{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T21:03:25Z","timestamp":1768424605711,"version":"3.49.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Qinghai Province Key Research and Development and Transformation Plan - Specific fund of Science and Technology Assistance to Qinghai","award":["2022-QY-216"],"award-info":[{"award-number":["2022-QY-216"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Women's Health"],"DOI":"10.1186\/s12905-025-04178-0","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T10:15:08Z","timestamp":1765448108000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vaginal microecological characterization of women of childbearing age at different altitudes: a multi-omics exploration"],"prefix":"10.1186","volume":"26","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linshen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mudan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dexiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daozhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"issue":"1","key":"4178_CR1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13073-016-0307-y","volume":"8","author":"J Lloyd-Price","year":"2016","unstructured":"Lloyd-Price J, Abu-Ali G, Huttenhower C. The healthy human microbiome. Genome Med. 2016;8(1):51.","journal-title":"Genome Med"},{"key":"4178_CR2","doi-asserted-by":"publisher","first-page":"2868","DOI":"10.3389\/fimmu.2018.02868","volume":"9","author":"MA Malla","year":"2018","unstructured":"Malla MA, Dubey A, Kumar A, Yadav S, Hashem A, Abd Allah EF. Exploring the human microbiome: the potential future role of Next-Generation sequencing in disease diagnosis and treatment. Front Immunol. 2018;9:2868.","journal-title":"Front Immunol"},{"issue":"3","key":"4178_CR3","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","volume":"76","author":"A Adak","year":"2019","unstructured":"Adak A, Khan MR. An insight into gut microbiota and its functionalities. Cell Mol Life Sci. 2019;76(3):473\u201393.","journal-title":"Cell Mol Life Sci"},{"issue":"9455","key":"4178_CR4","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0140-6736(05)70155-0","volume":"365","author":"KA Brogden","year":"2005","unstructured":"Brogden KA, Guthmiller JM, Taylor CE. Human polymicrobial infections. Lancet. 2005;365(9455):253\u20135.","journal-title":"Lancet"},{"issue":"7758","key":"4178_CR5","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/s41586-019-1238-8","volume":"569","author":"HMPRNC Integrative","year":"2019","unstructured":"Integrative HMPRNC. The integrative human microbiome project. Nature. 2019;569(7758):641\u20138.","journal-title":"Nature"},{"key":"4178_CR6","doi-asserted-by":"publisher","first-page":"1110001","DOI":"10.3389\/fimmu.2023.1110001","volume":"14","author":"K Takada","year":"2023","unstructured":"Takada K, Melnikov VG, Kobayashi R, Komine-Aizawa S, Tsuji NM, Hayakawa S. Female reproductive tract-organ axes. Front Immunol. 2023;14:1110001.","journal-title":"Front Immunol"},{"issue":"Suppl 1Suppl 1","key":"4178_CR7","doi-asserted-by":"publisher","first-page":"4680","DOI":"10.1073\/pnas.1002611107","volume":"108","author":"J Ravel","year":"2011","unstructured":"Ravel J, Gajer P, Abdo Z, Schneider GM, Koenig SS, McCulle SL, Karlebach S, Gorle R, Russell J, Tacket CO, et al. Vaginal Microbiome of reproductive-age women. Proc Natl Acad Sci U S A. 2011;108(Suppl 1Suppl 1):4680\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4178_CR8","doi-asserted-by":"publisher","first-page":"857299","DOI":"10.3389\/fimmu.2022.857299","volume":"13","author":"Y Wang","year":"2022","unstructured":"Wang Y, Wang X, Zhu M, Ge L, Liu X, Su K, Chen Z, Zhao W. The interplay between cervicovaginal microbial dysbiosis and cervicovaginal immunity. Front Immunol. 