{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:50:14Z","timestamp":1792421414598,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12906-017-1771-7","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T15:44:53Z","timestamp":1494949493000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthus niruri L. (Euphorbiaceae) leaves in experimental rats"],"prefix":"10.1186","volume":"17","author":[{"given":"Ronia","family":"Mostofa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanta","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mst. Marium","family":"Begum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Sohanur Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taslima","family":"Begum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siraj Uddin","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riazul Haque","family":"Tuhin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munny","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayhana","family":"Begum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"1771_CR1","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0149-2918(00)80018-1","volume":"7","author":"HB Fung","year":"1999","unstructured":"Fung HB, Kirschenbaum HL. Selective cyclooxygenase-2 inhibitors for the treatment of arthritis. Clin Ther. 1999;7:1131\u201357.","journal-title":"Clin Ther"},{"key":"1771_CR2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1248\/bpb.18.223","volume":"2","author":"M Kinoshita","year":"1995","unstructured":"Kinoshita M, Noto T, Tamaki H. Effect of a combination of ecabet sodium and cimetidine on experimentally induced gastric lesions and gastric mucosal resistance to ulcerogenic agents in rats. Biol Pharm Bull. 1995;2:223\u20136.","journal-title":"Biol Pharm Bull"},{"key":"1771_CR3","first-page":"69","volume":"28","author":"I Ariyphisi","year":"1986","unstructured":"Ariyphisi I, Toshiharu A, Sugimura F, Abe M, Matsuo Y, Honda T. Recurrence during maintenance therapy with histamine H2 receptors antagonist in cases of gastric ulcers. Nikon Univ J Med. 1986;28:69\u201374.","journal-title":"Nikon Univ J Med"},{"key":"1771_CR4","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1139\/y95-110","volume":"7","author":"MM Campos","year":"1995","unstructured":"Campos MM, Mata LV, Callxto JB. Expression of B1 kinin receptors mediating paw edema and formalin-induced nociception. Modulation by glucocorticoids. Can J Physiol Pharmacol. 1995;7:812\u20139.","journal-title":"Can J Physiol Pharmacol"},{"key":"1771_CR5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/path.1711040103","volume":"1","author":"ML Di Rosa","year":"1971","unstructured":"Di Rosa ML, Giroud JP, Willoughby DA. Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J Pathol. 1971;1:15\u201329.","journal-title":"J Pathol"},{"key":"1771_CR6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0041-0101(00)00154-9","volume":"5","author":"SMK Rates","year":"2001","unstructured":"Rates SMK. Plants as source of drugs. Toxicon. 2001;5:603\u201313.","journal-title":"Toxicon"},{"key":"1771_CR7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jep.2005.06.002","volume":"1","author":"G Schmeda-Hirschmann","year":"2005","unstructured":"Schmeda-Hirschmann G, Yesilada E. Traditional medicine and gastroprotective crude drugs. J Ethnopharmacol. 2005;1:61\u20136.","journal-title":"J Ethnopharmacol"},{"key":"1771_CR8","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.juro.2006.04.010","volume":"3","author":"S Micali","year":"2006","unstructured":"Micali S, Sighinolfi MC, Celia A, De Stefani S, Grande M, Cicero AF, Bianchi G. Can Phyllanthus niruri affect the efficacy of extracorporeal shock wave lithotripsy for renal stones? A randomized, prospective, long-term study. J Urol. 2006;3:1020\u20132.","journal-title":"J Urol"},{"key":"1771_CR9","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1046\/j.1464-410X.2002.02794.x","volume":"9","author":"AM Freitas","year":"2002","unstructured":"Freitas AM, Schor N, Boim MA. The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation. BJU Int. 2002;9:829\u201334.","journal-title":"BJU Int"},{"key":"1771_CR10","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1590\/S1677-55382010000600002","volume":"6","author":"MA Boim","year":"2010","unstructured":"Boim MA, Heilberg IP, Schor N. Phyllanthus niruri as a promising alternative treatment for nephrolithiasis. Int Braz J Urol. 2010;6:657\u201364.","journal-title":"Int Braz J Urol"},{"key":"1771_CR11","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jep.2011.09.040","volume":"2","author":"JR Patel","year":"2011","unstructured":"Patel JR, Tripathi P, Sharma V, Chauhan NS, Dixit VK. Phyllanthus amarus: ethnomedicinal uses, phytochemistry and pharmacology: a review. J Ethnopharmacol. 