{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:45:21Z","timestamp":1793724321071,"version":"4.6.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12906-016-1307-6","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T21:22:41Z","timestamp":1472160161000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation"],"prefix":"10.1186","volume":"16","author":[{"given":"Hwa-Young","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Wook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geum-Hwa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Kyung","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Wool","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Jun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Jeong","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Jung","family":"Chae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,26]]},"reference":[{"key":"1307_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.fct.2013.11.017","volume":"64","author":"JQ Ma","year":"2014","unstructured":"Ma JQ, Ding J, Zhang L, Liu CM. Hepatoprotective properties of sesamin against CCl4 induced oxidative stress-mediated apoptosis in mice via JNK pathway. Food Chem Toxicol. 2014;64:41\u20138.","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"1307_CR2","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2131\/jts.38.115","volume":"38","author":"M Kaneko","year":"2013","unstructured":"Kaneko M, Nagamine T, Nakazato K, Mori M. The anti-apoptotic effect of fucoxanthin on carbon tetrachloride-induced hepatotoxicity. J Toxicol Sci. 2013;38(1):115\u201326.","journal-title":"J Toxicol Sci"},{"issue":"2","key":"1307_CR3","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1113\/expphysiol.2008.044883","volume":"94","author":"V Savransky","year":"2009","unstructured":"Savransky V, Reinke C, Jun J, Bevans-Fonti S, Nanayakkara A, Li J, Myers AC, Torbenson MS, Polotsky VY. Chronic intermittent hypoxia and acetaminophen induce synergistic liver injury in mice. Exp Physiol. 2009;94(2):228\u201339.","journal-title":"Exp Physiol"},{"issue":"3","key":"1307_CR4","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3109\/10408447309082019","volume":"2","author":"RO Rechnagel","year":"1973","unstructured":"Rechnagel RO, Glende Jr EA. Carbon tetrachloride hepatotoxicity: an example of lethal cleavage. CRC Crit Rev Toxicol. 1973;2(3):263\u201397.","journal-title":"CRC Crit Rev Toxicol"},{"issue":"3","key":"1307_CR5","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1079\/PNS2006496","volume":"65","author":"E Albano","year":"2006","unstructured":"Albano E. Alcohol, oxidative stress and free radical damage. Proc Nutr Soc. 2006;65(3):278\u201390.","journal-title":"Proc Nutr Soc"},{"issue":"1-2","key":"1307_CR6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.mam.2004.02.019","volume":"25","author":"OR Koch","year":"2004","unstructured":"Koch OR, Pani G, Borrello S, Colavitti R, Cravero A, Farre S, Galeotti T. Oxidative stress and antioxidant defenses in ethanol-induced cell injury. Mol Asp Med. 2004;25(1-2):191\u20138.","journal-title":"Mol Asp Med"},{"issue":"1","key":"1307_CR7","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ejphar.2005.06.002","volume":"518","author":"Y Xu","year":"2005","unstructured":"Xu Y, Ku BS, Yao HY, Lin YH, Ma X, Zhang YH, Li XJ. The effects of curcumin on depressive-like behaviors in mice. Eur J Pharmacol. 2005;518(1):40\u20136.","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"1307_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0378-8741(95)01250-H","volume":"47","author":"R Selvam","year":"1995","unstructured":"Selvam R, Subramanian L, Gayathri R, Angayarkanni N. The anti-oxidant activity of turmeric (Curcuma longa). J Ethnopharmacol. 1995;47(2):59\u201367.","journal-title":"J Ethnopharmacol"},{"key":"1307_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-0-387-46401-5_1","volume":"595","author":"BB Aggarwal","year":"2007","unstructured":"Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1\u201375.","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"1307_CR10","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.cell.2007.08.021","volume":"130","author":"TW Corson","year":"2007","unstructured":"Corson TW, Crews CM. