{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:15:30Z","timestamp":1791918930194,"version":"4.3.4"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473547"],"award-info":[{"award-number":["81473547"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673829"],"award-info":[{"award-number":["81673829"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Med Ther"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Danhong injection (DHI), which is one of the most well-known Traditional Chinese Medicine (TCM) injections, widely used to treat unstable angina (UA). However, its underlying pharmacological mechanisms need to be further clarified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present study, network pharmacology was adopted. Firstly, the relative compounds were obtained by a wide-scaled literatures-mining and potential targets of these compounds by target fishing were collected. Then, we built the UA target database by DisGeNET, DigSee, TTD, OMIM. Based on data, protein-protein interaction (PPI) analysis, GO and KEGG pathway enrichment analysis were performed and screen the hub targets by topology. Furthermore, evaluation of the binding potential of key targets and compounds through molecular docking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that 12 ingredients of DHI and 27 putative known therapeutic targets were picked out. By systematic analysis, identified 4 hub targets (TNF, TLR4, NFKB1 and SERPINE1) mainly involved in the complex treating effects associated with coagulation and hemostasis, cell membrane region, platelet alpha granule, NF-kappa B signaling pathway and TNF signaling pathway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study preliminarily explained the potential targets and signaling pathways of DHI in the treatment of UA, which may help to laid a good foundation for experimental research and further clinical application.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12906-020-2853-5","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T17:13:04Z","timestamp":1583169184000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Investigating the multi-target pharmacological mechanism of danhong injection acting on unstable angina by combined network pharmacology and molecular docking"],"prefix":"10.1186","volume":"20","author":[{"given":"Siyu","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1617-6110","authenticated-orcid":false,"given":"Jiarui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinkui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengwei","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"issue":"10","key":"2853_CR1","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","volume":"139","author":"EJ Benjamin","year":"2019","unstructured":"Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Das SR, Delling FN, Djousse L, MSV E, Ferguson JF, Fornage M, Jordan LC, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, O'Flaherty M, Pandey A, Perak AM, Rosamond WD, Roth GA, UKA S, Satou GM, Schroeder EB, Shah SH, Spartano NL, Stokes A, Tirschwell DL, Tsao CW, Turakhia MP, LB VW, Wilkins JT, Wong SS, Virani SS. American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2019 update: a report from the American Heart Association. Circulation. 2019;139(10):e56\u2013e528.","journal-title":"Circulation"},{"issue":"29","key":"2853_CR2","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1093\/eurheartj\/ehz303","volume":"40","author":"S Xu","year":"2019","unstructured":"Xu S, Xu Y, Liu P, Zhang S, Liu H, Slavin S, Kumar S, Koroleva M, Luo J, Wu X, Rahman A, Pelisek J, Jo H, Si S, Miller CL, Jin ZG. The novel coronary artery disease risk gene JCAD\/KIAA1462 promotes endothelial dysfunction and atherosclerosis. Eur Heart J. 2019;40(29):2398\u2013408.","journal-title":"Eur Heart J"},{"issue":"2","key":"2853_CR3","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1056\/NEJM200001133420207","volume":"342","author":"Y Yeghiazarians","year":"2000","unstructured":"Yeghiazarians Y, Braunstein JB, Askari A, Stone PH. Unstable angina pectoris. N Engl J Med. 2000;342(2):101\u201314.","journal-title":"N Engl J Med"},{"key":"2853_CR4","doi-asserted-by":"publisher","unstructured":"Giannitsis E, Biener M, Hund H, Mueller-Hennessen M, Vafaie M, Gandowitz J, Riedle C, L\u00f6hr J, Katus HA, Stoyanov KM. Management and outcomes of patients with unstable angina with undetectable, normal, or intermediate hsTnT levels. Clin Res Cardiol. 