{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T09:32:54Z","timestamp":1768037574163,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12906-015-0769-2","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T23:48:41Z","timestamp":1438127321000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["In vitro effect of bergamot (Citrus bergamia) juice against cagA-positive and-negative clinical isolates of Helicobacter pylori"],"prefix":"10.1186","volume":"15","author":[{"given":"Angela","family":"Filocamo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Bisignano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Ferlazzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santa","family":"Cirmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Mandalari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Navarra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,7,30]]},"reference":[{"issue":"5418","key":"769_CR1","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1126\/science.284.5418.1328","volume":"284","author":"A Covacci","year":"1999","unstructured":"Covacci A, Telford JL, Del Giudice G, Parsonnet J, Rappuoli R. Helicobacter pylori virulence and genetic geography. Science. 1999;284(5418):1328\u201333.","journal-title":"Science"},{"issue":"5","key":"769_CR2","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/MAJ.0b013e3181d94fbc","volume":"340","author":"H Momtaz","year":"2010","unstructured":"Momtaz H, Souod N, Dabiri H. Comparison of the virulence factors of Helicobacter pylori isolated in stomach and saliva in Iran. Am J Med Sci. 2010;340(5):345\u20139.","journal-title":"Am J Med Sci"},{"key":"769_CR3","unstructured":"Hunt RH, Xiao SD, Megraud F, Leon-Barua R, Bazzoli F, van der Merwe S, et al. Helicobacter pylori in developing countries. World Gastroenterology Organisation Global Guideline. J Gastrointestin Liver Dis. 2011;20(3):299\u2013304."},{"issue":"30","key":"769_CR4","doi-asserted-by":"publisher","first-page":"17771","DOI":"10.1074\/jbc.270.30.17771","volume":"270","author":"JC Atherton","year":"1995","unstructured":"Atherton JC, Cao P, Peek Jr RM, Tummuru MK, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem. 1995;270(30):17771\u20137.","journal-title":"J Biol Chem"},{"key":"769_CR5","doi-asserted-by":"crossref","unstructured":"Akopyants NS, Clifton SW, Kersulyte D, Crabtree JE, Youree BE, Reece CA, et al. Analyses of the cag pathogenicity island of Helicobacter pylori. Mol Microbiol. 1998;28(1):37\u201353.","DOI":"10.1046\/j.1365-2958.1998.00770.x"},{"key":"769_CR6","unstructured":"Peek Jr RM, Blaser MJ, Mays DJ, Forsyth MH, Cover TL, Song SY, et al. Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle. Cancer Res. 1999;59(24):6124\u201331."},{"key":"769_CR7","doi-asserted-by":"crossref","unstructured":"Rudi J, Kolb C, Maiwald M, Kuck D, Sieg A, Galle PR, et al. Diversity of Helicobacter pylori vacA and cagA genes and relationship to VacA and CagA protein expression, cytotoxin production, and associated diseases. J Clin Microbiol. 1998;36(4):944\u20138.","DOI":"10.1128\/JCM.36.4.944-948.1998"},{"issue":"3","key":"769_CR8","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s10096-012-1773-9","volume":"32","author":"S Mishra","year":"2013","unstructured":"Mishra S. Is Helicobacter pylori good or bad? Eur J Clin Microbiol Infect Dis. 2013;32(3):301\u20134.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"2 Suppl 1","key":"769_CR9","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/S0016-5085(00)70003-5","volume":"118","author":"DY Graham","year":"2000","unstructured":"Graham DY. Therapy of Helicobacter pylori: current status and issues. Gastroenterology. 