{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:23:36Z","timestamp":1790796216261,"version":"4.1.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12906-017-1953-3","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T12:09:58Z","timestamp":1505131798000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Assessment of free radical scavenging and anti-proliferative activities of Tinospora cordifolia Miers (Willd)"],"prefix":"10.1186","volume":"17","author":[{"given":"Picheswara Rao","family":"Polu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udupa","family":"Nayanbhirama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleemulla","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajlexmi","family":"Maheswari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"1953_CR1","first-page":"65","volume":"30","author":"O Baris","year":"2006","unstructured":"Baris O, Gulluce M, Sahin F, Ozer H, Kilic H, Ozkan H, Sokmen M, Ozbek T. Biological activities of the essential oil and methanol extract of Achillea Biebersteinii Afan. (Asteraceae). Turkey J Biol. 2006;30:65\u201373.","journal-title":"Turkey J Biol"},{"key":"1953_CR2","first-page":"158","volume":"44","author":"F Shahidi","year":"2000","unstructured":"Shahidi F. Antioxidants in food and food antioxidants. Mol Nut Food Res. 2000;44:158\u201363.","journal-title":"Mol Nut Food Res"},{"key":"1953_CR3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1476-9255-4-15","volume":"4","author":"L Racko","year":"2007","unstructured":"Racko L, Oblozinsky M, Kostalova D, Kettmann V, Bezakova L. Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids. J Inflamm. 2007;4:15\u201321.","journal-title":"J Inflamm"},{"key":"1953_CR4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/10408399209527581","volume":"32","author":"F Shahidi","year":"1992","unstructured":"Shahidi F, Wanasundara PKJPD. Phenolic antioxidants. Crit Rev Food Sci Nutr. 1992;32:67\u2013103.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"1953_CR5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3109\/10715769709065791","volume":"27","author":"AT Diplock","year":"1997","unstructured":"Diplock AT. Will the \u2018good fairies\u2019 please proves to us that vitamin E lessens human degenerative of diseases? Free Radic Res. 1997;27:511\u201332.","journal-title":"Free Radic Res"},{"key":"1953_CR6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3109\/10715769509145649","volume":"22","author":"CA Rice-Evans","year":"1995","unstructured":"Rice-Evans CA, Miller NJ, Bolwell PG, Bramley PM, Pridham JB. The relative antioxidant activities of plant derived polyphenolic flavonoids. Free Radic Res. 1995;22:375\u201383.","journal-title":"Free Radic Res"},{"issue":"10","key":"1953_CR7","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1021\/jf990146l","volume":"47","author":"MP Kahkonen","year":"1999","unstructured":"Kahkonen MP, Hopia AI, Vuorela HJ, Rauha JP, Pihlaja K, Kujala TS, Heinonen M. Antioxidant activity of plant extracts containing phenolic compounds. J Agri Food Chem. 1999;47(10):3954\u201362.","journal-title":"J Agri Food Chem"},{"key":"1953_CR8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0300-483X(97)00078-4","volume":"122","author":"S Buxiang","year":"1997","unstructured":"Buxiang S, Fukuhara M. Effects of co-administration of butylated hydroxytoluene, butylated hydroxyanisole and flavonoide on the activation of mutagens and drugmetabolizing enzymes in mice. Toxicology. 1997;122:61\u201372.","journal-title":"Toxicology"},{"key":"1953_CR9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3923\/ijp.2011.257.262","volume":"7","author":"MH Rahman","year":"2011","unstructured":"Rahman MH, Alam MB, Chowdhury NS, Jha MK, Hasan M, Khan MM, Rahman MS, Haque MK. Antioxidant, analgesic and toxic potentiality of Stephania Japonica (Thunb.) Miers. Leaf. Int J Pharmacol. 2011;7:257\u201362.","journal-title":"Int J Pharmacol"},{"key":"1953_CR10","first-page":"1018","volume":"55","author":"GK Jayaprakasha","year":"2000","unstructured":"Jayaprakasha GK, Jaganmohan R. Phenolic constituents from lichen Parmontrema Stuppeum. Hale and antioxidant activity. Zeitsch Fur Naturf. 