{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:24:14Z","timestamp":1779125054794,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503477"],"award-info":[{"award-number":["81503477"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703584"],"award-info":[{"award-number":["81703584"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["7164313"],"award-info":[{"award-number":["7164313"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Altern Med"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12906-019-2607-4","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T14:04:31Z","timestamp":1564495471000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Velvet antler polypeptide partially rescue facet joint osteoarthritis-like phenotype in adult \u03b2-catenin conditional activation mice"],"prefix":"10.1186","volume":"19","author":[{"given":"Wan-qing","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-jian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-ru","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4060-9449","authenticated-orcid":false,"given":"Hong-xin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,30]]},"reference":[{"key":"2607_CR1","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1007\/s13244-018-0638-x","volume":"9","author":"R Perolat","year":"2018","unstructured":"Perolat R, Kastler A, Nicot B, Pellat J-M, Tahon F, Attye A, et al. Facet joint syndrome: from diagnosis to interventional management. Insights Imaging. 2018;9:773\u201389.","journal-title":"Insights Imaging"},{"key":"2607_CR2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.semarthrit.2007.01.007","volume":"37","author":"L Kalichman","year":"2007","unstructured":"Kalichman L, Hunter DJ. Lumbar facet joint osteoarthritis: a review. Semin Arthritis Rheum. 2007;37:69\u201380.","journal-title":"Semin Arthritis Rheum"},{"key":"2607_CR3","doi-asserted-by":"publisher","first-page":"2966","DOI":"10.1002\/art.30487","volume":"63","author":"J-S Kim","year":"2011","unstructured":"Kim J-S, Kroin JS, Buvanendran A, Li X, van Wijnen AJ, Tuman KJ, et al. Characterization of a new animal model for evaluation and treatment of back pain due to lumbar facet joint osteoarthritis. Arthritis Rheum. 2011;63:2966\u201373.","journal-title":"Arthritis Rheum"},{"key":"2607_CR4","doi-asserted-by":"publisher","first-page":"385","DOI":"10.4055\/cios.2014.6.4.385","volume":"6","author":"S Ko","year":"2014","unstructured":"Ko S, Vaccaro AR, Lee S, Lee J, Chang H. The prevalence of lumbar spine facet joint osteoarthritis and its association with low back pain in selected Korean populations. Clin Orthop Surg. 2014;6:385\u201391.","journal-title":"Clin Orthop Surg"},{"key":"2607_CR5","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nrrheum.2012.199","volume":"9","author":"AC Gellhorn","year":"2013","unstructured":"Gellhorn AC, Katz JN, Suri P. Osteoarthritis of the spine: the facet joints. Nat Rev Rheumatol. 2013;9:216\u201324.","journal-title":"Nat Rev Rheumatol"},{"key":"2607_CR6","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7402947","volume":"2018","author":"M De Santis","year":"2018","unstructured":"De Santis M, Di Matteo B, Chisari E, Cincinelli G, Angele P, Lattermann C, et al. The role of Wnt pathway in the pathogenesis of OA and its potential therapeutic implications in the field of regenerative medicine. Biomed Res Int. 2018;2018:7402947.","journal-title":"Biomed Res Int"},{"key":"2607_CR7","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s11926-017-0679-z","volume":"19","author":"Y Zhou","year":"2017","unstructured":"Zhou Y, Wang T, Hamilton JL, Chen D. Wnt\/\u03b2-catenin signaling in osteoarthritis and in other forms of arthritis. Curr Rheumatol Rep. 2017;19:53.","journal-title":"Curr Rheumatol Rep"},{"key":"2607_CR8","doi-asserted-by":"publisher","first-page":"5598","DOI":"10.1002\/jcp.26265","volume":"233","author":"M Majidinia","year":"2018","unstructured":"Majidinia M, Aghazadeh J, Jahanban-Esfahlani R, Yousefi B. The roles of Wnt\/\u03b2-catenin pathway in tissue development and regenerative medicine. J Cell Physiol. 2018;233:5598\u2013612.","journal-title":"J Cell Physiol"},{"key":"2607_CR9","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1359\/jbmr.080901","volume":"24","author":"M Zhu","year":"2009","unstructured":"Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, et al. Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice. J Bone Miner Res. 2009;24:12\u201321.","journal-title":"J Bone Miner Res"},{"key":"2607_CR10","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1002\/art.34469","volume":"64","author":"M Wang","year":"2012","unstructured":"Wang M, Tang D, Shu B, Wang B, Jin H, Hao S, et al. Conditional activation of \u03b2-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum. 2012;64:2611\u201323.","journal-title":"Arthritis Rheum"},{"key":"2607_CR11","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s13075-015-0675-5","volume":"17","author":"J Bleil","year":"2015","unstructured":"Bleil J, Sieper J, Maier R, Schlichting U, Hempfing A, Syrbe U, et al. Cartilage in facet joints of patients with ankylosing spondylitis (AS) shows signs of cartilage degeneration rather than chondrocyte hypertrophy: implications for joint remodeling in AS. Arthritis Res Ther. 2015;17:170.","journal-title":"Arthritis Res Ther"},{"key":"2607_CR12","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1745-6673-6-27","volume":"6","author":"J-H Lin","year":"2011","unstructured":"Lin J-H, Deng L-X, Wu Z-Y, Chen L, Zhang L. Pilose antler polypeptides promote chondrocyte proliferation via the tyrosine kinase signaling pathway. J Occup Med Toxicol. 2011;6:27.","journal-title":"J Occup Med Toxicol"},{"key":"2607_CR13","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1007\/s10753-017-0535-3","volume":"40","author":"C Ma","year":"2017","unstructured":"Ma C, Long H, Yang C, Cai W, Zhang T, Zhao W. Anti-inflammatory role of Pilose antler peptide in LPS-induced lung injury. Inflammation. 2017;40:904\u201312.","journal-title":"Inflammation."},{"key":"2607_CR14","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jep.2013.08.029","volume":"150","author":"L-Z Zhang","year":"2013","unstructured":"Zhang L-Z, Xin J-L, Zhang X-P, Fu Q, Zhang Y, Zhou Q-L. The anti-osteoporotic effect of velvet antler polypeptides from Cervus elaphus Linnaeus in ovariectomized rats. J Ethnopharmacol. 2013;150:181\u20136.","journal-title":"J Ethnopharmacol"},{"key":"2607_CR15","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3109\/13685538.2014.963042","volume":"18","author":"ZJ Zang","year":"2015","unstructured":"Zang ZJ, Ji SY, Dong W, Zhang YN, Zhang EH, Bin Z. A herbal medicine, saikokaryukotsuboreito, improves serum testosterone levels and affects sexual behavior in old male mice. Aging Male. 2015;18:106\u201311.","journal-title":"Aging Male"},{"key":"2607_CR16","doi-asserted-by":"publisher","first-page":"613","DOI":"10.4103\/1008-682X.166435","volume":"18","author":"Z-J Zang","year":"2016","unstructured":"Zang Z-J, Tang H-F, Tuo Y, Xing W-J, Ji S-Y, Gao Y, et al. Effects of velvet antler polypeptide on sexual behavior and testosterone synthesis in aging male mice. Asian J Androl. 2016;18:613\u20139.","journal-title":"Asian J Androl"},{"key":"2607_CR17","doi-asserted-by":"publisher","first-page":"297","DOI":"10.18388\/abp.2011_2239","volume":"58","author":"Z Zhang","year":"2011","unstructured":"Zhang Z, Liu X, Duan L, Li X, Zhang Y, Zhou Q. The effects of velvet antler polypeptides on the phenotype and related biological indicators of osteoarthritic rabbit chondrocytes. Acta Biochim Pol. 2011;58:297\u2013302.","journal-title":"Acta Biochim Pol"},{"key":"2607_CR18","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/dvg.20261","volume":"45","author":"M Chen","year":"2007","unstructured":"Chen M, Lichtler AC, Sheu T-J, Xie C, Zhang X, O\u2019Keefe RJ, et al. Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis. 2007;45:44\u201350.","journal-title":"Genesis."},{"key":"2607_CR19","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.joca.2007.08.001","volume":"16","author":"M Zhu","year":"2008","unstructured":"Zhu M, Chen M, Lichtler AC, O\u2019Keefe RJ, Chen D. Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice. Osteoarthr Cartil. 2008;16:129\u201330.","journal-title":"Osteoarthr Cartil"},{"key":"2607_CR20","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1097\/00007632-198304000-00017","volume":"8","author":"MA Adams","year":"1983","unstructured":"Adams MA, Hutton WC. The mechanical function of the lumbar apophyseal joints. Spine. 1983;8:327\u201330.","journal-title":"Spine."