{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:39:58Z","timestamp":1768289998115,"version":"3.49.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Science Research Foundation Programme of Zhejiang Provincial TCM Administration","award":["2021ZB005"],"award-info":[{"award-number":["2021ZB005"]}]},{"name":"Science Research Foundation Programme of Zhejiang Provincial TCM Administration","award":["2021ZB005"],"award-info":[{"award-number":["2021ZB005"]}]},{"name":"Science Research Foundation Programme of Zhejiang Provincial TCM Administration","award":["2021ZB005"],"award-info":[{"award-number":["2021ZB005"]}]},{"name":"Science Research Foundation Programme of Zhejiang Provincial TCM Administration","award":["2021ZB005"],"award-info":[{"award-number":["2021ZB005"]}]},{"name":"Science Research Foundation Programme of Zhejiang Provincial TCM Administration","award":["2021ZB005"],"award-info":[{"award-number":["2021ZB005"]}]},{"name":"Science Research Foundation Programme of Zhejiang Provincial TCM Administration","award":["2021ZB005"],"award-info":[{"award-number":["2021ZB005"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Med Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>As a common disorder of the gastrointestinal tract, irritable bowel syndrome (IBS) can have negative effects on patients and society, with irritable bowel syndrome with constipation(IBS-C) accounting for a large proportion of these effects. The main clinical manifestations of IBS-C are constipation, abdominal pain, and abdominal distension, which seriously impact the quality of life of patients. The mechanisms of IBS are complex, and the gut-brain axis has been an emerging and recognized theoretical system in recent years. Based on the theory of the gut-brain axis and the theory of Chinese medicine, we designed this study to evaluate the efficacy of one-finger meditation massage in treating IBS-C.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods\/design<\/jats:title>\n                <jats:p>This is a randomized controlled trial. Eligible patients with irritable bowel syndrome (IBS-C) wererandomized 1:1 to a test group (massage plus probiotics) and a control group (probiotics). Patients in the test group weretreated once every 10 days for three consecutive courses of treatment (i.e., three months) and weregiven Bifidobacterium trifolium capsules 630\u00a0mg\/dose three times daily 30\u00a0min after meals every day during the treatment period, with follow-up observations at the end of the third and sixth months of the treatment period. The control group weregiven Bifidobacterium trifolium capsules 630\u00a0mg\/dose, 3 times a day for 3 months, with follow-up observations at the end of the third and sixth months of the treatment period. The primary outcome indicators are the concentrations of 5-HT and substance P and the IBS Severity Scale (IBS-SSS) assessment. Secondary outcomes are the Bristol Rating Scale (BRSA) score, the IBS Quality of Life Questionnaire (IBS-QOL scale) score, and the assessment of the effectiveness of the evidence. The results wereassessed at the pretreatment, posttreatment, and follow-up stages. Any side effects weresubject to assessment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>The aim of this trial is to provide a new method of treatment based on pharmacological treatment that is easy to use, easy to promote and has proven efficacy and to establish the efficacy and safety of treating IBS-C through this trial.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Registration for Trial<\/jats:title>\n                <jats:p>Chinese Clinical Trial Registry ChiCTR2200066417 on 5 December 2022. <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.chictr.org.cn\/bin\/project\/edit?pid=183461\">https:\/\/www.chictr.org.cn\/bin\/project\/edit?pid=183461<\/jats:ext-link><\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12906-023-04019-3","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T19:09:07Z","timestamp":1686078547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical efficacy of one-finger meditation massage on IBS-C based on the \u201cgut-brain axis\u201d theory: study protocol for a randomized controlled trial"],"prefix":"10.1186","volume":"23","author":[{"given":"Xiayang","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhong","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinlei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianpeng","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"issue":"5","key":"4019_CR1","first-page":"1480","volume":"130","author":"F George","year":"2006","unstructured":"George F, Longstreth WGTW, Fermin Mearin ARCS. Funct Bowel Disorders Gastroenterol. 2006;130(5):1480\u201391.","journal-title":"Funct Bowel Disorders Gastroenterol"},{"issue":"6","key":"4019_CR2","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1053\/gast.2002.33741","volume":"122","author":"KW Olden","year":"2002","unstructured":"Olden KW. Diagnosis of irritable bowel Syndrome. Gastroenterology. 2002;122(6):1701\u201314.","journal-title":"Gastroenterology"},{"issue":"7","key":"4019_CR3","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.cgh.2012.02.029","volume":"10","author":"M Rebeccca","year":"2012","unstructured":"Rebeccca M, Lovell AC, Ford, et al. Global prevalence of and risk factors for irritable bowel Syndrome. Clin Gastroenterol Hepatol. 2012;10(7):712\u201321.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"4019_CR4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1440-1746.2006.04672.x","volume":"22","author":"Lu Fcac","year":"2007","unstructured":"Lu Fcac. Irritable bowel syndrome in the 21st century perspectives: perspectives from Asia or South-east Asia. Gastroenterol Hepatol. 