{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:39:49Z","timestamp":1792787989617,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1502226"],"award-info":[{"award-number":["U1502226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Engineering technology research center(development) of Guangdong general universities","award":["GCZX-A1408"],"award-info":[{"award-number":["GCZX-A1408"]}]},{"name":"the Innovation Academic Team of Guangzhou Education System","award":["13C07"],"award-info":[{"award-number":["13C07"]}]},{"name":"Collaborative Innovation major projects of Guangzhou health care","award":["201400000002"],"award-info":[{"award-number":["201400000002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12906-016-1528-8","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T23:50:56Z","timestamp":1483660256000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Inhibition of influenza virus via a sesquiterpene fraction isolated from Laggera pterodonta by targeting the NF-\u03baB and p38 pathways"],"prefix":"10.1186","volume":"17","author":[{"given":"YuTao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beixian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingguang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QiaoLian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Ti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WanYi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZiFeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XinHua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,6]]},"reference":[{"key":"1528_CR1","first-page":"1450","volume-title":"Fields virology","author":"P Palese","year":"2007","unstructured":"Palese P, Shaw ML. Orthomyxoviridae: the viruses and their replication. In: Knipe DM, Howley PM, editors. Fields virology. Philadelphia: Lippincott Williams &Wilkins; 2007. p. 1450."},{"issue":"12","key":"1528_CR2","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S1473-3099(14)70821-7","volume":"14","author":"J Dunning","year":"2014","unstructured":"Dunning J, Baillie JK, Cao B, Hayden FG. International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC). Antiviral combinations for severe influenza. Lancet Infect Dis. 2014;14(12):1259\u201370.","journal-title":"Lancet Infect Dis"},{"key":"1528_CR3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jgg.2013.12.005","volume":"41","author":"ZF Yang","year":"2014","unstructured":"Yang ZF, Li RF, Zhang TY. Evolution of Influenza A H7N9 Virus with an Emphasis on Gene Constellation. J Genet Genomics. 2014;41:3\u20136.","journal-title":"J Genet Genomics"},{"issue":"6","key":"1528_CR4","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/jac\/dkq100","volume":"65","author":"RB Moss","year":"2010","unstructured":"Moss RB, Davey RT, Steigbigel RT, Fang F. Targeting pandemic influenza: a primer on influenza antivirals and drug resistance. J Antimicrob Chemother. 2010;65(6):1086\u201393.","journal-title":"J Antimicrob Chemother"},{"issue":"7","key":"1528_CR5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/ptr.1918","volume":"20","author":"Y Wu","year":"2006","unstructured":"Wu Y, Zhou C, Li X, Song L, Wu X, Lin W, Chen H, Bai H, Zhao J, Zhang R, Sun H, Zhao Y. Evaluation of Antiinflammatory Activity of the Total Flavonoids of Laggera pterodonta on Acute and Chronic Inflammation Models. Phytother Res. 2006;20(7):585\u201390.","journal-title":"Phytother Res"},{"issue":"1","key":"1528_CR6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12935-014-0137-1","volume":"14","author":"C Cao","year":"2014","unstructured":"Cao C, Liu B, Zeng C, Lu Y, Chen S, Yang L, Li B, Li Y, Li Y. Polymethoxyflavone from Laggera pterodonta induces apoptosis in imatinib-resistant K562R cells via activation of the intrinsic apoptosis pathway. Cancer Cell Int. 2014;14(1):137.","journal-title":"Cancer Cell Int"},{"issue":"1","key":"1528_CR7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jchromb.2007.09.016","volume":"859","author":"S Shi","year":"2007","unstructured":"Shi S, Huang K, Zhang Y, Zhao Y, Du Q. Purification and identification of antiviral components from Laggera pterodonta by high-speed counter-current chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;859(1):119\u201324.","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"1528_CR8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.fitote.2013.12.011","volume":"93","author":"ZF Yang","year":"2014","unstructured":"Yang ZF, Bai LP, Huang WB, Li XZ, Zhao SS, Zhong NS, Jiang ZH. Comparison of in vitro antiviral activity of tea polyphenols against influenza A and B viruses and structure\u2013activity relationship analysis. Fitoterapia. 