{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:10:32Z","timestamp":1783955432544,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Women's Health"],"DOI":"10.1186\/s12905-026-04540-w","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:13:33Z","timestamp":1778930013000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cold-knife conization versus loop electrosurgical excision for cervical adenocarcinoma in situ: a retrospective cohort study"],"prefix":"10.1186","volume":"26","author":[{"given":"Salamaiti","family":"Abudurehemu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"issue":"6","key":"4540_CR1","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1002\/ijc.25723","volume":"128","author":"KA Ault","year":"2011","unstructured":"Ault KA, Joura EA, Kjaer SK, Iversen OE, Wheeler CM, Perez G, et al. Adenocarcinoma in situ and associated human papillomavirus type distribution observed in two clinical trials of a quadrivalent human papillomavirus vaccine. Int J Cancer. 2011;128(6):1344\u201353.","journal-title":"Int J Cancer"},{"issue":"4","key":"4540_CR2","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1097\/AOG.0000000000003761","volume":"135","author":"D Teoh","year":"2020","unstructured":"Teoh D, Musa F, Salani R, Huh W, Jimenez E. Diagnosis and Management of Adenocarcinoma in Situ: A Society of Gynecologic Oncology Evidence-Based Review and Recommendations. Obstet Gynecol. 2020;135(4):869\u201378.","journal-title":"Obstet Gynecol"},{"issue":"9","key":"4540_CR3","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1097\/IGC.0000000000000260","volume":"24","author":"A Baalbergen","year":"2014","unstructured":"Baalbergen A, Helmerhorst TJ. Adenocarcinoma in situ of the uterine cervix\u2013a systematic review. Int J Gynecol Cancer. 2014;24(9):1543\u20138.","journal-title":"Int J Gynecol Cancer"},{"issue":"3","key":"4540_CR4","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.ygyno.2013.03.015","volume":"129","author":"AB Costales","year":"2013","unstructured":"Costales AB, Milbourne AM, Rhodes HE, Munsell MF, Wallbillich JJ, Brown J, et al. Risk of residual disease and invasive carcinoma in women treated for adenocarcinoma in situ of the cervix. Gynecol Oncol. 2013;129(3):513\u20136.","journal-title":"Gynecol Oncol"},{"issue":"3","key":"4540_CR5","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.ijgo.2012.06.013","volume":"119","author":"C Kietpeerakool","year":"2012","unstructured":"Kietpeerakool C, Khunamornpong S, Srisomboon J, Kasunan A, Sribanditmongkol N, Siriaungkul S. Predictive value of negative cone margin status for risk of residual disease among women with cervical adenocarcinoma in situ. Int J Gynaecol Obstet. 2012;119(3):266\u20139.","journal-title":"Int J Gynaecol Obstet"},{"issue":"2","key":"4540_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1097\/LGT.0000000000000055","volume":"19","author":"NA Latif","year":"2015","unstructured":"Latif NA, Neubauer NL, Helenowski IB, Lurain JR. Management of adenocarcinoma in situ of the uterine cervix: a comparison of loop electrosurgical excision procedure and cold knife conization. J Low Genit Tract Dis. 2015;19(2):97\u2013102.","journal-title":"J Low Genit Tract Dis"},{"issue":"1","key":"4540_CR7","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ygyno.2011.09.006","volume":"124","author":"N van Hanegem","year":"2012","unstructured":"van Hanegem N, Barroilhet LM, Nucci MR, Bernstein M, Feldman S. Fertility-sparing treatment in younger women with adenocarcinoma in situ of the cervix. Gynecol Oncol. 2012;124(1):72\u20137.","journal-title":"Gynecol Oncol"},{"issue":"2","key":"4540_CR8","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1097\/LGT.0000000000000525","volume":"24","author":"RB Perkins","year":"2020","unstructured":"Perkins RB, Guido RS, Castle PE, Chelmow D, Einstein MH, Garcia F, et al. 