2019. https:\/\/doi.org\/10.1007\/s00392-019-01529-4.","DOI":"10.1007\/s00392-019-01529-4"},{"issue":"2","key":"2853_CR5","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1177\/2048872616658591","volume":"7","author":"Y Sandoval","year":"2018","unstructured":"Sandoval Y, Apple FS, Smith SW. High-sensitivity cardiac troponin assays and unstable angina. Eur Heart J Acute Cardiovasc Care. 2018;7(2):120\u20138.","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"issue":"24","key":"2853_CR6","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.1161\/CIRCULATIONAHA.113.001258","volume":"127","author":"E Braunwald","year":"2013","unstructured":"Braunwald E, Morrow DA. Unstable angina: is it time for a requiem? Circulation. 2013;127(24):2452\u20137.","journal-title":"Circulation."},{"issue":"8","key":"2853_CR7","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/S0002-9149(00)01102-4","volume":"86","author":"EY Chakhtoura","year":"2000","unstructured":"Chakhtoura EY, Shamoon FE, Haft JI, Obiedzinski GR, Cohen AJ, Watson RM. Comparison of platelet activation in unstable and stable angina pectoris and correlation with coronary angiographic findings. Am J Cardiol. 2000;86(8):835\u20139.","journal-title":"Am J Cardiol"},{"issue":"4","key":"2853_CR8","first-page":"3095","volume":"18","author":"R Peng","year":"2019","unstructured":"Peng R, Yang X, Liang X. Nicorandil effects on platelet function, Hs-CRP, MMP-9 and myocardial antioxidation in patients with unstable angina. Exp Ther Med. 2019;18(4):3095\u20139.","journal-title":"Exp Ther Med"},{"issue":"2","key":"2853_CR9","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1001\/jamainternmed.2018.5967","volume":"179","author":"CA McNeely","year":"2019","unstructured":"McNeely CA, Brown DL. Upcoding, fraud, and the stubborn persistence of unstable angina. JAMA Intern Med. 2019;179(2):261\u20133.","journal-title":"JAMA Intern Med"},{"issue":"10","key":"2853_CR10","doi-asserted-by":"publisher","first-page":"917","DOI":"10.4065\/84.10.917","volume":"84","author":"A Kumar","year":"2009","unstructured":"Kumar A, Cannon CP. Acute coronary syndromes: diagnosis and management, part I. Mayo Clin Proc. 2009;84(10):917\u201338.","journal-title":"Mayo Clin Proc"},{"issue":"7","key":"2853_CR11","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1056\/NEJMoa010746","volume":"345","author":"S Yusuf","year":"2001","unstructured":"Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK. Clopidogrel in unstable angina to prevent recurrent events trial investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345(7):494\u2013502.","journal-title":"N Engl J Med"},{"key":"2853_CR12","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.3389\/fphar.2019.01080","volume":"10","author":"S He","year":"2019","unstructured":"He S, Guo H, Zhao T, Meng Y, Chen R, Ren J, Pan L, Fan G, Jiang M, Qin G, Zhu Y, Gao X. A defined combination of four active principles from the Danhong injection is necessary and sufficient to accelerate EPC-mediated vascular repair and local angiogenesis. Front Pharmacol. 2019;10:1080.","journal-title":"Front Pharmacol"},{"issue":"7724","key":"2853_CR13","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/d41586-018-06782-7","volume":"561","author":"D Cyranoski","year":"2018","unstructured":"Cyranoski D. Why Chinese medicine is heading for clinics around the world. Nature. 2018;561(7724):448\u201350.","journal-title":"Nature."},{"key":"2853_CR14","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3389\/fphar.2017.00361","volume":"8","author":"T Zhao","year":"2017","unstructured":"Zhao T, Chang L, Zhang B, Lu M, Wang X, Orgah JO, Wang Y, Tian X, Yang J, Fan G, Zhang B, Zhu Y. Specific combination of salvianolic acids as core active ingredients of Danhong injection for treatment of arterial thrombosis and its derived dry gangrene. Front Pharmacol. 2017;8:361.","journal-title":"Front Pharmacol"},{"key":"2853_CR15","doi-asserted-by":"publisher","first-page":"109538","DOI":"10.1016\/j.biopha.2019.109538","volume":"120","author":"SN Li","year":"2019","unstructured":"Li SN, Li P, Liu WH, Shang JJ, Qiu SL, Zhou MX, Liu HX. Danhong injection enhances angiogenesis after myocardial infarction by activating MiR-126\/ERK\/VEGF pathway. Biomed Pharmacother. 