{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:13:44Z","timestamp":1787829224717,"version":"build-2784847793"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12906-015-0862-6","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T11:28:10Z","timestamp":1443698890000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Yiguanjian decoction and its ingredients inhibit angiogenesis in carbon tetrachloride-induced cirrhosis mice"],"prefix":"10.1186","volume":"15","author":[{"given":"Ya-Ning","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Ping","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Wei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Bing","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Li","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lie-Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,1]]},"reference":[{"issue":"3","key":"862_CR1","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.jhep.2010.03.021","volume":"53","author":"J Bosch","year":"2010","unstructured":"Bosch J, Abraldes JG, Fern\u00e1ndez M, Garc\u00eda-Pag\u00e1n JC. Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension. J Hepatol. 2010;53(3):558\u201367.","journal-title":"J Hepatol"},{"issue":"3","key":"862_CR2","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.jhep.2008.12.011","volume":"50","author":"M Fern\u00e1ndez","year":"2009","unstructured":"Fern\u00e1ndez M, Semela D, Bruix J, Colle I, Pinzani M, Bosch J. Angiogenesis in liver disease. J Hepatol. 2009;50(3):604\u201320.","journal-title":"J Hepatol"},{"issue":"5","key":"862_CR3","first-page":"444","volume":"62","author":"D Kajdaniuk","year":"2011","unstructured":"Kajdaniuk D, Marek B, Borgiel-Marek H, Kos-Kud\u0142a B. Vascular endothelial growth factor (VEGF) - part 1: in physiology and pathophysiology. Endokrynol Pol. 2011;62(5):444\u201355.","journal-title":"Endokrynol Pol"},{"issue":"4","key":"862_CR4","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1006\/bbrc.2002.6551","volume":"291","author":"LX Liu","year":"2002","unstructured":"Liu LX, Lu H, Luo Y, Date T, Belanger AJ, Vincent KA, et al. Stabilization of vascular endothelial growth factor mRNA by hypoxia-inducible factor 1. Biochem Biophys Res Commun. 2002;291(4):908\u201314.","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"862_CR5","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.jep.2011.02.013","volume":"134","author":"HJ Lin","year":"2011","unstructured":"Lin HJ, Chen JY, Lin CF, Kao ST, Cheng JC, Chen HL, et al. Hepatoprotective effects of Yi Guan Jian, an herbal medicine, in rats with dimethylnitrosamine-induced liver fibrosis. J Ethnopharmacol. 2011;134(3):953\u201360.","journal-title":"J Ethnopharmacol"},{"issue":"25","key":"862_CR6","first-page":"3235","volume":"18","author":"XL Wang","year":"2012","unstructured":"Wang XL, Jia DW, Liu HY, Yan XF, Ye TJ, Hu XD, et al. Effect of Yiguanjian decoction on cell differentiation and proliferation in CCl4-treated mice. World J Gastroenterol. 2012;18(25):3235\u201349.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"862_CR7","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jep.2008.09.032","volume":"121","author":"Y Mu","year":"2009","unstructured":"Mu Y, Liu P, Du G, Du J, Wang G, Long A, et al. Action mechanism of Yi Guan Jian Decoction on CCl4 induced cirrhosis in rats. J Ethnopharmacol. 2009;121(1):35\u201342.","journal-title":"J Ethnopharmacol"},{"key":"862_CR8","doi-asserted-by":"crossref","first-page":"459531","DOI":"10.1155\/2011\/459531","volume":"2011","author":"HJ Lin","year":"2011","unstructured":"Lin HJ, Tseng CP, Lin CF, Liao MH, Chen CM, Kao ST, et al. A Chinese herbal decoction, modified Yi Guan Jian, induces apoptosis in hepatic stellate cells through an ROS-mediated mitochondrial\/caspase pathway. Evid Based Complement Alternat Med. 2011;2011:459531.","journal-title":"Evid Based Complement Alternat Med."},{"issue":"6","key":"862_CR9","first-page":"1465","volume":"26","author":"B Hu","year":"2011","unstructured":"Hu B, An HM, Shen KP, Xu L, Du Q, Deng S, et al. Modified Yi Guan Jian, a Chinese herbal formula, induces anoikis in Bel-7402 human hepatocarcinoma cells in vitro. Oncol Rep. 2011;26(6):1465\u201370.","journal-title":"Oncol Rep"},{"issue":"1","key":"862_CR10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1053\/jhep.2001.25349","volume":"34","author":"B Schnabl","year":"2001","unstructured":"Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA, Brenner DA. The role of Smad3 in mediating mouse hepatic stellate cell activation. Hepatology. 