2011;2:286\u2013313.","journal-title":"J Ethnopharmacol"},{"key":"1771_CR12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1590\/S0102-695X2013000100019","volume":"1","author":"CRC Porto","year":"2013","unstructured":"Porto CRC, Soares LAL, Souza TP, Petrovick PR, Lyra IL, Ara\u00fajo RF Jr, Aurigena SMZL, Ferreira AA, Guerra GCB. Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract. Rev Bras Farmacogn. 2013;1:138\u201344.","journal-title":"Rev Bras Farmacogn"},{"key":"1771_CR13","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.2042-7158.1994.tb03897.x","volume":"9","author":"AR Santos","year":"1994","unstructured":"Santos AR. Analgesic effects of callus culture extracts from selected species of Phyllanthus in mice. J Pharm Pharmacol. 1994;9:755\u20139.","journal-title":"J Pharm Pharmacol"},{"key":"1771_CR14","first-page":"226","volume":"5","author":"AA Mahmood","year":"2010","unstructured":"Mahmood AA, Khaled AAA, Fouad HA, Yaghma M. Gastroprotective effect of Phyllanthus niruri leaf extract against ethanol-induced gastric mucosal injury in rats. Afr J Pharm Pharmacol. 2010;5:226\u201330.","journal-title":"Afr J Pharm Pharmacol"},{"key":"1771_CR15","first-page":"19","volume":"20","author":"KR Raphael","year":"2000","unstructured":"Raphael KR, Sabu MC. Antidiabetic activity of Phyllanthus niruri. Amala Res Bull. 2000;20:19\u201325.","journal-title":"Amala Res Bull"},{"key":"1771_CR16","first-page":"470","volume":"7","author":"U Latha","year":"1999","unstructured":"Latha U, Rajesh MG. Hepatoprotective effect of an Ayurvedic medicine. Indian Drugs. 1999;7:470\u20133.","journal-title":"Indian Drugs"},{"key":"1771_CR17","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1248\/cpb.37.2531","volume":"9","author":"M Shimizu","year":"1989","unstructured":"Shimizu M. Studies on aldose reductase inhibitors from natural products. II. Active components of a Paraguayan crude drug Para-parai mi, Phyllanthus niruri. Chem Pharm Bull. 1989;9:2531\u20132.","journal-title":"Chem Pharm Bull"},{"key":"1771_CR18","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0140-6736(88)92416-6","volume":"2","author":"SP Thyagarajan","year":"1988","unstructured":"Thyagarajan SP, Subramanian S. Effect of Phyllanthus niruri on chronic carriers of hepatitis B virus. Lancet. 1988;2:764\u20136.","journal-title":"Lancet"},{"key":"1771_CR19","first-page":"34","volume":"1","author":"S Neraliya","year":"2004","unstructured":"Neraliya S, Gaur R. Juvenoid activity in plant extracts against filarial mosquito Culex quinquefasciatus. J Med Aromat Plant Sci. 2004;1:34\u20138.","journal-title":"J Med Aromat Plant Sci"},{"key":"1771_CR20","first-page":"298","volume-title":"Medicinal Plants","author":"RC Grewal","year":"1984","unstructured":"Grewal RC. Medicinal Plants. 1st ed. New Delhi: Campus Book International; 1984. p. 298\u2013304.","edition":"1"},{"key":"1771_CR21","first-page":"191","volume":"11","author":"I Nimmi","year":"2013","unstructured":"Nimmi I, Jahan IA, Hossain MH, Uddin MB, Rana MS, Haq MM. A comparative study on antioxidant properties of two Phyllanthus species growing in Bangladesh, Dhaka University. J Pharm Sci. 2013;11:191\u20137.","journal-title":"J Pharm Sci"},{"key":"1771_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-13-14","volume":"13","author":"AS Formagio","year":"2013","unstructured":"Formagio AS, Kassuya CA, Neto FF, Volobuff CR, Iriguchi EK, Do C Vieira M, Foglio MA. The flavonoid content and antiproliferative, hypoglycaemic, anti-inflammatory and free radical scavenging activities of Annona dioica St. Hill. BMC Complement Altern Med. 2013;13:1\u20138.","journal-title":"BMC Complement Altern Med"},{"key":"1771_CR23","first-page":"86","volume":"2","author":"SG Alsabri","year":"2013","unstructured":"Alsabri SG, Rmeli NB, Zetrini AA, Mohamed SB, Meshri MI, Aburas KM, Bensaber SM, Mrema IA, Mosbah AA, Allahresh KA, Hermann A. Phytochemical, anti-oxidant, anti-microbial, anti-inflammatory and anti-ulcer properties of Helianthemum lippii. J Pharmacogn Phytochem. 2013;2:86\u201396.","journal-title":"J Pharmacogn Phytochem"},{"key":"1771_CR24","unstructured":"Kokate CK, Purohit AP, Gokhale SB. \u201cA Textbook of Pharmacognosy\u201d. Nirali Prakashan, Pune. 20087. 2005;145\u2013190."