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This condition has a complex pathogenesis associated with behavioral, cognitive and motor sequels in humans and current antimalarial therapies have shown little effect in those aspects. Natural products with antioxidant and anti-inflammatory properties have become a valuable alternative therapeutic option in the treatment of distinct conditions. In this context, this study investigated the neuroprotective effect of<jats:italic>Euterpe oleracea<\/jats:italic>(a\u00e7ai) enriched diet during the development of experimental cerebral malaria induced by the inoculation of Swiss albino mice with<jats:italic>Plasmodium berghei<\/jats:italic>ANKA strain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After<jats:italic>Plasmodium<\/jats:italic>infection, animals were maintained on a feeding with<jats:italic>Euterpe oleracea<\/jats:italic>enriched ration and parameters such as survival curve, parasitemia and body weight were routinely monitored. The present study has also evaluated the effect of a\u00e7ai-enriched diet on the blood-brain barrier leakage, histological alterations and neurocognitive impairments in mice developing cerebral malaria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results demonstrate that between 7th\u201319th day post infection the survival rate of the group treated with a\u00e7ai enriched ration was higher when compared with<jats:italic>Plasmodium-<\/jats:italic>infected mice in which 100% of mice died until the 11th days post-infection, demonstrating that a\u00e7ai diet has a protective effect on the survival of infected treated animals. The same was observed in the brain vascular extravasation, where Evans blue dye assays showed significantly less dye extravasation in the brains of<jats:italic>Plasmodium-<\/jats:italic>infected mice treated with a\u00e7ai enriched ration, demonstrating more preserved blood-brain barrier integrity. A\u00e7ai-enriched diet also attenuate the histopathological alterations elicited by<jats:italic>Plasmodium berghei<\/jats:italic>infection. We also showed a decrease of the neurological impairments arising from the exposure of cerebral parenchyma in the group treated with a\u00e7ai diet, ameliorating motor and neuropsychiatric changes, analyzed through the SHIRPA protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With these results, we conclude that the treatment with a\u00e7ai enriched ration decreased the mortality of infected animals, as well as protected the blood-brain barrier and the neurocognitive deficits in<jats:italic>Plasmodium<\/jats:italic>-infected animals.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12906-021-03495-9","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T07:02:46Z","timestamp":1641884566000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Euterpe oleracea fruit (A\u00e7ai)-enriched diet suppresses the development of experimental cerebral malaria induced by Plasmodium berghei (ANKA) infection"],"prefix":"10.1186","volume":"22","author":[{"given":"Karen Renata Herculano Matos","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie Lujan Marques","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayara","family":"Kauffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda Jaqueline","family":"de Azevedo Ata\u00edde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00edvia","family":"de Souza Franco Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Medeiros","family":"dos Anjos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosivaldo","family":"dos Santos Borges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlomagno Pacheco","family":"Bahia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana Ketlen Reis","family":"Le\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelaide","family":"da Concei\u00e7\u00e3o Fonseca Passos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson Manoel","family":"Herculano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evander","family":"de Jesus Oliveira Batista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"issue":"6","key":"3495_CR1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/MOP.0000000000000823","volume":"31","author":"DG Postels","year":"2019","unstructured":"Postels DG, Soldatos A, LaRovere KL. 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