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell. 2007;130(5):769\u201374.","journal-title":"Cell"},{"issue":"9","key":"1307_CR11","doi-asserted-by":"publisher","first-page":"3343","DOI":"10.1016\/j.fct.2012.05.050","volume":"50","author":"CT Tu","year":"2012","unstructured":"Tu CT, Yao QY, Xu BL, Wang JY, Zhou CH, Zhang SC. Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression. Food Chem Toxicol. 2012;50(9):3343\u201351.","journal-title":"Food Chem Toxicol"},{"key":"1307_CR12","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/1472-6882-12-156","volume":"12","author":"QY Yao","year":"2012","unstructured":"Yao QY, Xu BL, Wang JY, Liu HC, Zhang SC, Tu CT. Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats. BMC Complement Altern Med. 2012;12:156.","journal-title":"BMC Complement Altern Med"},{"issue":"1","key":"1307_CR13","doi-asserted-by":"publisher","first-page":"G20","DOI":"10.1152\/ajpgi.00474.2002","volume":"285","author":"J Xu","year":"2003","unstructured":"Xu J, Fu Y, Chen A. Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth. Am J Physiol Gastrointest Liver Physiol. 2003;285(1):G20\u201330.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"8","key":"1307_CR14","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1139\/o59-099","volume":"37","author":"EG Bligh","year":"1959","unstructured":"Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37(8):911\u20137.","journal-title":"Can J Biochem Physiol"},{"issue":"3","key":"1307_CR15","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","volume":"134","author":"G Wu","year":"2004","unstructured":"Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004;134(3):489\u201392.","journal-title":"J Nutr"},{"issue":"8","key":"1307_CR16","doi-asserted-by":"publisher","first-page":"853","DOI":"10.2174\/138920006779010601","volume":"7","author":"IA Blair","year":"2006","unstructured":"Blair IA. Endogenous glutathione adducts. Curr Drug Metab. 2006;7(8):853\u201372.","journal-title":"Curr Drug Metab"},{"issue":"4359","key":"1307_CR17","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1126\/science.210504","volume":"201","author":"I Fridovich","year":"1978","unstructured":"Fridovich I. The biology of oxygen radicals. Science. 1978;201(4359):875\u201380.","journal-title":"Science"},{"issue":"2","key":"1307_CR18","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/BF01082441","volume":"24","author":"SJ Johnson","year":"1992","unstructured":"Johnson SJ, Hines JE, Burt AD. Immunolocalization of proliferating perisinusoidal cells in rat liver. Histochem J. 1992;24(2):67\u201372.","journal-title":"Histochem J"},{"issue":"1","key":"1307_CR19","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/j.1523-1755.2004.00713.x","volume":"66","author":"J Gaedeke","year":"2004","unstructured":"Gaedeke J, Noble NA, Border WA. Curcumin blocks multiple sites of the TGF-beta signaling cascade in renal cells. Kidney Int. 2004;66(1):112\u201320.","journal-title":"Kidney Int"},{"issue":"5","key":"1307_CR20","first-page":"1452","volume":"7","author":"RA Sharma","year":"2001","unstructured":"Sharma RA, Ireson CR, Verschoyle RD, Hill KA, Williams ML, Leuratti C, Manson MM, Marnett LJ, Steward WP, Gescher A. Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels. Clin Cancer Res. 2001;7(5):1452\u20138.","journal-title":"Clin Cancer Res"},{"issue":"2","key":"1307_CR21","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/sj.bjp.0703578","volume":"131","author":"D Punithavathi","year":"2000","unstructured":"Punithavathi D, Venkatesan N, Babu M. Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats. Br J Pharmacol. 2000;131(2):169\u201372.","journal-title":"Br J Pharmacol"},{"issue":"4","key":"1307_CR22","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.jhep.2012.05.019","volume":"57","author":"MA Abdelmegeed","year":"2012","unstructured":"Abdelmegeed MA, Banerjee A, Yoo SH, Jang S, Gonzalez FJ, Song BJ. Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis. J Hepatol. 2012;57(4):860\u20136.","journal-title":"J Hepatol"},{"issue":"11","key":"1307_CR23","doi-asserted-by":"publisher","first-page":"18767","DOI":"10.3390\/molecules191118767","volume":"19","author":"Y Zhao","year":"2014","unstructured":"Zhao Y, Ma X, Wang J, He X, Hu Y, Zhang P, Wang R, Li R, Gong M, Luo S, et al. Curcumin protects against CCl4-induced liver fibrosis in rats by inhibiting HIF-1alpha through an ERK-dependent pathway. Molecules. 