{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:20:11Z","timestamp":1776115211588,"version":"3.50.1"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["90th anniversary of Chulalongkorn University fund"],"award-info":[{"award-number":["90th anniversary of Chulalongkorn University fund"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["Overseas Research Experience Scholarship for Graduate Student and a Grant for Joint Funding, Ratchadaphiseksomphot Endowment Fund"],"award-info":[{"award-number":["Overseas Research Experience Scholarship for Graduate Student and a Grant for Joint Funding, Ratchadaphiseksomphot Endowment Fund"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001775","name":"University of Technology Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12906-018-2288-4","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T04:38:56Z","timestamp":1532407136000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Acid-base fractions separated from Streblus asper leaf ethanolic extract exhibited antibacterial, antioxidant, anti-acetylcholinesterase, and neuroprotective activities"],"prefix":"10.1186","volume":"18","author":[{"given":"Anchalee","family":"Prasansuklab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsadang","family":"Theerasri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Payne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison T.","family":"Ung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tewin","family":"Tencomnao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,7,24]]},"reference":[{"issue":"16","key":"2288_CR1","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1056\/NEJMp1306826","volume":"369","author":"PA Ubel","year":"2013","unstructured":"Ubel PA, Abernethy AP, Zafar SY. Full disclosure--out-of-pocket costs as side effects. N Engl J Med. 2013;369(16):1484\u20136.","journal-title":"N Engl J Med"},{"key":"2288_CR2","doi-asserted-by":"crossref","unstructured":"Wang Z, Liu X, Ho RL, Lam CW, Chow MS. Precision or personalized medicine for Cancer chemotherapy: is there a role for herbal medicine. Molecules. 2016;21(7)","DOI":"10.3390\/molecules21070889"},{"key":"2288_CR3","doi-asserted-by":"crossref","unstructured":"Augustine NR, Madhavan G, Nass SJ (Eds). Committee on Ensuring Patient Access to Affordable Drug Therapies; Board on Health Care Services; Health and Medicine Division; National Academies of Sciences, Engineering, and Medicine, Making Medicines Affordable A National Imperative. Washington (DC): National Academies Press (US); 2017.","DOI":"10.17226\/24946"},{"key":"2288_CR4","doi-asserted-by":"crossref","unstructured":"Kroger E, Mouls M, Wilchesky M, Berkers M, Carmichael PH, van Marum R, et al. Adverse drug reactions reported with cholinesterase inhibitors: an analysis of 16 years of individual case safety reports from VigiBase. Ann Pharmacother 2015; 49(11):1197\u20131206.","DOI":"10.1177\/1060028015602274"},{"issue":"6","key":"2288_CR5","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1086\/591126","volume":"47","author":"N Shehab","year":"2008","unstructured":"Shehab N, Patel PR, Srinivasan A, Budnitz DS. Emergency department visits for antibiotic-associated adverse events. Clin Infect Dis. 2008;47(6):735\u201343.","journal-title":"Clin Infect Dis"},{"issue":"4","key":"2288_CR6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/alzrt269","volume":"6","author":"JL Cummings","year":"2014","unstructured":"Cummings JL, Morstorf T, Zhong K. Alzheimer's disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res Ther. 2014;6(4):37.","journal-title":"Alzheimers Res Ther"},{"issue":"1","key":"2288_CR7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12929-017-0355-7","volume":"24","author":"SY Hung","year":"2017","unstructured":"Hung SY, Fu WM. Drug candidates in clinical trials for Alzheimer's disease. J Biomed Sci. 2017;24(1):47.","journal-title":"J Biomed Sci"},{"issue":"4","key":"2288_CR8","first-page":"277","volume":"40","author":"CL Ventola","year":"2015","unstructured":"Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. P