2014;93:47\u201353.","journal-title":"Fitoterapia"},{"key":"1528_CR9","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","volume":"27","author":"LJ Reed","year":"1938","unstructured":"Reed LJ, Muench H. A simple method of estimating fifty percent endpoints. Am J Epidemiol. 1938;27:493\u20137.","journal-title":"Am J Epidemiol"},{"key":"1528_CR10","doi-asserted-by":"crossref","unstructured":"Wu W, Li R, Li X, He J, Jiang S, Liu S, Yang J. Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses. 2016;8(1).","DOI":"10.3390\/v8010006"},{"key":"1528_CR11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.antiviral.2014.03.019","volume":"106","author":"CK Mok","year":"2014","unstructured":"Mok CK, Kang SS, Chan RW, Yue PY, Mak NK, Poon LL, Wong RN, Peiris JS, Chan MC. Anti-inflammatory and antiviral effects of indirubin derivatives in influenza A (H5N1) virus infected primary human peripheral blood-derived macrophages and alveolar epithelial cells. Antiviral Res. 2014;106:95\u2013104.","journal-title":"Antiviral Res"},{"issue":"3","key":"1528_CR12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0031-9422(96)00521-3","volume":"44","author":"Y Zhao","year":"1997","unstructured":"Zhao Y, Yue JM, Lin ZW, Ding JK, Sun HD. Eudesmane sesquiterpenes from Laggera pterodonta. Phytochemistry. 1997;44(3):459\u201364.","journal-title":"Phytochemistry"},{"key":"1528_CR13","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/rcm.1494","volume":"18","author":"CE Ardanaz","year":"2004","unstructured":"Ardanaz CE, Tonn CE, Donadel OJ, Guerreiro E, Kurina MB. Mass spectral studies of a sesquiterpene: 1(10),2,11(13)-eremophylatrien-12-oic acid. Rapid Commun Mass Spectrom. 2004;18:1407\u201310.","journal-title":"Rapid Commun Mass Spectrom"},{"key":"1528_CR14","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1741-7015-10-104","volume":"10","author":"S Barik","year":"2012","unstructured":"Barik S. New treatments for influenza. BMC Med. 2012;10:104.","journal-title":"BMC Med"},{"issue":"24","key":"1528_CR15","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMoa1305584","volume":"368","author":"HN Gao","year":"2013","unstructured":"Gao HN, Lu HZ, Cao B, Du B, Shang H, Gan JH, Lu SH, Yang YD, Fang Q, Shen YZ, Xi XM, Gu Q, Zhou XM, Qu HP, Yan Z, Li FM, Zhao W, Gao ZC, Wang GF, Ruan LX, Wang WH, Ye J, Cao HF, Li XW, Zhang WH, Fang XC, He J, Liang WF, Xie J, Zeng M, Wu XZ, Li J, Xia Q, Jin ZC, Chen Q, Tang C, Zhang ZY, Hou BM, Feng ZX, Sheng JF, Zhong NS, Li LJ. Clinical findings in 111 cases of influenza A H7N9) virus infection. N Engl J Med. 2013;368(24):2277\u201385.","journal-title":"N Engl J Med"},{"issue":"5","key":"1528_CR16","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ptr.1892","volume":"20","author":"X Wang","year":"2006","unstructured":"Wang X, Jia W, Zhao A, Wang X. Anti-influenza agents from plants and traditional Chinese medicine. Phytother Res. 2006;20(5):335\u201341.","journal-title":"Phytother Res"},{"issue":"7282","key":"1528_CR17","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nature08699","volume":"463","author":"R K\u00f6nig","year":"2010","unstructured":"K\u00f6nig R, Stertz S, Zhou Y, Inoue A, Hoffmann HH, Bhattacharyya S, Alamares JG, Tscherne DM, Ortigoza MB, Liang Y, Gao Q, Andrews SE, Bandyopadhyay S, De Jesus P, Tu BP, Pache L, Shih C, Orth A, Bonamy G, Miraglia L, Ideker T, Garc\u00eda-Sastre A, Young JA, Palese P, Shaw ML, Chanda SK. Human Host Factors Required for Influenza Virus Replication. Nature. 2010;463(7282):813\u20137.","journal-title":"Nature"},{"issue":"8","key":"1528_CR18","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.bbamcr.2006.11.011","volume":"1773","author":"AJ Whitmarsh","year":"2007","unstructured":"Whitmarsh AJ. Regulation of gene transcription by mitogen-activated protein kinase signaling pathways. Biochim Biophys Acta. 2007;1773(8):1285\u201398.","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"1528_CR19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/35060098","volume":"3","author":"S Pleschka","year":"2001","unstructured":"Pleschka S, Wolff T, Ehrhardt C, Hobom G, Planz O, Rapp UR, Ludwig S. Influenza virus propagation is impaired by inhibition of the Raf\/MEK\/ERK signalling cascade. Nat Cell Biol. 2001;3(3):301\u20135.","journal-title":"Nat Cell Biol"},{"issue":"4","key":"1528_CR20","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1039\/c2mb05335g","volume":"8","author":"M Vitiello","year":"2012","unstructured":"Vitiello M, Galdiero M, Finamore E, Galdiero S, Galdiero M. NF-kB as a potential therapeutic target in microbial diseases. Mol Biosyst. 