2000;55:1018\u201322.","journal-title":"Zeitsch Fur Naturf"},{"key":"1953_CR11","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrc1189","volume":"3","author":"YJ Surh","year":"2003","unstructured":"Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer. 2003;3:768\u201380.","journal-title":"Nat Rev Cancer"},{"key":"1953_CR12","doi-asserted-by":"crossref","first-page":"S491","DOI":"10.1093\/ajcn\/70.3.491s","volume":"70","author":"WJ Craig","year":"1999","unstructured":"Craig WJ. Health-promoting properties of common herbs. Am J Clin Nutr. 1999;70:S491\u20139.","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"1953_CR13","first-page":"257","volume":"3","author":"S Kirti","year":"2004","unstructured":"Kirti S, Mishra NP, Singh J, Khanuja SPS. Tinospora cordifolia (Guduchi), a reservoir plant for therapeutic applications: a review. Indian J Tradi Know. 2004;3(3):257\u201370.","journal-title":"Indian J Tradi Know"},{"issue":"1","key":"1953_CR14","first-page":"149","volume":"6","author":"S Singh","year":"2010","unstructured":"Singh S, Srivastava R, Choudhary S. Antifungal and HPLC analysis of the crude extracts of Acorus calamus, Tinospora cordifolia and Celestrus paniculatus. J Agri Tech. 2010;6(1):149\u201358.","journal-title":"J Agri Tech"},{"issue":"3","key":"1953_CR15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/ptr.707","volume":"15","author":"P Stanely","year":"2001","unstructured":"Stanely P, Prince M, Menon VP. Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats. Phytother Res. 2001;15(3):213\u20138.","journal-title":"Phytother Res"},{"key":"1953_CR16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-8741(99)00136-1","volume":"70","author":"P Stanely","year":"2000","unstructured":"Stanely P, Prince M, Menon VP. Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxaninduced diabetic rats. J Ethnopharmacol. 2000;70:9\u201315.","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"1953_CR17","first-page":"127","volume":"5","author":"D Bansal","year":"2012","unstructured":"Bansal D, Bhasin P, Punia A. Evaluation of antimicrobial activity and phytochemical screening of extracts of Tinospora cordifolia against some pathogenic microbes. J Pharma Res. 2012;5(1):127\u20139.","journal-title":"J Pharma Res"},{"issue":"30","key":"1953_CR18","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.3748\/wjg.14.4753","volume":"14","author":"MR Adhvaryu","year":"2008","unstructured":"Adhvaryu MR, Reddy MN, Vakharia BC. Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach. World J Gastroenterol. 2008;14(30):4753\u201362.","journal-title":"World J Gastroenterol"},{"key":"1953_CR19","first-page":"1","volume":"27","author":"N Singh","year":"2005","unstructured":"Singh N, Singh SM, Shrivastava P. Effect of Tinospora cordifolia on the antitumor activity of tumor-associated macrophages-derived dendritic cells. Immunopharm Immunot. 2005;27:1\u201314.","journal-title":"Immunopharm Immunot"},{"key":"1953_CR20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1081\/IPH-120029952","volume":"26","author":"N Singh","year":"2004","unstructured":"Singh N, Singh SM, Shrivastava P. Immunomodulatory and antitumor actions of medicinal plant Tinospora cordifolia are mediated through activation of tumor-associated macrophages. Immunopharm Immunot. 2004;26:145\u201362.","journal-title":"Immunopharm Immunot"},{"key":"1953_CR21","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.intimp.2004.07.024","volume":"4","author":"PK Nair","year":"2004","unstructured":"Nair PK, Rodriguez S, Ramachandran R. Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. Int J Immunopharmacol. 2004;4:1645\u201359.","journal-title":"Int J Immunopharmacol"},{"key":"1953_CR22","unstructured":"Rawal AK, Muddeshwar MG, Biswas SK. Rubia cordifolia. Fagonia cretica Linn and Tinospora cordifolia exert neuroprotection by modulating the antioxidant system in rat hippocampal slices subjected to oxygen glucose deprivation BMC Complement Alter Med. 2004;4:11."},{"key":"1953_CR23","volume-title":"Trease and Evans Pharmacognosy","author":"WC Evans","year":"2009","unstructured":"Evans WC. Trease and Evans Pharmacognosy. Saunders\/Elsevier Limited: UK; 2009."