2022;13:857299.","journal-title":"Front Immunol"},{"issue":"4","key":"4178_CR9","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/s41585-020-0286-z","volume":"17","author":"P Laniewski","year":"2020","unstructured":"Laniewski P, Ilhan ZE, Herbst-Kralovetz MM. The microbiome and gynaecological cancer development, prevention and therapy. Nat Rev Urol. 2020;17(4):232\u201350.","journal-title":"Nat Rev Urol"},{"key":"4178_CR10","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3389\/fcimb.2020.00467","volume":"10","author":"Y Moosa","year":"2020","unstructured":"Moosa Y, Kwon D, de Oliveira T, Wong EB. Determinants of vaginal microbiota composition. Front Cell Infect Microbiol. 2020;10:467.","journal-title":"Front Cell Infect Microbiol"},{"key":"4178_CR11","doi-asserted-by":"publisher","first-page":"949002","DOI":"10.3389\/fmicb.2022.949002","volume":"13","author":"H Liu","year":"2022","unstructured":"Liu H, Han X, Zhao N, Hu L, Wang X, Luo C, et al. The gut microbiota determines the High-Altitude adaptability of Tibetan wild asses (Equus kiang) in Qinghai-Tibet plateau. Front Microbiol. 2022;13:949002.","journal-title":"Front Microbiol"},{"key":"4178_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01929","volume":"8","author":"B Zeng","year":"2017","unstructured":"Zeng B, Zhao J, Guo W, Zhang S, Hua Y, Tang J, et al. High-altitude living shapes the skin microbiome in humans and pigs. Front Microbiol. 2017;8:1929.","journal-title":"Front Microbiol"},{"issue":"1","key":"4178_CR13","doi-asserted-by":"publisher","first-page":"4038","DOI":"10.1038\/s41598-023-30963-8","volume":"13","author":"M Kumari","year":"2023","unstructured":"Kumari M, Bhushan B, Eslavath MR, Srivastava AK, Meena RC, Varshney R, et al. Impact of high altitude on composition and functional profiling of oral microbiome in Indian male population. Sci Rep. 2023;13(1):4038.","journal-title":"Sci Rep"},{"issue":"6","key":"4178_CR14","doi-asserted-by":"publisher","first-page":"G1003","DOI":"10.1152\/ajpgi.00253.2018","volume":"315","author":"JP Karl","year":"2018","unstructured":"Karl JP, Berryman CE, Young AJ, Radcliffe PN, Branck TA, Pantoja-Feliciano IG, Rood JC, Pasiakos SM. Associations between the gut microbiota and host responses to high altitude. Am J Physiol Gastrointest Liver Physiol. 2018;315(6):G1003\u201315.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"17","key":"4178_CR15","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.1007\/s00018-019-03122-4","volume":"76","author":"AK Yadav","year":"2019","unstructured":"Yadav AK, Yadav PK, Chaudhary GR, Tiwari M, Gupta A, Sharma A, Pandey AN, Pandey AK, Chaube SK. Autophagy in hypoxic ovary. Cell Mol Life Sci. 2019;76(17):3311\u201322.","journal-title":"Cell Mol Life Sci"},{"key":"4178_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2020.05.002","volume":"486","author":"Q Xiong","year":"2020","unstructured":"Xiong Q, Liu B, Ding M, Zhou J, Yang C, Chen Y. Hypoxia and cancer related pathology. Cancer Lett. 2020;486:1\u20137.","journal-title":"Cancer Lett"},{"issue":"8","key":"4178_CR17","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1111\/cns.13849","volume":"28","author":"X Wang","year":"2022","unstructured":"Wang X, Sun H, Cui L, Wang X, Ren C, Tong Z, Ji X. Acute high-altitude hypoxia exposure causes neurological deficits via formaldehyde accumulation. CNS Neurosci Ther. 2022;28(8):1183\u201394.","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"4178_CR18","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12929-020-00658-7","volume":"27","author":"PS Chen","year":"2020","unstructured":"Chen PS, Chiu WT, Hsu PL, Lin SC, Peng IC, Wang CY, Tsai SJ. Pathophysiological implications of hypoxia in human diseases. J Biomed Sci. 2020;27(1):63.","journal-title":"J Biomed Sci"},{"issue":"6","key":"4178_CR19","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1007\/s00404-023-07014-8","volume":"307","author":"Z Xiong","year":"2023","unstructured":"Xiong Z, Liu X, Wang Q, Ji B, Jia J. Effects of high-altitude hypoxia on embryonic developmental potential in women undergoing IVF\/ICSI procedures. Arch Gynecol Obstet. 