{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:35:49Z","timestamp":1787506549628,"version":"build-2736575974"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Med Ther"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>An emerging body of evidence indicates that puerarin (PUE) plays an important role in the treatment of angina pectoris, myocardial ischemia-reperfusion injury, hypertension and other cardiovascular diseases, but how PUE affects the vascular remodeling of hypertensive rats has not been reported yet. This study aimed to investigate the effect and mechanism of PUE on carotid arteries of spontaneously hypertensive rats (SHR) to provide the basis for the clinical application of PUE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty male SHR and six male Wistar Kyoto rats (WKY) aged 3\u2009months were used in this study, SHR rats were randomly divided into 5 groups, PUE(40 or 80\u2009mg\/kg\/d, ip) and telmisartan (TELMI) (30\u2009mg\/kg\/d, ig) were administrated for 3\u2009months. We use DMT myography pressure-diameter system to investigate biomechanical properties of carotid arteries, 10\u2009\u03bcM pan-classical transient receptor potential channels (TRPCs) inhibitor SKF96365, 200\u2009nM specific TRPC6 inhibitor SAR7334 and 100\u2009\u03bcM Orai1 inhibitor ANCOA4 were used in the mechanical test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PUE can significantly decrease systolic and diastolic blood pressure, long-term administration of PUE resulted in a mild reduction of thickness and inner diameter of carotid artery. PUE ameliorate NE-response and vascular remodeling mainly through inhibiting TRPCs channel activities of VSMC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PUE can ameliorate biomechanical remodeling of carotid arteries through inhibiting TRPCs channel activities of VSMC in spontaneously hypertensive rats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12906-021-03345-8","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T20:02:38Z","timestamp":1624305758000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ameliorated biomechanical properties of carotid arteries by puerarin in spontaneously hypertensive rats"],"prefix":"10.1186","volume":"21","author":[{"given":"Xiaoxia","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songhe","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiufang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiju","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"issue":"7","key":"3345_CR1","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/S0828-282X(06)70275-6","volume":"22","author":"A Chockalingam","year":"2006","unstructured":"Chockalingam A, Campbell NR, Fodor JG. Worldwide epidemic of hypertension. Can J Cardiol. 2006;22(7):553\u20135. https:\/\/doi.org\/10.1016\/S0828-282X(06)70275-6.","journal-title":"Can J Cardiol"},{"key":"3345_CR2","doi-asserted-by":"publisher","unstructured":"Somlyo AP, Somlyo AV. Signal transduction and regulation in smooth muscle. Nature. 1994;372(17):231\u20136. https:\/\/doi.org\/10.1038\/372231a0.","DOI":"10.1038\/372231a0"},{"issue":"2","key":"3345_CR3","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1152\/physrev.1999.79.2.387","volume":"79","author":"MJ Davis","year":"1999","unstructured":"Davis MJ, Hill MA. Signaling mechanisms underlying the vascular myogenic response. Physiol Rev. 1999;79(2):387\u2013423. https:\/\/doi.org\/10.1152\/physrev.1999.79.2.387.","journal-title":"Physiol Rev"},{"key":"3345_CR4","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1111\/j.1742-7843.2010.00548.x","volume":"107","author":"W Hu","year":"2010","unstructured":"Hu W, Zhang Q, Yang X, Wang Y, Sun L. Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris. Basic Clin Pharmacol Toxicol. 