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors. J Low Genit Tract Dis. 2020;24(2):102\u201331.","journal-title":"J Low Genit Tract Dis"},{"issue":"16","key":"4540_CR9","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1001\/jama.287.16.2120","volume":"287","author":"TC Wright Jr","year":"2002","unstructured":"Wright TC Jr, Cox JT, Massad LS, Twiggs LB, Wilkinson EJ. 2001 Consensus Guidelines for the management of women with cervical cytological abnormalities. JAMA. 2002;287(16):2120\u20139.","journal-title":"JAMA"},{"issue":"9","key":"4540_CR10","doi-asserted-by":"publisher","first-page":"102826","DOI":"10.1016\/j.jogoh.2024.102826","volume":"53","author":"M Le Gac","year":"2024","unstructured":"Le Gac M, Benoit L, Koual M, Bentivegna E, Bolze PA, Kerbage Y, Raimond E, Lecointre L, Carcopino X, Canlorbe G, Philip CA, Nguyen-Xuan HT, Bats AS, Aza\u00efs H. Exploring uterine involvement in hysterectomy samples following conization for adenocarcinoma in situ of the uterine cervix: Insights from a multicenter study by the FRANCOGYN group. J Gynecol Obstet Hum Reprod. 2024;53(9):102826.","journal-title":"J Gynecol Obstet Hum Reprod"},{"issue":"2","key":"4540_CR11","doi-asserted-by":"publisher","first-page":"e1821","DOI":"10.1016\/j.ajog.2008.09.012","volume":"200","author":"R Salani","year":"2009","unstructured":"Salani R, Puri I, Bristow RE. Adenocarcinoma in situ of the uterine cervix: a metaanalysis of 1278 patients evaluating the predictive value of conization margin status. Am J Obstet Gynecol. 2009;200(2):e1821\u20135.","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"4540_CR12","doi-asserted-by":"publisher","first-page":"5738","DOI":"10.3390\/curroncol30060431","volume":"30","author":"K Willows","year":"2023","unstructured":"Willows K, Selk A, Auclair MH, Jim B, Jumah N, Nation J, et al. 2023 Canadian Colposcopy Guideline: A Risk-Based Approach to Management and Surveillance of Cervical Dysplasia. Curr Oncol. 2023;30(6):5738\u201368.","journal-title":"Curr Oncol"},{"issue":"1","key":"4540_CR13","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1006\/gyno.2000.5962","volume":"79","author":"CH Shin","year":"2000","unstructured":"Shin CH, Schorge JO, Lee KR, Sheets EE. Conservative management of adenocarcinoma in situ of the cervix. Gynecol Oncol. 2000;79(1):6\u201310.","journal-title":"Gynecol Oncol"},{"issue":"11","key":"4540_CR14","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.3390\/cancers17111839","volume":"17","author":"G Delli Carpini","year":"2025","unstructured":"Delli Carpini G, Cicoli C, Bernardi M, Di Giuseppe J, Giannella L, Ciavattini A. Clinical Outcomes of Cervical Adenocarcinoma In Situ According to Conservative or Demolitive Treatment: A Systematic Review and Meta-Analysis. Cancers. 2025;17(11):1839.","journal-title":"Cancers"},{"key":"4540_CR15","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.ygyno.2024.05.004","volume":"187","author":"L Adolph","year":"2024","unstructured":"Adolph L, Mann A, Liu XQ, Roberts L, Robinson C, Popowich S, Dean E, Kean S, Fischer G, Altman AD. Follow-up of women with cervical adenocarcinoma in situ treated by conization: A single centre clinical experience. Gynecol Oncol. 2024;187:74\u20139.","journal-title":"Gynecol Oncol"},{"issue":"1","key":"4540_CR16","doi-asserted-by":"publisher","first-page":"e8","DOI":"10.3802\/jgo.2023.34.e8","volume":"34","author":"J Liu","year":"2023","unstructured":"Liu J, Wang Y, Wan X, Zou J, Zhu Y, Lv W, Shen Y. Comparison of the safety between cervical conization and hysterectomy for patients with cervical adenocarcinoma in situ. J Gynecol Oncol. 2023;34(1):e8.","journal-title":"J Gynecol Oncol"},{"issue":"3","key":"4540_CR17","doi-asserted-by":"publisher","first-page":"e2721","DOI":"10.1016\/j.ajog.2016.11.1044","volume":"216","author":"A Munro","year":"2017","unstructured":"Munro A, Codde J, Spilsbury K, Steel N, Stewart CJ, Salfinger SG, et al. Risk of persistent and recurrent cervical neoplasia following incidentally detected adenocarcinoma in situ. Am J Obstet Gynecol. 