},{"key":"1953_CR24","volume-title":"Practical Pharmacognosy","author":"CK Kokate","year":"1991","unstructured":"Kokate CK. Practical Pharmacognosy. Vallabh Prakashan: New Delhi, India; 1991."},{"key":"1953_CR25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5344\/ajev.1977.28.1.49","volume":"28","author":"J Slinkard","year":"1977","unstructured":"Slinkard J, Singleton VL. Total phenol analysis: automation and comparison with manual methods. Am J Enol Viti. 1977;28:49\u201355.","journal-title":"Am J Enol Viti"},{"key":"1953_CR26","first-page":"178","volume":"10","author":"C Chang","year":"2002","unstructured":"Chang C, Yang MH, Wen HM, Chern JC. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal. 2002;10:178\u201382.","journal-title":"J Food Drug Anal"},{"key":"1953_CR27","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.apsb.2011.10.006","volume":"1","author":"P Bansal","year":"2011","unstructured":"Bansal P, Paul P, Nayak PG, Pannakal ST, Zou JH, Laatsch H. Phenolic compounds isolated from Pilea microphylla prevent radiation-induced cellular DNA damage. Acta Pharm Sin B. 2011;1:226\u201335.","journal-title":"Acta Pharm Sin B"},{"key":"1953_CR28","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.foodchem.2006.07.034","volume":"103","author":"S Tachakittirungrod","year":"2007","unstructured":"Tachakittirungrod S, Okonogi S, Chowwanapoonpohn S. Study on antioxidant activity of certain plants in Thailand: mechanism of antioxidant action of guava leaf extract. Food Chem. 2007;103:381\u20138.","journal-title":"Food Chem"},{"key":"1953_CR29","first-page":"11","volume":"30","author":"K Gouthamchandra","year":"2010","unstructured":"Gouthamchandra K, Mahmood R, Manjunatha H. Free radical scavenging, antioxidant enzymes and wound healing activities of leaves extracts from Clerodendrum infortunatum L. Environ ToxicolPharmaco. 2010;30:11\u20138.","journal-title":"Environ ToxicolPharmaco"},{"key":"1953_CR30","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0039-9140(87)80229-1","volume":"34","author":"A Besada","year":"1987","unstructured":"Besada A. A facile and sensitive spectrophotometric determination of ascorbic acid. Talanta. 1987;34:731\u20132.","journal-title":"Talanta"},{"key":"1953_CR31","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.talanta.2007.01.019","volume":"72","author":"KI Berker","year":"2007","unstructured":"Berker KI, Guclu K, Tor I, Apak R. Comparative evaluation of Fe(III) reducing power-based antioxidant capacity assays in the presence of phenanthroline, batho-phenanthroline, tripyridyltriazine (FRAP) and ferricyanide reagents. Talanta. 2007;72:1157\u201365.","journal-title":"Talanta"},{"key":"1953_CR32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1006\/abio.1999.4019","volume":"269","author":"P Prieto","year":"1999","unstructured":"Prieto P, Pineda M, Aguilar MM. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E. Ann Biochem. 1999;269:337\u201341.","journal-title":"Ann Biochem"},{"key":"1953_CR33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mossman","year":"1983","unstructured":"Mossman T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65:55\u201363.","journal-title":"J Immunol Methods"},{"key":"1953_CR34","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ymeth.2007.01.003","volume":"42","author":"P Houghton","year":"2007","unstructured":"Houghton P, Fang R, Techatanawat I, Steventon G, Hylands PJ, Lee CC. The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity. Methods. 2007;42:377\u201387.","journal-title":"Methods"},{"key":"1953_CR35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000094272","volume":"15","author":"R Piyanuch","year":"2006","unstructured":"Piyanuch R, Wandee G, Leena S. Determination of berberine content in the stem extracts of Coscinum fenestratum by TLC densitometry. Med Princ Pract. 