{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:25:31Z","timestamp":1787761531760,"version":"build-2784847793"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Med Ther"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Acute radiation-induced proctitis (ARP) is the most common side effect following radiotherapy for malignant pelvic disease. This study evaluated the efficacy of <jats:italic>Aloe vera<\/jats:italic> ointment in prevention of ARP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Forty-two patients receiving external-beam radiotherapy (RT) for pelvic malignancies were randomized to receive either <jats:italic>Aloe vera<\/jats:italic> 3% or placebo topical ointment during radiotherapy for 6\u2009weeks. These patients were evaluated based on the severity (grade 0\u20134) of the following symptoms weekly: rectal bleeding, abdominal\/rectal pain, diarrhea, or fecal urgency. RTOG acute toxicity criteria and psychosocial status of the patients were also recorded weekly. Lifestyle impact of the symptoms, and quantitative measurement of C-reactive protein (CRP), an indicator of systemic inflammation, were also measured.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The results of present study demonstrated a significant preventive effect for <jats:italic>Aloe vera<\/jats:italic> in occurrence of symptom index for diarrhea (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), rectal bleeding (p\u2009&lt;\u20090.001), and fecal urgency (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). The median lifestyle score improved significantly with <jats:italic>Aloe vera<\/jats:italic> during RT (p\u2009&lt;\u20090.001). Intervention patients had a significant lower burden of systemic inflammation as the values for quantitative CRP decreased significantly over 6\u2009weeks of follow-up (<jats:italic>p<\/jats:italic>\u2009=\u20090.009).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This study showed that <jats:italic>Aloe vera<\/jats:italic> topical ointment was effective in prevention of symptoms of ARP in patients undergoing RT for pelvic cancers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/fa.irct.ir\/user\/trial\/1652\/view\">IRCT201606042027N6<\/jats:ext-link>. Registration date: 2016-09-04.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12906-020-02935-2","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T12:03:36Z","timestamp":1589371416000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prevention of acute radiation-induced Proctitis by Aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in Pelvic Cancer patients"],"prefix":"10.1186","volume":"20","author":[{"given":"Adeleh","family":"Sahebnasagh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jafar","family":"Akbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Alipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Lashkardoost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Ala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Jalal","family":"Hosseinimehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8162-6950","authenticated-orcid":false,"given":"Ebrahim","family":"Salehifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"issue":"2","key":"2935_CR1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0360-3016(99)00443-5","volume":"46","author":"JM Michalski","year":"2000","unstructured":"Michalski JM, Purdy JA, Winter K, et al. 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All patients received verbal and printed information, and all provided written consent before entry into this study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"\u201cNot applicable\u201d.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors of present study declare that they have no conflict of interest. Seyed Jalal Hosseinimehr as an author of this manuscript is a member of editorial board of BMC complementary and alternative medicine has no conflict of interest to this manuscript that was submitted to this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"146"}}