{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:11:41Z","timestamp":1792800701742,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515011880, 2023A1515011688"],"award-info":[{"award-number":["2022A1515011880, 2023A1515011688"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"name":"President Foundation of Zhujiang Hospital, Southern Medical University","award":["yzjj2022ms18"],"award-info":[{"award-number":["yzjj2022ms18"]}],"id":[{"id":"https:\/\/ror.org\/01vjw4z39","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Women's Health"],"DOI":"10.1186\/s12905-025-03689-0","type":"journal-article","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T22:56:16Z","timestamp":1743980176000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Gut microbiome in patients with early-stage and late-stage endometriosis"],"prefix":"10.1186","volume":"25","author":[{"given":"Zhaoxia","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"3689_CR1","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1056\/NEJMra1810764","volume":"382","author":"KT Zondervan","year":"2020","unstructured":"Zondervan KT, Becker CM, Missmer SA, Endometriosis. N Engl J Med. 2020;382:1244\u201356.","journal-title":"N Engl J Med"},{"key":"3689_CR2","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","volume":"397","author":"HS Taylor","year":"2021","unstructured":"Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet. 2021;397:839\u201352.","journal-title":"Lancet"},{"key":"3689_CR3","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","volume":"7","author":"K Hou","year":"2022","unstructured":"Hou K, Wu Z-X, Chen X-Y, Wang J-Q, Zhang D, Xiao C, et al. Microbiota in health and diseases. Sig Transduct Target Ther. 2022;7:135.","journal-title":"Sig Transduct Target Ther"},{"key":"3689_CR4","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/s41579-021-00667-9","volume":"20","author":"MT Sorbara","year":"2022","unstructured":"Sorbara MT, Pamer EG. Microbiome-based therapeutics. Nat Rev Microbiol. 2022;20:365\u201380.","journal-title":"Nat Rev Microbiol"},{"key":"3689_CR5","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1038\/s41598-019-39700-6","volume":"9","author":"B Ata","year":"2019","unstructured":"Ata B, Yildiz S, Turkgeldi E, Brocal VP, Dinleyici EC, Moya A, et al. The endobiota study: comparison of vaginal, cervical and gut microbiota between women with stage 3\/4 endometriosis and healthy controls. Sci Rep. 2019;9:2204.","journal-title":"Sci Rep"},{"key":"3689_CR6","doi-asserted-by":"crossref","unstructured":"Akiyama K, Nishioka K, Khan KN, Tanaka Y, Mori T, Nakaya T et al. Molecular detection of microbial colonization in cervical mucus of women with and without endometriosis. Am J Reprod Immunol. 2019;82.","DOI":"10.1111\/aji.13147"},{"key":"3689_CR7","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12941-020-00356-0","volume":"19","author":"W Wei","year":"2020","unstructured":"Wei W, Zhang X, Tang H, Zeng L, Wu R. Microbiota composition and distribution along the female reproductive tract of women with endometriosis. Ann Clin Microbiol Antimicrob. 2020;19:15.","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"3689_CR8","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1007\/s43032-019-00113-5","volume":"27","author":"AR Perrotta","year":"2020","unstructured":"Perrotta AR, Borrelli GM, Martins CO, Kallas EG, Sanabani SS, Griffith LG, et al. The vaginal Microbiome as a tool to predict rASRM stage of disease in endometriosis: a pilot study. Reprod Sci. 2020;27:1064\u201373.","journal-title":"Reprod Sci"},{"key":"3689_CR9","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1007\/s43032-021-00506-5","volume":"28","author":"A Svensson","year":"2021","unstructured":"Svensson A, Brunkwall L, Roth B, Orho-Melander M, Ohlsson B. Associations between endometriosis and gut microbiota. Reprod Sci. 2021;28:2367\u201377.","journal-title":"Reprod Sci"},{"key":"3689_CR10","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/s41467-017-00901-0","volume":"8","author":"C Chen","year":"2017","unstructured":"Chen C, Song X, Wei W, Zhong H, Dai J, Lan Z, et al. The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. Nat Commun. 