2000;118(2 Suppl 1):S2\u20138.","journal-title":"Gastroenterology"},{"issue":"11","key":"769_CR10","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S1473-3099(06)70627-2","volume":"6","author":"MM Gerrits","year":"2006","unstructured":"Gerrits MM, van Vliet AH, Kuipers EJ, Kusters JG. Helicobacter pylori and antimicrobial resistance: molecular mechanisms and clinical implications. Lancet Infect Dis. 2006;6(11):699\u2013709.","journal-title":"Lancet Infect Dis"},{"issue":"12","key":"769_CR11","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/S0024-3205(02)01864-7","volume":"71","author":"T Fukai","year":"2002","unstructured":"Fukai T, Marumo A, Kaitou K, Kanda T, Terada S, Nomura T. Anti-Helicobacter pylori flavonoids from licorice extract. Life Sci. 2002;71(12):1449\u201363.","journal-title":"Life Sci"},{"issue":"3","key":"769_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1055\/s-2005-837816","volume":"71","author":"JE Shin","year":"2005","unstructured":"Shin JE, Kim JM, Bae EA, Hyun YJ, Kim DH. In vitro inhibitory effect of flavonoids on growth, infection and vacuolation of Helicobacter pylori. Planta Med. 2005;71(3):197\u2013201.","journal-title":"Planta Med"},{"key":"769_CR13","doi-asserted-by":"crossref","unstructured":"Nostro A, Cellini L, Di Bartolomeo S, Di Campli E, Grande R, Cannatelli MA, et al. Antibacterial effect of plant extracts against Helicobacter pylori. Phytother Res. 2005;19(3):198\u2013202.","DOI":"10.1002\/ptr.1640"},{"key":"769_CR14","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/1471-2180-13-103","volume":"13","author":"C Bisignano","year":"2013","unstructured":"Bisignano C, Filocamo A, La Camera E, Zummo S, Fera MT, Mandalari G. Antibacterial activities of almond skins on cagA-positive and-negative clinical isolates of Helicobacter pylori. BMC Microbiol. 2013;13:103.","journal-title":"BMC Microbiol"},{"key":"769_CR15","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3389\/fphar.2015.00036","volume":"6","author":"M Navarra","year":"2015","unstructured":"Navarra M, Mannucci C, Delbo M, Calapai G. Citrus bergamia essential oil: from basic research to clinical application. Front Pharmacol. 2015;6:36.","journal-title":"Front Pharmacol"},{"key":"769_CR16","doi-asserted-by":"crossref","unstructured":"Delle Monache S, Sanita P, Trapasso E, Ursino MR, Dugo P, Russo M, et al. Mechanisms Underlying the Anti-Tumoral Effects of Citrus bergamia Juice. PLoS One. 2013;8(4):e61484.","DOI":"10.1371\/journal.pone.0061484"},{"key":"769_CR17","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.fitote.2014.02.009","volume":"95","author":"M Navarra","year":"2014","unstructured":"Navarra M, Ursino MR, Ferlazzo N, Russo M, Schumacher U, Valentiner U. Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models. Fitoterapia. 2014;95:83\u201392.","journal-title":"Fitoterapia"},{"key":"769_CR18","doi-asserted-by":"crossref","unstructured":"Visalli G, Ferlazzo N, Cirmi S, Campiglia P, Gangemi S, Di Pietro A, et al. Bergamot Juice Extract Inhibits Proliferation by Inducing Apoptosis in Human Colon Cancer Cells. Anti-Cancer Agent Me. 2014;14(10):1402\u201313.","DOI":"10.2174\/1871520614666140829120530"},{"key":"769_CR19","doi-asserted-by":"crossref","unstructured":"Ferlazzo N, Visalli G, Smeriglio A, Cirmi S, Lombardo GE, Campiglia P, et al. Flavonoid fraction of orange and bergamot juice protect human lung epithelial cells from hydrogen peroxide-induced oxidative stress. Evid-Based Compl Altern Med. 2015;1: 14.","DOI":"10.1155\/2015\/957031"},{"key":"769_CR20","doi-asserted-by":"crossref","unstructured":"Risitano R, Curro M, Cirmi S, Ferlazzo N, Campiglia P, Caccamo D, et al. Flavonoid Fraction of Bergamot Juice Reduces LPS-Induced Inflammatory Response through SIRT1-Mediated NF-kappa B Inhibition in THP-1 Monocytes. PLoS One. 2014;9(9):e107431.0.","DOI":"10.1371\/journal.pone.0107431"},{"key":"769_CR21","doi-asserted-by":"publisher","unstructured":"Impellizzeri D, Bruschetta G, Di Paola R, Ahmad A, Campolo M, Cuzzocrea S, et al. The anti-inflammatory and antioxidant effects of bergamot juice extract (BJe) in an experimental model of inflammatory bowel disease. Clin Nutr. 2014. doi:10.1016\/j.clnu.2014.11.012.","DOI":"10.1016\/j.clnu.2014.11.012"},{"key":"769_CR22","doi-asserted-by":"crossref","unstructured":"Marino A, Paterniti I, Cordaro M, Morabito R, Campolo M, Navarra M, et al. Role of natural antioxidants and potential use of bergamot in treating rheumatoid arthritis. Pharma Nutrition. 