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In this investigation, 40 male Wistar rats weighing 200\u2013250\u00a0g were randomly divided into 5 groups: group I was used as control, group II received carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) (IP, 1\u00a0mL\/kg) on day 21, group III and group IV received <jats:italic>S. pachycarpa<\/jats:italic> seed extract at doses of 150\u00a0mg\/kg and 300\u00a0mg\/kg, respectively for 21\u00a0days by oral gavage and CCl<jats:sub>4<\/jats:sub> on day 21, group V received silymarin (300\u00a0mg\/kg) for 21\u00a0days by oral gavage and CCl<jats:sub>4<\/jats:sub> on day 21. CCl<jats:sub>4<\/jats:sub> showed an increase of serum renal and hepatic markers creatinine, urea, blood urea nitrogen (BUN), and uric acid, alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT). Also, it significantly increased MDA level, and decreased CAT, FRAP, GSH, and SOD in the liver and kidney tissues. These changes and also hematological and histopathological alterations were significantly ameliorated by <jats:italic>S. pachycarpa<\/jats:italic> seed extract before CCl<jats:sub>4<\/jats:sub> administration. In conclusion, the data obtained in our investigation confirm the protective effect of <jats:italic>S. pachycarpa<\/jats:italic> against acute exposure to CCl<jats:sub>4<\/jats:sub>-induced organ toxicity in rats.<\/jats:p>","DOI":"10.1186\/s12906-022-03554-9","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T18:05:26Z","timestamp":1647540326000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Protective effect of Sophora pachycarpa seed extract on carbon tetrachloride-induced toxicity in rats"],"prefix":"10.1186","volume":"22","author":[{"given":"Hamed","family":"Aramjoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouria","family":"Mohammadparast-Tabas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahereh","family":"Farkhondeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Zardast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh","family":"Makhdoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Samarghandian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Kiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"3554_CR1","doi-asserted-by":"crossref","unstructured":"Rice-Evans C, Slater T, Sies H. 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