2017;8:875.","journal-title":"Nat Commun"},{"key":"3689_CR11","doi-asserted-by":"publisher","first-page":"788836","DOI":"10.3389\/fcimb.2021.788836","volume":"11","author":"L Huang","year":"2021","unstructured":"Huang L, Liu B, Liu Z, Feng W, Liu M, Wang Y, et al. Gut microbiota exceeds cervical microbiota for early diagnosis of endometriosis. Front Cell Infect Microbiol. 2021;11:788836.","journal-title":"Front Cell Infect Microbiol"},{"key":"3689_CR12","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1093\/humrep\/dez041","volume":"34","author":"SB Chadchan","year":"2019","unstructured":"Chadchan SB, Cheng M, Parnell LA, Yin Y, Schriefer A, Mysorekar IU, et al. Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota. Hum Reprod. 2019;34:1106\u201316.","journal-title":"Hum Reprod"},{"key":"3689_CR13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12958-024-01184-z","volume":"22","author":"Z Zhou","year":"2024","unstructured":"Zhou Z, Feng Y, Xie L, Ma S, Cai Z, Ma Y. Alterations in gut and genital microbiota associated with gynecological diseases: a systematic review and meta-analysis. Reprod Biol Endocrinol. 2024;22:13.","journal-title":"Reprod Biol Endocrinol"},{"key":"3689_CR14","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s42003-021-02018-z","volume":"4","author":"X-X Hou","year":"2021","unstructured":"Hou X-X, Wang X-Q, Zhou W-J, Li D-J. Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu. Commun Biol. 2021;4:499.","journal-title":"Commun Biol"},{"key":"3689_CR15","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/s41598-019-57207-y","volume":"10","author":"OB Poli-Neto","year":"2020","unstructured":"Poli-Neto OB, Meola J, Rosa-e-Silva JC, Tiezzi D. Transcriptome meta-analysis reveals differences of immune profile between eutopic endometrium from stage I-II and III-IV endometriosis independently of hormonal milieu. Sci Rep. 2020;10:313.","journal-title":"Sci Rep"},{"key":"3689_CR16","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1080\/09513590.2019.1683821","volume":"36","author":"AS Lagan\u00e0","year":"2020","unstructured":"Lagan\u00e0 AS, Salmeri FM, Ban Frange\u017e H, Ghezzi F, Vrta\u010dnik-Bokal E, Granese R. Evaluation of M1 and M2 macrophages in ovarian endometriomas from women affected by endometriosis at different stages of the disease. Gynecol Endocrinol. 2020;36:441\u20134.","journal-title":"Gynecol Endocrinol"},{"key":"3689_CR17","doi-asserted-by":"publisher","first-page":"4715","DOI":"10.1210\/jc.2019-00350","volume":"104","author":"KN Khan","year":"2019","unstructured":"Khan KN, Yamamoto K, Fujishita A, Muto H, Koshiba A, Kuroboshi H, et al. Differential levels of regulatory T cells and T-Helper-17 cells in women with early and advanced endometriosis. J Clin Endocrinol Metabolism. 2019;104:4715\u201329.","journal-title":"J Clin Endocrinol Metabolism"},{"key":"3689_CR18","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.fertnstert.2003.07.037","volume":"81","author":"KN Khan","year":"2004","unstructured":"Khan KN, Masuzaki H, Fujishita A, Kitajima M, Sekine I, Ishimaru T. Differential macrophage infiltration in early and advanced endometriosis and adjacent peritoneum. Fertil Steril. 