2010;107:637\u201342.","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"06","key":"3345_CR5","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1142\/S0192415X17500641","volume":"45","author":"CX Tan","year":"2017","unstructured":"Tan CX, Wang AM, Liu C, Li Y, Shi YP, Zhou MS. Puerarin improves vascular insulin resistance and cardiovascular remodeling in salt-sensitive hypertension. Am J Chin Med. 2017;45(06):1169\u201384. https:\/\/doi.org\/10.1142\/S0192415X17500641.","journal-title":"Am J Chin Med"},{"issue":"5","key":"3345_CR6","doi-asserted-by":"publisher","first-page":"7421","DOI":"10.3892\/mmr.2018.8754","volume":"17","author":"BQ Guo","year":"2018","unstructured":"Guo BQ, Xu JB, Xiao M, Ding M, Duan LJ. Puerarin reduces ischemia\/reperfusion-induced myocardial injury in diabetic rats via Upregulation of vascular endothelial growth factor a\/angiotensin-1 and suppression of apoptosis. Mol Med Rep. 2018;17(5):7421\u20137. https:\/\/doi.org\/10.3892\/mmr.2018.8754.","journal-title":"Mol Med Rep"},{"issue":"2","key":"3345_CR7","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.taap.2009.12.023","volume":"244","author":"KM Kim","year":"2010","unstructured":"Kim KM, Jung DH, Jang DS, Kim YS, Kim JM, Kim HN, et al. Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression. Toxicol Appl Pharmacol. 2010;244(2):106\u201313. https:\/\/doi.org\/10.1016\/j.taap.2009.12.023.","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"3345_CR8","doi-asserted-by":"publisher","first-page":"235","DOI":"10.18433\/J3N318","volume":"18","author":"C Gang","year":"2015","unstructured":"Gang C, Qiang C, Xiangli C, Shifen P, Chong S, Lihong L. Puerarin suppresses angiotensin II-induced cardiac hypertrophy by inhibiting NADPH oxidase activation and oxidative stress-triggered AP-1 signaling pathways. J Pharm Pharm Sci. 2015;18(2):235\u201348. https:\/\/doi.org\/10.18433\/J3N318.","journal-title":"J Pharm Pharm Sci"},{"issue":"2","key":"3345_CR9","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/pr.2011.23","volume":"71","author":"J Rodebaugh","year":"2012","unstructured":"Rodebaugh J, Sekulic M, Davies W, Montgomery S, Khraibi A, Solhaug MJ, et al. Neuronal nitric oxide synthase, nNOS, regulates renal hemodynamics in the postnatal developing piglet. Pediatr Res. 2012;71(2):144\u20139. https:\/\/doi.org\/10.1038\/pr.2011.23.","journal-title":"Pediatr Res"},{"issue":"1","key":"3345_CR10","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41401-020-0401-y","volume":"42","author":"N Hou","year":"2021","unstructured":"Hou N, Huang Y, Cai SA, Yuan WC, Li LR, Liu XW, et al. Puerarin ameliorated pressure overload-induced cardiac hypertrophy in Ovariectomized rats through activation of the PPAR\u03b1\/PGC-1 pathway. Acta Pharmacol Sin. 2021;42(1):55\u201367. https:\/\/doi.org\/10.1038\/s41401-020-0401-y.","journal-title":"Acta Pharmacol Sin"},{"key":"3345_CR11","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.1016\/j.csbj.2020.11.010","volume":"18","author":"B Pan","year":"2020","unstructured":"Pan B, Fang S, Zhang J, Pan Y, Liu H, Wang Y, et al. Chinese herbal compounds against SARS-CoV-2: Puerarin and Quercetin impair the binding of viral S-protein to ACE2 receptor. Comput Struct Biotechnol J. 2020;18:3518\u201327. https:\/\/doi.org\/10.1016\/j.csbj.2020.11.010.","journal-title":"Comput Struct Biotechnol J"},{"issue":"4","key":"3345_CR12","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S0531-5565(99)00030-3","volume":"34","author":"L Robert","year":"1999","unstructured":"Robert L. Aging of the Vascular-Wall and atherosclerosis. Exp Gerontol. 1999;34(4):491\u2013501. https:\/\/doi.org\/10.1016\/S0531-5565(99)00030-3.","journal-title":"Exp Gerontol"},{"issue":"7","key":"3345_CR13","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1139\/y96-075","volume":"74","author":"S Laurent","year":"1996","unstructured":"Laurent S, Lacolley P, Girerd X, Boutouyrie P, Bezie Y, Safar M. Arterial stiffening: opposing effects of age- and hypertension-associated structural changes. Can J Physiol Pharmacol. 