2006;15:373\u20138.","journal-title":"Med Princ Pract"},{"key":"1953_CR36","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0308-8146(03)00151-1","volume":"83","author":"J Javanraedi","year":"2003","unstructured":"Javanraedi J, Stushnoff C, Locke E, Vivanco JM. Antioxidant activity and total phenolic content of Iranian Ocimum accessions. Food Chem. 2003;83:547\u201350.","journal-title":"Food Chem"},{"key":"1953_CR37","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ifset.2009.05.009","volume":"10","author":"KN Prasad","year":"2009","unstructured":"Prasad KN, Yang B, Dong X, Jiang G, Zhang H, Xie H. Flavonoid contents and antioxidant activities from Cinnamomum species. Innov Food Sci & Emerg technol. 2009;10:627\u201332.","journal-title":"Innov Food Sci & Emerg technol"},{"key":"1953_CR38","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.foodchem.2010.08.012","volume":"125","author":"M Leopoldini","year":"2011","unstructured":"Leopoldini M, Russo N, Toscano M. The molecular basis of working mechanism of natural polyphenolic antioxidants. Food Chem. 2011;125:288\u2013306.","journal-title":"Food Chem"},{"key":"1953_CR39","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.talanta.2012.04.036","volume":"97","author":"AL Dawidowicz","year":"2012","unstructured":"Dawidowicz AL, Olszowy M. Mechanism change in estimating of antioxidant activity of phenolic compounds. Talanta. 2012;97:312\u20137.","journal-title":"Talanta"},{"key":"1953_CR40","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.indcrop.2012.09.008","volume":"44","author":"F Abbes","year":"2013","unstructured":"Abbes F, Wissal K, Christophe B, Marc O, Georges L, Hamadi A, Souhail B. Effect of processing conditions on phenolic compounds and antioxidant properties of date syrup. Ind Crop Prod. 2013;44:634\u201342.","journal-title":"Ind Crop Prod"},{"key":"1953_CR41","first-page":"2","volume":"2102","author":"PRR Sre","year":"1696","unstructured":"Sre PRR, Sheila T, Murugesan K. Phytochemical screening and in-vitro anti-oxidant activity of methanolic root extract of Erythrina indica. Asian Pac J Trop Biomed. 1696\u20131700;2102:2.","journal-title":"Asian Pac J Trop Biomed"},{"issue":"4","key":"1953_CR42","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1007\/s11164-015-2208-x","volume":"42","author":"B Mistry","year":"2015","unstructured":"Mistry B, Keum Y, Kim DH. Synthesis and antioxidant and anticancer screening of berberine\u2013indole conjugates. Res Chem Intermediat. 2015;42(4):3241\u201356.","journal-title":"Res Chem Intermediat"},{"key":"1953_CR43","first-page":"211","volume":"26","author":"P Molyneux","year":"2004","unstructured":"Molyneux P. The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin J Sci Technol. 2004;26:211\u20139.","journal-title":"Songklanakarin J Sci Technol"},{"issue":"2","key":"1953_CR44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.5530\/ax.2012.2.2.7","volume":"2","author":"DM Nagmoti","year":"2011","unstructured":"Nagmoti DM, Khatri DK, Juvekar PR, Juvekar AR. Antioxidant activity and free radicle scavenging potential of Pithecellobium dulce Benth seed extracts. Free Radic antioxidant. 2011;2(2):37\u201343.","journal-title":"Free Radic antioxidant"},{"issue":"2","key":"1953_CR45","first-page":"148","volume":"2","author":"BN Panda","year":"2009","unstructured":"Panda BN, Raj AB, Shrivastava NR, Pranathi AR. The evaluation of nitric oxide scavenging activity of Acalypha indica Linn root. Asian J Res Chem. 2009;2(2):148\u201350.","journal-title":"Asian J Res Chem"},{"key":"1953_CR46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1472-6882-9-21","volume":"9","author":"ASVC Rao","year":"2009","unstructured":"Rao ASVC, Reddy SG, Babu PP, Reddy AR. The antioxidant and antiproliferative activities of methanolic extracts from Njavara rice bran. BMC Complement Altern Med. 2009;9:21.","journal-title":"BMC Complement Altern Med"},{"key":"1953_CR47","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.freeradbiomed.2008.11.008","volume":"46","author":"B Halliwell","year":"2009","unstructured":"Halliwell B. The wanderings of a free radical. Free Radic Biol Med. 2009;46:531\u201342.","journal-title":"Free Radic Biol Med"},{"key":"1953_CR48","first-page":"142","volume":"4","author":"L Pan","year":"2013","unstructured":"Pan L, Kinghorn D. Discovery of new anticancer agents from higher plants. Front Biosci. 