2004;81:652\u201361.","journal-title":"Fertil Steril"},{"key":"3689_CR19","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1093\/biolre\/iox132","volume":"97","author":"KN Dodds","year":"2017","unstructured":"Dodds KN, Beckett EAH, Evans SF, Hutchinson MR. Lesion development is modulated by the natural estrous cycle and mouse strain in a minimally invasive model of endometriosis\u2020. Biol Reprod. 2017;97:810\u201321.","journal-title":"Biol Reprod"},{"key":"3689_CR20","doi-asserted-by":"publisher","first-page":"e2666","DOI":"10.1038\/cddis.2017.95","volume":"8","author":"K-K Chang","year":"2017","unstructured":"Chang K-K, Liu L-B, Jin L-P, Zhang B, Mei J, Li H, et al. IL-27 triggers IL-10 production in Th17 cells via a c-Maf\/ROR\u03b3t\/Blimp-1 signal to promote the progression of endometriosis. Cell Death Dis. 2017;8:e2666\u20132666.","journal-title":"Cell Death Dis"},{"key":"3689_CR21","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.bbi.2022.06.002","volume":"104","author":"V Caputi","year":"2022","unstructured":"Caputi V, Bastiaanssen TFS, Peterson V, Sajjad J, Murphy A, Stanton C, et al. Sex, pain, and the microbiome: the relationship between baseline gut microbiota composition, gender and somatic pain in healthy individuals. Brain Behav Immun. 2022;104:191\u2013204.","journal-title":"Brain Behav Immun"},{"key":"3689_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-023-00777-3","author":"NT Fiore","year":"2023","unstructured":"Fiore NT, Debs SR, Hayes JP, Duffy SS, Moalem-Taylor G. Pain-resolving immune mechanisms in neuropathic pain. Nat Rev Neurol. 2023. https:\/\/doi.org\/10.1038\/s41582-023-00777-3.","journal-title":"Nat Rev Neurol"},{"key":"3689_CR23","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/s41579-018-0029-9","volume":"16","author":"R Knight","year":"2018","unstructured":"Knight R, Vrbanac A, Taylor BC, Aksenov A, Callewaert C, Debelius J, et al. Best practices for analysing microbiomes. Nat Rev Microbiol. 2018;16:410\u201322.","journal-title":"Nat Rev Microbiol"},{"key":"3689_CR24","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","volume":"37","author":"E Bolyen","year":"2019","unstructured":"Bolyen E, Rideout JR, Dillon MR, Bokulich NA, Abnet CC, Al-Ghalith GA, et al. Reproducible, interactive, scalable and extensible Microbiome data science using QIIME 2. Nat Biotechnol. 2019;37:852\u20137.","journal-title":"Nat Biotechnol"},{"key":"3689_CR25","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41587-020-0550-z","volume":"38","author":"MD Gavin","year":"2020","unstructured":"Gavin MD, Vincent JM, Jesse RZ, Svetlana NY, James RB, Christopher MT, et al. PICRUSt2 for prediction of metagenome functions. Nat Biotechnol. 2020;38:669\u201373.","journal-title":"Nat Biotechnol"},{"key":"3689_CR26","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","volume":"13","author":"BJ Callahan","year":"2016","unstructured":"Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJA, Holmes SP. DADA2: High-resolution sample inference from illumina amplicon data. Nat Methods. 2016;13:581\u20133.","journal-title":"Nat Methods"},{"key":"3689_CR27","doi-asserted-by":"publisher","first-page":"D590","DOI":"10.1093\/nar\/gks1219","volume":"41","author":"C Quast","year":"2012","unstructured":"Quast C, Pruesse E, Yilmaz P, Gerken J, Schweer T, Yarza P, et al. The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Nucleic Acids Res. 2012;41:D590\u20136.","journal-title":"Nucleic Acids Res"},{"key":"3689_CR28","doi-asserted-by":"publisher","first-page":"803627","DOI":"10.3389\/fgene.2021.803627","volume":"12","author":"B Liu","year":"2022","unstructured":"Liu B, Huang L, Liu Z, Pan X, Cui Z, Pan J, et al. EasyMicroPlot: an efficient and convenient R package in Microbiome downstream analysis and visualization for clinical study. Front Genet. 