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HE staining was used to detect the histopathologic changes of the synovial tissue of joint. Immunohistochemical method was used to detect the protein expressions of P-38, p-P38, JNK, p-JNK, ERK1\/2, p-ERK1\/2, MEK1\/2, p-MEK1\/2, MKK4, p-MKK4, ICAM1, VCAM1, and PPAR\u03b3 in the synovial tissue of joint. Realtime PCR and WB methods were used to detect the mRNA and protein expressions of PPAR\u03b3 and AdipoR2 in the synovial tissue of joint. The contents of CXCL1 and ADP in the blood serum were measured by Elisa method.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Our study showed that RDN could improve the situation of the synovial tissue, reduce the protein expressions of MKK4, p-MEK1\/2, p-JNK, p-ERK1\/2, ICAM1. They could also decrease the content of CXCL1 and increase the content of ADP in the blood serum.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>RDN has good effect of anti-inflammation. This is in part realized by influencing MAPK signalling pathway. It provides a new visual angle to reveal the mechanism of RDN to treat GA.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12906-020-03055-7","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T09:03:36Z","timestamp":1598346216000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Anti-inflammation effects of the total saponin fraction from Dioscorea nipponica Makino on rats with gouty arthritis by influencing MAPK signalling pathway"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0229-8811","authenticated-orcid":false,"given":"Qi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Juan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi Hong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"issue":"5","key":"3055_CR1","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s40265-019-01081-5","volume":"79","author":"MK Gupta","year":"2019","unstructured":"Gupta MK, Singh JA. 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