{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:33:19Z","timestamp":1759483999504},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Med Ther"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Inflammation is one of the key components in the initiation and progression of hepatic diseases. If not treated, inflammation may cause cell dysplasia, and ultimately cancer. In the current study, we investigated the anti-inflammatory and anti-cancer activities of plant isolated compound Lirioresinol B Dimethyl Ether (LBDE) extracted from the seeds of <jats:italic>Magnolia fargesii<\/jats:italic> CHENG (Magnoliaceae) against HepG2 cells as well as in BALB\/C male mice.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We assessed the antioxidant and anti-proliferative effects of plant compounds using DPPH assay and HepG2 cell lines. Carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) and Diethylnitrosamine (DEN) were used to induce liver cell dysplasia followed by hepatocellular carcinoma (HCC) in BALB\/C male mice for 12\u2009weeks. We investigated the underlying mechanism by using histopathology and immunoblot experiments.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Intraperitoneal injection of LBDE (50\u2009mg\/kg body weight\/day) inhibited CCl<jats:sub>4<\/jats:sub>-induced HCC. Free radical scavenging assay shows the strong anti-oxidant activity of LBDE. Western blot results show that LBDE down-regulated nuclear factor kappa B (NF\u03baB) and cyclooxygenase (COX-2) by preventing the phosphorylation of I kappa B alpha (I\u03baB\u03b1) in CCl<jats:sub>4<\/jats:sub> treated group. LBDE also improved liver function by decreasing Alkaline Phosphatase (ALP), aspartate aminotransferase (AST) and Alanine Aminotransferase (ALT) levels. Histopathology results revealed that LBDE decreased granulomas and express normal morphology of hepatocytes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These preliminary results show that LBDE has the potential to inhibit CCl<jats:sub>4<\/jats:sub>-induced liver cell dysplasia and prevents cancer development by regulating NF\u03baB\/COX-2 activation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12906-020-2839-3","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T17:05:41Z","timestamp":1581440741000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lirioresinol B dimethyl ether inhibits NF-\u03baB and COX-2 and activates I\u03baB\u03b1 expression in CCl4-induced hepatic fibrosis"],"prefix":"10.1186","volume":"20","author":[{"given":"Adeeb","family":"Shehzad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shagufta","family":"Rehmat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman","family":"Ul-Islam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizwan","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meneerah","family":"Aljafary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor A.","family":"Alrushaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebtesam A.","family":"Al-Suhaimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"2839_CR1","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1002\/path.4127","volume":"229","author":"W Janssen","year":"2013","unstructured":"Janssen W, Pullamsetti SS, Cooke J, Weissmann N, Guenther A, Schermuly RT. The role of dimethylarginine dimethylaminohydrolase (DDAH) in pulmonary fibrosis. J Pathol. 2013;229:242\u20139.","journal-title":"J Pathol"},{"key":"2839_CR2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/biof.1066","volume":"39","author":"A Shehzad","year":"2013","unstructured":"Shehzad A, Rehman G, Lee YS. Curcumin in inflammatory diseases. Biofactors. 2013;39:69\u201377.","journal-title":"Biofactors."},{"key":"2839_CR3","first-page":"7","volume":"68","author":"RL Siegel","year":"2018","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA: CA Cancer J Clin. 2018;68:7\u201330.","journal-title":"CA: CA Cancer J Clin"},{"key":"2839_CR4","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jhep.2005.07.027","volume":"44","author":"JI Tsui","year":"2014","unstructured":"Tsui JI, Pletcher MJ, Vittinghoff E, Seal K, Gonzales R. Hepatitis C and hospital outcomes in patients admitted with alcohol-related problems. J Hepatology. 