{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:52:34Z","timestamp":1789822354117,"version":"4.0.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12906-017-2053-0","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T07:12:05Z","timestamp":1513753925000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Upper airway stabilization by osteopathic manipulation of the sphenopalatine ganglion versus sham manipulation in OSAS patients: a proof-of-concept, randomized, crossover, double-blind, controlled study"],"prefix":"10.1186","volume":"17","author":[{"given":"Olivier","family":"Jacq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Arnulf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Similowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5444-9223","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Attali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,20]]},"reference":[{"issue":"9918","key":"2053_CR1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0140-6736(13)60734-5","volume":"383","author":"AS Jordan","year":"2014","unstructured":"Jordan AS, McSharry DG, Malhotra A. Adult obstructive sleep apnoea. Lancet. 2014;383(9918):736\u201347.","journal-title":"Lancet"},{"issue":"11","key":"2053_CR2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1056\/NEJM199903183401104","volume":"340","author":"J Teran-Santos","year":"1999","unstructured":"Teran-Santos J, Jimenez-Gomez A, Cordero-Guevara J. The association between sleep apnea and the risk of traffic accidents. Cooperative Group Burgos-Santander. N Engl J Med. 1999;340(11):847\u201351.","journal-title":"N Engl J Med"},{"issue":"9464","key":"2053_CR3","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0140-6736(05)74229-X","volume":"365","author":"JM Marin","year":"2005","unstructured":"Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005;365(9464):1046\u201353.","journal-title":"Lancet"},{"issue":"1","key":"2053_CR4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1440-1843.2012.02255.x","volume":"18","author":"RS Bucks","year":"2013","unstructured":"Bucks RS, Olaithe M, Eastwood P. Neurocognitive function in obstructive sleep apnoea: a meta-review. Respirology. 2013;18(1):61\u201370.","journal-title":"Respirology"},{"key":"2053_CR5","doi-asserted-by":"crossref","first-page":"15015","DOI":"10.1038\/nrdp.2015.15","volume":"1","author":"P Levy","year":"2015","unstructured":"Levy P, Kohler M, McNicholas WT, Barbe F, McEvoy RD, Somers VK, Lavie L, Pepin JL. Obstructive sleep apnoea syndrome. Nat Rev Dis Prim. 2015;1:15015.","journal-title":"Nat Rev Dis Prim"},{"key":"2053_CR6","unstructured":"Vecchierini MF, Attali V, Collet JM, d'Ortho MP, El Chater P, Kerbrat JB, Leger D, Monaca C, Monteyrol PJ, Morin L, et al. A custom-made mandibular repositioning device for obstructive sleep apnoea-hypopnoea syndrome: the ORCADES study. Sleep Med. 2015;19(2016):131\u2013140."},{"key":"2053_CR7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.sleep.2016.10.004","volume":"27-28","author":"V Attali","year":"2016","unstructured":"Attali V, Chaumereuil C, Arnulf I, Golmard JL, Tordjman F, Morin L, Goudot P, Similowski T, Collet JM. Predictors of long-term effectiveness to mandibular repositioning device treatment in obstructive sleep apnea patients after 1000 days. Sleep Med. 2016;27-28:107\u201314.","journal-title":"Sleep Med"},{"issue":"7","key":"2053_CR8","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1177\/2047487314537916","volume":"22","author":"E Skobel","year":"2015","unstructured":"Skobel E, Kamke W, Bonner G, Alt B, Purucker HC, Schwaab B, Einwang HP, Schroder K, Langheim E, Voller H, et al. Risk factors for, and prevalence of, sleep apnoea in cardiac rehabilitation facilities in Germany: the Reha-Sleep registry. Eur J Prev Cardiol. 2015;22(7):820\u201330.","journal-title":"Eur J Prev Cardiol"},{"issue":"8","key":"2053_CR9","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1164\/rccm.201303-0448OC","volume":"188","author":"DJ Eckert","year":"2013","unstructured":"Eckert DJ, White DP, Jordan AS, Malhotra A, Wellman A. Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets. Am J Respir Crit Care Med. 2013;188(8):996\u20131004.","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"2053_CR10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1053\/smrv.2001.0163","volume":"6","author":"F Series","year":"2002","unstructured":"Series F. Upper airway muscles awake and asleep. Sleep Med Rev. 2002;6(3):229\u201342.","journal-title":"Sleep Med Rev"},{"issue":"3","key":"2053_CR11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1183\/09031936.04.00099404","volume":"23","author":"M Carrera","year":"2004","unstructured":"Carrera M, Barbe F, Sauleda J, Tomas M, Gomez C, Santos C, Agusti AG. Effects of obesity upon genioglossus structure and function in obstructive sleep apnoea. Eur Respir J. 2004;23(3):425\u20139.","journal-title":"Eur Respir J"},{"issue":"11","key":"2053_CR12","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1164\/rccm.201310-1753OC","volume":"189","author":"AM Kim","year":"2014","unstructured":"Kim AM, Keenan BT, Jackson N, Chan EL, Staley B, Torigian DA, Alavi A, Schwab RJ. Metabolic activity of the tongue in obstructive sleep apnea. A novel application of FDG positron emission tomography imaging. Am J Respir Crit Care Med. 2014;189(11):1416\u201325.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"2053_CR13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/lary.21371","volume":"121","author":"O Sunnergren","year":"2011","unstructured":"Sunnergren O, Brostrom A, Svanborg E. Soft palate sensory neuropathy in the pathogenesis of obstructive sleep apnea. Laryngoscope. 2011;121(2):451\u20136.","journal-title":"Laryngoscope"},{"issue":"2","key":"2053_CR14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/mus.21690","volume":"42","author":"S Ramchandren","year":"2010","unstructured":"Ramchandren S, Gruis KL, Chervin RD, Lisabeth LD, Concannon M, Wolfe J, Albers JW, Brown DL. Hypoglossal nerve conduction findings in obstructive sleep apnea. Muscle Nerve. 2010;42(2):257\u201361.","journal-title":"Muscle Nerve"},{"issue":"11","key":"2053_CR15","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.5665\/sleep.5156","volume":"38","author":"C Launois","year":"2015","unstructured":"Launois C, Attali V, Georges M, Raux M, Morawiec E, Rivals I, Arnulf I, Similowski T. Cortical drive to breathe during wakefulness in patients with obstructive sleep apnea syndrome. Sleep. 2015;38(11):1743\u20139.","journal-title":"Sleep"},{"issue":"2","key":"2053_CR16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.smrv.2012.05.005","volume":"17","author":"YJ Tsai","year":"2013","unstructured":"Tsai YJ, Ramar K, Liang YJ, Chiu PH, Powell N, Chi CY, Lung TC, Wen-Yang Lin W, Tseng PJ, MY W, et al. Peripheral neuropathology of the upper airway in obstructive sleep apnea syndrome. Sleep Med Rev. 2013;17(2):161\u20138.","journal-title":"Sleep Med Rev"},{"issue":"3","key":"2053_CR17","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1155\/2015\/583549","volume":"22","author":"E Rousseau","year":"2015","unstructured":"Rousseau E, Silva C, Gakwaya S, Series F. Effects of one-week tongue task training on sleep apnea severity: a pilot study. Can Respir J. 2015;22(3):176\u20138.","journal-title":"Can Respir J"},{"issue":"10","key":"2053_CR18","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1164\/rccm.200806-981OC","volume":"179","author":"KC Guimaraes","year":"2009","unstructured":"Guimaraes KC, Drager LF, Genta PR, Marcondes BF, Lorenzi-Filho G. Effects of oropharyngeal exercises on patients with moderate obstructive sleep apnea syndrome. Am J Respir Crit Care Med. 2009;179(10):962\u20136.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"2053_CR19","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/head.12729","volume":"56","author":"MS Robbins","year":"2016","unstructured":"Robbins MS, Robertson CE, Kaplan E, Ailani J, Charleston L, Kuruvilla D, Blumenfeld A, Berliner R, Rosen NL, Duarte R, et al. The sphenopalatine ganglion: anatomy, pathophysiology, and therapeutic targeting in headache. Headache. 