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Here we assessed the antidyslipidemic and antiatherosclerotic effects of this spice in repeated heated mix vegetable oils (RHMVO)-induced atherosclerotic models.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Aqueous extract of <jats:italic>M. koenigii<\/jats:italic> leaves (Mk LE) was prepared and its phytoconstituents were determined. Rabbits were divided into 5 groups (<jats:italic>n<\/jats:italic>\u2009=\u200910). Except for the control group, all the other four groups were treated with RHMVO for 16\u2009weeks (dose\u2009=\u20092\u2009ml\/kg\/day) to induce dyslipidemia and atherosclerosis. These groups were further treated for 10\u2009weeks either with 300 and 500\u2009mg\/kg\/day Mk LE, lovastatin, RHMVO, or left untreated. Body and organ weights were measured along with oxidative stress and tissue damage parameters. Lipid profile and hepatic function markers were studied. Atheroma measurement and histopathological examination were also performed in control and treated groups.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Mk LE significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) attenuated RHMVO-induced dyslipidemia and atheroma formation. Furthermore, fat accumulation and lipid peroxidation in hepatic tissues were reduced by Mk LE in a dose-dependent manner. Our results indicated that the antidyslipidemic effects of Mk LE in 500\u2009mg\/kg\/day dose were comparable to lovastatin. Additionally, oxidative stress markers were reduced much more significantly in Mk LE-500 than in the statin group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This study recommends Mk LE as a potent antioxidant and lipid-lowering natural medicine that can attenuate the RHMVO-induced atherosclerotic in optimal doses and duration. Therefore, Mk LE can be accessible, cheap, and free of adverse effects alternate to statins.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12906-020-03012-4","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T13:38:34Z","timestamp":1594733914000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Repeatedly heated mix vegetable oils-induced atherosclerosis and effects of Murraya koenigii"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6287-6898","authenticated-orcid":false,"given":"Gul","family":"Ambreen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshan","family":"Siddiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashif","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Saboor","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zara","family":"Naz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"issue":"suppl_D","key":"3012_CR1","doi-asserted-by":"crossref","first-page":"D3","DOI":"10.1093\/eurheartj\/sui021","volume":"7","author":"G Alberti","year":"2005","unstructured":"Alberti G. 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