2014;44:262\u20136.","journal-title":"J Hepatology"},{"key":"2839_CR5","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s12016-008-8091-0","volume":"36","author":"F Tacke","year":"2008","unstructured":"Tacke F, Luedde T, Trautwein C. Inflammatory pathways in liver homeostasis and liver injury. Clin Rev Allergy Immunol. 2008;36:4\u201312.","journal-title":"Clin Rev Allergy Immunol"},{"key":"2839_CR6","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.ejphar.2012.05.044","volume":"689","author":"SW Santos Rocha","year":"2012","unstructured":"Santos Rocha SW, Silva BS, Gomes FO, Soares e Silva AK, Raposo C, Barbosa KP, Torres Dde O, dos Santos AC, Peixoto CA. Effect of diethylcarbamazine on chronic hepatic inflammation induced by alcohol in C57BL\/6 mice. Eur J Pharmacol. 2012;689:194\u2013203.","journal-title":"Eur J Pharmacol"},{"key":"2839_CR7","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1111\/1750-3841.13793","volume":"82","author":"A Shehzad","year":"2017","unstructured":"Shehzad A, Qureshi M, Anwar MN, Lee YS. Multifunctional Curcumin mediate multitherapeutic effects. J Food Sci. 2017;82:2006\u201315.","journal-title":"J Food Sci"},{"key":"2839_CR8","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s00011-017-1114-7","volume":"67","author":"A Shehzad","year":"2018","unstructured":"Shehzad A, Parveen S, Qureshi M, Subhan F, Lee YS. Decursin and decursinol angelate: molecular mechanism and therapeutic potential in inflammatory diseases. Inflamm Res. 2018;67:209\u201318.","journal-title":"Inflamm Res"},{"key":"2839_CR9","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.cellsig.2010.10.017","volume":"23","author":"D Arias-Salvatierra","year":"2011","unstructured":"Arias-Salvatierra D, Silbergeld EK, Acosta-Saavedra LC, Calderon-Aranda ES. Role of nitric oxide produced by iNOS through NF-\u03baB pathway in migration of cerebellar granule neurons induced by lipopolysaccharide. Cell Signal. 2011;23:425\u201335.","journal-title":"Cell Signal"},{"key":"2839_CR10","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1038\/bjp.2008.338","volume":"155","author":"GM Campo","year":"2008","unstructured":"Campo GM, Avenoso A, Campo S, Nastasi G, Traina P, Dascola A, Rugolo CA, Calatroni A. The antioxidant activity of chondroitin-4-sulphate, in carbon tetrachloride-induced acute hepatitis in mice, involves NF-\u03baB and caspase activation. Br J Pharmacol. 2008;155:945\u201356.","journal-title":"Br J Pharmacol"},{"key":"2839_CR11","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/ardp.200900319","volume":"343","author":"A Shehzad","year":"2010","unstructured":"Shehzad A, Wahid F, Lee YS. Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm (Weinheim). 2010;343:489\u201399.","journal-title":"Arch Pharm (Weinheim)"},{"key":"2839_CR12","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.bmcl.2008.11.103","volume":"19","author":"JY Kim","year":"2009","unstructured":"Kim JY, Lim HJ, Lee da Y, Kim JS, Kim DH, Lee HJ, Kim HD, Jeon R, Ryu JH. In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii. Bioorg Med Chem Lett. 2009;19:937\u201340.","journal-title":"Bioorg Med Chem Lett"},{"key":"2839_CR13","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/j.fitote.2012.08.020","volume":"83","author":"AY Jun","year":"2012","unstructured":"Jun AY, Kim HJ, Park KK, Son KH, Lee DH, Woo MH, Kim YS, Lee SK, Chung WY. Extract of Magnoliae Flos inhibits ovariectomy-induced osteoporosis by blocking osteoclastogenesis and reducing osteoclast-mediated bone resorption. Fitoterapia. 2012;83:1523\u201331.","journal-title":"Fitoterapia."