2019;120:109538.","journal-title":"Biomed Pharmacother"},{"key":"2853_CR16","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.phrs.2018.07.020","volume":"135","author":"W Xu","year":"2018","unstructured":"Xu W, Zhang Y, Yu Y, Li B, Liu J, Wang P, Wu H, Liu Q, Wei Z, Xiao H, Wang Z. Dose-dependent target diversion of Danhong injection on the Glu-GLT-1\/Gly-GlyR\u03b1 dynamic balance module of cerebral ischemia. Pharmacol Res. 2018;135:80\u20138.","journal-title":"Pharmacol Res"},{"key":"2853_CR17","first-page":"378","volume":"2019","author":"C Li","year":"1602","unstructured":"Li C, Yang J, Tong X, Zhao C, He Y, Wan H. Precursor ion scan enhanced rapid identification of the chemical constituents of Danhong injection by liquid chromatography\u2013tandem mass spectrometry: an integrated strategy. J Chromatogr A. 1602;2019:378\u201385.","journal-title":"J Chromatogr A"},{"key":"2853_CR18","doi-asserted-by":"publisher","first-page":"833","DOI":"10.3389\/fphar.2017.00833","volume":"8","author":"JP Li","year":"2017","unstructured":"Li JP, Liu Y, Guo JM, Shang EX, Zhu ZH, Zhu KY, Tang YP, Zhao BC, Tang ZS, Duan JA. A comprehensive strategy to evaluate compatible stability of chinese medicine injection and infusion solutions based on chemical analysis and bioactivity assay. Front Pharmacol. 2017;8:833.","journal-title":"Front Pharmacol"},{"key":"2853_CR19","doi-asserted-by":"publisher","first-page":"550","DOI":"10.3389\/fphar.2018.00550","volume":"9","author":"JB Zou","year":"2018","unstructured":"Zou JB, Zhang XF, Wang J, Wang F, Cheng JX, Yang FY, Song X, Wang Y, Liang YL, Shi YJ. The therapeutic efficacy of Danhong injection combined with percutaneous coronary intervention in acute coronary syndrome: a systematic review and meta-analysis. Front Pharmacol. 2018;9:550.","journal-title":"Front Pharmacol"},{"key":"2853_CR20","first-page":"358028","volume":"2015","author":"X Zhang","year":"2015","unstructured":"Zhang X, Wang H, Chang Y, Wang Y, Lei X, Fu S, Zhang J. An overview of meta-analyses of Danhong injection for unstable angina. Evid Based Complement Alternat Med. 2015;2015:358028.","journal-title":"Evid Based Complement Alternat Med"},{"issue":"Suppl 11","key":"2853_CR21","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1186\/1471-2105-11-S11-S6","volume":"11","author":"S Li","year":"2010","unstructured":"Li S, Zhang B, Jiang D, Wei Y, Zhang N. Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae. BMC Bioinformatics. 2010;11(Suppl 11):S6.","journal-title":"BMC Bioinformatics"},{"issue":"10","key":"2853_CR22","doi-asserted-by":"publisher","first-page":"E591","DOI":"10.3390\/biom9100591","volume":"9","author":"Y Song","year":"2019","unstructured":"Song Y, Wang H, Pan Y, Liu T. Investigating the multi-target pharmacological mechanism of Hedyotis diffusa Willd acting on prostate Cancer: a network pharmacology approach. Biomolecules. 2019;9(10):E591.","journal-title":"Biomolecules."},{"issue":"2","key":"2853_CR23","doi-asserted-by":"publisher","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","volume":"11","author":"S Li","year":"2013","unstructured":"Li S, Zhang B. Traditional Chinese medicine network pharmacology: theory, methodology and application. Chin J Nat Med. 2013;11(2):110\u201320.","journal-title":"Chin J Nat Med"},{"issue":"D1","key":"2853_CR24","doi-asserted-by":"publisher","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","volume":"44","author":"S Kim","year":"2016","unstructured":"Kim S, Thiessen PA, Bolton EE, Chen J, Fu G, Gindulyte A, Han L, He J, He S, Shoemaker BA, Wang J, Yu B, Zhang J, Bryant SH. PubChem substance and compound databases. Nucleic Acids Res. 2016;44(D1):D1202\u201313.","journal-title":"Nucleic Acids Res"},{"issue":"42","key":"2853_CR25","doi-asserted-by":"publisher","first-page":"11140","DOI":"10.1002\/anie.201405820","volume":"53","author":"DA Evans","year":"2014","unstructured":"Evans DA. History of the Harvard ChemDraw project. Angew Chem Int Ed Engl. 2014;53(42):11140\u20135.","journal-title":"Angew Chem Int Ed Engl"},{"key":"2853_CR26","doi-asserted-by":"publisher","first-page":"W26","DOI":"10.1093\/nar\/gku477","volume":"42","author":"J Nickel","year":"2014","unstructured":"Nickel J, Gohlke BO, Erehman J, Banerjee P, Rong WW, Goede A, Dunkel M, Preissner R. SuperPred: update on drug classification and target prediction. Nucleic Acids Res. 2014;42:W26\u201331.","journal-title":"Nucleic