2001;34(1):89\u2013100.","journal-title":"Hepatology"},{"issue":"3","key":"862_CR11","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.jep.2014.03.019","volume":"153","author":"YN Zhou","year":"2014","unstructured":"Zhou YN, Sun MY, Mu YP, Yang T, Ning BB, Ren S, et al. Xuefuzhuyu Decoction Inhibition of Angiogenesis Attenuates Liver Fibrosis Induced by CCl4 in Mice. J Ethnopharmacol. 2014;153(3):659\u201366.","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"862_CR12","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1002\/hep.21921","volume":"46","author":"S Tugues","year":"2007","unstructured":"Tugues S, Fernandez-Varo G, Munoz-Luque J, Ros J, Arroyo V, Rod\u00e9s J, et al. Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Hepatology. 2007;46(6):1919\u201326.","journal-title":"Hepatology"},{"issue":"8","key":"862_CR13","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/nrgastro.2010.97","volume":"7","author":"SL Friedman","year":"2010","unstructured":"Friedman SL. Evolving challenges in hepatic fibrosis. Nat Rev Gastroenterol Hepatol. 2010;7(8):425\u201336.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"3","key":"862_CR14","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1055\/s-0030-1255355","volume":"30","author":"O Rosmorduc","year":"2010","unstructured":"Rosmorduc O, Housset C. Hypoxia: A Link between Fibrogenesis, Angiogenesis, and Carcinogenesis in Liver Disease. Semin Liver Dis. 2010;30(3):258\u201370.","journal-title":"Semin Liver Dis"},{"issue":"6","key":"862_CR15","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3109\/10715762.2012.669041","volume":"46","author":"H Niecknig","year":"2012","unstructured":"Niecknig H, Tug S, Reyes BD, Kirsch M, Fandrey J, Berchner-Pfannschmidt U. Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia. Free Radic Res. 2012;46(6):705\u201317.","journal-title":"Free Radic Res"},{"issue":"7","key":"862_CR16","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1111\/j.1478-3231.2009.02015.x","volume":"29","author":"BL Copple","year":"2009","unstructured":"Copple BL, Bustamante JJ, Welch TP, Kim ND, Moon JO. Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes. Liver Int. 2009;29(7):1010\u201321.","journal-title":"Liver Int"},{"issue":"9","key":"862_CR17","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1136\/gut.52.9.1347","volume":"52","author":"H Yoshiji","year":"2003","unstructured":"Yoshiji H, Kuriyama S, Yoshii J, Ikenaka Y, Noguchi R, Hicklin DJ, et al. Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis. Gut. 2003;52(9):1347\u201354.","journal-title":"Gut"},{"key":"862_CR18","first-page":"1195","volume":"16","author":"YZ Zhao","year":"2006","unstructured":"Zhao YZ, Wang B, Wang TC. Effect of vascular endothelial growth factor in experimental biliary cirrhosis. Chin J Mod Med. 2006;16:1195\u20136.","journal-title":"Chin J Mod Med."},{"key":"862_CR19","first-page":"224","volume":"23","author":"CN Sheng","year":"2001","unstructured":"Sheng CN, Luo Y, Gao W, Chen WB. Relationship between vascular endothelial growth factor and hepatitis B. J Nanjing Mil Med Coll. 2001;23:224\u20136.","journal-title":"J Nanjing Mil Med Coll."},{"issue":"3","key":"862_CR20","first-page":"150","volume":"8","author":"J Yan","year":"2000","unstructured":"Yan J, Chen W, Ma Y, Sun X. Expression of vascular endothelial growth factor in liver tissues of hepatitis B. Zhonghua Gan Zang Bing Za Zhi. 2000;8(3):150\u20132.","journal-title":"Zhonghua Gan Zang Bing Za Zhi"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-015-0862-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12906-015-0862-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-015-0862-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T21:49:27Z","timestamp":1748641767000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-015-0862-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["862"],"URL":"https:\/\/doi.org\/10.1186\/s12906-015-0862-6","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,1]]},"article-number":"342"}}