},{"key":"2839_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10637-013-9969-0","volume":"32","author":"AY Jun","year":"2014","unstructured":"Jun AY, Kim HJ, Park KK, Son KH, Lee DH, Woo MH, Chung WY. Tetrahydrofurofuran-type lignans inhibit breast cancer-mediated bone destruction by blocking the vicious cycle between cancer cells, osteoblasts and osteoclasts. Investig New Drugs. 2014;32:1\u201313.","journal-title":"Investig New Drugs"},{"key":"2839_CR15","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1002\/ptr.2783","volume":"23","author":"H Lim","year":"2009","unstructured":"Lim H, Son KH, Bae KH, Hung TM, Kim YS, Kim HP. 5-lipoxygenase-inhibitory constituents from Schizandra fructus and Magnolia flos. Phytother Res. 2009;23:1489\u201392.","journal-title":"Phytother Res"},{"key":"2839_CR16","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.fct.2010.12.006","volume":"49","author":"R Domitrovi\u0107","year":"2011","unstructured":"Domitrovi\u0107 R, Jakovac H. Effects of standardized bilberry fruit extract (Mirtoselect\u00ae) on resolution of CCl4-induced liver fibrosis in mice. Food Chem Toxicol. 2011;49:848\u201354.","journal-title":"Food Chem Toxicol"},{"key":"2839_CR17","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1248\/cpb.55.137","volume":"55","author":"J Lee","year":"2007","unstructured":"Lee J, Lee D, Jang DS, Nam JW, Kim JP, Park KH, Yang MS, Seo EK. Two new stereoisomers of Tetrahydrofuranoid lignans from the flower buds of Magnolia fargesii. Chem Pharm Bull (Tokyo). 2007;55:137\u20139.","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"2839_CR18","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12906-019-2432-9","volume":"19","author":"R Pardeep Kaur","year":"2019","unstructured":"Pardeep Kaur R, Mehta RG, Singh B, Arora S. Development of aqueous-based multi-herbal combination using principal component analysis and its functional significance in HepG2 cells. BMC Complement Altern Med. 2019;19:18.","journal-title":"BMC Complement Altern Med"},{"key":"2839_CR19","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1021\/jf011348w","volume":"50","author":"H Kikuzaki","year":"2002","unstructured":"Kikuzaki H, Hisamoto M, Hirose K, Akiyama K, Taniguchi H. Antioxidant properties of ferulic acid and its related compounds. J Agric Food Chem. 2002;50:2161\u20138.","journal-title":"J Agric Food Chem"},{"key":"2839_CR20","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1177\/2156587217717417","volume":"22","author":"SA Adebayo","year":"2017","unstructured":"Adebayo SA, Steel HC, Shai LJ, Eloff JN. Investigation of the mechanism of anti-inflammatory action and cytotoxicity of a semipurified fraction and isolated compounds from the leaf of Peltophorum africanum (Fabaceae). J Evid Based Complement Altern Med. 2017;22:840\u20135.","journal-title":"J Evid Based Complement Altern Med"},{"key":"2839_CR21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/1472-6882-10-55","volume":"10","author":"W Mahavorasirikul","year":"2010","unstructured":"Mahavorasirikul W, Viyanant V, Chaijaroenkul W, Itharat A, Na-Bangchang K. Cytotoxic activity of Thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro. BMC Complement Altern Med. 2010;10:55.","journal-title":"BMC Complement Altern Med"},{"key":"2839_CR22","doi-asserted-by":"publisher","first-page":"e93599","DOI":"10.1371\/journal.pone.0093599","volume":"9","author":"Y Xu","year":"2014","unstructured":"Xu Y, Long L, Yang C, Lu Y, Cheng M. Maotai ameliorates diethylnitrosamine-initiated hepatocellular carcinoma formation in mice. PLoS One. 2014;9:e93599.","journal-title":"PLoS One"},{"key":"2839_CR23","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.intimp.2019.05.020","volume":"73","author":"Y Su","year":"2019","unstructured":"Su Y, Xiong S, Lan H, Xu L, Wei X. Molecular mechanism underlying anti-inflammatory activities of lirioresinol B dimethyl ether through suppression of NF-\u03baB and MAPK signaling in in vitro and in vivo models. Int Immunopharmacol. 