int J Mol Cell Med. 2023;12(1):70\u201380.","journal-title":"Int J Mol Cell Med"},{"issue":"5","key":"3405_CR25","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1111\/j.1365-2265.2009.03523.x","volume":"71","author":"D Glintborg","year":"2009","unstructured":"Glintborg D, et al. Plasma monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha are increased in patients with polycystic ovary syndrome (PCOS) and associated with adiposity, but unaffected by pioglitazone treatment. Clin Endocrinol (Oxf). 2009;71(5):652\u20138.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"3405_CR26","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1017\/S0007114521003585","volume":"128","author":"IM Perovic Blagojevic","year":"2022","unstructured":"Perovic Blagojevic IM, et al. Overweight and obesity in polycystic ovary syndrome: association with inflammation, oxidative stress and dyslipidaemia. Br J Nutr. 2022;128(4):604\u201312.","journal-title":"Br J Nutr"},{"key":"3405_CR27","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00404-014-3199-3","volume":"290","author":"R Keskin Kurt","year":"2014","unstructured":"Keskin Kurt R, et al. The effect of obesity on inflammatory markers in patients with PCOS: a BMI-matched case \u2013 control study. Arch Gynecol Obstetr. 2014;290:315\u20139.","journal-title":"Arch Gynecol Obstetr"},{"issue":"22","key":"3405_CR28","first-page":"2768","volume":"44","author":"XH Yang","year":"2023","unstructured":"Yang XH, et al. Study on the relationship between peripheral blood inflammatory markers NLR, PLR, MLR, dNLR, SII and PCOS. Chin J Lab Med. 2023;44(22):2768\u201372.","journal-title":"Chin J Lab Med"}],"container-title":["BMC Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-024-03405-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12905-024-03405-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-024-03405-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T21:02:20Z","timestamp":1729198940000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcwomenshealth.biomedcentral.com\/articles\/10.1186\/s12905-024-03405-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3405"],"URL":"https:\/\/doi.org\/10.1186\/s12905-024-03405-4","relation":{},"ISSN":["1472-6874"],"issn-type":[{"value":"1472-6874","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,17]]},"assertion":[{"value":"7 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval for this study was obtained from the ethics Review Board of the First Hospital of Lanzhou University.Informed consent was waived by the institutional ethics committee of the First Hospital of Lanzhou University due to the retrospective nature of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"564"}}