T. 2015;40(4):277\u201383.","journal-title":"P T"},{"issue":"5","key":"2288_CR9","first-page":"344","volume":"40","author":"CL Ventola","year":"2015","unstructured":"Ventola CL. The antibiotic resistance crisis: part 2: management strategies and new agents. P T. 2015;40(5):344\u201352.","journal-title":"P T"},{"key":"2288_CR10","doi-asserted-by":"crossref","unstructured":"Rex JH, Talbot GH, Goldberger MJ, Eisenstein BI, Echols RM, Tomayko JF, et al. Progress in the fight against multidrug-resistant Bacteria 2005-2016: modern noninferiority trial designs enable antibiotic development in advance of epidemic bacterial resistance. Clin Infect Dis 2017; 65(1):141\u2013146.","DOI":"10.1093\/cid\/cix246"},{"issue":"3","key":"2288_CR11","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","volume":"79","author":"DJ Newman","year":"2016","unstructured":"Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. J Nat Prod. 2016;79(3):629\u201361.","journal-title":"J Nat Prod"},{"key":"2288_CR12","unstructured":"Owen L, Laird K. Synchronous application of antibiotics and essential oils: dual mechanisms of action as a potential solution to antibiotic resistance. Crit Rev Microbiol. 2018:1\u201322."},{"issue":"2","key":"2288_CR13","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1177\/153331750602100211","volume":"21","author":"S Akhondzadeh","year":"2006","unstructured":"Akhondzadeh S, Abbasi SH. Herbal medicine in the treatment of Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2006;21(2):113\u20138.","journal-title":"Am J Alzheimers Dis Other Demen"},{"issue":"5","key":"2288_CR14","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/alzrt54","volume":"2","author":"J Tian","year":"2010","unstructured":"Tian J, Shi J, Zhang X, Wang Y. Herbal therapy: a new pathway for the treatment of Alzheimer's disease. Alzheimers Res Ther. 2010;2(5):30.","journal-title":"Alzheimers Res Ther"},{"key":"2288_CR15","doi-asserted-by":"crossref","unstructured":"Yang WT, Zheng XW, Chen S, Shan CS, Xu QQ, Zhu JZ, et al. Chinese herbal medicine for Alzheimer's disease: clinical evidence and possible mechanism of neurogenesis. Biochem Pharmacol 2017; 141:143\u2013155.","DOI":"10.1016\/j.bcp.2017.07.002"},{"key":"2288_CR16","first-page":"11","volume":"4","author":"AN Syad","year":"2014","unstructured":"Syad AN, Devi K. Botanics: a potential source of new therapies for Alzheimer\u2019s disease. Botanics. 2014;4:11\u20136.","journal-title":"Botanics"},{"key":"2288_CR17","first-page":"63","volume":"55","author":"A Kumar","year":"2017","unstructured":"Kumar A, Singh A, Aggarwal A. Therapeutic potentials of herbal drugs for Alzheimer\u2019s disease - an overview. Indian J Exp Biol. 2017;55:63\u201373.","journal-title":"Indian J Exp Biol"},{"issue":"3","key":"2288_CR18","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/S0091-3057(03)00111-4","volume":"75","author":"A Zangara","year":"2003","unstructured":"Zangara A. The psychopharmacology of huperzine a: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease. Pharmacol Biochem Behav. 2003;75(3):675\u201386.","journal-title":"Pharmacol Biochem Behav"},{"key":"2288_CR19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/molecules21091243","volume":"21","author":"G Mazzanti","year":"2016","unstructured":"Mazzanti G, Di Giacomo S. Curcumin and resveratrol in the Management of Cognitive Disorders: what is the clinical evidence? Molecules. 2016;21:9.","journal-title":"Molecules"},{"issue":"1\u20132","key":"2288_CR20","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1159\/000085383","volume":"14","author":"K Suk","year":"2005","unstructured":"Suk K. Regulation of neuroinflammation by herbal medicine and its implications for neurodegenerative diseases. A focus on traditional medicines and flavonoids. Neurosignals. 