2022;12:803627.","journal-title":"Front Genet"},{"key":"3689_CR29","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1126\/science.aan4834","volume":"357","author":"SA Smits","year":"2017","unstructured":"Smits SA, Leach J, Sonnenburg ED, Gonzalez CG, Lichtman JS, Reid G, et al. Seasonal cycling in the gut Microbiome of the Hadza hunter-gatherers of Tanzania. Science. 2017;357:802\u20136.","journal-title":"Science"},{"key":"3689_CR30","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41591-020-01183-8","volume":"27","author":"F Asnicar","year":"2021","unstructured":"Asnicar F, Berry SE, Valdes AM, Nguyen LH, Piccinno G, Drew DA, et al. Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals. Nat Med. 2021;27:321\u201332.","journal-title":"Nat Med"},{"key":"3689_CR31","doi-asserted-by":"publisher","first-page":"e0261362","DOI":"10.1371\/journal.pone.0261362","volume":"16","author":"N Le","year":"2021","unstructured":"Le N, Cregger M, Brown V, Loret de Mola J, Bremer P, Nguyen L, et al. Association of microbial dynamics with urinary Estrogens and Estrogen metabolites in patients with endometriosis. PLoS ONE. 2021;16:e0261362.","journal-title":"PLoS ONE"},{"key":"3689_CR32","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3390\/diagnostics10030163","volume":"10","author":"C Hernandes","year":"2020","unstructured":"Hernandes C, Silveira P, Rodrigues Sereia AF, Christoff AP, Mendes H, de Valter LF, et al. Microbiome profile of deep endometriosis patients: comparison of vaginal fluid, endometrium and lesion. Diagnostics. 2020;10:163.","journal-title":"Diagnostics"},{"key":"3689_CR33","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s00404-021-06057-z","volume":"304","author":"J Shan","year":"2021","unstructured":"Shan J, Ni Z, Cheng W, Zhou L, Zhai D, Sun S, et al. Gut microbiota imbalance and its correlations with hormone and inflammatory factors in patients with stage 3\/4 endometriosis. Arch Gynecol Obstet. 2021;304:1363\u201373.","journal-title":"Arch Gynecol Obstet"},{"key":"3689_CR34","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ejogrb.2016.01.040","volume":"199","author":"KN Khan","year":"2016","unstructured":"Khan KN, Fujishita A, Masumoto H, Muto H, Kitajima M, Masuzaki H, et al. Molecular detection of intrauterine microbial colonization in women with endometriosis. Eur J Obstet Gynecol Reproductive Biology. 2016;199:69\u201375.","journal-title":"Eur J Obstet Gynecol Reproductive Biology"},{"key":"3689_CR35","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1007\/s00404-021-06338-7","volume":"305","author":"W Yuan","year":"2022","unstructured":"Yuan W, Wu Y, Chai X, Wu X. The colonized microbiota composition in the peritoneal fluid in women with endometriosis. Arch Gynecol Obstet. 2022;305:1573\u201380.","journal-title":"Arch Gynecol Obstet"},{"key":"3689_CR36","doi-asserted-by":"publisher","first-page":"104085","DOI":"10.1016\/j.ebiom.2022.104085","volume":"81","author":"Y Ma","year":"2022","unstructured":"Ma Y, Liu X, Wang J. Small molecules in the big picture of gut microbiome-host cross-talk. eBioMedicine. 2022;81:104085.","journal-title":"eBioMedicine"},{"key":"3689_CR37","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1016\/j.immuni.2023.07.011","volume":"56","author":"AJ Macpherson","year":"2023","unstructured":"Macpherson AJ, Pachnis V, Prinz M. Boundaries and integration between microbiota, the nervous system, and immunity. Immunity. 2023;56:1712\u201326.","journal-title":"Immunity"},{"key":"3689_CR38","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1016\/j.cell.2021.04.041","volume":"184","author":"PTK Saunders","year":"2021","unstructured":"Saunders PTK, Horne AW, Endometriosis. Etiology, pathobiology, and therapeutic prospects. Cell. 2021;184:2807\u201324.","journal-title":"Cell"},{"key":"3689_CR39","doi-asserted-by":"publisher","first-page":"e25887","DOI":"10.7554\/eLife.25887","volume":"6","author":"P Luczynski","year":"2017","unstructured":"Luczynski P, Tramullas M, Viola M, Shanahan F, Clarke G, O\u2019Mahony S, et al. Microbiota regulates visceral pain in the mouse. eLife. 