Acids Res"},{"key":"2853_CR27","doi-asserted-by":"publisher","first-page":"W32","DOI":"10.1093\/nar\/gku293","volume":"42","author":"D Gfeller","year":"2014","unstructured":"Gfeller D, Grosdidier A, Wirth M, Daina A, Michielin O, Zoete V. SwissTargetPrediction: a web server for target prediction of bioactive small molecules. Nucleic Acids Res. 2014;42:W32\u20138.","journal-title":"Nucleic Acids Res"},{"key":"2853_CR28","doi-asserted-by":"publisher","first-page":"21146","DOI":"10.1038\/srep21146","volume":"6","author":"Z Liu","year":"2016","unstructured":"Liu Z, Guo F, Wang Y, Li C, Zhang X, Li H, Diao L, Gu J, Wang W, Li D, He F. BATMAN-TCM: a bioinformatics analysis tool for molecular mechANism of traditional Chinese medicine. Sci Rep. 2016;6:21146.","journal-title":"Sci Rep"},{"key":"2853_CR29","doi-asserted-by":"publisher","first-page":"7735","DOI":"10.12659\/MSM.919768","volume":"25","author":"J Liu","year":"2019","unstructured":"Liu J, Li Y, Zhang Y, Huo M, Sun X, Xu Z, Tan N, Du K, Wang Y, Zhang J, Wang W. A network pharmacology approach to explore the mechanisms of Qishen granules in heart failure. Med Sci Monit. 2019;25:7735\u201345.","journal-title":"Med Sci Monit"},{"key":"2853_CR30","doi-asserted-by":"publisher","first-page":"W510","DOI":"10.1093\/nar\/gkt531","volume":"41","author":"J Kim","year":"2013","unstructured":"Kim J, So S, Lee HJ, Park JC, Kim JJ, Lee H. DigSee: disease gene search engine with evidence sentences (version cancer). Nucleic Acids Res. 2013;41:W510\u20137.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"2853_CR31","doi-asserted-by":"publisher","first-page":"D833","DOI":"10.1093\/nar\/gkw943","volume":"45","author":"J Pi\u00f1ero","year":"2017","unstructured":"Pi\u00f1ero J, Bravo \u00c0, Queralt-Rosinach N, Guti\u00e9rrez-Sacrist\u00e1n A, Deu-Pons J, Centeno E, Garc\u00eda-Garc\u00eda J, Sanz F, Furlong LI. DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants. Nucleic Acids Res. 2017;45(D1):D833\u20139.","journal-title":"Nucleic Acids Res"},{"key":"2853_CR32","doi-asserted-by":"publisher","first-page":"D789","DOI":"10.1093\/nar\/gku1205","volume":"43","author":"JS Amberger","year":"2015","unstructured":"Amberger JS, Bocchini CA, Schiettecatte F, Scott AF, Hamosh A. OMIM. Org: online Mendelian inheritance in man (OMIM\u00ae), an online catalog of human genes and genetic disorders. Nucleic Acids Res. 2015;43:D789\u201398.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"2853_CR33","doi-asserted-by":"publisher","first-page":"D1069","DOI":"10.1093\/nar\/gkv1230","volume":"44","author":"H Yang","year":"2016","unstructured":"Yang H, Qin C, Li YH, Tao L, Zhou J, Yu CY, Xu F, Chen Z, Zhu F, Chen YZ. Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information. Nucleic Acids Res. 2016;44(D1):D1069\u201374.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"2853_CR34","doi-asserted-by":"publisher","first-page":"D362","DOI":"10.1093\/nar\/gkw937","volume":"45","author":"D Szklarczyk","year":"2017","unstructured":"Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, Jensen LJ, von Mering C. The STRING database in 2017: quality-controlled protein\u2013protein association networks, made broadly accessible. Nucleic Acids Res. 2017;45(D1):D362\u20138.","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"2853_CR35","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/bioinformatics\/btv557","volume":"32","author":"M Franz","year":"2016","unstructured":"Franz M, Lopes CT, Huck G, Dong Y, Sumer O, Bader GD. Cytoscape.Js: a graph theory library for visualisation and analysis. Bioinformatics. 2016;32(2):309\u201311.","journal-title":"Bioinformatics."},{"issue":"6833","key":"2853_CR36","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/35075138","volume":"411","author":"H Jeong","year":"2001","unstructured":"Jeong H, Mason SP, Barab\u00e1si AL, Oltvai ZN. Lethality and centrality in protein networks. Nature. 2001;411(6833):41\u20132.","journal-title":"Nature."},{"issue":"3","key":"2853_CR37","doi-asserted-by":"publisher","first-page":"188","DOI":"10.2174\/157489309789071129","volume":"4","author":"S Li","year":"2009","unstructured":"Li S. Network systems underlying traditional Chinese medicine syndrome and herb formula. Curr Bioinforma. 