2005;14(1\u20132):23\u201333.","journal-title":"Neurosignals"},{"key":"2288_CR21","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/978-3-319-18365-7_5","volume":"863","author":"HM Hugel","year":"2015","unstructured":"Hugel HM. Brain food for Alzheimer-free ageing: focus on herbal medicines. Adv Exp Med Biol. 2015;863:95\u2013116.","journal-title":"Adv Exp Med Biol"},{"key":"2288_CR22","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.biopha.2016.11.074","volume":"85","author":"AI Abushouk","year":"2017","unstructured":"Abushouk AI, Negida A, Ahmed H, Abdel-Daim MM. Neuroprotective mechanisms of plant extracts against MPTP induced neurotoxicity: future applications in Parkinson's disease. Biomed Pharmacother. 2017;85:635\u201345.","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"2288_CR23","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.biotechadv.2016.12.005","volume":"35","author":"A Dey","year":"2017","unstructured":"Dey A, Bhattacharya R, Mukherjee A, Pandey DK. Natural products against Alzheimer's disease: Pharmaco-therapeutics and biotechnological interventions. Biotechnol Adv. 2017;35(2):178\u2013216.","journal-title":"Biotechnol Adv"},{"key":"2288_CR24","unstructured":"Alzheimer's Association: 2018 Alzheimer\u2019s Disease Facts and Figures. \n                    https:\/\/www.alz.org\/media\/HomeOffice\/Facts%20and%20Figures\/facts-and-figures.pdf\n                    \n                  . Accessed 18 July 2018."},{"issue":"1","key":"2288_CR25","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1582-4934.2008.00595.x","volume":"13","author":"Y Biran","year":"2009","unstructured":"Biran Y, Masters CL, Barnham KJ, Bush AI, Adlard PA. Pharmacotherapeutic targets in Alzheimer's disease. J Cell Mol Med. 2009;13(1):61\u201386.","journal-title":"J Cell Mol Med"},{"issue":"Suppl 3","key":"2288_CR26","first-page":"3","volume":"67","author":"GL Wenk","year":"2006","unstructured":"Wenk GL. Neuropathologic changes in Alzheimer's disease: potential targets for treatment. J Clin Psychiatry. 2006;67(Suppl 3):3\u20137.","journal-title":"J Clin Psychiatry"},{"issue":"3","key":"2288_CR27","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/1756285609102724","volume":"2","author":"KL Lanctot","year":"2009","unstructured":"Lanctot KL, Rajaram RD, Herrmann N. Therapy for Alzheimer's disease: how effective are current treatments? Ther Adv Neurol Disord. 2009;2(3):163\u201380.","journal-title":"Ther Adv Neurol Disord"},{"issue":"4","key":"2288_CR28","first-page":"208","volume":"35","author":"DA Casey","year":"2010","unstructured":"Casey DA, Antimisiaris D, O\u2019Brien J. Drugs for Alzheimer\u2019s disease: are they effective? P T. 2010;35(4):208.","journal-title":"P T"},{"issue":"21","key":"2288_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta16210","volume":"16","author":"M Bond","year":"2012","unstructured":"Bond M, Rogers G, Peters J, Anderson R, Hoyle M, Miners A, et al. The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of technology appraisal no. 111): a systematic review and economic model. Health Technol Assess. 2012;16(21):1\u2013470.","journal-title":"Health Technol Assess"},{"issue":"6","key":"2288_CR30","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1080\/17460441.2018.1457645","volume":"13","author":"R Cacabelos","year":"2018","unstructured":"Cacabelos R. Have there been improvements in Alzheimer\u2019s disease drug discovery over the past 5 years? Expert Opin Drug Discov. 2018;13(6):523\u201338.","journal-title":"Expert Opin Drug Discov"},{"issue":"25","key":"2288_CR31","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.2174\/138161210793176572","volume":"16","author":"P Agostinho","year":"2010","unstructured":"Agostinho P, Cunha RA, Oliveira C. Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease. Curr Pharm Des. 2010;16(25):2766\u201378.","journal-title":"Curr Pharm Des"},{"issue":"1","key":"2288_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/alzrt24","volume":"2","author":"E Zotova","year":"2010","unstructured":"Zotova E, Nicoll JA, Kalaria R, Holmes C, Boche D. Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy. Alzheimers Res Ther. 2010;2(1):1.","journal-title":"Alzheimers Res Ther"},{"key":"2288_CR33","first-page":"316523","volume":"2013","author":"Y Zhao","year":"2013","unstructured":"Zhao Y, Zhao B. Oxidative stress and the pathogenesis of Alzheimer's disease. Oxidative Med Cell Longev. 