},{"key":"1771_CR25","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3181\/00379727-111-27849","volume":"3","author":"CA Winter","year":"1962","unstructured":"Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Proc Soc Exp Biol Med. 1962;3:544\u20137.","journal-title":"Proc Soc Exp Biol Med"},{"key":"1771_CR26","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1476-5381.1971.tb07124.x","volume":"3","author":"P Crunkhorn","year":"1971","unstructured":"Crunkhorn P, Meacock SCR. Mediators of the inflammation induced in the rat paw by carrageenin. Br J Pharmacol. 1971;3:392\u2013402.","journal-title":"Br J Pharmacol"},{"key":"1771_CR27","first-page":"485","volume":"5","author":"SE Zhuikova","year":"2004","unstructured":"Zhuikova SE, Badmaeva KE, Bakaeva ZV, Samonina GE. Antiulcer effects of the tripeptide PGP and its possible metabolites (PG, GP, glycine, and proline) in different models of ulcer induction in rats. Izv Akad Nauk Ser Biol. 2004;5:485\u20138.","journal-title":"Izv Akad Nauk Ser Biol"},{"key":"1771_CR28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3103\/S0096392509010027","volume":"1","author":"KE Baglikova","year":"2009","unstructured":"Baglikova KE, Trufanova AV, Bakaeva ZV, Samonina GE, Andreeva LA, Klimova PA, Vas\u2019kovsky BV. The influence of hydroxyproline-and proline-containing glyproline on ethanol-induced gastric lesions in rats. Mosc Univ Biol Sci Bull. 2009;1:7\u201311.","journal-title":"Mosc Univ Biol Sci Bull"},{"key":"1771_CR29","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1139\/y73-113","volume":"10","author":"AK Ganguly","year":"1973","unstructured":"Ganguly AK, Bhatnagar OP. Effect of bilateral adrenalectomy on production of restraint ulcers in the stomach of albino rats. Can J Physiol Pharmacol. 1973;10:748\u201350.","journal-title":"Can J Physiol Pharmacol"},{"key":"1771_CR30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1749-6632.2002.tb02905.x","volume":"1","author":"W Bors","year":"2002","unstructured":"Bors W, Michel C. Chemistry of the antioxidant effect of polyphenols. Ann N Y Acad Sci. 2002;1:57\u201369.","journal-title":"Ann N Y Acad Sci"},{"key":"1771_CR31","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1046\/j.1472-8206.2003.00156.x","volume":"4","author":"FV DeFeudis","year":"2003","unstructured":"DeFeudis FV, Papadopoulos V, Drieu K. Ginkgo biloba extracts and cancer: a research area in its infancy. Fundam Clin Pharmacol. 2003;4:405\u201317.","journal-title":"Fundam Clin Pharmacol"},{"key":"1771_CR32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3748\/wjg.v10.i1.37","volume":"1","author":"JC Chao","year":"2004","unstructured":"Chao JC, Chu CC. Effects of Ginkgo biloba extract on cell proliferation and cytotoxicity in human hepatocellular carcinoma cells. World J Gastroenterol. 2004;1:37\u201341.","journal-title":"World J Gastroenterol"},{"key":"1771_CR33","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0006-2952(01)00767-5","volume":"9","author":"J Hong","year":"2001","unstructured":"Hong J, Smith TJ, Ho CT, August DA, Yang CS. Effects of purified green and black tea polyphenols on cyclooxygenase-and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. Biochem Pharmacol. 2001;9:1175\u201383.","journal-title":"Biochem Pharmacol"},{"key":"1771_CR34","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0022-3565(25)28209-X","volume":"1","author":"R Vinegar","year":"1969","unstructured":"Vinegar R, Schreiber W, Hugo R. Biphasic development of carrageenin edema in rats. J Pharmacol Exp Ther. 1969;1:96\u2013103.","journal-title":"J Pharmacol Exp Ther"},{"key":"1771_CR35","first-page":"9","volume":"1","author":"KA Matyas","year":"1991","unstructured":"Matyas KA. Platelet Activating Factor (PAF)-a review of its effects, antagonists and possible future clinical implication, Part I. Drugs. 1991;1:9\u201329.","journal-title":"Drugs"},{"key":"1771_CR36","first-page":"909","volume":"13","author":"AH Soll","year":"1990","unstructured":"Soll AH. Pathogenesis of peptic ulcer and implications for therapy. N Engl J Med. 1990;13:909\u201316.","journal-title":"N Engl J Med"},{"key":"1771_CR37","first-page":"253","volume":"3","author":"S Surendra","year":"1999","unstructured":"Surendra S. Evaluation of gastric anti-ulcer activity of fixed oil of tulsi and possible mechanism. Indian J Exp Biol. 1999;3:253\u20137.","journal-title":"Indian J Exp Biol"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-017-1771-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T16:52:18Z","timestamp":1750265538000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-017-1771-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,16]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1771"],"URL":"https:\/\/doi.org\/10.1186\/s12906-017-1771-7","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,16]]},"article-number":"267"}}