2023;307(6):1983\u20139.","journal-title":"Arch Gynecol Obstet"},{"issue":"41","key":"4178_CR20","doi-asserted-by":"publisher","first-page":"e34989","DOI":"10.1097\/MD.0000000000034989","volume":"102","author":"YX Zhou","year":"2023","unstructured":"Zhou YX, Wang L, Wang TT, Qu XL, Zhang XQ. Analysis of HPV prevalence among individuals with reproductive tract infections in a Chinese population. Med (Baltim). 2023;102(41):e34989.","journal-title":"Med (Baltim)"},{"issue":"6","key":"4178_CR21","doi-asserted-by":"publisher","first-page":"e807","DOI":"10.1016\/S2214-109X(22)00093-6","volume":"10","author":"BP Goncalves","year":"2022","unstructured":"Goncalves BP, Procter SR, Paul P, Chandna J, Lewin A, Seedat F, Koukounari A, Dangor Z, Leahy S, Santhanam S, et al. Group B Streptococcus infection during pregnancy and infancy: estimates of regional and global burden. Lancet Glob Health. 2022;10(6):e807\u201319.","journal-title":"Lancet Glob Health"},{"issue":"1","key":"4178_CR22","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1038\/s41467-024-45336-6","volume":"15","author":"V Mercado-Evans","year":"2024","unstructured":"Mercado-Evans V, Mejia ME, Zulk JJ, Ottinger S, Hameed ZA, Serchejian C, Marunde MG, Robertson CM, Ballard MB, Ruano SH, et al. Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota. Nat Commun. 2024;15(1):1035.","journal-title":"Nat Commun"},{"key":"4178_CR23","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.3389\/fmicb.2017.01162","volume":"8","author":"VK Gupta","year":"2017","unstructured":"Gupta VK, Paul S, Dutta C. Geography, ethnicity or subsistence-specific variations in human microbiome composition and diversity. Front Microbiol. 2017;8:1162.","journal-title":"Front Microbiol"},{"key":"4178_CR24","doi-asserted-by":"publisher","first-page":"631972","DOI":"10.3389\/fcimb.2021.631972","volume":"11","author":"X Chen","year":"2021","unstructured":"Chen X, Lu Y, Chen T, Li R. The female vaginal microbiome in health and bacterial vaginosis. Front Cell Infect Microbiol. 2021;11:631972.","journal-title":"Front Cell Infect Microbiol"},{"key":"4178_CR25","doi-asserted-by":"publisher","first-page":"919728","DOI":"10.3389\/fimmu.2022.919728","volume":"13","author":"MS Kwon","year":"2022","unstructured":"Kwon MS, Lee HK. Host and microbiome interplay shapes the vaginal microenvironment. Front Immunol. 2022;13:919728.","journal-title":"Front Immunol"},{"issue":"1","key":"4178_CR26","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/s12866-021-02300-4","volume":"21","author":"L Cheng","year":"2021","unstructured":"Cheng L, Gao Y, Xia Q, Wang H, Xie X, Liu Y, Shang H, Diao Y. Reproductive tract microbiota of women in childbearing age shifts upon gynecological infections and menstrual cycle. BMC Microbiol. 2021;21(1):252.","journal-title":"BMC Microbiol"},{"key":"4178_CR27","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20201766","author":"D Li","year":"2020","unstructured":"Li D, Chi XZ, Zhang L, Chen R, Cao JR, Sun XY, et al. Vaginal microbiome analysis of healthy women during different periods of gestation. Biosci Rep. 2020. https:\/\/doi.org\/10.1042\/BSR20201766.","journal-title":"Biosci Rep"},{"key":"4178_CR28","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01851-20","author":"A Oliver","year":"2020","unstructured":"Oliver A, LaMere B, Weihe C, Wandro S, Lindsay KL, Wadhwa PD, et al. Cervicovaginal microbiome composition is associated with metabolic profiles in healthy pregnancy. mBio. 2020. https:\/\/doi.org\/10.1128\/mBio.01851-20.","journal-title":"mBio"},{"key":"4178_CR29","doi-asserted-by":"publisher","first-page":"e15537","DOI":"10.7717\/peerj.15537","volume":"11","author":"Q Zhou","year":"2023","unstructured":"Zhou Q, Chen Y, Liu G, Qiao P, Tang C. A preliminary study of the salivary microbiota of young male subjects before, during, and after acute high-altitude exposure. PeerJ. 