2016;56(2):240\u201358.","journal-title":"Headache"},{"issue":"5","key":"2053_CR20","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1177\/0333102413512032","volume":"34","author":"S Khan","year":"2014","unstructured":"Khan S, Schoenen J, Ashina M. Sphenopalatine ganglion neuromodulation in migraine: what is the rationale? Cephalalgia. 2014;34(5):382\u201391.","journal-title":"Cephalalgia"},{"issue":"6","key":"2053_CR21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11916-017-0626-8","volume":"21","author":"J Mojica","year":"2017","unstructured":"Mojica J, Mo B, Ng A. Sphenopalatine ganglion block in the management of chronic headaches. Curr Pain Headache Rep. 2017;21(6):27.","journal-title":"Curr Pain Headache Rep"},{"key":"2053_CR22","unstructured":"Caporrossi: traitement ost\u00e9opathique de la sph\u00e8re ORL. In: Trait\u00e9 pratique d'ost\u00e9opathie cr\u00e2nienne. edn. D. V. Editor. France:Aix en provence; 1992. p. 758."},{"key":"2053_CR23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/2045-709X-21-17","volume":"21","author":"A Kalamir","year":"2013","unstructured":"Kalamir A, Graham PL, Vitiello AL, Bonello R, Pollard H. Intra-oral myofascial therapy versus education and self-care in the treatment of chronic, myogenous temporomandibular disorder: a randomised, clinical trial. Chiropr Man Therap. 2013;21:17.","journal-title":"Chiropr Man Therap"},{"issue":"2","key":"2053_CR24","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1152\/jappl.1988.64.2.535","volume":"64","author":"AR Schwartz","year":"1988","unstructured":"Schwartz AR, Smith PL, Wise RA, Gold AR, Permutt S. Induction of upper airway occlusion in sleeping individuals with subatmospheric nasal pressure. J Appl Physiol (1985). 1988;64(2):535\u201342.","journal-title":"J Appl Physiol (1985)"},{"issue":"3","key":"2053_CR25","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.resp.2008.03.004","volume":"161","author":"S MC","year":"2008","unstructured":"MC S, Chiu KL, Ruttanaumpawan P, Shiota S, Yumino D, Redolfi S, Haight JS, Bradley TD. Lower body positive pressure increases upper airway collapsibility in healthy subjects. Respir Physiol Neurobiol. 2008;161(3):306\u201312.","journal-title":"Respir Physiol Neurobiol"},{"issue":"6","key":"2053_CR26","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","volume":"14","author":"MW Johns","year":"1991","unstructured":"Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14(6):540\u20135.","journal-title":"Sleep"},{"key":"2053_CR27","first-page":"581","volume":"8","author":"MS Zeev","year":"2014","unstructured":"Zeev MS, Miller DD, Latkany R. Diagnosis of dry eye disease and emerging technologies. Clin Ophthalmol. 2014;8:581\u201390.","journal-title":"Clin Ophthalmol"},{"key":"2053_CR28","volume-title":"R: a language and environment for statistical computing","author":"R Development Core Team","year":"2008","unstructured":"R Development Core Team. R: a language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2008."},{"key":"2053_CR29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1465-9921-6-99","volume":"6","author":"F Series","year":"2005","unstructured":"Series F, Verin E, Similowski T. Impediment in upper airway stabilizing forces assessed by phrenic nerve stimulation in sleep apnea patients. Respir Res. 2005;6:99.","journal-title":"Respir Res"},{"issue":"4","key":"2053_CR30","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/sleep\/34.4.459","volume":"34","author":"JP Kirkness","year":"2011","unstructured":"Kirkness JP, Peterson LA, Squier SB, McGinley BM, Schneider H, Meyer A, Schwartz AR, Smith PL, Patil SP. Performance characteristics of upper airway critical collapsing pressure measurements during sleep. Sleep. 2011;34(4):459\u201367.","journal-title":"Sleep"},{"issue":"2","key":"2053_CR31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3109\/08037059209077502","volume":"1","author":"L Hansson","year":"1992","unstructured":"Hansson L, Hedner T, Dahlof B. Prospective randomized open blinded end-point (PROBE) study. A novel design for intervention trials. Prospective Randomized Open Blinded End-Point. Blood Press. 