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However, its association with nephrotoxicity limits its therapeutic use.\n                      <jats:italic>Ocimum gratissimum<\/jats:italic>\n                      leaf is a medicinal plant with numerous pharmacological and therapeutic efficacies, such as antioxidant, anti-inflammation, and anti-apoptotic properties.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The present study was designed to evaluate the protective effect of\n                      <jats:italic>Ocimum gratissimum<\/jats:italic>\n                      (OG) against CP-induced kidney dysfunction in rats. Rats were pre-treated with 400\u2009mg\/kg b.w. of leave extract of\n                      <jats:italic>Ocimum gratissimum<\/jats:italic>\n                      (\n                      <jats:italic>Ocimum G.<\/jats:italic>\n                      ) for 4\u2009days and then 50\u2009mg\/kg b.w. of CP was co-administered from day 5 to day 7 along with\n                      <jats:italic>Ocimum G.<\/jats:italic>\n                      Markers of renal function and oxidative stress, food and water intake, electrolytes, aldosterone, leukocytes infiltration, inflammation and histopathological alteration were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Obvious renal inflammation and kidney injuries were observed in CP treated groups. However, administration of leave extract of\n                      <jats:italic>Ocimum G.<\/jats:italic>\n                      prevented oxidative stress, kidney injuries, attenuated inflammation, increased aldosterone production and reduced sodium ion and water loss in rats. The plasma creatinine, urea and urine albumin concentration were normalized after the administration of\n                      <jats:italic>Ocimum G.<\/jats:italic>\n                      extract in rats treated with CP.\n                      <jats:italic>Ocimum G.<\/jats:italic>\n                      also decreased the plasma concentrations of Interleukin-(IL)-6, C-reactive protein and activity of myeloperoxidase and malondialdehyde in CP treated rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Ocimum G.<\/jats:italic>\n                      prevented kidney injury and enhanced renal function via inhibiting inflammation and oxidant-induced CP toxicity. The efficacy of\n                      <jats:italic>Ocimum G.<\/jats:italic>\n                      is related to the presence of various phytochemicals in the plant.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12906-021-03447-3","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T01:02:31Z","timestamp":1635814951000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats"],"prefix":"10.1186","volume":"21","author":[{"given":"Quadri K.","family":"Alabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufus O.","family":"Akomolafe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph G.","family":"Omole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayodeji","family":"Aturamu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mokolade S.","family":"Ige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyindasola O.","family":"Kayode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Kajewole-Alabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"3447_CR1","first-page":"1389","volume-title":"Goodman and Gilman\u2019s the pharmacological basis of therapeutics","author":"BA Chabner","year":"2001","unstructured":"Chabner BA, Ryand DP, Pax-Ares L, Garcis-Carbonero, Calaresi P. 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