{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:27:13Z","timestamp":1783034833145,"version":"3.54.6"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12906-015-0736-y","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T13:09:10Z","timestamp":1435842550000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of phytochemical content, antimicrobial, cytotoxic and antitumor activities of extract from Rumex hastatus D. Don roots"],"prefix":"10.1186","volume":"15","author":[{"given":"Sumaira","family":"Sahreen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Rashid","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahmat Ali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taibi Ben","family":"Hadda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,3]]},"reference":[{"key":"736_CR1","first-page":"1","volume":"320","author":"J Srivastava","year":"1996","unstructured":"Srivastava J, Lambert J, Vietmeyer N. Medicinal plants: an expanding role in development. World Bank Tech Paper. 1996;320:1\u201321.","journal-title":"World Bank Tech Paper"},{"key":"736_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1746-4269-2-14","volume":"2","author":"SK Uniyal","year":"2006","unstructured":"Uniyal SK, Singh KN, Jamwal P, Lal B. Traditional use of medicinal plants among the tribal communities of Chhota Bhangal, Western Himalayan. J Ethnobiol Ethnomed. 2006;2:1\u201314.","journal-title":"J Ethnobiol Ethnomed"},{"key":"736_CR3","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.foodchem.2010.03.120","volume":"122","author":"S Sahreen","year":"2010","unstructured":"Sahreen S, Khan MR, Khan RA. Evaluation of antioxidant activities of various solvent extracts of Carissa opaca fruits. Food Chem. 2010;122:1205\u201311.","journal-title":"Food Chem"},{"key":"736_CR4","first-page":"97","volume":"1","author":"D Krishnaiah","year":"2007","unstructured":"Krishnaiah D, Sarbatly R, Bono A. Phytochemical antioxidants for health and medicine: a move towards nature. Biotechnol Mol Biol Rev. 2007;1:97\u2013104.","journal-title":"Biotechnol Mol Biol Rev"},{"key":"736_CR5","first-page":"442","volume-title":"In Bioactive natural products detection, isolation, and structural determination","author":"TW Sam","year":"1993","unstructured":"Sam TW. Toxicity testing using the brine shrimp: artemia salina. In: Colegate SM, Molyneux RJ, editors. In Bioactive natural products detection, isolation, and structural determination. Boca Raton, FL: CRC Press; 1993. p. 442\u201356."},{"key":"736_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1055\/s-2007-971236","volume":"45","author":"BN Meyer","year":"1982","unstructured":"Meyer BN, Ferrigni NR, Putnam JE, Jacobsen LB, Nichols DE, McLaughlin JL. Brine shrimp: a convenient general bioassay for active plant constituents. Planta Med. 1982;45:31\u20134.","journal-title":"Planta Med"},{"key":"736_CR7","first-page":"139","volume-title":"Flora of Pakistan","author":"M Qaiser","year":"2001","unstructured":"Qaiser M. Polygonaceae. In: Ali SI, Qaiser M, editors. Flora of Pakistan. Department of Botany: University of Karachi, Karachi; 2001. p. 139\u201341."},{"key":"736_CR8","first-page":"49","volume-title":"Phytochemical methods. A guide to modern techniques of plant analysis","author":"JB Harborne","year":"1973","unstructured":"Harborne JB. Phytochemical methods. A guide to modern techniques of plant analysis. London, New York: Chapman and Hall Ltd; 1973. p. 49\u2013188."},{"key":"736_CR9","first-page":"60","volume-title":"Pharmacognosy","author":"GE Trease","year":"1989","unstructured":"Trease GE, Evans WC. Pharmacognosy. 11th ed. London: Brailliar Tiridel Can Macmillan Publishers; 1989. p. 60\u201375.","edition":"11"},{"key":"736_CR10","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0378-8741(93)90017-Y","volume":"38","author":"AE Sofowora","year":"1993","unstructured":"Sofowora AE. Recent trends in research into African medicinal plants. J Ethnopharmacol. 