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There is a need to explore the biological activities and chemical constituents of this medicinal plant.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this work, the biochemical potential of <jats:italic>M. buxifolia<\/jats:italic> (Falc.) A. DC was explored and linked with its biological activities. Methanol and chloroform extracts from leaves and stems were investigated for total phenolic and flavonoid contents. Ultrahigh-performance liquid chromatography coupled with mass spectrometry (UHPLC\u2013MS) was used to determine secondary-metabolite composition, while high-performance liquid chromatography coupled with photodiode array detection (HPLC\u2013PDA) was used for polyphenolic quantification. In addition, we carried out in vitro assays to determine antioxidant potential and the enzyme-inhibitory response of <jats:italic>M. buxifolia<\/jats:italic> extracts.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Phenolics (91\u2009mg gallic-acid equivalent (GAE)\/g) and flavonoids (48.86\u2009mg quercetin equivalent (QE)\/g) exhibited their highest concentration in the methanol extract of stems and the chloroform extract of leaves, respectively. UHPLC\u2013MS analysis identified a number of important phytochemicals, belonging to the flavonoid, phenolic, alkaloid, and terpenoid classes of secondary metabolites. The methanol extract of leaves contained a diosgenin derivative and polygalacin D, while kaempferol and robinin were most abundant in the chloroform extract. The methanol extract of stems contained a greater peak area for diosgenin and kaempferol, whereas this was true for lucidumol A and 3-<jats:italic>O<\/jats:italic>-<jats:italic>cis<\/jats:italic>-coumaroyl maslinic acid in the chloroform extract. Rutin, epicatechin, and catechin were the main phenolics identified by HPLC\u2013PDA analysis. The methanol extract of stems exhibited significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2\u2032-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical-scavenging activities (145.18 and 279.04\u2009mmol Trolox equivalent (TE)\/g, respectively). The maximum cupric reducing antioxidant capacity (CUPRAC) (361.4\u2009mg TE\/g), ferric-reducing antioxidant power (FRAP) (247.19\u2009mg TE\/g), and total antioxidant potential (2.75\u2009mmol TE\/g) were depicted by the methanol extract of stems. The methanol extract of leaves exhibited stronger inhibition against acetylcholinesterase (AChE) and glucosidase, while the chloroform extract of stems was most active against butyrylcholinesterase (BChE) (4.27\u2009mg galantamine equivalent (GALAE)\/g). Similarly, the highest tyrosinase (140\u2009mg kojic-acid equivalent (KAE)\/g) and amylase (0.67\u2009mmol acarbose equivalent (ACAE)\/g) inhibition was observed for the methanol extract of stems.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>UHPLC\u2013MS analysis and HPLC\u2013PDA quantification identified a number of bioactive secondary metabolites of <jats:italic>M. buxifolia<\/jats:italic>, which may be responsible for its antioxidant potential and enzyme-inhibitory response. <jats:italic>M. buxifolia<\/jats:italic> can be further explored for the isolation of its active components to be used as a drug.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12906-020-03093-1","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T12:02:43Z","timestamp":1602849763000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Metabolic fingerprinting, antioxidant characterization, and enzyme-inhibitory response of Monotheca buxifolia (Falc.) 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