2015;3(2):53\u20139.","DOI":"10.1016\/j.phanu.2015.03.002"},{"key":"769_CR23","doi-asserted-by":"crossref","unstructured":"Mollace V, Sacco I, Janda E, Malara C, Ventrice D, Colica C, et al. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies. Fitoterapia. 2011;82(3):309\u201316.","DOI":"10.1016\/j.fitote.2010.10.014"},{"key":"769_CR24","doi-asserted-by":"crossref","unstructured":"Miceli N, Mondello MR, Monforte MT, Sdrafkakis\u00a0V,\u00a0Dugo\u00a0P,\u00a0Crupi\u00a0ML,\u00a0et\u00a0al. Hypolipidemic effects of Citrus bergamia Risso et Poieteau juice in rats fed a hypercholesterolemic diet. J Agric Food Chem. 2007;55(26):10671\u20137.","DOI":"10.1021\/jf071772i"},{"key":"769_CR25","unstructured":"Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; twentieth informational supplement. M100-S22. Wayne: PA: CLSI; 2012."},{"key":"769_CR26","doi-asserted-by":"crossref","unstructured":"White RL, Burgess DS, Manduru M, Bosso JA. Comparison of three different in vitro methods of detecting synergy: time-kill, checkerboard, and E test. Antimicrob Agents Chemother. 1996;40(8):1914\u20138.","DOI":"10.1128\/AAC.40.8.1914"},{"key":"769_CR27","doi-asserted-by":"crossref","unstructured":"Filocamo A, Bisignano C, D'Arrigo M, Ginestra G, Mandalari G, Galati EM. Norfloxacin and ursolic acid: in vitro association and postantibiotic effect against Staphylococcus aureus. Lett Appl Microbiol. 2011;53(2):193\u20137.","DOI":"10.1111\/j.1472-765X.2011.03090.x"},{"key":"769_CR28","doi-asserted-by":"crossref","unstructured":"Trombetta D, Castelli F, Sarpietro MG, Venuti V, Cristani M, Daniele C, et al. Mechanisms of antibacterial action of three monoterpenes. Antimicrob Agents Chemother. 2005;49(6):2474\u20138.","DOI":"10.1128\/AAC.49.6.2474-2478.2005"},{"key":"769_CR29","doi-asserted-by":"crossref","unstructured":"Xiao ZP, Shi DH, Li HQ, Zhang LN, Xu C, Zhu HL. Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease.Bioorgan Med Chem. 2007;15(11):3703\u201310.","DOI":"10.1016\/j.bmc.2007.03.045"},{"key":"769_CR30","doi-asserted-by":"crossref","unstructured":"Ansari FL, Umbreen S, Hussain L, Makhmoor T, Nawaz SA, Lodhi MA, et al. Syntheses and biological activities of chalcone and 1,5-benzothiazepine derivatives: promising new free-radical scavengers, and esterase, urease, and alpha-glucosidase inhibitors. Chem Biodivers. 2005;2(4):487\u201396.","DOI":"10.1002\/cbdv.200590029"},{"key":"769_CR31","doi-asserted-by":"crossref","unstructured":"Tombola F, Campello S, De Luca L, Ruggiero P, Del Giudice G, Papini E, et al. Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori. FEBS Lett. 2003;543(1\u20133):184\u20139.32.","DOI":"10.1016\/S0014-5793(03)00443-5"},{"key":"769_CR32","doi-asserted-by":"crossref","unstructured":"Mandalari G, Bennett RN, Bisignano G, Trombetta D, Saija A, Faulds CB, et al. Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry. J Appl Microbiol. 2007;103(6):2056\u201364.","DOI":"10.1111\/j.1365-2672.2007.03456.x"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12906-015-0769-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-015-0769-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-015-0769-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-015-0769-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T18:40:01Z","timestamp":1630608001000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-015-0769-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,30]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["769"],"URL":"https:\/\/doi.org\/10.1186\/s12906-015-0769-2","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,30]]},"assertion":[{"value":"5 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"256"}}