2009;4(3):188\u201396.","journal-title":"Curr Bioinforma"},{"issue":"1","key":"2853_CR38","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.socnet.2004.11.009","volume":"27","author":"MEJ Newman","year":"2005","unstructured":"Newman MEJ. A measure of betweenness centrality based on random walks. Soc Networks. 2005;27(1):39\u201354.","journal-title":"Soc Networks"},{"key":"2853_CR39","first-page":"6517034","volume":"2018","author":"X Liu","year":"2018","unstructured":"Liu X, Wu J, Zhang D, Wang K, Duan X, Zhang X. A network pharmacology approach to uncover the multiple mechanisms of hedyotis diffusa willd on colorectal cancer. Evid Based Complement Alternat Med. 2018;2018:6517034.","journal-title":"Evid Based Complement Alternat Med"},{"key":"2853_CR40","first-page":"7802639","volume":"2018","author":"X Liu","year":"2018","unstructured":"Liu X, Wu J, Zhang D, Wang K, Duan X, Meng Z, Zhang X. Network pharmacology-based approach to investigate the mechanisms of hedyotis diffusa willd in the treatment of gastric cancer. Evid Based Complement Alternat Med. 2018;2018:7802639.","journal-title":"Evid Based Complement Alternat Med"},{"issue":"4","key":"2853_CR41","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/BF02289527","volume":"31","author":"G Sabidussi","year":"1966","unstructured":"Sabidussi G. The centrality index of a graph. Psychometrika. 1966;31(4):581\u2013603.","journal-title":"Psychometrika."},{"issue":"1","key":"2853_CR42","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1471-2105-4-2","volume":"4","author":"GD Bader","year":"2003","unstructured":"Bader GD, Hogue CWV. An automated method for finding molecular complexes in large protein interaction networks. BMC bioinformatics. 2003;4(1):2.","journal-title":"BMC bioinformatics"},{"issue":"1","key":"2853_CR43","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13048-019-0508-2","volume":"12","author":"H Feng","year":"2019","unstructured":"Feng H, Gu ZY, Li Q, Liu QH, Yang XY, Zhang JJ. Identification of significant genes with poor prognosis in ovarian cancer via bioinformatical analysis. J ovarian res. 2019;12(1):35.","journal-title":"J ovarian res"},{"issue":"2","key":"2853_CR44","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nmeth.3252","volume":"12","author":"W Huber","year":"2015","unstructured":"Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Ole\u015b AK, Pag\u00e8s H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M. Orchestrating high-throughput genomic analysis with bioconductor. Nat Methods. 2015;12(2):115\u201321.","journal-title":"Nat Methods"},{"issue":"D1","key":"2853_CR45","doi-asserted-by":"publisher","first-page":"D331","DOI":"10.1093\/nar\/gkw1108","volume":"45","author":"The Gene Ontology Consortium","year":"2017","unstructured":"The Gene Ontology Consortium. Expansion of the gene ontology knowledgebase and resources. Nucleic Acids Res. 2017;45(D1):D331\u20138.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2853_CR46","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):27\u201330.","journal-title":"Nucleic Acids Res"},{"issue":"16","key":"2853_CR47","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"GM Morris","year":"2009","unstructured":"Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, Olson AJ. AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. J Comput Chem. 2009;30(16):2785\u201391.","journal-title":"J Comput Chem"},{"key":"2853_CR48","doi-asserted-by":"publisher","unstructured":"Goodsell DS, Zardecki C, Di Costanzo L, Duarte JM, Hudson BP, Persikova I, Segura J, Shao C, Voigt M, Westbrook JD, Young JY, Burley SK. RCSB protein data Bank: enabling biomedical research and drug discovery. Protein Sci. 2019. https:\/\/doi.org\/10.1002\/pro.3730.","DOI":"10.1002\/pro.3730"},{"issue":"2","key":"2853_CR49","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott O, Olson AJ. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 2010;31(2):455\u201361.","journal-title":"J Comput Chem"},{"issue":"12","key":"2853_CR50","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1016\/j.str.2016.11.012","volume":"24","author":"S Yuan","year":"2016","unstructured":"Yuan S, Chan HCS, Filipek S, Vogel H. PyMOL and Inkscape bridge the data and the data visualization. Structure. 2016;24(12):2041\u20132.","journal-title":"Structure."