1996;74(7):842\u20139. https:\/\/doi.org\/10.1139\/y96-075.","journal-title":"Can J Physiol Pharmacol"},{"issue":"12","key":"3345_CR14","first-page":"1212","volume":"24","author":"GQ Zhang","year":"2003","unstructured":"Zhang GQ, Hao XM, Dai DZ, Fu Y, Zhou PA, Wu CH. Puerarin blocks Na+ current in rat ventricular myocytes. Acta Pharmacol Sin. 2003;24(12):1212\u20136.","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"3345_CR15","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1124\/jpet.107.125567","volume":"323","author":"XH Sun","year":"2007","unstructured":"Sun XH, Ding JP, Li H, Pan N, Gan L, Yang XL, et al. Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation. J Pharmacol Exp Ther. 2007;323(1):391\u20137. https:\/\/doi.org\/10.1124\/jpet.107.125567.","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"3345_CR16","first-page":"248","volume":"29","author":"XG Guo","year":"2004","unstructured":"Guo XG, Chen JZ, Zhang X, Xia Q. Effect of puerarin on L-type calcium channel in isolated rat ventricular myocytes. Zhongguo Zhong Yao Za Zhi. 2004;29(3):248\u201351.","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"3","key":"3345_CR17","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1159\/000485450","volume":"44","author":"L Wang","year":"2017","unstructured":"Wang L, Cui Y, Liu Q, Song Y, Hu Q, Tang M, et al. Puerarin enhances Ca2+ reuptake and Ca2+ content of sarcoplasmic reticulum in murine embryonic stem cell-derived Cardiomyocytes via Upregulation of SERCA2a. Cell Physiol Biochem. 2017;44(3):1199\u2013212. https:\/\/doi.org\/10.1159\/000485450.","journal-title":"Cell Physiol Biochem"},{"issue":"6","key":"3345_CR18","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.3892\/ijmm.2017.3186","volume":"40","author":"W Li","year":"2017","unstructured":"Li W, Lu M, Zhang Y, Xia D, Chen Z, Wang L, et al. Puerarin attenuates the daunorubicin induced apoptosis of H9c2 cells by activating the PI3K\/Akt signaling pathway via the inhibition of Ca2+ influx. Int J Mol Med. 2017;40(6):1889\u201394. https:\/\/doi.org\/10.3892\/ijmm.2017.3186.","journal-title":"Int J Mol Med"},{"key":"3345_CR19","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.etap.2017.03.015","volume":"52","author":"H Cheng","year":"2017","unstructured":"Cheng H, Chou C, Liang W, Kuo C, Shieh P, Wang J, et al. Effects of puerarin on intracellular Ca(2+) and cell viability of MDCK renal tubular cells. Environ Toxicol Pharmacol. 2017;52:83\u20139.","journal-title":"Environ Toxicol Pharmacol"},{"key":"3345_CR20","first-page":"142","volume":"37","author":"Y Wu","year":"2019","unstructured":"Wu Y, Xu YF, He XJ, Zhang WJ, He Y, Jian MC, et al. Effect of puerarin on relaxation of mesenteric artery in spontaneously hypertensive rats. Chin J Clin Anat. 2019;37:142\u20137.","journal-title":"Chin J Clin Anat"},{"issue":"5","key":"3345_CR21","doi-asserted-by":"publisher","first-page":"C748","DOI":"10.1152\/ajpcell.00312.2011","volume":"302","author":"B Yang","year":"2012","unstructured":"Yang B, Gwozdz T, Dutko-Gwozdz J, Bolotina VM. Orai1 and Ca2+-independent phospholipase A2 are required for store-operated Icat-SOC current, Ca2+ entry, and proliferation of primary vascular smooth muscle cells. Am J Physiol Cell Physiol. 2012;302(5):C748\u201356. https:\/\/doi.org\/10.1152\/ajpcell.00312.2011.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"9","key":"3345_CR22","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1111\/j.1440-1681.2008.05018.x","volume":"35","author":"Y Wang","year":"2008","unstructured":"Wang Y, Deng X, Hewavitharana T, Soboloff J, Gill DL. Stim, ORAI and TRPC channels in the control of calcium entry signals in smooth muscle. Clin Exp Pharmacol Physiol. 2008;35(9):1127\u201333. https:\/\/doi.org\/10.1111\/j.1440-1681.2008.05018.x.","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"7","key":"3345_CR23","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1161\/01.RES.0000216596.73005.3c","volume":"98","author":"BR Wamhoff","year":"2006","unstructured":"Wamhoff BR, Bowles DK, Owens GK. Owens. Excitation\u2013transcription coupling in arterial smooth muscle. Circ Res. 2006;98(7):868\u201378. https:\/\/doi.org\/10.1161\/01.RES.0000216596.73005.3c.","journal-title":"Circ Res"},{"key":"3345_CR24","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/aps.2013.185","volume":"35","author":"G Chen","year":"2014","unstructured":"Chen G, Pan SQ, Shen C, Pan SF, Zhang XM, He QY. Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1\/2, p38 and NF-\u03baB pathways. Acta Pharmacol Sin. 2014;35:463\u201375.","journal-title":"Acta Pharmacol Sin"},{"key":"3345_CR25","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jjcc.2013.06.008","volume":"63","author":"Y Yuan","year":"2014","unstructured":"Yuan Y, Zong J, Zhou H, Bian ZY, Deng W, Dai J, et al. Puerarin attenuates pressure overload-induced cardiac hypertrophy. J Cardiol. 2014;63:73\u201381.","journal-title":"J Cardiol"},{"issue":"10","key":"3345_CR26","first-page":"4425","volume":"8","author":"Z Tao","year":"2016","unstructured":"Tao Z, Ge Y, Zhou N, Wang Y, Cheng W, Yang Z. Puerarin inhibits cardiac fibrosis via monocyte chemoattractant protein (MCP)-1 and the transforming growth factor-\u03b21 (TGF-\u03b21) pathway in myocardial infarction mice. Am J Transl Res. 2016;8(10):4425\u201333.","journal-title":"Am J Transl Res"},{"key":"3345_CR27","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.vph.2008.11.003","volume":"50","author":"XH Meng","year":"2009","unstructured":"Meng XH, Ni C, Zhu L, Shen YL, Wang LL, Chen YY. Puerarin protects against high glucose-induced acute vascular dysfunction: role of heme oxygenase-1 in rat thoracic aorta. Vasc Pharmacol. 2009;50:110\u20135.","journal-title":"Vasc Pharmacol"},{"issue":"1","key":"3345_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1142\/S0192415X19500010","volume":"47","author":"W Shi","year":"2019","unstructured":"Shi W, Yuan R, Chen X. Puerarin reduces blood pressure in spontaneously hypertensive rats by targeting eNOS. Am J Chin Med. 2019;47(1):1\u201320.","journal-title":"Am J Chin Med"},{"key":"3345_CR29","first-page":"2231","volume":"24","author":"JJ Ma","year":"2003","unstructured":"Ma JJ, Ma H, Wang YM, Li HM, Pei JM. Vasodilation effect of puerarin on abdominal aortic artery in the rat and the underlying mechanism. Disi Junyi Daxue Xuebao. 2003;24:2231\u20134.","journal-title":"Disi Junyi Daxue Xuebao"},{"issue":"1-3","key":"3345_CR30","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ejphar.2006.08.078","volume":"552","author":"DK Yeung","year":"2006","unstructured":"Yeung DK, Leung SW, Xu YC, Vanhoutte PM, Man RY. Puerarin, an isoflavonoid derived from radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery. Eur J Pharmacol. 2006;552(1-3):105\u201311. https:\/\/doi.org\/10.1016\/j.ejphar.2006.08.078.","journal-title":"Eur J Pharmacol"},{"key":"3345_CR31","first-page":"42","volume":"149","author":"S Gheibi","year":"2018","unstructured":"Gheibi S. S Jeddi, K Kashfi and a Ghasemi. Regulation of vascular tone homeostasis by NO and H2S: implications in hypertension. Biochem. Pharmacol. 2018;149:42\u201359.","journal-title":"Pharmacol."},{"key":"3345_CR32","doi-asserted-by":"publisher","unstructured":"Dong K, Tao QM, Shan QX, Jin HF, Pan GB, Chen JZ, et al. Endothelium-independent vasorelaxant effect of puerarin on rat thoracic aorta. Conf Proc IEEE Eng Med Biol Soc. 2004;4:3757\u201360. https:\/\/doi.org\/10.1109\/IEMBS.2004.1404054.","DOI":"10.1109\/IEMBS.2004.1404054"},{"issue":"1","key":"3345_CR33","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.jep.2011.11.021","volume":"139","author":"Y Deng","year":"2012","unstructured":"Deng Y, Ng ES, Yeung JH, Kwan YW, Lau CB, Koon JC, et al. Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated basilar artery. J Ethnopharmacol. 