2013;4:142\u201356.","journal-title":"Front Biosci"},{"key":"1953_CR49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phytol.2009.11.005","volume":"3","author":"L Pan","year":"2010","unstructured":"Pan L, Chai H, Kinghorn D. The continuing search for antitumor agents from higher plants. Phytochem Lett. 2010;3:1\u20138.","journal-title":"Phytochem Lett"},{"key":"1953_CR50","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s12906-016-1302-y","volume":"16","author":"S Ahmad","year":"2016","unstructured":"Ahmad S, Ullah F, Zeb A, Ayaz M, Ullah F, Sadiq A. Evaluation of Rumex Hastatus D. Don for cytotoxic potential against HeLa and NIH\/ 3T3 cell lines: chemical characterization of chloroform fraction and identification of bioactive compounds. BMC Complement Altern Med. 2016;16:308\u201318.","journal-title":"BMC Complement Altern Med"},{"key":"1953_CR51","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-1-61779-012-6_9","volume":"716","author":"PW Sylvester","year":"2011","unstructured":"Sylvester PW. Optimization of the tetrazolium dye (MTT) colorimetric assay for cellular growth and viability. Methods Mol Biol. 2011;716:157\u201368.","journal-title":"Methods Mol Biol"},{"key":"1953_CR52","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.lfs.2004.04.001","volume":"75","author":"CB Lau","year":"2004","unstructured":"Lau CB, Ho CY, Kim CF, Leung KN, Fung KP, Tse TF, Chan HH, Chow MS. Cytotoxic activities of Coriolus versicolor (Yunzhi) extract on human leukemia and lymphoma cells by induction of apoptosis. Life Sci. 2004;75:797\u2013808.","journal-title":"Life Sci"},{"key":"1953_CR53","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1055\/s-2002-32073","volume":"68","author":"G Bruggiser","year":"2002","unstructured":"Bruggiser G, Daeniken K, Jundt G, Schaffner W, Tullber-Reinert H. Intereference of plant extracts, phytoestrogens and antioxidants with the MTT tetrazolium assay. Planta Med. 2002;68:445\u20138.","journal-title":"Planta Med"},{"key":"1953_CR54","first-page":"39","volume":"110","author":"W Voiqt","year":"2005","unstructured":"Voiqt W. Sulforhodamine B assay and chemosensitivity. Methods Mol Med. 2005;110:39\u201348.","journal-title":"Methods Mol Med"},{"key":"1953_CR55","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/157016310791162730","volume":"7","author":"M Youns","year":"2010","unstructured":"Youns M, Hoheisel JD, Efferth T. Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours. Curr Drug Discov Technol. 2010;7:37\u201345.","journal-title":"Curr Drug Discov Technol"},{"key":"1953_CR56","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1139\/m69-190","volume":"15","author":"AH Amin","year":"1969","unstructured":"Amin AH, Subbaiah TV, Abbasi KM. Berberine sulfate: antimicrobial activity, bioassay, and mode of action. Can J Microbiol. 1969;15:1067\u201376.","journal-title":"Can J Microbiol"},{"key":"1953_CR57","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.tiv.2006.07.015","volume":"21","author":"S Jantova","year":"2007","unstructured":"Jantova S, Cipak L, Letasiova S. Berberine induces apoptosis through a mitochondrial\/caspase pathway in human promonocytic U937 cells. Toxicol in Vitro. 2007;21:25\u201331.","journal-title":"Toxicol in Vitro"},{"key":"1953_CR58","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s10822-004-7878-1","volume":"18","author":"V Kettmann","year":"2004","unstructured":"Kettmann V, Kost'alova D, Holtje HD. Human topoisomerase I poisoning: docking protoberberines into a structure-based binding site model. J Comput Aided Mol Des. 2004;18:785\u201396.","journal-title":"J Comput Aided Mol Des"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-017-1953-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T16:24:47Z","timestamp":1692980687000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-017-1953-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,11]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1953"],"URL":"https:\/\/doi.org\/10.1186\/s12906-017-1953-3","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,11]]},"article-number":"457"}}