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The present study aimed to evaluate the antidiarrheal, antisecretary, antispasmodic, antiulcer and anti motility properties of <jats:italic>Ficus palmata.<\/jats:italic><\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>In-vivo, in-vitro and <jats:italic>in-silico<\/jats:italic> techniques were used to investigate various gastrointestinal effects of <jats:italic>Ficus palmata<\/jats:italic>. Antidiarrheal, antisecretary, antispasmodic, antiulcer, anti motility and molecular docking were performed using castor oil induced diarrhea and fluid accumulation, isolated tissue preparations, ethanol-HCl induced ulcer assay, charcoal meal transit time and Auto Doc Vina.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p><jats:italic>Ficus palmata<\/jats:italic> crude extract (Fp.Cr) exhibited protection against castor oil-induced diarrhea in mice and dose-dependently inhibited intestinal fluid secretions. Fp.Cr caused relaxation of spontaneous and K<jats:sup>+<\/jats:sup> (80\u2009Mm)-induced contractions in isolated rabbit jejunum preparations. It showed protective effect against gastric ulcers induced by ethanol-hydrochloric acid in rats. Fp.Cr reduced distance travelled by charcoal meal in the gastrointestinal transit model in mice. The plant constituents: psoralenoside and bergapten showed high binding affinities (E-value \u2265 \u2212\u20096.5 Kcal\/mol) against histaminergic H<jats:sub>1<\/jats:sub>, calmodulin and voltage gated L-type calcium channels, while showed moderate affinities (E-value \u22657 Kcal\/mol) against dopaminergic D<jats:sub>2<\/jats:sub>, adrenergic \u03b1<jats:sub>1,<\/jats:sub> muscranic M<jats:sub>3<\/jats:sub>, mu-opioid, whereas revealed lower affinities (E-value \u22659.5 Kcal\/mol) vs. muscranic M<jats:sub>1<\/jats:sub>, histaminergic H<jats:sub>2<\/jats:sub> and H<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup> ATPase pump. Germanicol acetate and psoralene exhibited weak affinities against aforementioned targets.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This study reveals that <jats:italic>Ficus palmata<\/jats:italic> possesses anti-diarrheal, anti-secretory, anti-spasmodic, anti-motility and anti-ulcer activities. The various constituents reveal different binding affinities against target proteins, which mediate the gastrointestinal functions.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12906-019-2759-2","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T05:00:01Z","timestamp":1576472401000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pharmacological and computational evaluation of fig for therapeutic potential in hyperactive gastrointestinal disorders"],"prefix":"10.1186","volume":"19","author":[{"given":"Muhammad Bilal","family":"Riaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arif-ullah","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelam Gul","family":"Qazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,3]]},"reference":[{"key":"2759_CR1","first-page":"60","volume":"5","author":"SN Dwivedi","year":"2006","unstructured":"Dwivedi SN, Dwivedi S, Patel PC. 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