2019;73:321\u201332.","journal-title":"Int Immunopharmacol"},{"key":"2839_CR24","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1046\/j.1440-1827.2002.01410.x","volume":"52","author":"M Nakaji","year":"2002","unstructured":"Nakaji M, Hayashi Y, Ninomiya T, Yano Y, Yoon S, Seo Y, Nagano H, Komori H, Hashimoto K, Orino A, Shirane H, Yokozaki H, Kasuga M. Histological grading and staging in chronic hepatitis: its practical correlation. Pathol Int. 2002;52:683\u201390.","journal-title":"Pathol Int"},{"key":"2839_CR25","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.3748\/wjg.v11.i9.1339","volume":"11","author":"H Dong","year":"2005","unstructured":"Dong H, Lu FE, Gao ZQ, Xu LJ, Wang KF, et al. Effects of emodin on treating murine nonalcoholic fatty liver induced by high caloric laboratory chaw. World J Gastroenterol. 2005;11:1339\u201344.","journal-title":"World J Gastroenterol"},{"key":"2839_CR26","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.cbi.2013.10.007","volume":"206","author":"A Shehzad","year":"2013","unstructured":"Shehzad A, Park JW, Lee J, Lee YS. Curcumin induces radiosensitivity of in vitro and in vivo cancer models by modulating pre-mRNA processing factor 4 (Prp4). Chem Biol Interact. 2013;206:394\u2013402.","journal-title":"Chem Biol Interact"},{"key":"2839_CR27","doi-asserted-by":"publisher","first-page":"899","DOI":"10.14348\/molcells.2014.0212","volume":"37","author":"A Shehzad","year":"2014","unstructured":"Shehzad A, Ul Islam S, Lee J, Lee YS. Prostaglandin E2 reverses curcumin-induced inhibition of survival signal pathways in human colorectal carcinoma (HCT-15) cell lines. Mol Cells. 2014;37:899\u2013906.","journal-title":"Mol Cells"},{"key":"2839_CR28","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3389\/fimmu.2016.00160","volume":"7","author":"MA Sugimoto","year":"2016","unstructured":"Sugimoto MA, Sousa LP, Pinho V, Perretti M, Teixeira MM. Resolution of inflammation: what controls its onset? Front Immunol. 2016;7:160.","journal-title":"Front Immunol"},{"key":"2839_CR29","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.jep.2006.07.042","volume":"109","author":"TY Lee","year":"2007","unstructured":"Lee TY, Chang HH, Chen JH, Hsueh ML, Kuo JJ. Herb medicine yin-Chen-Hao-tang ameliorates hepatic fibrosis in bile duct ligation rats. J Ethnopharmol. 2007;109:318\u201324.","journal-title":"J Ethnopharmol"},{"key":"2839_CR30","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","volume":"134","author":"SL Friedman","year":"2008","unstructured":"Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology. 2008;134:1655\u201369.","journal-title":"Gastroenterology."},{"key":"2839_CR31","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.tox.2010.04.014","volume":"273","author":"GL Tipoe","year":"2010","unstructured":"Tipoe GL, Leung TM, Liong EC, Lau TY, Fung ML, Nanji AA. Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice. Toxicology. 2010;273:45\u201352.","journal-title":"Toxicology."},{"key":"2839_CR32","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2131\/jts.18.3_185","volume":"18","author":"YK Ahn","year":"1993","unstructured":"Ahn YK, Kim JH. Preventive effects of diphenyl dimethyl dicarboxylate on the immunotoxicity of carbon tetrachloride in ICR mice. J Toxicol Sci. 1993;18:185\u201395.","journal-title":"J Toxicol Sci"},{"key":"2839_CR33","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1006\/taap.1994.1095","volume":"126","author":"B Delaney","year":"1994","unstructured":"Delaney B. Carbon tetrachloride suppresses T-cell-dependent immune responses by induction of transforming growth factor-1. Toxicol Appl Pharmacol. 1994;126:98\u2013107.","journal-title":"Toxicol Appl Pharmacol"},{"key":"2839_CR34","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3109\/01480547809034433","volume":"1","author":"RB Drotman","year":"1978","unstructured":"Drotman RB, Lawhorn GT. Serum enzymes as indicators of chemically induced liver damage. Drug Chem Toxicol. 