2012;139(1):294\u2013304. https:\/\/doi.org\/10.1016\/j.jep.2011.11.021.","journal-title":"J Ethnopharmacol"},{"key":"3345_CR34","doi-asserted-by":"publisher","unstructured":"Fusi F, Trezza A, Tramaglino M, Sgaragli G, Saponara S, Spiga O. The beneficial health effects of flavonoids on the cardiovascular system: focus on K+ channels. Pharmacol Res. 2020;2(152):104625. https:\/\/doi.org\/10.1016\/j.phrs.2019.104625.","DOI":"10.1016\/j.phrs.2019.104625"},{"issue":"7","key":"3345_CR35","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1161\/CIRCRESAHA.111.300220","volume":"112","author":"JC Gonz\u00e1lez-Cobos","year":"2013","unstructured":"Gonz\u00e1lez-Cobos JC, Zhang X, Zhang W, Ruhle B, Motiani RK, Schindl R, et al. Store-independent Orai1\/3 channels activated by Intracrine leukotriene C4: role in Neointimal hyperplasia. Circ Res. 2013;112(7):1013\u201325. https:\/\/doi.org\/10.1161\/CIRCRESAHA.111.300220.","journal-title":"Circ Res"},{"key":"3345_CR36","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/978-3-319-57732-6_22","volume":"993","author":"J Tanwar","year":"2017","unstructured":"Tanwar J, Trebak M, Motiani RK. Cardiovascular and hemostatic disorders: role of STIM and Orai proteins in vascular disorders. Adv Exp Med Biol. 2017;993:425\u201352. https:\/\/doi.org\/10.1007\/978-3-319-57732-6_22.","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"3345_CR37","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/mt.2008.291","volume":"17","author":"FC Aubart","year":"2009","unstructured":"Aubart FC, Sassi Y, Coulombe A, Mougenot N, Vrignaud C, Leprince P, et al. RNA interference targeting STIM1 suppresses vascular smooth muscle cell proliferation and neointima formation in the rat. Mol Ther. 2009;17(3):455\u201362. https:\/\/doi.org\/10.1038\/mt.2008.291.","journal-title":"Mol Ther"},{"issue":"5","key":"3345_CR38","doi-asserted-by":"publisher","first-page":"C1103","DOI":"10.1152\/ajpcell.00283.2009","volume":"297","author":"SG Baryshnikov","year":"2009","unstructured":"Baryshnikov SG, Pulina MV, Zulian A, Linde CI, Golovina VA. Orai1, a critical component of store-operated Ca2+ entry, is functionally associated with Na+\/Ca2+ exchanger and plasma membrane Ca2+ pump in proliferating human arterial myocytes. Am J Physiol Cell Physiol. 2009;297(5):C1103\u201312. https:\/\/doi.org\/10.1152\/ajpcell.00283.2009.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"3345_CR39","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/1465-9921-10-123","volume":"10","author":"C Wang","year":"2009","unstructured":"Wang C, Li JF, Zhao L, Liu J, Wan J, Wang YX, et al. Inhibition of SOC\/Ca2 +\/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells. Respir Res. 2009;10(1):123. https:\/\/doi.org\/10.1186\/1465-9921-10-123.","journal-title":"Respir Res"},{"issue":"17","key":"3345_CR40","doi-asserted-by":"publisher","first-page":"4201","DOI":"10.1113\/jphysiol.2012.233353","volume":"590","author":"M Trebak","year":"2012","unstructured":"Trebak M. STIM\/Orai Signalling complexes in vascular smooth muscle. J Physiol. 2012;590(17):4201\u20138. https:\/\/doi.org\/10.1113\/jphysiol.2012.233353.","journal-title":"J Physiol"},{"issue":"2","key":"3345_CR41","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1160\/TH09-08-0517","volume":"103","author":"A Dietrich","year":"2010","unstructured":"Dietrich A, Kalwa H, Gudermann T. TRPC channels in vascular cell function. Thromb Haemost. 2010;103(2):262\u201370. https:\/\/doi.org\/10.1160\/TH09-08-0517.","journal-title":"Thromb Haemost"},{"issue":"5","key":"3345_CR42","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s00424-012-1090-2","volume":"463","author":"DJ Beech","year":"2012","unstructured":"Beech DJ. Orai1 calcium channels in the vasculature. Pflugers Arch. 2012;463(5):635\u201347. https:\/\/doi.org\/10.1007\/s00424-012-1090-2.","journal-title":"Pflugers Arch"},{"issue":"5","key":"3345_CR43","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1161\/CIRCRESAHA.111.246777","volume":"109","author":"W Zhang","year":"2011","unstructured":"Zhang W, Halligan KE, Zhang X, Bisaillon JM, Gonzalez-Cobos JC, Motiani RK, et al. Orai1-mediated I (CRAC) is essential for neointima formation after vascular injury. Circ Res. 2011;109(5):534\u201342. https:\/\/doi.org\/10.1161\/CIRCRESAHA.111.246777.","journal-title":"Circ Res"},{"issue":"5","key":"3345_CR44","doi-asserted-by":"publisher","first-page":"H1770","DOI":"10.1152\/ajpheart.00535.2010","volume":"300","author":"JH Zhu","year":"2011","unstructured":"Zhu JH, Chen CL, Flavahan S, Harr J, Su B, Flavahan NA. Cyclic stretch stimulates vascular smooth muscle cell alignment by redox-dependent activation of Notch3. Am J Physiol Heart Circ Physiol. 