2023;11:e15537.","journal-title":"PeerJ"},{"issue":"1","key":"4178_CR30","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13568-021-01200-0","volume":"11","author":"F Liu","year":"2021","unstructured":"Liu F, Liang T, Zhang Z, Liu L, Li J, Dong W, Zhang H, Bai S, Ma L, Kang L. Effects of altitude on human oral microbes. AMB Express. 2021;11(1):41.","journal-title":"AMB Express"},{"issue":"1","key":"4178_CR31","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1021\/acs.chemrev.2c00431","volume":"123","author":"N Aggarwal","year":"2023","unstructured":"Aggarwal N, Kitano S, Puah GRY, Kittelmann S, Hwang IY, Chang MW. Microbiome and human health: current understanding, engineering, and enabling technologies. Chem Rev. 2023;123(1):31\u201372.","journal-title":"Chem Rev"},{"issue":"12","key":"4178_CR32","doi-asserted-by":"publisher","first-page":"7341","DOI":"10.1111\/1462-2920.15722","volume":"23","author":"S Mills","year":"2021","unstructured":"Mills S, Ross RP. Colliding and interacting microbiomes and microbial communities - consequences for human health. Environ Microbiol. 2021;23(12):7341\u201354.","journal-title":"Environ Microbiol"},{"key":"4178_CR33","doi-asserted-by":"publisher","first-page":"1055632","DOI":"10.3389\/fmicb.2022.1055632","volume":"13","author":"J Lv","year":"2022","unstructured":"Lv J, Qi P, Bai LH, Yan XD, Zhang L. Review of the relationship and underlying mechanisms between the Qinghai-Tibet plateau and host intestinal flora. Front Microbiol. 2022;13:1055632.","journal-title":"Front Microbiol"},{"issue":"6 Suppl","key":"4178_CR34","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1378\/chest.09-2445","volume":"137","author":"MA Pasha","year":"2010","unstructured":"Pasha MA, Newman JH. High-altitude disorders: pulmonary hypertension: pulmonary vascular disease: the global perspective. Chest. 2010;137(6 Suppl):S13\u20139.","journal-title":"Chest"},{"issue":"9","key":"4178_CR35","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1111\/mec.14905","volume":"28","author":"TA Suzuki","year":"2019","unstructured":"Suzuki TA, Martins FM, Nachman MW. Altitudinal variation of the gut microbiota in wild house mice. Mol Ecol. 2019;28(9):2378\u201390.","journal-title":"Mol Ecol"},{"issue":"1","key":"4178_CR36","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1186\/s12879-021-06355-6","volume":"21","author":"Y Huang","year":"2021","unstructured":"Huang Y, Pan H, Xu X, Lv P, Wang X, Zhao Z. Droplet digital PCR (ddPCR) for the detection and quantification of Ureaplasma spp. BMC Infect Dis. 2021;21(1):804.","journal-title":"BMC Infect Dis"},{"issue":"1","key":"4178_CR37","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1186\/s12879-020-05324-9","volume":"20","author":"Y Chen","year":"2020","unstructured":"Chen Y, Qiu X, Wang W, Li D, Wu A, Hong Z, et al. Human papillomavirus infection and cervical intraepithelial neoplasia progression are associated with increased vaginal microbiome diversity in a Chinese cohort. BMC Infect Dis. 2020;20(1):629.","journal-title":"BMC Infect Dis"},{"issue":"1","key":"4178_CR38","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41522-022-00270-7","volume":"8","author":"KV Lithgow","year":"2022","unstructured":"Lithgow KV, Buchholz VCH, Ku E, Konschuh S, D\u2019Aubeterre A, Sycuro LK. Protease activities of vaginal Porphyromonas species disrupt coagulation and extracellular matrix in the cervicovaginal niche. NPJ Biofilms Microbiomes. 