2017;6:e25887.","journal-title":"eLife"},{"key":"3689_CR40","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.tim.2023.03.010","volume":"31","author":"S Cotton","year":"2023","unstructured":"Cotton S, Clayton CA, Tropini C. Microbial endocrinology: the mechanisms by which the microbiota influences host sex steroids. Trends Microbiol. 2023;31:1131\u201342.","journal-title":"Trends Microbiol"},{"key":"3689_CR41","doi-asserted-by":"publisher","first-page":"18586","DOI":"10.1074\/jbc.RA119.010950","volume":"294","author":"SM Ervin","year":"2019","unstructured":"Ervin SM, Li H, Lim L, Roberts LR, Liang X, Mani S, et al. Gut microbial \u03b2-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens. J Biol Chem. 2019;294:18586\u201399.","journal-title":"J Biol Chem"},{"key":"3689_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aninu.2020.11.005","volume":"7","author":"T Hussain","year":"2021","unstructured":"Hussain T, Murtaza G, Kalhoro DH, Kalhoro MS, Metwally E, Chughtai MI, et al. Relationship between gut microbiota and host-metabolism: emphasis on hormones related to reproductive function. Anim Nutr. 2021;7:1\u201310.","journal-title":"Anim Nutr"},{"key":"3689_CR43","volume-title":"Microbial endocrinology","year":"2010","unstructured":"Lyte M, Freestone PPE, editors. Microbial endocrinology. New York, NY: Springer New York; 2010."},{"key":"3689_CR44","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/S0022-2275(20)37722-1","volume":"25","author":"J Winter","year":"1984","unstructured":"Winter J, Morris GN, O\u2019Rourke-Locascio S, Bokkenheuser VD, Mosbach EH, Cohen BI, et al. Mode of action of steroid desmolase and reductases synthesized by clostridium Scindens (formerly clostridium strain 19). J Lipid Res. 1984;25:1124\u201331.","journal-title":"J Lipid Res"},{"key":"3689_CR45","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1128\/iai.35.1.256-263.1982","volume":"35","author":"KS Kornman","year":"1982","unstructured":"Kornman KS, Loesche WJ. Effects of estradiol and progesterone on bacteroides melaninogenicus and bacteroides gingivalis. Infect Immun. 1982;35:256\u201363.","journal-title":"Infect Immun"},{"key":"3689_CR46","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.1432-1033.1969.tb00607.x","volume":"9","author":"H Eriksson","year":"1969","unstructured":"Eriksson H, Gustafsson J-\u00c5, Sj\u00f6vall J. Steroids in germfree and conventional rats: free steroids in faeces from conventional rats. Eur J Biochem. 1969;9:286\u201390.","journal-title":"Eur J Biochem"},{"key":"3689_CR47","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/dev.21827","volume":"61","author":"I Kamimura","year":"2019","unstructured":"Kamimura I, Watarai A, Takamura T, Takeo A, Miura K, Morita H, et al. Gonadal steroid hormone secretion during the juvenile period depends on host-specific microbiota and contributes to the development of odor preference. Dev Psychobiol. 2019;61:670\u20138.","journal-title":"Dev Psychobiol"},{"key":"3689_CR48","doi-asserted-by":"publisher","first-page":"G816","DOI":"10.1152\/ajpgi.00026.2020","volume":"318","author":"J Walsh","year":"2020","unstructured":"Walsh J, Olavarria-Ramirez L, Lach G, Boehme M, Dinan TG, Cryan JF, et al. Impact of host and environmental factors on \u03b2-glucuronidase enzymatic activity: implications for Gastrointestinal serotonin. Am J Physiology-Gastrointestinal Liver Physiol. 