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Consumption of the conventional drugs has shown several side effects and drug resistance. This study was aimed to screen some Iranian medicinal plants extracts and their fractions against influenza A virus.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p><jats:italic>Glycyrrhiza glabra<\/jats:italic> (rhizome), <jats:italic>Myrtus \u2009commonis<\/jats:italic> (leaves), <jats:italic>Melissa officinalis<\/jats:italic> (leaves), <jats:italic>Hypericum perforatum<\/jats:italic> (aerial parts), <jats:italic>Tilia platyphyllos<\/jats:italic> (flower), <jats:italic>Salix alba<\/jats:italic> (bark), and <jats:italic>Camellia sinensis<\/jats:italic> (green and fermented leaves) were extracted with 80% methanol and fractionated with chloroform and methanol, respectively. The cytotoxicity of the compounds were determined by MTT colorimetric assay on MDCK cells. The effective concentrations (EC<jats:sub>50<\/jats:sub>) of the compounds were calculated from the MTT results compared to the negative control with no significant effects on cell viability. The effects of EC<jats:sub>50<\/jats:sub> of the compounds on viral surface glycoproteins and viral titer were tested by HI and HA virological assays, respectively and compared with oseltamivir and amantadine. Preliminary phytochemical analysis were done for promising anti-IAV extracts and fractions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The most effective samples against IAV titer (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.05) were crude extracts of <jats:italic>G. glabra<\/jats:italic>, <jats:italic>M. officinalis<\/jats:italic> and <jats:italic>S. alba<\/jats:italic>; methanol fractions of <jats:italic>M. communis<\/jats:italic> and <jats:italic>M. officinalis<\/jats:italic>; and chloroform fractions of <jats:italic>M. communis<\/jats:italic> and <jats:italic>C. sinensis<\/jats:italic> (fermented) mostly in co- and pre-penetration combined treatments. The potential extracts and fractions were rich in flavonoids, tannins, steroids and triterpenoids.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The outcomes confirmed a scientific basis for anti-influenza A virus capacity of the extracts and fractions from the selected plants for the first time, and correlated their effects with their phytochemical constituents. It is worth focusing on elucidating pure compounds and identifying their mechanism(s) of action.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12906-021-03423-x","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T09:02:48Z","timestamp":1633078968000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Potential antiviral effects of some native Iranian medicinal plants extracts and fractions against influenza A virus"],"prefix":"10.1186","volume":"21","author":[{"given":"Parvaneh","family":"Mehrbod","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanieh","family":"Safari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Mollai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Fotouhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasaman","family":"Mirfakhraei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanieh","family":"Entezari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saied","family":"Goodarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-6595","authenticated-orcid":false,"given":"Zahra","family":"Tofighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"3423_CR1","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1128\/mr.56.1.152-179.1992","volume":"56","author":"R Webster","year":"1992","unstructured":"Webster R, Bean WGO, Chambers T, Kawaoka Y. 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