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In this study, the neuroprotective potentials of sulfated polysaccharides isolated from <jats:italic>Ecklonia maxima<\/jats:italic> (PKPM), <jats:italic>Gelidium pristoides<\/jats:italic> (PMNP), <jats:italic>Ulva lactuca<\/jats:italic> (PULV), <jats:italic>Ulva rigida<\/jats:italic> (PURL) and <jats:italic>Gracilaria gracilis<\/jats:italic> (PGCL) against Zn-induced neurodegeneration in rats\u2019 hippocampal neuronal cells (HT-22) were assessed.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Cells were cultured and maintained at 37\u2009\u00b0C. Control cells did not contain Zinc sulphate (ZnSO<jats:sub>4<\/jats:sub>) while other experimental groups contain Zn (50\u2009\u03bcM) alone or in combination with sulfated polysaccharides (0.4 or 0.8\u2009mg\/mL). Cell viability was assessed using MTT assay while apoptotic assay was also determined using acridine orange and ethidium bromide staining technique. Oxidative stress parameters (superoxide dismutase and catalase activities, glutathione and nitric oxide levels) and acetylcholinesterase activity were also assessed in neuronal cells treated with or without Zn.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Zn significantly reduced cell viability to about 50%. However, sulfated polysaccharides improved cell viability to about 95%. The sulfated polysaccharides also prevented late apoptosis and necrosis triggered by Zn. Furthermore, superoxide dismutase and catalase activities including glutathione content were significantly low in cells induced with Zn. Treatment with sulfated polysaccharides triggered a significant increase in antioxidant enzymes and glutathione content as well as a decrease in the activity of acetylcholinesterase in cells treated with Zn.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>PKPM, PGCL, PURL, PULV and PMNP exhibit neuroprotective effects against neuronal damage induced by Zn and this may be attributed to inhibition of apoptosis, oxidative damage and acetylcholinesterase activity. These polysaccharides may be good therapeutic agents to protect neuronal cells against Zn -\u00a0induced pathological processes associated with Alzheimer\u2019s disease.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12906-020-03047-7","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T17:03:12Z","timestamp":1597424592000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Sulfated polysaccharides of some seaweeds exhibit neuroprotection via mitigation of oxidative stress, cholinergic dysfunction and inhibition of Zn \u2013 induced neuronal damage in HT-22 cells"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0379-3838","authenticated-orcid":false,"given":"Tosin A.","family":"Olasehinde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademola O.","family":"Olaniran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony I.","family":"Okoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"issue":"10","key":"3047_CR1","first-page":"136","volume":"3","author":"WY Wang","year":"2015","unstructured":"Wang WY, Tan MS, Yu JT, Tan L. 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