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Accordingly, the aim of our study was to detection<jats:italic>of adeABC<\/jats:italic>efllux pump encoding genes and antimicrobial effect of the essential oil of<jats:italic>Mentha longifolia<\/jats:italic>and<jats:italic>Menthol<\/jats:italic>on the minimum inhibitory concentration (MIC) of imipenem and ciprofloxacin in clinical isolates of<jats:italic>A. baumannii.<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 75 clinical isolates of<jats:italic>A. baumannii<\/jats:italic>were collected. The presence of efflux pump genes was detected by polymerase chain reaction (PCR). The minimum inhibitory concentration (MIC) of the essential oil of<jats:italic>Mentha longifolia<\/jats:italic>and Menthol and their combined effect with antibiotics were measured by microbroth dilution method and fractional inhibitory concentration (FIC) index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of<jats:italic>adeA<\/jats:italic>,<jats:italic>adeB<\/jats:italic>, and<jats:italic>adeC<\/jats:italic>genes in clinical isolates of<jats:italic>A. baumannii<\/jats:italic>were 86.7, 90.7, and 92%, respectively. When the essential oil of<jats:italic>Mentha longifolia<\/jats:italic>was combined with ciprofloxacin and imipenem, MICs decreased 4- and 8-fold, respectively. In the combination of menthol with imipenem, the resistance to imipenem was reduced from 0- to 16-fold in 90% (63\/70) of the isolates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of efflux pump genes in more than 90% of<jats:italic>A. baumannii<\/jats:italic>isolates indicates its potential role in inducing imipenem- and ciprofloxacin-resistance in this bacterium. Menthol has an antimicrobial effect as an active ingredient in<jats:italic>Mentha longifolia<\/jats:italic>. In the future, the combination of medicinal plants with antibiotics can be used as a complement in treating diseases caused by drug-resistant bacteria such as<jats:italic>A. baumannii<\/jats:italic>infections.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12906-020-02887-7","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T12:04:25Z","timestamp":1584619465000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Detection of adeABC efllux pump encoding genes and antimicrobial effect of Mentha longifolia and Menthol on MICs of imipenem and ciprofloxacin in clinical isolates of Acinetobacter baumannii"],"prefix":"10.1186","volume":"20","author":[{"given":"Hassan","family":"Mahmoudi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leili","family":"Shokoohizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayreh","family":"Zare Fahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mohamadi Bardebari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Moradkhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Yousef","family":"Alikhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,19]]},"reference":[{"issue":"4","key":"2887_CR1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1089\/10962960152813331","volume":"2","author":"YD Podnos","year":"2001","unstructured":"Podnos YD, Cinat ME, Wilson SE, Cooke J, Gornick W, Thrupp LD. 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