1993;38:209\u201314.","journal-title":"J Ethnopharmacol"},{"key":"736_CR11","doi-asserted-by":"crossref","first-page":"668","DOI":"10.4315\/0362-028X-66.4.668","volume":"66","author":"CF Bagamboula","year":"2003","unstructured":"Bagamboula CF, Uyttendaele M, Debevere J. Antimicrobial effect of spices and herbs on Shigella sonnei and Shigella flexneri. J Food Prot. 2003;66:668\u201373.","journal-title":"J Food Prot"},{"key":"736_CR12","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.jep.2009.02.020","volume":"123","author":"V Duraipandiyan","year":"2009","unstructured":"Duraipandiyan V, Ignacimuthu S. Antibacterial and antifungal activity of Flindersine isolated from the traditional medicinal plant, Toddalia asiatica (L.) Lam. J Ethnopharmacol. 2009;123:494\u20138.","journal-title":"J Ethnopharmacol"},{"key":"736_CR13","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0016-5085(92)91804-D","volume":"102","author":"A Meyer-Alber","year":"1992","unstructured":"Meyer-Alber A, Hartmann H, Sumpel F, Creutzfeldt W. Mechanism of insulin resistance in CCl4-induced cirrhosis of rats. Gastroenterology. 1992;102:223\u20139.","journal-title":"Gastroenterology"},{"key":"736_CR14","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1021\/np50024a005","volume":"45","author":"NR Ferrigini","year":"1982","unstructured":"Ferrigini NR, Putnam JE, Anderson B, Jacobsen LB, Nichols DE, Moore DS, et al. Modification and evaluation of the potato disc assay and antitumor screening of Euphorbiacae seeds. J Nat Prod. 1982;45:679\u201386.","journal-title":"J Nat Prod"},{"key":"736_CR15","first-page":"13","volume":"28","author":"WHO","year":"1993","unstructured":"WHO. Summar WHO guidelines for the assessment of herbal medicines. Herbal Grom. 1993;28:13\u20134.","journal-title":"Herbal Grom"},{"issue":"4","key":"736_CR16","first-page":"151","volume":"3","author":"EU Etuk","year":"2009","unstructured":"Etuk EU, Agaie BM, Ladan MJ, Garba I. The modulatory effect of Cochlospermum tinctorium a rich aqueous root extract on liver damage induced by carbon tetrachloride in rats. African Journal of Pharmacy and Pharmacology. 2009;3(4):151\u20137.","journal-title":"African Journal of Pharmacy and Pharmacology"},{"key":"736_CR17","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CMR.12.4.564","volume":"12","author":"MM Cowan","year":"1999","unstructured":"Cowan MM. Plant products as antimicrobial agents. Clin Microbiol Rev. 1999;12:564\u201382.","journal-title":"Clin Microbiol Rev"},{"key":"736_CR18","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jep.2005.05.029","volume":"100","author":"L Pieters","year":"2005","unstructured":"Pieters L, Vlietnick AJ. Bioguide isolation of pharmacologically active plant components, still a valuable strategy for the finding of new lead compounds. J Ethnopharmacol. 2005;100:57\u201360.","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"736_CR19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2174\/1568011053352550","volume":"5","author":"I Kostova","year":"2005","unstructured":"Kostova I. Synthetic and Natural Coumarins as Cytotoxic Agents. Curr Med Chem-Anti-Cancer Agents. 2005;5(1):29\u201346.","journal-title":"Curr Med Chem-Anti-Cancer Agents"},{"key":"736_CR20","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1046\/j.1365-2672.2000.01017.x","volume":"88","author":"RJW Lambert","year":"2000","unstructured":"Lambert RJW, Pearson J. Susceptibility testing: accurate and reproducible minimum inhibitory concentration (MIC) and non\u2013inhibitory concentration (NIC) values. J Appl Microbiol. 2000;88:784\u201390.","journal-title":"J Appl Microbiol"},{"key":"736_CR21","first-page":"309","volume-title":"Pharmacognosie: Phytochimie","author":"J Bruneton","year":"1999","unstructured":"Bruneton J. Pharmacognosie: Phytochimie. Paris: Plantes m\u00e9dicinales. Tec & Doc; 1999. p. 309\u201354."},{"key":"736_CR22","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jep.2008.07.026","volume":"120","author":"V Kuete","year":"2008","unstructured":"Kuete V, Ngamenib B, Fotso-Simoc CC, Kengap-Tankeuc R, Tchaleu-Ngadjuib B, Meyer JJM, et al. Antimicrobial activity of the crude extracts and compounds from Ficus chlamydocarpa and Ficus cordata (Moraceae). J Ethnopharmcol. 