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The present study therefore investigates the hepatoprotective and nephroprotective potentials of its leaves extract with a view to providing a potent alternative in the management of liver and kidney diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Forty male albino rats were randomly placed into eight groups comprising five animals each. Animals in group I were administered with the distilled water, while groups II and VI were exposed to CCl<jats:sub>4<\/jats:sub>and rifampicin respectively. Animals in groups III and IV were initially exposed CCl<jats:sub>4<\/jats:sub>and treated with 50 and 100\u2009mg\/kg bw<jats:italic>M. pruriens<\/jats:italic>respectively. Similarly, groups VII and VIII animals were exposed to rifampicin and treated with 50 and 100\u2009mg\/kg bw<jats:italic>M. pruriens<\/jats:italic>respectively. Animals in group V were treated with 100\u2009mg\/kg bw silymarin by oral gavage after an initial exposure to CCl<jats:sub>4<\/jats:sub>. Selected biomarkers of liver and kidney damage were determined in the serum and organs homogenate. Liver and kidney slices of experimental animals were also stained for histopathological examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Exposure to CCl<jats:sub>4<\/jats:sub>and rifampicin respectively resulted in marked distortion in lipid profile, inhibition of antioxidant enzymes and a surge in ALT, AST, ALP, urea, uric acid, bilirubin and creatine kinase. Treatment with<jats:italic>M. pruriens<\/jats:italic>extract reversed all deranged biochemical and histopathological parameters in a dose-dependent manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Extract of<jats:italic>M. pruriens<\/jats:italic>leaves restored deranged biochemical and histopathological parameters in the liver and kidney with similar potency to silymarin. Hence, leaf extract of<jats:italic>M. pruriens<\/jats:italic>is a potential hepatoprotective and nephroprotective agent that can be exploited in the management of liver and kidney diseases.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12906-021-03455-3","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T11:03:18Z","timestamp":1637146998000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ethanolic extract of Mucuna pruriens leaves ameliorates carbon tetrachloride and rifampicin-induced hepatotoxicity and nephrotoxicity in wistar albino rat"],"prefix":"10.1186","volume":"21","author":[{"given":"Temidayo","family":"Ogunmoyole","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayomide Micheal","family":"Ola-Awe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omotola Grace","family":"Fatile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"3455_CR1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4236\/ym.2017.14023","volume":"1","author":"AE Azab","year":"2017","unstructured":"Azab AE, Albasha MO, Elsayed AS. 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