1992;1(2):113\u20139.","journal-title":"Blood Press"},{"key":"2053_CR32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1741-7015-8-18","volume":"8","author":"KF Schulz","year":"2010","unstructured":"Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMC Med. 2010;8:18.","journal-title":"BMC Med"},{"issue":"1","key":"2053_CR33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1164\/rccm.200309-1239OC","volume":"170","author":"SP Patil","year":"2004","unstructured":"Patil SP, Punjabi NM, Schneider H, O'Donnell CP, Smith PL, Schwartz AR. A simplified method for measuring critical pressures during sleep in the clinical setting. Am J Respir Crit Care Med. 2004;170(1):86\u201393.","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"2053_CR34","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/thx.2010.150334","volume":"66","author":"V Bosshard","year":"2011","unstructured":"Bosshard V, Masse JF, Series F. Prediction of oral appliance efficiency in patients with apnoea using phrenic nerve stimulation while awake. Thorax. 2011;66(3):220\u20135.","journal-title":"Thorax"},{"issue":"5","key":"2053_CR35","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1172\/JCI115751","volume":"89","author":"WS Mezzanotte","year":"1992","unstructured":"Mezzanotte WS, Tangel DJ, White DP. Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism). J Clin Invest. 1992;89(5):1571\u20139.","journal-title":"J Clin Invest"},{"issue":"6 Pt 1","key":"2053_CR36","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1164\/ajrccm.153.6.8665050","volume":"153","author":"WS Mezzanotte","year":"1996","unstructured":"Mezzanotte WS, Tangel DJ, White DP. Influence of sleep onset on upper-airway muscle activity in apnea patients versus normal controls. Am J Respir Crit Care Med. 1996;153(6 Pt 1):1880\u20137.","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"2053_CR37","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1096\/fasebj.10.8.8666167","volume":"10","author":"F Series","year":"1996","unstructured":"Series F, Cote C, Simoneau JA, St Pierre S, Marc I. Upper airway collapsibility, and contractile and metabolic characteristics of musculus uvulae. FASEB J. 1996;10(8):897\u2013904.","journal-title":"FASEB J"},{"issue":"4","key":"2053_CR38","first-page":"638","volume":"49","author":"KP Strohl","year":"1980","unstructured":"Strohl KP, Hensley MJ, Hallett M, Saunders NA, Ingram RH Jr. Activation of upper airway muscles before onset of inspiration in normal humans. J Appl Physiol Respir Environ Exerc Physiol. 1980;49(4):638\u201342.","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"issue":"5","key":"2053_CR39","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1164\/ajrccm\/148.5.1385","volume":"148","author":"RJ Schwab","year":"1993","unstructured":"Schwab RJ, Gefter WB, Hoffman EA, Gupta KB, Pack AI. Dynamic upper airway imaging during awake respiration in normal subjects and patients with sleep disordered breathing. Am Rev Respir Dis. 1993;148(5):1385\u2013400.","journal-title":"Am Rev Respir Dis"},{"issue":"4","key":"2053_CR40","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1526-4610.2008.01226.x","volume":"49","author":"S Narouze","year":"2009","unstructured":"Narouze S, Kapural L, Casanova J, Mekhail N. Sphenopalatine ganglion radiofrequency ablation for the management of chronic cluster headache. Headache. 2009;49(4):571\u20137.","journal-title":"Headache"},{"issue":"10","key":"2053_CR41","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1177\/0333102412473667","volume":"33","author":"J Schoenen","year":"2013","unstructured":"Schoenen J, Jensen RH, Lanteri-Minet M, Lainez MJ, Gaul C, Goodman AM, Caparso A, May A. Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: a randomized, sham-controlled study. Cephalalgia. 2013;33(10):816\u201330.","journal-title":"Cephalalgia"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-017-2053-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T05:15:29Z","timestamp":1570511729000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-017-2053-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["2053"],"URL":"https:\/\/doi.org\/10.1186\/s12906-017-2053-0","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]},"article-number":"546"}}