2013;2013:316523.","journal-title":"Oxidative Med Cell Longev"},{"key":"2288_CR34","doi-asserted-by":"crossref","unstructured":"Bibi F, Yasir M, Sohrab SS, Azhar EI, Al-Qahtani MH, Abuzenadah AM, et al. Link between chronic bacterial inflammation and Alzheimer disease. CNS Neurol Disord Drug Targets 2014; 13(7):1140\u20131147.","DOI":"10.2174\/1871527313666140917115741"},{"key":"2288_CR35","doi-asserted-by":"crossref","unstructured":"Itzhaki RF, Lathe R, Balin BJ, Ball MJ, Bearer EL, Braak H, et al. Microbes and Alzheimer's disease. J Alzheimers Dis 2016; 51(4):979\u2013984.","DOI":"10.3233\/JAD-160152"},{"issue":"4","key":"2288_CR36","doi-asserted-by":"publisher","first-page":"575","DOI":"10.18632\/aging.100921","volume":"8","author":"J Miklossy","year":"2016","unstructured":"Miklossy J, McGeer PL. Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation. Aging (Albany NY). 2016;8(4):575\u201388.","journal-title":"Aging (Albany NY)"},{"key":"2288_CR37","doi-asserted-by":"crossref","unstructured":"Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, et al. The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. PLoS One 2010; 5(3):e9505.","DOI":"10.1371\/journal.pone.0009505"},{"key":"2288_CR38","doi-asserted-by":"crossref","unstructured":"Kumar DK, Choi SH, Washicosky KJ, Eimer WA, Tucker S, Ghofrani J, et al. Amyloid-beta peptide protects against microbial infection in mouse and worm models of Alzheimer's disease. Sci Transl Med 2016; 8(340):340ra372.","DOI":"10.1126\/scitranslmed.aaf1059"},{"key":"2288_CR39","doi-asserted-by":"crossref","unstructured":"Harach T, Marungruang N, Duthilleul N, Cheatham V, Mc Coy KD, Frisoni G, et al. Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota. Sci Rep 2017; 7:41802.","DOI":"10.1038\/srep41802"},{"key":"2288_CR40","doi-asserted-by":"crossref","unstructured":"Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, et al. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE\/PS1DeltaE9 murine model of Alzheimer's disease. Sci Rep 2017; 7(1):10411.","DOI":"10.1038\/s41598-017-11047-w"},{"key":"2288_CR41","doi-asserted-by":"crossref","unstructured":"Emery DC, Shoemark DK, Batstone TE, Waterfall CM, Coghill JA, Cerajewska TL, et al. 16S rRNA next generation sequencing analysis shows Bacteria in Alzheimer's post-mortem brain. Front Aging Neurosci 2017; 9:195.","DOI":"10.3389\/fnagi.2017.00195"},{"issue":"4","key":"2288_CR42","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.3233\/JAD-160388","volume":"53","author":"HB Allen","year":"2016","unstructured":"Allen HB. Alzheimer's disease: assessing the role of spirochetes, biofilms, the immune system, and amyloid-beta with regard to potential treatment and prevention. J Alzheimers Dis. 2016;53(4):1271\u20136.","journal-title":"J Alzheimers Dis"},{"key":"2288_CR43","doi-asserted-by":"publisher","first-page":"13441","DOI":"10.1038\/ncomms13441","volume":"7","author":"JK Hefendehl","year":"2016","unstructured":"Hefendehl JK, LeDue J, Ko RW, Mahler J, Murphy TH, MacVicar BA. Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Abeta plaques by iGluSnFR two-photon imaging. Nat Commun. 2016;7:13441.","journal-title":"Nat Commun"},{"issue":"2","key":"2288_CR44","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1093\/ecam\/nel018","volume":"3","author":"S Rastogi","year":"2006","unstructured":"Rastogi S, Kulshreshtha DK, Rawat AK. Streblus asper Lour. (Shakhotaka): a review of its chemical, pharmacological and Ethnomedicinal properties. Evid Based Complement Alternat Med. 2006;3(2):217\u201322.","journal-title":"Evid Based Complement Alternat Med"},{"issue":"2","key":"2288_CR45","first-page":"65","volume":"1","author":"NK Verma","year":"2015","unstructured":"Verma NK, Singh SP, Singh AP, Singh R, Rai PK, Tripathi AK. A brief study on Strebulus asper L.