1978;1:163\u201371.","journal-title":"Drug Chem Toxicol"},{"key":"2839_CR35","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","volume":"8","author":"T Luedde","year":"2011","unstructured":"Luedde T, Schwabe RF. NF-\u03baB in the liver\u2014linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 2011;8:108\u201318.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2839_CR36","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1080\/15384047.2016.1210740","volume":"17","author":"A Shehzad","year":"2016","unstructured":"Shehzad A, Islam SU, Ahn EM, Lee YM, Lee YS. Decursinol angelate inhibits PGE2-induced survival of the human leukemia HL-60 cell line via regulation of the EP2 receptor and NF\u03baB pathway. Cancer Biol Ther. 2016;17:985\u201393.","journal-title":"Cancer Biol Ther"},{"key":"2839_CR37","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.cell.2005.04.014","volume":"121","author":"S Maeda","year":"2005","unstructured":"Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell. 2005;121:977\u201390.","journal-title":"Cell."},{"key":"2839_CR38","doi-asserted-by":"publisher","first-page":"3572","DOI":"10.3748\/wjg.v23.i20.3572","volume":"23","author":"P Mart\u00edn-Sanz","year":"2017","unstructured":"Mart\u00edn-Sanz P, Casado M, Bosc\u00e1 L. Cyclooxygenase 2 in liver dysfunction and carcinogenesis: facts and perspectives. World J Gastroenterol. 2017;23:3572\u201380.","journal-title":"World J Gastroenterol"},{"key":"2839_CR39","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1159\/000343852","volume":"2","author":"G Ramakrishna","year":"2013","unstructured":"Ramakrishna G, Rastogi A, Trehanpati N, Sen B, Khosla R, Sarin SK. From cirrhosis to hepatocellular carcinoma: new molecular insights on inflammation and cellular senescence. Liver Cancer. 2013;2:367\u201383.","journal-title":"Liver Cancer"},{"key":"2839_CR40","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jep.2018.04.017","volume":"221","author":"YR Li","year":"2018","unstructured":"Li YR, Fu CS, Yang WJ, Wang XL, Feng D, Wang XN, Ren DM, Lou HX, Shen T. Investigation of constituents from Cinnamomum camphora (L.) J. Presl and evaluation of their anti-inflammatory properties in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Ethnopharmacol. 2018;221:37\u201347.","journal-title":"J Ethnopharmacol"},{"key":"2839_CR41","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1002\/biof.1068","volume":"39","author":"A Shehzad","year":"2013","unstructured":"Shehzad A, Lee J, Lee YS. Curcumin in various cancers. Biofactors. 2013;39:56\u201368.","journal-title":"Biofactors."},{"key":"2839_CR42","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1002\/tox.22746","volume":"34","author":"HW Chun","year":"2019","unstructured":"Chun HW, Kim SJ, Pham TH, Bak Y, Oh J, Ryu HW, Oh SR, Hong JT, Yoon DY. Epimagnolin a inhibits IL-6 production by inhibiting p38\/NF-kappa B and AP-1 signaling pathways in PMA-stimulated THP-1 cells. Environ Toxicol. 2019;34:796\u2013803.","journal-title":"Environ Toxicol"}],"container-title":["BMC Complementary Medicine and Therapies"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-020-2839-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12906-020-2839-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-020-2839-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:47:43Z","timestamp":1612918063000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-020-2839-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,11]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["2839"],"URL":"https:\/\/doi.org\/10.1186\/s12906-020-2839-3","relation":{},"ISSN":["2662-7671"],"issn-type":[{"value":"2662-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,11]]},"assertion":[{"value":"20 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The experimental protocol was approved by the Institutional Review Board and Ethics Committee <i>IRB\/SMME\/NUST\/12\u20133\/2018<\/i> and agrees with international laws and policies (NIH Guide for the Care and Use of Laboratory Animals, NIH publication No. 85\u201323, 1985).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"49"}}