},{"key":"2853_CR51","doi-asserted-by":"publisher","first-page":"104621","DOI":"10.1016\/j.antiviral.2019.104621","volume":"172","author":"DJ Viegas","year":"2019","unstructured":"Viegas DJ, Edwards TG, Bloom DC, Abreu PA. Virtual screening identified compounds that bind to cyclin dependent kinase 2 and prevent herpes simplex virus type 1 replication and reactivation in neurons. Antivir Res. 2019;172:104621.","journal-title":"Antivir Res"},{"key":"2853_CR52","doi-asserted-by":"publisher","first-page":"460378","DOI":"10.1016\/j.chroma.2019.460378","volume":"1606","author":"LL Xu","year":"2019","unstructured":"Xu LL, Shang ZP, Bo T, Sun L, Guo QL, Qiao X, Ye M. Rapid quantitation and identification of the chemical constituents in Danhong Injection by liquid chromatography coupled with orbitrap mass spectrometry. J Chromatogr A. 2019;1606:460378.","journal-title":"J Chromatogr A"},{"issue":"1","key":"2853_CR53","doi-asserted-by":"publisher","first-page":"11418","DOI":"10.1038\/s41598-018-29764-1","volume":"8","author":"H Zuo","year":"2018","unstructured":"Zuo H, Zhang Q, Su S, Chen Q, Yang F, Hu Y. A network pharmacology-based approach to analyse potential targets of traditional herbal formulas: an example of Yu ping Feng decoction. Sci Rep. 2018;8(1):11418.","journal-title":"Sci Rep"},{"issue":"3","key":"2853_CR54","doi-asserted-by":"publisher","first-page":"e20180424","DOI":"10.1590\/0001-3765201920180424","volume":"91","author":"Z Shu","year":"2019","unstructured":"Shu Z, Wu T, Shahen M, Guo Z, Shu J, Wang HE, Shar AH, Farag MR, Alagawany M, El-Hack MEA, Liu C. System-pharmacology dissection of traditional Chinese herbs SINI decoction for treatment of cardiovascular diseases. An Acad Bras Cienc. 2019;91(3):e20180424.","journal-title":"An Acad Bras Cienc"},{"issue":"7","key":"2853_CR55","doi-asserted-by":"publisher","first-page":"556","DOI":"10.2174\/1389200220666190618101526","volume":"20","author":"DC Hao","year":"2019","unstructured":"Hao DC, Xiao PG. Impact of drug metabolism\/pharmacokinetics and their relevance upon traditional medicine-based cardiovascular drug research. Curr Drug Metab. 2019;20(7):556\u201374.","journal-title":"Curr Drug Metab"},{"issue":"24","key":"2853_CR56","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1016\/j.jacc.2017.04.041","volume":"69","author":"P Hao","year":"2017","unstructured":"Hao P, Jiang F, Cheng J, Ma L, Zhang Y, Zhao Y. Traditional Chinese medicine for cardiovascular disease: evidence and potential mechanisms. J Am Coll Cardiol. 2017;69(24):2952\u201366.","journal-title":"J Am Coll Cardiol"},{"issue":"16","key":"2853_CR57","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1161\/01.CIR.99.16.2079","volume":"99","author":"LM Biasucci","year":"1999","unstructured":"Biasucci LM, Liuzzo G, Fantuzzi G, Caligiuri G, Rebuzzi AG, Ginnetti F, Dinarello CA, Maseri A. Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events. Circulation. 1999;99(16):2079\u201384.","journal-title":"Circulation."},{"issue":"8","key":"2853_CR58","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.arcmed.2008.09.003","volume":"39","author":"D Huang","year":"2008","unstructured":"Huang D, Yang CZ, Yao L, Wang Y, Liao YH, Huang K. Activation and overexpression of PARP-1 in circulating mononuclear cells promote TNF-\u03b1 and IL-6 expression in patients with unstable angina. Arch Med Res. 2008;39(8):775\u201384.","journal-title":"Arch Med Res"},{"issue":"8","key":"2853_CR59","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/j.1365-2362.2007.01834.x","volume":"37","author":"D Tousoulis","year":"2007","unstructured":"Tousoulis D, Antoniades C, Nikolopoulou A, Koniari K, Vasiliadou C, Marinou K, Koumallos N, Papageorgiou N, Stefanadi E, Siasos G, Stefanadis C. Interaction between cytokines and sCD40L in patients with stable and unstable coronary syndromes. Eur J Clin Investig. 2007;37(8):623\u20138.","journal-title":"Eur J Clin Investig"},{"issue":"5","key":"2853_CR60","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1002\/jlb.67.5.591","volume":"67","author":"GW Sullivan","year":"2000","unstructured":"Sullivan GW, Sarembock IJ, Linden J. The role of inflammation in vascular diseases. J Leukoc Biol. 2000;67(5):591\u2013602.","journal-title":"J Leukoc Biol"},{"issue":"11","key":"2853_CR61","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1046\/j.1365-2362.2002.01069.x","volume":"32","author":"T Waehre","year":"2002","unstructured":"Waehre T, Halvorsen B, Dam\u00e5s JK, Yndestad A, Brosstad F, Gullestad L, Kjekshus J, Fr\u00f8land SS, Aukrust P. Inflammatory imbalance between IL-10 and TNF\u03b1 in unstable angina potential plaque stabilizing effects of IL-10. Eur J Clin Investig. 