2020;318:G816\u201326.","journal-title":"Am J Physiology-Gastrointestinal Liver Physiol"},{"key":"3689_CR49","doi-asserted-by":"publisher","first-page":"1943289","DOI":"10.1080\/19490976.2021.1943289","volume":"13","author":"LL Blais","year":"2021","unstructured":"Blais LL, Montgomery TL, Amiel E, Deming PB, Krementsov DN. Probiotic and commensal gut microbial therapies in multiple sclerosis and its animal models: a comprehensive review. Gut Microbes. 2021;13:1943289.","journal-title":"Gut Microbes"},{"key":"3689_CR50","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1038\/s41423-021-00760-2","volume":"18","author":"X Yan","year":"2021","unstructured":"Yan X, Liu X-Y, Zhang D, Zhang Y-D, Li Z-H, Liu X, et al. Construction of a sustainable 3-hydroxybutyrate-producing probiotic Escherichia coli for treatment of colitis. Cell Mol Immunol. 2021;18:2344\u201357.","journal-title":"Cell Mol Immunol"},{"key":"3689_CR51","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/s41586-023-06409-6","volume":"620","author":"LM Sanmarco","year":"2023","unstructured":"Sanmarco LM. Lactate limits CNS autoimmunity by stabilizing HIF-1\u03b1 in dendritic cells. Nature. 2023;620:881\u20139.","journal-title":"Nature"},{"key":"3689_CR52","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1038\/s41591-021-01390-x","volume":"27","author":"BM Scott","year":"2021","unstructured":"Scott BM, Guti\u00e9rrez-V\u00e1zquez C, Sanmarco LM, Da Silva Pereira JA, Li Z, Plasencia A, et al. Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease. Nat Med. 2021;27:1212\u201322.","journal-title":"Nat Med"},{"key":"3689_CR53","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1126\/science.aao5774","volume":"359","author":"L Zhao","year":"2018","unstructured":"Zhao L, Zhang F, Ding X, Wu G, Lam YY, Wang X, et al. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science. 2018;359:1151\u20136.","journal-title":"Science"},{"key":"3689_CR54","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw029","author":"K Maryann","year":"2016","unstructured":"Maryann K, Claudia SP, Martin JB, Sylvia A. The intestinal Microbiome and Estrogen Receptor\u2013Positive female breast cancer. JNCI: J Natl Cancer Inst. 2016. https:\/\/doi.org\/10.1093\/jnci\/djw029.","journal-title":"JNCI: J Natl Cancer Inst"},{"key":"3689_CR55","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.chom.2011.10.003","volume":"10","author":"CS Plottel","year":"2011","unstructured":"Plottel CS, Blaser MJ. Microbiome and malignancy. Cell Host Microbe. 2011;10:324\u201335.","journal-title":"Cell Host Microbe"}],"container-title":["BMC Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-025-03689-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12905-025-03689-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-025-03689-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T12:23:27Z","timestamp":1744201407000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcwomenshealth.biomedcentral.com\/articles\/10.1186\/s12905-025-03689-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3689"],"URL":"https:\/\/doi.org\/10.1186\/s12905-025-03689-0","relation":{},"ISSN":["1472-6874"],"issn-type":[{"value":"1472-6874","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,7]]},"assertion":[{"value":"29 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All research-related protocols were approved by the Medical Ethics Committee of Zhujiang Hospital of Southern Medical University (2021-KY-035-02) and registered at clinicalTrials.gov (NCT05086484, Registration Date: Oct, 21, 2021). Informed consent to participate was obtained from all of the participants in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Patients included in this article agree that the relevant information included is for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"163"}}