},{"key":"2607_CR21","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S1529-9430(02)00142-0","volume":"2","author":"T Iida","year":"2002","unstructured":"Iida T, Abumi K, Kotani Y, Kaneda K. Effects of aging and spinal degeneration on mechanical properties of lumbar supraspinous and interspinous ligaments. Spine J. 2002;2:95\u2013100.","journal-title":"Spine J"},{"key":"2607_CR22","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/00007632-197812000-00004","volume":"3","author":"WH Kirkaldy-Willis","year":"1978","unstructured":"Kirkaldy-Willis WH, Wedge JH, Yong-Hing K, Reilly J. Pathology and pathogenesis of lumbar spondylosis and stenosis. Spine. 1978;3:319\u201328.","journal-title":"Spine."},{"key":"2607_CR23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.tripleo.2005.07.013","volume":"102","author":"K Yoshida","year":"2006","unstructured":"Yoshida K, Takatsuka S, Hatada E, Nakamura H, Tanaka A, Ueki K, et al. Expression of matrix metalloproteinases and aggrecanase in the synovial fluids of patients with symptomatic temporomandibular disorders. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:22\u20137.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"2607_CR24","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1479-7364-4-1-43","volume":"4","author":"CN Brocker","year":"2009","unstructured":"Brocker CN, Vasiliou V, Nebert DW. Evolutionary divergence and functions of the ADAM and ADAMTS gene families. Hum Genomics. 2009;4:43\u201355.","journal-title":"Hum Genomics"},{"issue":"1","key":"2607_CR25","doi-asserted-by":"publisher","first-page":"529","DOI":"10.2741\/1817","volume":"11","author":"Peter, S. Burrage","year":"2006","unstructured":"Burrage PS, Mix KS, Brinckerhoff CE. Matrix metalloproteinases: role in arthritis. Front Biosci. 2006;11:529\u201343.","journal-title":"Frontiers in Bioscience"},{"key":"2607_CR26","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00296-008-0744-z","volume":"29","author":"KSC Cheung","year":"2009","unstructured":"Cheung KSC, Hashimoto K, Yamada N, Roach HI. Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation. Rheumatol Int. 2009;29:525\u201334.","journal-title":"Rheumatol Int"},{"key":"2607_CR27","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.matbio.2012.12.001","volume":"32","author":"Y He","year":"2013","unstructured":"He Y, Zheng Q, Simonsen O, Petersen KK, Christiansen TG, Karsdal MA, et al. The development and characterization of a competitive ELISA for measuring active ADAMTS-4 in a bovine cartilage ex vivo model. Matrix Biol. 2013;32:143\u201351.","journal-title":"Matrix Biol"},{"key":"2607_CR28","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/089419301750072202","volume":"14","author":"U Klinge","year":"2001","unstructured":"Klinge U, Si ZY, Zheng H, Schumpelick V, Bhardwaj RS, Klosterhalfen B. Collagen I\/III and matrix metalloproteinases (MMP) 1 and 13 in the fascia of patients with incisional hernias. J Investig Surg. 2001;14:47\u201354.","journal-title":"J Investig Surg"},{"key":"2607_CR29","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1080\/07391102.2016.1153521","volume":"35","author":"A Nash","year":"2017","unstructured":"Nash A, Birch HL, de Leeuw NH. Mapping intermolecular interactions and active site conformations: from human MMP-1 crystal structure to molecular dynamics free energy calculations. J Biomol Struct Dyn. 2017;35:564\u201373.","journal-title":"J Biomol Struct Dyn"},{"key":"2607_CR30","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1074\/jbc.274.4.2446","volume":"274","author":"L Ravanti","year":"1999","unstructured":"Ravanti L, Heino J, L\u00f3pez-Ot\u00edn C, K\u00e4h\u00e4ri VM. Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase. J Biol Chem. 1999;274:2446\u201355.","journal-title":"J Biol Chem"}],"container-title":["BMC Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-019-2607-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12906-019-2607-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-019-2607-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T23:07:44Z","timestamp":1595977664000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-019-2607-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,30]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2607"],"URL":"https:\/\/doi.org\/10.1186\/s12906-019-2607-4","relation":{},"ISSN":["1472-6882"],"issn-type":[{"value":"1472-6882","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,30]]},"assertion":[{"value":"27 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The research was approved by the ethics committee of Liaoning University of Traditional Chinese Medicine experimental animal ethics committee (Shenyang, China).committee reference #: 20160305.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"191"}}