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The present report describes the antiplasmodial and anticancer activities of samples isolated from the methanol extract of <jats:italic>Albizia zygia<\/jats:italic> (Mimosaseae).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Material<\/jats:title>\n<jats:p>The plant extract was prepared by maceration in methanol. Standard chromatographic, HPLC and spectroscopic methods were used to isolate and identify six compounds (<jats:bold>1\u20136<\/jats:bold>). The acetylated derivatives (<jats:bold>7\u201310<\/jats:bold>) were prepared by modifying 2-<jats:italic>O<\/jats:italic>-<jats:italic>\u03b2<\/jats:italic>-D-glucopyranosyl-4-hydroxyphenylacetic acid and quercetin 3-<jats:italic>O<\/jats:italic>-<jats:italic>\u03b1<\/jats:italic>-L-rhamnopyranoside, previously isolated from <jats:italic>A. zygia<\/jats:italic> (Mimosaceae). A two-fold serial micro-dilution method was used to determine the IC<jats:sub>50s<\/jats:sub> against five tumor cell lines and <jats:italic>Plasmodium falciparum<\/jats:italic>.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>In general, compounds showed moderate activity against the human pancreatic carcinoma cell line MiaPaca-2 (10 &lt; IC<jats:sub>50<\/jats:sub> &lt; 20\u2009\u03bcM) and weak activity against other tumor cell lines such as lung (A-549), hepatocarcinoma (HepG2) and\u00a0human breast adenocarcinoma (MCF-7and A2058) (IC<jats:sub>50<\/jats:sub> &gt; 20\u2009\u03bcM). Additionally, the two semi-synthetic derivatives of quercetin 3-<jats:italic>O<\/jats:italic>-<jats:italic>\u03b1<\/jats:italic>-L-rhamnopyranoside exhibited significant activity against <jats:italic>P. falciparum<\/jats:italic> with IC<jats:sub>50<\/jats:sub> of 7.47\u2009\u00b1\u20090.25\u2009\u03bcM for compound <jats:bold>9<\/jats:bold> and 6.77\u2009\u00b1\u20090.25\u2009\u03bcM for compound <jats:bold>10<\/jats:bold>, higher than that of their natural precursor (IC<jats:sub>50<\/jats:sub> 25.1\u2009\u00b1\u20090.25\u2009\u03bcM).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The results of this study clearly suggest that, the appropriate introduction of acetyl groups into some flavonoids could lead to more useful derivatives for the development\u00a0of an antiplasmodial agent.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12906-019-2792-1","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T13:02:22Z","timestamp":1579093342000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) 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