2022;8(1):8.","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"5","key":"4178_CR39","doi-asserted-by":"publisher","first-page":"e0155863","DOI":"10.1371\/journal.pone.0155863","volume":"11","author":"K Li","year":"2016","unstructured":"Li K, Dan Z, Gesang L, Wang H, Zhou Y, Du Y, et al. Comparative analysis of gut microbiota of native Tibetan and Han populations living at different altitudes. PLoS One. 2016;11(5):e0155863.","journal-title":"PLoS One"},{"issue":"37","key":"4178_CR40","first-page":"2928","volume":"97","author":"KL Zhai","year":"2017","unstructured":"Zhai KL, Zhuo G, Chi HB, Lan Z. [Comparisons of prevalence and clinical and environmental characteristics between Tibetan and Han women with polycystic ovarian syndrome in Tibetan Plateau]. Zhonghua Yi Xue Za Zhi. 2017;97(37):2928\u201331.","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"4178_CR41","doi-asserted-by":"publisher","first-page":"1251440","DOI":"10.3389\/fpubh.2023.1251440","volume":"11","author":"J Li","year":"2023","unstructured":"Li J, Li X, Sheng X. Four-year analysis of high-risk human papillomavirus infection among women in rural areas of Nyingchi City, Tibet. Front Public Health. 2023;11:1251440.","journal-title":"Front Public Health"},{"key":"4178_CR42","doi-asserted-by":"publisher","first-page":"126447","DOI":"10.1016\/j.micres.2020.126447","volume":"235","author":"B Zeng","year":"2020","unstructured":"Zeng B, Zhang S, Xu H, Kong F, Yu X, Wang P, Yang M, Li D, Zhang M, Ni Q, et al. Gut microbiota of Tibetans and Tibetan pigs varies between high and low altitude environments. Microbiol Res. 2020;235:126447.","journal-title":"Microbiol Res"},{"issue":"3","key":"4178_CR43","doi-asserted-by":"publisher","first-page":"e0282301","DOI":"10.1371\/journal.pone.0282301","volume":"18","author":"J Gao","year":"2023","unstructured":"Gao J, Zhao M, Cheng X, Yue X, Hao F, Wang H, et al. Metabolomic analysis of human plasma sample after exposed to high altitude and return to sea level. PLoS One. 2023;18(3):e0282301.","journal-title":"PLoS One"},{"key":"4178_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/biom13091361","author":"AN Vaganova","year":"2023","unstructured":"Vaganova AN, Maslennikova DD, Konstantinova VV, Kanov EV, Gainetdinov RR. The expression of trace amine-associated receptors (TAARs) in breast cancer is coincident with the expression of neuroactive ligand-receptor systems and depends on tumor intrinsic subtype. Biomolecules. 2023. https:\/\/doi.org\/10.3390\/biom13091361.","journal-title":"Biomolecules"},{"key":"4178_CR45","doi-asserted-by":"publisher","first-page":"114570","DOI":"10.1016\/j.biopha.2023.114570","volume":"161","author":"S Zhang","year":"2023","unstructured":"Zhang S, Wang X, Yang Q, Xia Q, Zhao Y, Zheng X, Zhang Y, Liu K. Isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate plays an anti-hypoxic role through regulating neuroactive ligand-receptor interaction signaling pathway in larval zebrafish. Biomed Pharmacother. 2023;161:114570.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"4178_CR46","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.cmet.2020.04.018","volume":"32","author":"MA Aon","year":"2020","unstructured":"Aon MA, Bernier M, Mitchell SJ, Di Germanio C, Mattison JA, Ehrlich MR, Colman RJ, Anderson RM, de Cabo R. Untangling determinants of enhanced health and lifespan through a Multi-omics approach in mice. Cell Metab. 2020;32(1):100\u2013e116104.","journal-title":"Cell Metab"},{"issue":"5","key":"4178_CR47","doi-asserted-by":"publisher","first-page":"100213","DOI":"10.1016\/j.animal.2021.100213","volume":"15","author":"J van Milgen","year":"2021","unstructured":"van Milgen J. The role of energy, serine, glycine, and 1-carbon units in the cost of nitrogen excretion in mammals and birds. Animal. 