-a review. RJP. 2015;1(2):65\u201371.","journal-title":"RJP"},{"key":"2288_CR46","first-page":"1","volume":"41","author":"S Luanchoy","year":"2014","unstructured":"Luanchoy S, Tiangkul S, Wongkrajang Y, Temsiririrkkul R, Peungvicha P, Nakornchai S. Antioxidant activity of a Thai traditional formula for longevity. Mahidol J Pharm Sci. 2014;41:1\u20135.","journal-title":"Mahidol J Pharm Sci"},{"key":"2288_CR47","doi-asserted-by":"crossref","unstructured":"Ren Y, Chen W-L, Lantvit DD, Sass EJ, Shriwas P, Ninh TN, et al. Cardiac glycoside constituents of Streblus asper with potential antineoplastic activity. J Nat Prod 2016; 80(3):648\u2013658.","DOI":"10.1021\/acs.jnatprod.6b00924"},{"issue":"2","key":"2288_CR48","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/ptr.705","volume":"15","author":"S Wongkham","year":"2001","unstructured":"Wongkham S, Laupattarakasaem P, Pienthaweechai K, Areejitranusorn P, Wongkham C, Techanitiswad T. Antimicrobial activity of Streblus asper leaf extract. Phytother Res. 2001;15(2):119\u201321.","journal-title":"Phytother Res"},{"issue":"1","key":"2288_CR49","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/0035-9203(91)90147-Q","volume":"85","author":"MK Das","year":"1991","unstructured":"Das MK, Beuria MK. Anti-malarial property of an extract of the plant Streblus asper in murine malaria. Trans R Soc Trop Med Hyg. 1991;85(1):40\u20131.","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"1","key":"2288_CR50","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ddr.430260106","volume":"26","author":"RK Chatterjee","year":"1992","unstructured":"Chatterjee RK, Fatma N, Murthy PK, Sinha P, Kulshrestha DK, Dhawan BN. Macrofilaricidal activity of the stembark of Streblus asper and its major active constituents. Drug Dev Res. 1992;26(1):67\u201378.","journal-title":"Drug Dev Res"},{"issue":"3","key":"2288_CR51","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.jep.2009.04.061","volume":"124","author":"B Sripanidkulchai","year":"2009","unstructured":"Sripanidkulchai B, Junlatat J, Wara-aswapati N, Hormdee D. Anti-inflammatory effect of Streblus asper leaf extract in rats and its modulation on inflammation-associated genes expression in RAW 264.7 macrophage cells. J Ethnopharmacol. 2009;124(3):566\u201370.","journal-title":"J Ethnopharmacol"},{"key":"2288_CR52","doi-asserted-by":"crossref","unstructured":"Li J, Huang Y, Guan XL, Li J, Deng SP, Wu Q, et al. Anti-hepatitis B virus constituents from the stem bark of Streblus asper. Phytochemistry 2012; 82:100\u2013109.","DOI":"10.1016\/j.phytochem.2012.06.023"},{"key":"2288_CR53","doi-asserted-by":"crossref","unstructured":"Singsai K, Akaravichien T, Kukongviriyapan V, Sattayasai J. Protective effects of Streblus asper leaf extract on H2O2-induced ROS in SK-N-SH cells and MPTP-induced Parkinson\u2019s disease-like symptoms in C57BL\/6 mouse. Evid Based Complement Alternat Med. 2015;2015:970354\u20139.","DOI":"10.1155\/2015\/970354"},{"issue":"1","key":"2288_CR54","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1186\/s12906-017-2050-3","volume":"17","author":"A Prasansuklab","year":"2017","unstructured":"Prasansuklab A, Meemon K, Sobhon P, Tencomnao T. Ethanolic extract of Streblus asper leaves protects against glutamate-induced toxicity in HT22 hippocampal neuronal cells and extends lifespan of Caenorhabditis elegans. BMC Complement Altern Med. 2017;17(1):551.","journal-title":"BMC Complement Altern Med"},{"issue":"4","key":"2288_CR55","first-page":"901","volume":"76","author":"K Iriyama","year":"1974","unstructured":"Iriyama K, Ogura N. Takamiya a. A simple method for extraction and partial purification of chlorophyll from plant material, using dioxane. J Biochem. 