2017;216(3):e2721\u20137.","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"4540_CR18","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.ygyno.2004.01.028","volume":"93","author":"P Bryson","year":"2004","unstructured":"Bryson P, Stulberg R, Shepherd L, McLelland K, Jeffrey J. Is electrosurgical loop excision with negative margins sufficient treatment for cervical ACIS? Gynecol Oncol. 2004;93(2):465\u20138.","journal-title":"Gynecol Oncol"},{"issue":"1","key":"4540_CR19","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3802\/jgo.2011.22.1.25","volume":"22","author":"ML Kim","year":"2011","unstructured":"Kim ML, Hahn HS, Lim KT, Lee KH, Kim HS, Hong SR, et al. The safety of conization in the management of adenocarcinoma in situ of the uterine cervix. J Gynecol Oncol. 2011;22(1):25\u201331.","journal-title":"J Gynecol Oncol"},{"key":"4540_CR20","doi-asserted-by":"crossref","unstructured":"Bell SG, McAllister KK, Fialkowski EA, Lanneau GS, Brown JV 3. Fertility and Pregnancy Outcomes After Conservative Management of Adenocarcinoma In Situ of the Cervix. J Low Genit Tract Dis. 2021;25(4):270\u20135.","DOI":"10.1097\/LGT.0000000000000621"},{"key":"4540_CR21","doi-asserted-by":"publisher","first-page":"1172706","DOI":"10.3389\/fonc.2023.1161631","volume":"13","author":"F Zhong","year":"2023","unstructured":"Zhong F, Lin Y, Jing L, et al. HPV genotyping of cervical histologic specimens of 61,422 patients from the largest women hospital in China. Front Oncol. 2023;13:1172706.","journal-title":"Front Oncol"},{"key":"4540_CR22","doi-asserted-by":"publisher","first-page":"200226","DOI":"10.1016\/j.tvr.2021.200221","volume":"12","author":"S Lagstr\u00f6m","year":"2021","unstructured":"Lagstr\u00f6m S, Udd\u00e9n M, Rannikko J, et al. HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples. Tumour Virus Res. 2021;12:200226.","journal-title":"Tumour Virus Res"},{"issue":"8","key":"4540_CR23","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1111\/jog.15995","volume":"50","author":"A Taguchi","year":"2024","unstructured":"Taguchi A, et al. Impact of human papillomavirus types on uterine cervical neoplasia. J Obstet Gynaecol Res. 2024;50(8):1283\u20138.","journal-title":"J Obstet Gynaecol Res"},{"issue":"7","key":"4540_CR24","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.3390\/jcm15072499","volume":"15","author":"NA Vural","year":"2026","unstructured":"Vural NA, Ald\u0131ka\u00e7t\u0131o\u011flu Talma\u00e7 M, G\u00fcnay \u0130, Temel Y\u00fcksel \u0130, G\u00fcner G, Canaz E, et al. Clinical and Virologic Outcomes of Topical Imiquimod in Vaginal Intraepithelial Neoplasia: A Retrospective Cohort Study. J Clin Med. 2026;15(7):2499.","journal-title":"J Clin Med"}],"container-title":["BMC Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12905-026-04540-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-026-04540-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12905-026-04540-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:02:10Z","timestamp":1783954930000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12905-026-04540-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,16]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4540"],"URL":"https:\/\/doi.org\/10.1186\/s12905-026-04540-w","relation":{},"ISSN":["1472-6874"],"issn-type":[{"value":"1472-6874","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,16]]},"assertion":[{"value":"21 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective study was approved by the Ethics Committee of the First Affiliated Hospital of Sun Yat-Sen University and adhered to the principles of the Helsinki Declaration as well as national and international standards. The patients provided written informed consent to participate in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"348"}}