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This study investigated the anti-inflammatory, antioxidant and anti-asthmatic effects of <jats:italic>L. javanica<\/jats:italic> using a rat model of asthma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A 5% w\/v <jats:italic>L. javanica<\/jats:italic> tea infusion was prepared and characterised by liquid chromatography\u2013mass spectrometer (LC-MS). Animals were intraperitoneally sensitized with ovalbumin (OVA) and subsequently challenged intranasal with OVA on day 15 except the control group. Animals were grouped (<jats:italic>n<\/jats:italic>\u2009=\u20095\/group) for treatment: unsensitised control, sensitised control, sensitised + prednisolone and sensitised + <jats:italic>L. javanica<\/jats:italic> at 50\u2009mg\/kg\/day and 100\u2009mg\/kg\/day \u2013 equivalent to 1 and 2 cups of tea per day, respectively. After 2\u2009weeks of treatment, bronchoalveolar lavage fluid (BALF) was collected for total and differential white blood cell\u00a0(WBC) count. Nitric oxide (NO), lipid peroxidation and antioxidants were also\u00a0assessed\u00a0in BALF. Ovalbumin specific IgE antibody and inflammatory cytokines: IL-4, IL-5, IL-13 and TNF-alpha were measured in serum.\u00a0Lung and muscle tissues were histological examined.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p><jats:italic>L. javanica<\/jats:italic> was rich in phenolic compounds. OVA sensitisation resulted in development of allergic asthma in rats. <jats:italic>L. javanica<\/jats:italic> treatment resulted in a reduction in total WBC count as well as eosinophils, lymphocytes and neutrophils in BALF. <jats:italic>L. javanica<\/jats:italic> inhibited Th2-mediated immune response, which was evident by a decrease in serum IgE and inflammatory cytokines: IL-4, IL-5, IL-13 and TNF-\u03b1. <jats:italic>L. javanica<\/jats:italic> treatment also reduced malondialdehyde (MDA) and NO, and increased superoxide dismutase, glutathione and total antioxidant capacity. Histology showed significant attenuation of lung infiltration of inflammatory cells, alveolar thickening, and bronchiole smooth muscle thickening.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p><jats:italic>L. javanica<\/jats:italic> suppressed allergic airway inflammation by reducing Th2-mediated immune response and oxidative stress in OVA-sensitized rats which may be attributed to the presence of phenolic compound in the plant<jats:italic>.<\/jats:italic> This finding validates the traditional use of <jats:italic>L. javanica<\/jats:italic> in the treatment of respiratory disorders.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12906-021-03361-8","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T14:03:14Z","timestamp":1625493794000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Lippia javanica (Zumbani) herbal tea infusion attenuates allergic airway inflammation via inhibition of Th2 cell activation and suppression of oxidative stress"],"prefix":"10.1186","volume":"21","author":[{"given":"Mvuyisi O. 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