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The patients were randomized to receive 144\u2009mg cranberry capsule or placebo for 6\u2009months. The primary efficacy of the treatment was lipid profile, glycemic measurements, and liver enzyme levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The data were reported for 46 in the supplementation group and 48 in the placebo group. The patient\u2019s mean (SD) age was 43.16 (11.08) years. No significant differences between groups were observed regarding the post-intervention level of liver enzyme. The mean after-intervention levels of total cholesterol (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and triglyceride (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) were significantly lower in the intervention group compared with the placebo group. At the end of the study, the mean insulin and HOMA-IR levels were significantly lower in the cranberry group compared with the placebo group. Significantly more patients in the cranberry group experienced a decrease in steatosis level compared with the control group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The results of the present study showed that cranberry supplementation had a positive effect on some lipid profiles, insulin resistance, and hepatic steatosis in patients with NAFLD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/en.irct.ir\/trial\/49884\">IRCT20200725048200N1<\/jats:ext-link>; first registration date: 11.8.2020.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12906-021-03436-6","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T08:02:53Z","timestamp":1637308973000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of cranberry supplementation on liver enzymes and cardiometabolic risk factors in patients with NAFLD: a randomized clinical trial"],"prefix":"10.1186","volume":"21","author":[{"given":"Kourosh","family":"Masnadi Shirazi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Shirinpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arman","family":"Masnadi Shirazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeinab","family":"Nikniaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"issue":"3","key":"3436_CR1","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.cld.2004.04.004","volume":"8","author":"AJ McCullough","year":"2004","unstructured":"McCullough AJ. 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The ethics committee of Tabriz University of medical sciences approved the study protocol (Ethics code: IR.TBZMED.REC.1399.090). The study was carried out in accordance with the ethical guidelines of Tabriz University of medical sciences.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"283"}}