2011;300(5):H1770\u201380. https:\/\/doi.org\/10.1152\/ajpheart.00535.2010.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"3345_CR45","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/978-94-007-0265-3_36","volume":"704","author":"C Guibert","year":"2011","unstructured":"Guibert C, Ducret T, Savineau JP. Expression and physiological roles of TRP channels in smooth muscle cells. Adv Exp Med Biol. 2011;704:687\u2013706. https:\/\/doi.org\/10.1007\/978-94-007-0265-3_36.","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"3345_CR46","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.pharmthera.2006.05.013","volume":"112","author":"A Dietrich","year":"2006","unstructured":"Dietrich A, Chubanov V, Kalwa H, Rost BR, Gudermann T. Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells. Pharmacol Ther. 2006;112(3):744\u201360. https:\/\/doi.org\/10.1016\/j.pharmthera.2006.05.013.","journal-title":"Pharmacol Ther"},{"issue":"Pt 5","key":"3345_CR47","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1113\/jphysiol.2011.221358","volume":"590","author":"Y Imai","year":"2012","unstructured":"Imai Y, Itsuki K, Okamura Y, Inoue R, Mori MX. A self-limiting regulation of vasoconstrictor-activated TRPC3\/C6\/C7 channels coupled to PI(4,5)P(2)-diacylglycerol signalling. J Physiol. 2012;590(Pt 5):1101\u201319. https:\/\/doi.org\/10.1113\/jphysiol.2011.221358.","journal-title":"J Physiol"},{"issue":"Pt 9","key":"3345_CR48","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1113\/jphysiol.2009.185256","volume":"588","author":"M Ju","year":"2010","unstructured":"Ju M, Shi J, Saleh SN, Albert AP, Large WA. Ins(1,4,5)P3 interacts with PIP2 to regulate activation of TRPC6\/C7 channels by diacylglycerol in native vascular myocytes. J Physiol. 2010;588(Pt 9):1419\u201333. https:\/\/doi.org\/10.1113\/jphysiol.2009.185256.","journal-title":"J Physiol"},{"issue":"12","key":"3345_CR49","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1161\/01.RES.0000226495.34949.28","volume":"98","author":"Y Maruyama","year":"2006","unstructured":"Maruyama Y, Nakanishi Y, Walsh EJ, Wilson DP, Welsh DG, Cole WC. Hetero multimeric TRPC6-TRPC7 channels contribute to arginine vasopressin-induced cation current of A7r5 vascular smooth muscle cells. Circ Res. 2006;98(12):1520\u20137. https:\/\/doi.org\/10.1161\/01.RES.0000226495.34949.28.","journal-title":"Circ Res"}],"container-title":["BMC Complementary Medicine and Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-021-03345-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12906-021-03345-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-021-03345-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T20:02:49Z","timestamp":1624305769000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-021-03345-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,22]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3345"],"URL":"https:\/\/doi.org\/10.1186\/s12906-021-03345-8","relation":{},"ISSN":["2662-7671"],"issn-type":[{"value":"2662-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,22]]},"assertion":[{"value":"8 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All methods were performed in accordance with the relevant guidelines and regulations. Animal breeding, handling and drug delivery protocols were reviewed, approved and monitored by the Animal Care and Use Committee of Hubei University of Medicine. The study was carried out in compliance with the ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors of this paper are in agreement with the manuscript publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"173"}}