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Corticosteroids, non-steroidal anti-inflammatory drugs exert potential side effects on long term use. This study was aimed to investigate the acute oral toxicity, anti-inflammatory and analgesic activities of leaf and bark extracts of <jats:italic>Albizia procera<\/jats:italic> in experimental animal models.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Ethyl acetate, ethanol, and hydroalcoholic extracts of <jats:italic>Albizia procera<\/jats:italic> (leaf and bark) were subjected for acute oral toxicity, anti-inflammatory and analgesic screening. Carrageenan and cotton pellet granuloma models were used to assess acute and chronic anti-inflammatory effects, respectively. Intraplanar formalin test was used to assess the analgesic activity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All the extracts of <jats:italic>Albizia procera<\/jats:italic> were found to be well-tolerated up to 2000\u2009mg\/kg in female rats. Ethanolic leaf (ETLE) and bark (ETBE) of <jats:italic>Albizia procera<\/jats:italic> showed anti-inflammatory actions. But, only ETBE produced significant protection in chronic inflammation and analgesic activity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In summary, <jats:italic>Albizia procera<\/jats:italic> possess significant anti-inflammatory and analgesic properties. This study adds evidence on the traditional use of <jats:italic>Albizia procera<\/jats:italic> plant for treating painful inflammatory disorders.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12906-021-03497-7","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T18:02:57Z","timestamp":1645812177000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Analgesic, anti-inflammatory and acute oral toxicity profile of leaf and bark extracts of Albizia procera"],"prefix":"10.1186","volume":"22","author":[{"given":"Sangeetha","family":"Mani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chamundeeswari","family":"Duraipandian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saravana Babu","family":"Chidambaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"3497_CR1","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ejmech.2019.06.034","volume":"179","author":"N Kishore","year":"2019","unstructured":"Kishore N, Kumar P, Shanker K, Verma A. 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