2014;19(11):18767\u201380.","journal-title":"Molecules"},{"issue":"2","key":"1307_CR24","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1124\/mol.107.039818","volume":"73","author":"Y Fu","year":"2008","unstructured":"Fu Y, Zheng S, Lin J, Ryerse J, Chen A. Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol. 2008;73(2):399\u2013409.","journal-title":"Mol Pharmacol"},{"issue":"20","key":"1307_CR25","doi-asserted-by":"publisher","first-page":"6847","DOI":"10.1158\/1078-0432.CCR-04-0744","volume":"10","author":"RA Sharma","year":"2004","unstructured":"Sharma RA, Euden SA, Platton SL, Cooke DN, Shafayat A, Hewitt HR, Marczylo TH, Morgan B, Hemingway D, Plummer SM, et al. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res. 2004;10(20):6847\u201354.","journal-title":"Clin Cancer Res"},{"issue":"8","key":"1307_CR26","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1080\/01635581.2010.513802","volume":"62","author":"R Epelbaum","year":"2010","unstructured":"Epelbaum R, Schaffer M, Vizel B, Badmaev V, Bar-Sela G. Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutr Cancer. 2010;62(8):1137\u201341.","journal-title":"Nutr Cancer"},{"issue":"2","key":"1307_CR27","first-page":"139","volume":"25","author":"AB Saba","year":"2010","unstructured":"Saba AB, Oyagbemi AA, Azeez OI. Amelioration of carbon tetrachloride-induced hepatotoxicity and haemotoxicity by aqueous leaf extract of Cnidoscolus aconitifolius in rats. Niger J Physiol Sci. 2010;25(2):139\u201347.","journal-title":"Niger J Physiol Sci"},{"issue":"1","key":"1307_CR28","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1080\/003130299105494","volume":"31","author":"T Yoshida","year":"1999","unstructured":"Yoshida T, Adachi E, Nigi H, Fujii S, Yanagi M. Changes of sinusoidal basement membrane collagens in early hepatic fibrosis induced with CCl4 in cynomolgus monkeys. Pathology. 1999;31(1):29\u201335.","journal-title":"Pathology"},{"issue":"1-2","key":"1307_CR29","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0300-483X(03)00157-4","volume":"189","author":"S Basu","year":"2003","unstructured":"Basu S. Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients. Toxicology. 2003;189(1-2):113\u201327.","journal-title":"Toxicology"},{"issue":"5","key":"1307_CR30","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.etp.2010.03.001","volume":"63","author":"SR Naik","year":"2011","unstructured":"Naik SR, Thakare VN, Patil SR. Protective effect of curcumin on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats: evidence of its antioxidant property. Exp Toxicol Pathol. 2011;63(5):419\u201331.","journal-title":"Exp Toxicol Pathol"},{"issue":"1-2","key":"1307_CR31","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0891-5849(96)00327-9","volume":"22","author":"G Poli","year":"1997","unstructured":"Poli G, Parola M. Oxidative damage and fibrogenesis. Free Radic Biol Med. 1997;22(1-2):287\u2013305.","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"1307_CR32","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0168-8278(01)00142-8","volume":"35","author":"M Parola","year":"2001","unstructured":"Parola M, Robino G. Oxidative stress-related molecules and liver fibrosis. J Hepatol. 2001;35(2):297\u2013306.","journal-title":"J Hepatol"},{"issue":"1 Suppl Proceed","key":"1307_CR33","first-page":"S40","volume":"8","author":"HR Behrman","year":"2001","unstructured":"Behrman HR, Kodaman PH, Preston SL, Gao S. Oxidative stress and the ovary. J Soc Gynecol Investig. 2001;8(1 Suppl Proceedings):S40\u201342.","journal-title":"J Soc Gynecol Investig"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-016-1307-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12906-016-1307-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-016-1307-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-016-1307-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T19:49:14Z","timestamp":1568317754000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-016-1307-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,26]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["1307"],"URL":"https:\/\/doi.org\/10.1186\/s12906-016-1307-6","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,26]]},"article-number":"316"}}