1974;76(4):901\u20134.","journal-title":"J Biochem"},{"key":"2288_CR56","doi-asserted-by":"crossref","unstructured":"Mungkornasawakul P, Pyne SG, Jatisatienr A, Supyen D, Lie W, Ung AT, et al. Stemocurtisine, the first pyrido[1,2-a]azapine Stemona alkaloid. J Nat Prod 2003; 66(7):980\u2013982.","DOI":"10.1021\/np020612s"},{"issue":"1","key":"2288_CR57","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/pca.623","volume":"13","author":"A Marston","year":"2002","unstructured":"Marston A, Kissling J, Hostettmann K. A rapid TLC bioautographic method for the detection of acetylcholinesterase and butyrylcholinesterase inhibitors in plants. Phytochem Anal. 2002;13(1):51\u20134.","journal-title":"Phytochem Anal"},{"issue":"1","key":"2288_CR58","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0378-8741(99)00140-3","volume":"70","author":"S Taweechaisupapong","year":"2000","unstructured":"Taweechaisupapong S, Wongkham S, Chareonsuk S, Suparee S, Srilalai P, Chaiyarak S. Selective activity of Streblus asper on Mutans streptococci. J Ethnopharmacol. 2000;70(1):73\u20139.","journal-title":"J Ethnopharmacol"},{"key":"2288_CR59","first-page":"177","volume-title":"ISHS Acta Horticulturae 680: III WOCMAP congress on medicinal and aromatic plants, Vol. 6. Traditional medicine and nutraceuticals","author":"S Taweechaisupapong","year":"2005","unstructured":"Taweechaisupapong S, Singhara S, Choopan T. Effect of Streblus asper leaf extract on selected anaerobic Bacteria. In: ISHS Acta Horticulturae 680: III WOCMAP congress on medicinal and aromatic plants, Vol. 6. Traditional medicine and nutraceuticals; 2005. p. 177\u201381."},{"key":"2288_CR60","doi-asserted-by":"crossref","unstructured":"Tong SY, Davis JS, Eichenberger E, Holland TL, Fowler VG, Jr. Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev 2015; 28(3):603\u2013661.","DOI":"10.1128\/CMR.00134-14"},{"issue":"23","key":"2288_CR61","doi-asserted-by":"publisher","first-page":"5157","DOI":"10.1016\/j.febslet.2005.08.028","volume":"579","author":"CJ Zheng","year":"2005","unstructured":"Zheng CJ, Yoo JS, Lee TG, Cho HY, Kim YH, Kim WG. Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids. FEBS Lett. 2005;579(23):5157\u201362.","journal-title":"FEBS Lett"},{"issue":"5","key":"2288_CR62","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s11274-005-9054-8","volume":"22","author":"RK Asthana","year":"2006","unstructured":"Asthana RK, Srivastava A, Kayastha AM, Nath G, Singh SP. Antibacterial potential of \u03b3-linolenic acid from Fischerella sp. colonizing neem tree bark. World J Microbiol Biotechnol. 2006;22(5):443\u20138.","journal-title":"World J Microbiol Biotechnol"},{"issue":"8","key":"2288_CR63","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.archoralbio.2010.05.009","volume":"55","author":"CB Huang","year":"2010","unstructured":"Huang CB, George B, Ebersole JL. Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms. Arch Oral Biol. 2010;55(8):555\u201360.","journal-title":"Arch Oral Biol"},{"issue":"11","key":"2288_CR64","doi-asserted-by":"publisher","first-page":"4544","DOI":"10.3390\/md11114544","volume":"11","author":"AP Desbois","year":"2013","unstructured":"Desbois AP, Lawlor KC. Antibacterial activity of long-chain polyunsaturated fatty acids against Propionibacterium acnes and Staphylococcus aureus. Mar Drugs. 2013;11(11):4544\u201357.","journal-title":"Mar Drugs"},{"issue":"1","key":"2288_CR65","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0925-4439(00)00040-5","volume":"1502","author":"MA Smith","year":"2000","unstructured":"Smith MA, Rottkamp CA, Nunomura A, Raina AK, Perry G. Oxidative stress in Alzheimer's disease. Biochim Biophys Acta. 2000;1502(1):139\u201344.","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"2288_CR66","first-page":"231","volume":"3","author":"K Gadidasu","year":"2009","unstructured":"Gadidasu K, Reddy ARN, Umate P, Reddy YN. Antioxidant and anti-diabetic activities from leaf extracts of Streblus asper Lour. Biotechnol Ind J. 2009;3(4):231\u20135.","journal-title":"Biotechnol Ind J"},{"issue":"3","key":"2288_CR67","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3390\/antiox2030156","volume":"2","author":"NM Ibrahim","year":"2013","unstructured":"Ibrahim NM, Mat I, Lim V, Ahmad R. Antioxidant activity and phenolic content of Streblus asper leaves from various drying methods. Antioxidants (Basel). 