2008;120:17\u201324.","journal-title":"J Ethnopharmcol"},{"issue":"5","key":"736_CR23","first-page":"407","volume":"4","author":"NP Peteros","year":"2010","unstructured":"Peteros NP, Uy MM. Antioxidant and cytotoxic activities and phytochemical screening of four Philippine medicinal plants. J Med Plant Res. 2010;4(5):407\u201314.","journal-title":"J Med Plant Res"},{"issue":"5","key":"736_CR24","doi-asserted-by":"publisher","first-page":"770","DOI":"10.5897\/AJB09.232","volume":"9","author":"F Hussain","year":"2010","unstructured":"Hussain F, Hameed I, Dastagir G, Shams-un N, Khan I, Ahmad B. Cytotoxicity and phytotoxicity of some selected medicinal plants of the family Polygonaceae. Afr J Biotechnol. 2010;9(5):770\u20134.","journal-title":"Afr J Biotechnol"},{"key":"736_CR25","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/340190a0","volume":"340","author":"SE Stachel","year":"1989","unstructured":"Stachel SE, Zambryski PC. Generic trans- kingdom sex. Nature. 1989;340:190\u20131.","journal-title":"Nature"},{"key":"736_CR26","first-page":"1","volume-title":"In Methods in Plant Biochemistry","author":"JL McLaughlin","year":"1991","unstructured":"McLaughlin JL. Crown gall tumors on potato discs and brine shrimp lethality: Two single bioassays for plant screening and fractionation. In: Hostettmann K, editor. In Methods in Plant Biochemistry. 6th ed. London: Academic; 1991. p. 1\u201331.","edition":"6"},{"key":"736_CR27","first-page":"407","volume-title":"Plant diseases caused by prokaryotes: bacteria and mollicutes","author":"GN Agrios","year":"1997","unstructured":"Agrios GN. Plant diseases caused by prokaryotes: bacteria and mollicutes. San Diego: Plant Pathology. Academic Press; 1997. p. 407\u201370."},{"key":"736_CR28","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1177\/009286159803200223","volume":"32","author":"LM Jerry","year":"1998","unstructured":"Jerry LM, Lingling LR. The use of biological assays to evaluate botanicals. Drug Inf J. 1998;32:513\u201324.","journal-title":"Drug Inf J"},{"key":"736_CR29","first-page":"19","volume":"31","author":"A Hussain","year":"2007","unstructured":"Hussain A, Zia M, Mirza B. Cytotoxic and antitumor potential of Fagonia cretica L. Turk J of Biol. 2007;31:19\u201324.","journal-title":"Turk J of Biol"},{"issue":"1","key":"736_CR30","first-page":"79","volume":"6","author":"MS Islam","year":"2010","unstructured":"Islam MS, Rahman MM, Rahman MA, Qayum MA, Alam MF. In vitro evaluation of Croton bonplandianum Baill. as potential antitumor properties using Agrobacterium tumefaciens. Journal of Agricultural Technology. 2010;6(1):79\u201386.","journal-title":"Journal of Agricultural Technology"},{"issue":"24","key":"736_CR31","first-page":"6945","volume":"8","author":"N Fatima","year":"2009","unstructured":"Fatima N, Zia MM, Riaz-ur R, Rizvi ZF, Ahmad S, Mirza B, et al. Biological activities of Rumex dentatus L: Evaluation of methanol and hexane extracts. Afr J Biotechnol. 2009;8(24):6945\u201351.","journal-title":"Afr J Biotechnol"},{"key":"736_CR32","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jfda.2014.05.007","volume":"23","author":"A Ashraf","year":"2015","unstructured":"Ashraf A, Sarfraz RA, Rashid MA, Shahid M. Antioxidant, antimicrobial, antitumor, and cytotoxic activities of an important medicinal plant (Euphorbia royleana) from Pakistan. J food drug anal. 2015;23:109\u201315.","journal-title":"J food drug anal"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12906-015-0736-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-015-0736-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-015-0736-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-015-0736-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T16:27:21Z","timestamp":1630600041000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-015-0736-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,3]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["736"],"URL":"https:\/\/doi.org\/10.1186\/s12906-015-0736-y","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,3]]},"assertion":[{"value":"29 January 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"211"}}