2021;15(5):100213.","journal-title":"Animal"},{"key":"4178_CR48","doi-asserted-by":"publisher","DOI":"10.3390\/nu13082592","author":"Q Tang","year":"2021","unstructured":"Tang Q, Tan P, Ma N, Ma X. Physiological functions of threonine in animals: beyond nutrition metabolism. Nutrients. 2021. https:\/\/doi.org\/10.3390\/nu13082592.","journal-title":"Nutrients"},{"issue":"11","key":"4178_CR49","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.4103\/1673-5374.335829","volume":"17","author":"YL Zhang","year":"2022","unstructured":"Zhang YL, Wang J, Zhang ZN, Su Q, Guo JH. The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer\u2019s disease. Neural Regen Res. 2022;17(11):2355\u201363.","journal-title":"Neural Regen Res"},{"key":"4178_CR50","doi-asserted-by":"crossref","unstructured":"Milovic E, Jankovic N, Petronijevic J, Joksimovic N, Kosanic M, Stanojkovic T, et al. Synthesis, characterization, and biological evaluation of tetrahydropyrimidines: dual-activity and mechanism of action. Pharmaceutics. 2022;14(10):2254.","DOI":"10.3390\/pharmaceutics14102254"},{"key":"4178_CR51","doi-asserted-by":"publisher","first-page":"856699","DOI":"10.3389\/fphys.2022.856699","volume":"13","author":"X Qin","year":"2022","unstructured":"Qin X, Liu B, Gao F, Hu Y, Chen Z, Xu J, Zhang X. Gluconolactone alleviates myocardial Ischemia\/Reperfusion injury and arrhythmias via activating PKCepsilon\/Extracellular Signal-Regulated kinase signaling. Front Physiol. 2022;13:856699.","journal-title":"Front Physiol"},{"issue":"1","key":"4178_CR52","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/nyas.14536","volume":"1498","author":"TJ Smith","year":"2021","unstructured":"Smith TJ, Johnson CR, Koshy R, Hess SY, Qureshi UA, Mynak ML, Fischer PR. Thiamine deficiency disorders: a clinical perspective. Ann N Y Acad Sci. 2021;1498(1):9\u201328.","journal-title":"Ann N Y Acad Sci"},{"issue":"11","key":"4178_CR53","doi-asserted-by":"publisher","first-page":"6307","DOI":"10.1007\/s12035-023-03464-y","volume":"60","author":"X Yang","year":"2023","unstructured":"Yang X, Yang Y, Gao F, Lu K, Wang C. N-acetyl serotonin provides neuroprotective effects by inhibiting ferroptosis in the neonatal rat hippocampus following hypoxic brain injury. Mol Neurobiol. 2023;60(11):6307\u201315.","journal-title":"Mol Neurobiol"}],"container-title":["BMC Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-025-04178-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12905-025-04178-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-025-04178-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T12:05:49Z","timestamp":1768392349000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12905-025-04178-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,11]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4178"],"URL":"https:\/\/doi.org\/10.1186\/s12905-025-04178-0","relation":{},"ISSN":["1472-6874"],"issn-type":[{"value":"1472-6874","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,11]]},"assertion":[{"value":"29 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of the Second People\u2019s Hospital of Haidong City and the participating units (Approval No.: 2021-05-21-006), and written informed consent was obtained from each subject. The study was registered with the China Clinical Trial Registry (registration number: ChiCTR2300076479, registration date: October 10, 2023), and all methods were performed in strict accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have read the manuscript and agreed to consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"27"}}