2013;2(3):156\u201366.","journal-title":"Antioxidants (Basel)"},{"issue":"2","key":"2288_CR68","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S2222-1808(12)60032-2","volume":"2","author":"RS Kumar","year":"2012","unstructured":"Kumar RS, Kar B, Dolai N, Bala A, Haldar PK. Evaluation of antihyperglycemic and antioxidant properties of Streblus asper Lour against streptozotocin\u2013induced diabetes in rats. Asian Pac J Trop Dis. 2012;2(2):139\u201343.","journal-title":"Asian Pac J Trop Dis"},{"key":"2288_CR69","unstructured":"Kumar RB, Kar B, Dolai N, Karmakar I, Haldar S, Bhattacharya S, et al. Antitumor activity and antioxidant role of Streblus asper bark against Ehrlich ascites carcinoma in Swiss albino mice. J Exp Ther Oncol 2013; 10(3):197\u2013202."},{"issue":"3","key":"2288_CR70","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1515\/intox-2015-0019","volume":"8","author":"RB Kumar","year":"2015","unstructured":"Kumar RB, Kar B, Dolai N, Karmakar I, Bhattacharya S, Haldar PK. Antitumor activity and antioxidant status of Streblus asper bark against Dalton's ascitic lymphoma in mice. Interdiscip Toxicol. 2015;8(3):125\u201330.","journal-title":"Interdiscip Toxicol"},{"issue":"3","key":"2288_CR71","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.foodchem.2006.09.024","volume":"103","author":"J Lachman","year":"2007","unstructured":"Lachman J, \u0160ulc M, Schilla M. Comparison of the total antioxidant status of bohemian wines during the wine-making process. Food Chem. 2007;103(3):802\u20137.","journal-title":"Food Chem"},{"issue":"7","key":"2288_CR72","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.jfca.2011.01.008","volume":"24","author":"A Floegel","year":"2011","unstructured":"Floegel A, Kim D-O, Chung S-J, Koo SI, Chun OK. Comparison of ABTS\/DPPH assays to measure antioxidant capacity in popular antioxidant-rich US foods. J Food Compost Anal. 2011;24(7):1043\u20138.","journal-title":"J Food Compost Anal"},{"issue":"6","key":"2288_CR73","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.neubiorev.2011.03.001","volume":"35","author":"LA Craig","year":"2011","unstructured":"Craig LA, Hong NS, McDonald RJ. Revisiting the cholinergic hypothesis in the development of Alzheimer's disease. Neurosci Biobehav Rev. 2011;35(6):1397\u2013409.","journal-title":"Neurosci Biobehav Rev"},{"issue":"6","key":"2288_CR74","doi-asserted-by":"publisher","first-page":"497","DOI":"10.2174\/1568026013394741","volume":"1","author":"S Tan","year":"2001","unstructured":"Tan S, Schubert D, Maher P. Oxytosis: a novel form of programmed cell death. Curr Top Med Chem. 2001;1(6):497\u2013506.","journal-title":"Curr Top Med Chem"},{"issue":"6\u20137","key":"2288_CR75","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.neuint.2007.03.012","volume":"51","author":"AL Sheldon","year":"2007","unstructured":"Sheldon AL, Robinson MB. The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention. Neurochem Int. 2007;51(6\u20137):333\u201355.","journal-title":"Neurochem Int"},{"key":"2288_CR76","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fncel.2015.00091","volume":"9","author":"AA Kritis","year":"2015","unstructured":"Kritis AA, Stamoula EG, Paniskaki KA, Vavilis TD. Researching glutamate - induced cytotoxicity in different cell lines: a comparative\/collective analysis\/study. Front Cell Neurosci. 2015;9:91.","journal-title":"Front Cell Neurosci"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-018-2288-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12906-018-2288-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-018-2288-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T11:44:27Z","timestamp":1569152667000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-018-2288-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,24]]},"references-count":76,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["2288"],"URL":"https:\/\/doi.org\/10.1186\/s12906-018-2288-4","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,24]]},"assertion":[{"value":"3 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declared that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"223"}}