2002;32(11):803\u201310.","journal-title":"Eur J Clin Investig"},{"key":"2853_CR62","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1196\/annals.1354.037","volume":"1067","author":"G Candore","year":"2006","unstructured":"Candore G, Aquino A, Balistreri CR, Bulati M, Di Carlo D, Grimaldi MP, List\u00ec F, Orlando V, Vasto S, Caruso M, Colonna-Romano G, Lio D, Caruso C. Inflammation, longevity, and cardiovascular diseases: role of polymorphisms of TLR4. Ann N Y Acad Sci. 2006;1067:282\u20137.","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"2853_CR63","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1365-2796.2005.01509.x","volume":"258","author":"GD Norata","year":"2005","unstructured":"Norata GD, Garlaschelli K, Ongari M, Raselli S, Grigore L, Benvenuto F, Maggi FM, Catapano AL. Effect of the toll-like receptor 4 (TLR-4) variants on intima-media thickness and monocyte-derived macrophage response to LPS. J Intern Med. 2005;258(1):21\u20137.","journal-title":"J Intern Med"},{"key":"2853_CR64","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.cyto.2018.06.008","volume":"113","author":"AS Justo-Junior","year":"2019","unstructured":"Justo-Junior AS, Villarejos LM, Lima XTV, Nadruz W Jr, Sposito AC, Mamoni RL, Abdalla R, Fernandes JL, Oliveira RTD, Blotta MHSL. Monocytes of patients with unstable angina express high levels of chemokine and pattern-recognition receptors. Cytokine. 2019;113:61\u20137.","journal-title":"Cytokine."},{"issue":"4","key":"2853_CR65","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1007\/s10753-015-0116-2","volume":"38","author":"J Yang","year":"2015","unstructured":"Yang J, Liu C, Zhang L, Liu Y, Guo A, Shi H, Liu X, Cheng Y. Intensive atorvastatin therapy attenuates the inflammatory responses in monocytes of patients with unstable angina undergoing percutaneous coronary intervention via peroxisome proliferator-activated receptor \u03b3 activation. Inflammation. 2015;38(4):1415\u201323.","journal-title":"Inflammation."},{"issue":"21","key":"2853_CR66","doi-asserted-by":"publisher","first-page":"9658","DOI":"10.1128\/MCB.24.21.9658-9667.2004","volume":"24","author":"S Beinke","year":"2004","unstructured":"Beinke S, Robinson MJ, Hugunin M, Ley SC. Lipopolysaccharide activation of the TPL-2\/MEK\/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105. Mol Cell Biol. 2004;24(21):9658\u201367.","journal-title":"Mol Cell Biol"},{"issue":"9","key":"2853_CR67","doi-asserted-by":"publisher","first-page":"E133","DOI":"10.3390\/cells7090133","volume":"7","author":"J Concetti","year":"2018","unstructured":"Concetti J, Wilson CL. NFKB1 and cancer: friend or foe? Cells. 2018;7(9):E133.","journal-title":"Cells."},{"issue":"4","key":"2853_CR68","doi-asserted-by":"publisher","first-page":"BSR20182292","DOI":"10.1042\/BSR20182292","volume":"39","author":"SY Jin","year":"2019","unstructured":"Jin SY, Luo JY, Li XM, Liu F, Ma YT, Gao XM, Yang YN. NFKB1 gene rs28362491 polymorphism is associated with the susceptibility of acute coronary syndrome. Biosci Rep. 2019;39(4):BSR20182292.","journal-title":"Biosci Rep"},{"issue":"3","key":"2853_CR69","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.ahj.2007.04.059","volume":"154","author":"DE Lanfear","year":"2007","unstructured":"Lanfear DE, Jones PG, Marsh S, Cresci S, Spertus JA, McLeod HL. Connexin37 (GJA4) genotype predicts survival after an acute coronary syndrome. Am Heart J. 2007;154(3):561\u20136.","journal-title":"Am Heart J"},{"issue":"3","key":"2853_CR70","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1172\/JCI10373","volume":"107","author":"T Collins","year":"2001","unstructured":"Collins T, Cybulsky MI. NF-\u03baB: pivotal mediator or innocent bystander in atherogenesis? J Clin Invest. 2001;107(3):255\u201364.","journal-title":"J Clin Invest"},{"issue":"15","key":"2853_CR71","doi-asserted-by":"publisher","first-page":"5634","DOI":"10.1073\/pnas.0401060101","volume":"101","author":"C Monaco","year":"2004","unstructured":"Monaco C, Andreakos E, Kiriakidis S, Mauri C, Bicknell C, Foxwell B, Cheshire N, Paleolog E, Feldmann M. Canonical pathway of nuclear factor \u03baB activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis. Proc Natl Acad Sci U S A. 2004;101(15):5634\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5174","key":"2853_CR72","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1126\/science.8052854","volume":"265","author":"E Kopp","year":"1994","unstructured":"Kopp E, Ghosh S. