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And yet, definitive therapies or preventive measures are not present. Herbal medicines have been a source of various antiviral compounds such as Oseltamivir, extracted using shikimic acid from star anise (\n                      <jats:italic>Illicium verum<\/jats:italic>\n                      ) and Acyclovir from\n                      <jats:italic>Carissa edulis<\/jats:italic>\n                      are FDA (Food and Drug Administration) approved antiviral drugs. In this study, we dissect the anti-coronavirus infection activity of\n                      <jats:italic>Cissampelos pareira<\/jats:italic>\n                      L (\n                      <jats:italic>Cipa<\/jats:italic>\n                      ) extract using an integrative approach.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analysed the signature similarities between predicted antiviral agents and\n                      <jats:italic>Cipa<\/jats:italic>\n                      using the connectivity map (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clue.io\/\">https:\/\/clue.io\/<\/jats:ext-link>\n                      ). Next, we tested the anti-SARS-COV-2 activity of\n                      <jats:italic>Cipa<\/jats:italic>\n                      in vitro. Molecular docking analyses of constituents of with key targets of SARS-CoV2 protein viz. spike protein, RNA\u2011dependent RNA\u2011polymerase (RdRp) and 3C\u2011like proteinase. was also performed. A three-way comparative analysis of\n                      <jats:italic>Cipa<\/jats:italic>\n                      transcriptome, COVID-19 BALF transcriptome and CMAP signatures of small compounds was also performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Several predicted antivirals showed a high positive connectivity score with\n                      <jats:italic>Cipa<\/jats:italic>\n                      such as apcidin, emetine, homoharringtonine etc. We also observed 98% inhibition of SARS-COV-2 replication in infected Vero cell cultures with the whole extract. Some of its prominent pure constituents e.g. pareirarine, cissamine, magnoflorine exhibited 40\u201380% inhibition. Comparison of genes between BALF and\n                      <jats:italic>Cipa<\/jats:italic>\n                      showed an enrichment of biological processes like transcription regulation and response to lipids, to be downregulated in\n                      <jats:italic>Cipa<\/jats:italic>\n                      while being upregulated in COVID-19. CMAP also showed that Triciribine, torin-1 and VU-0365114\u20132 had positive connectivity with BALF 1 and 2, and negative connectivity with\n                      <jats:italic>Cipa<\/jats:italic>\n                      . Amongst all the tested compounds, Magnoflorine and Salutaridine exhibited the most potent and consistent strong in silico binding profiles with SARS-CoV2 therapeutic targets.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12906-022-03584-3","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T12:02:54Z","timestamp":1650628974000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Anti-SARS-CoV-2 potential of Cissampelos pareira L. identified by connectivity map-based analysis and in vitro studies"],"prefix":"10.1186","volume":"22","author":[{"given":"Madiha","family":"Haider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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