2012;8(4):1108\u201320.","journal-title":"Mol Biosyst"},{"issue":"7","key":"1528_CR21","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/cmi.12108","volume":"15","author":"C Ehrhardt","year":"2013","unstructured":"Ehrhardt C, R\u00fcckle A, Hrincius ER, Haasbach E, Anhlan D, Ahmann K, Banning C, Reiling SJ, K\u00fchn J, Strobl S, Vitt D, Leban J, Planz O, Ludwig S. The NF-kB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance. Cell Microbiol. 2013;15(7):1198\u2013211.","journal-title":"Cell Microbiol"},{"issue":"1","key":"1528_CR22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00430-010-0173-y","volume":"200","author":"J Geiler","year":"2011","unstructured":"Geiler J, Michaelis M, Sithisarn P, Cinatl Jr J. Comparison of pro-inflammatory cytokine expression and cellular signal transduction in human macrophages infected with different influenza A viruses. Med Microbiol Immunol. 2011;200(1):53\u201360.","journal-title":"Med Microbiol Immunol"},{"issue":"1","key":"1528_CR23","doi-asserted-by":"crossref","first-page":"e0147034","DOI":"10.1371\/journal.pone.0147034","volume":"11","author":"W Pan","year":"2016","unstructured":"Pan W, Yu H, Huang S, Zhu P. Resveratrol Protects against TNF-\u03b1-Induced Injury in Human Umbilical Endothelial Cells through Promoting Sirtuin-1-Induced Repression of NF-KB and p38 MAPK. PLoS One. 2016;11(1):e0147034.","journal-title":"PLoS One"},{"issue":"1","key":"1528_CR24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00441-010-1043-z","volume":"343","author":"CJ Sanders","year":"2011","unstructured":"Sanders CJ, Doherty PC, Thomas PG. Respiratory epithelial cells in innate immunity to influenza virus infection. Cell Tissue Res. 2011;343(1):13\u201321.","journal-title":"Cell Tissue Res"},{"issue":"6","key":"1528_CR25","doi-asserted-by":"crossref","first-page":"e38214","DOI":"10.1371\/journal.pone.0038214","volume":"7","author":"SG Paquette","year":"2012","unstructured":"Paquette SG, Banner D, Zhao Z, Fang Y, Huang SS, Le\u03ccn AJ, Ng DC, Almansa R, Martin-Loeches I, Ramirez P, Socias L, Loza A, Blanco J, Sansonetti P, Rello J, Andaluz D, Shum B, Rubino S, de Lejarazu RO, Tran D, Delogu G, Fadda G, Krajden S, Rubin BB, Bermejo-Martin JF, Kelvin AA, Kelvin DJ. Interleukin-6 Is a Potential Biomarker for Severe Pandemic H1N1 Influenza A Infection. PLoS One. 2012;7(6):e38214.","journal-title":"PLoS One"},{"issue":"3","key":"1528_CR26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/10286020600603924","volume":"9","author":"YB Liu","year":"2007","unstructured":"Liu YB, Jia W, Yao Z, Pan Q, Takaishi Y, Duan HQ. Two eudesmane sesquiterpenes from Laggera pterodonta. J Asian Nat Prod Res. 2007;9(3):233\u20137.","journal-title":"J Asian Nat Prod Res"},{"issue":"5","key":"1528_CR27","first-page":"517","volume":"52","author":"AH Zhao","year":"1994","unstructured":"Zhao AH, Wei JX. Studies on the Constituent of decoctum of Laggera Pterodonta(DC) Benth II. Acta Chimica Sinica. 1994;52(5):517\u201320.","journal-title":"Acta Chimica Sinica"},{"issue":"3","key":"1528_CR28","first-page":"349","volume":"18","author":"SL Li","year":"1996","unstructured":"Li SL, Ding JK. Four new sesquiterpenoids from Laggera pterodonta. Acta Botanica Yunnanica. 1996;18(3):349\u201352.","journal-title":"Acta Botanica Yunnanica"},{"issue":"4","key":"1528_CR29","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/hlca.201200289","volume":"96","author":"ZJ Zhang","year":"2013","unstructured":"Zhang ZJ, He J, Li Y, Wu XD, Gao X, Peng LY, Cheng X, Li RT, Zhao QS. Three New Sesquiterpenes from Laggera pterodonta. Helv Chim Acta. 2013;96(4):732\u20137.","journal-title":"Helv Chim Acta"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-016-1528-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T02:28:46Z","timestamp":1568687326000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-016-1528-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,6]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1528"],"URL":"https:\/\/doi.org\/10.1186\/s12906-016-1528-8","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,6]]},"article-number":"25"}}