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994;265(5174):956\u20139.","journal-title":"Science."},{"issue":"1","key":"2853_CR73","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0021-9150(01)00546-9","volume":"160","author":"SH Wilson","year":"2002","unstructured":"Wilson SH, Best PJ, Edwards WD, Holmes DR Jr, Carlson PJ, Celermajer DS, Lerman A. Nuclear factor-\u03baB immunoreactivity is present in human coronary plaque and enhanced in patients with unstable angina pectoris. Atherosclerosis. 2002;160(1):147\u201353.","journal-title":"Atherosclerosis."},{"issue":"3","key":"2853_CR74","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1182\/blood-2003-05-1450","volume":"103","author":"E Kanters","year":"2004","unstructured":"Kanters E, Gijbels MJ, van der Made I, Vergouwe MN, Heeringa P, Kraal G, Hofker MH, de Winther MP. Hematopoietic NF-\u03baB1 deficiency results in small atherosclerotic lesions with an inflammatory phenotype. Blood. 2004;103(3):934\u201340.","journal-title":"Blood."},{"issue":"17","key":"2853_CR75","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1161\/01.CIR.98.17.1707","volume":"98","author":"ME Ritchie","year":"1998","unstructured":"Ritchie ME. Nuclear factor-\u03baB is selectively and markedly activated in humans with unstable angina pectoris. Circulation. 1998;98(17):1707\u201313.","journal-title":"Circulation."},{"issue":"2","key":"2853_CR76","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jacc.2006.07.071","volume":"49","author":"G Liuzzo","year":"2007","unstructured":"Liuzzo G, Santamaria M, Biasucci LM, Narducci M, Colafrancesco V, Porto A, Brugaletta S, Pinnelli M, Rizzello V, Maseri A, Crea F. Persistent activation of nuclear factor kappa-B signaling pathway in patients with unstable angina and elevated levels of C-reactive protein evidence for a direct proinflammatory effect of azide and lipopolysaccharide-free C-reactive protein on human monocytes via nuclear factor kappa-B activation. J Am Coll Cardiol. 2007;49(2):185\u201394.","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"2853_CR77","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1017\/S1466252317000081","volume":"18","author":"M Alagawany","year":"2017","unstructured":"Alagawany M, Abd El-Hack ME, Farag MR, Gopi M, Karthik K, Malik YS, Dhama K. Rosmarinic acid: modes of action, medicinal values and health benefits. Anim Health Res Rev. 2017;18(2):167\u201376.","journal-title":"Anim Health Res Rev"},{"issue":"8","key":"2853_CR78","doi-asserted-by":"publisher","first-page":"E2027","DOI":"10.3390\/ijms20082027","volume":"20","author":"S Joardar","year":"2019","unstructured":"Joardar S, Dewanjee S, Bhowmick S, Dua TK, Das S, Saha A, De Feo V. Rosmarinic acid attenuates cadmium-induced nephrotoxicity via inhibition of oxidative stress, apoptosis, inflammation and fibrosis. Int J Mol Sci. 2019;20(8):E2027.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2853_CR79","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/sj.bjp.0706728","volume":"148","author":"J Lee","year":"2006","unstructured":"Lee J, Jung E, Kim Y, Lee J, Park J, Hong S, Hyun CG, Park D, Kim YS. Rosmarinic acid as a downstream inhibitor of IKK-\u03b2 in TNF-\u03b1-induced upregulation of CCL11 and CCR3. Br J Pharmacol. 2006;148(3):366\u201375.","journal-title":"Br J Pharmacol"}],"container-title":["BMC Complementary Medicine and Therapies"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-020-2853-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12906-020-2853-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-020-2853-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T12:43:05Z","timestamp":1722516185000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-020-2853-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,2]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["2853"],"URL":"https:\/\/doi.org\/10.1186\/s12906-020-2853-5","relation":{},"ISSN":["2662-7671"],"issn-type":[{"value":"2662-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,2]]},"assertion":[{"value":"9 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflicts of interests regarding the publication of this paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"66"}}