2007;22(1):4\u201312.","journal-title":"Gastroenterol Hepatol"},{"issue":"2","key":"4019_CR5","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1159\/000051878","volume":"63","author":"M Simr\u00e9n","year":"2001","unstructured":"Simr\u00e9n M, M\u00e5nsson A, Langkilde AM, et al. Food-Related gastrointestinal symptoms in the irritable bowel Syndrome. Digestion. 2001;63(2):108\u201315.","journal-title":"Digestion"},{"issue":"3","key":"4019_CR6","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1053\/j.gastro.2011.01.032","volume":"140","author":"L Chang","year":"2011","unstructured":"Chang L. The role of stress on physiologic responses and clinical symptoms in irritable bowel syndrome. Gastroenterology. 2011;140(3):761\u20135.","journal-title":"Gastroenterology"},{"key":"4019_CR7","doi-asserted-by":"crossref","unstructured":"Motoyori \u00b7 Kanazawa\/Kanazawa M, Yuka \u00b7 Endo\/Endo Y et al. Patients and nonconsulters with irritable bowel syndrome reporting a parental history of bowel problems have more impaired psychological distress. Digestive diseases and sciences, 2004,49(6):1046\u20131053.","DOI":"10.1023\/B:DDAS.0000034570.52305.10"},{"issue":"4","key":"4019_CR8","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1097\/PSY.0000000000000161","volume":"77","author":"KAM Janssens","year":"2015","unstructured":"Janssens KAM, Zijlema WL, Joustra ML, et al. Mood and anxiety Disorders in chronic fatigue syndrome, Fibromyalgia, and irritable bowel syndrome: results from the LifeLines Cohort Study. Psychosom Med. 2015;77(4):449\u201357.","journal-title":"Psychosom Med"},{"issue":"6","key":"4019_CR9","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.jpsychores.2013.03.004","volume":"74","author":"MAL Tilburg","year":"2013","unstructured":"Tilburg MAL, Palsson OS, Whitehead WE. Which psychological factors exacerbate irritable bowel syndrome? Development of a comprehensive model. J Psychosom Res. 2013;74(6):486\u201392.","journal-title":"J Psychosom Res"},{"key":"4019_CR10","doi-asserted-by":"crossref","unstructured":"Vassallo M, Camilleri M, Phillips SF et al. Transit through the proximal colon influences stool weight in the irritable bowel syndrome. Gastroenterology (New York, N.Y. 1943), 1992,102(1):102.","DOI":"10.1016\/0016-5085(92)91789-7"},{"key":"4019_CR11","doi-asserted-by":"crossref","unstructured":"Bazzocchi G, Ellis J, Villanueva-Meyer J et al. Postprandial colonic transit and motor activity in chronic constipation. Gastroenterology (New York, N.Y. 1943), 1990,98(3):686.","DOI":"10.1016\/0016-5085(90)90289-D"},{"key":"4019_CR12","doi-asserted-by":"crossref","unstructured":"Mertz H, Naliboff B, Munakata J et al. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology (New York, N.Y. 1943), 1995,109(1):40\u201352.","DOI":"10.1016\/0016-5085(95)90267-8"},{"issue":"1","key":"4019_CR13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0016-5085(95)90267-8","volume":"109","author":"C Robin","year":"1995","unstructured":"Robin C. Spiller. Postinfectious irritable bowel syndrome. Gastroenterology. 1995;109(1):40\u201352.","journal-title":"Gastroenterology"},{"issue":"12","key":"4019_CR14","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1136\/gut.52.12.1703","volume":"52","author":"JS Kalantar","year":"2003","unstructured":"Kalantar JS, Locke GR, Zinsmeister AR, et al. Familial aggregation of irritable bowel syndrome: a prospective study. Gut. 2003;52(12):1703\u20137.","journal-title":"Gut"},{"issue":"7","key":"4019_CR15","doi-asserted-by":"publisher","first-page":"907","DOI":"10.4065\/75.9.907","volume":"75","author":"G Richard Locke","year":"2000","unstructured":"Richard Locke G, Alan III, Zinsmeister R, et al. Familial association in adults with functional gastrointestinal disorders. Mayo Clin Proc. 2000;75(7):907\u201312.","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"4019_CR16","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/j.1572-0241.2000.01678.x","volume":"95","author":"G Richard Locke","year":"2000","unstructured":"Richard Locke G, Alan III, Zinsmeister R, et al. Risk factors for irritable bowel syndrome role of analgesics and food sensitivities. Am J Gastroenterol. 2000;95(1):157\u201365.","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"4019_CR17","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1136\/gut.47.6.861","volume":"47","author":"MAYER E A","year":"2000","unstructured":"MAYER E A. The neurobiology of stress and gastrointestinal disease. Gut. 2000;47(6):861\u20139.","journal-title":"Gut"},{"key":"4019_CR18","doi-asserted-by":"crossref","unstructured":"Harris ML, Aziz Q. Brain-gut interaction in irritable bowel syndrome. Hospital medicine (London, England : 1998), 2003,64(5):264.","DOI":"10.12968\/hosp.2003.64.5.1757"},{"issue":"5","key":"4019_CR19","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1080\/19490976.2016.1218585","volume":"7","author":"H Raskov","year":"2016","unstructured":"Raskov H, Burcharth J, Pommergaard H, et al. Irritable bowel syndrome, the microbiota and the gut-brain axis. Gut Microbes. 2016;7(5):365\u201383.","journal-title":"Gut Microbes"},{"issue":"3\u20134","key":"4019_CR20","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s10354-017-0592-0","volume":"168","author":"G Moser","year":"2018","unstructured":"Moser G, Fournier C, Peter J. Intestinal microbiome-gut-brain axis and irritable bowel syndrome. Wien Med Wochenschr. 2018;168(3\u20134):62\u20136.","journal-title":"Wien Med Wochenschr"},{"issue":"1","key":"4019_CR21","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/s40168-021-01188-6","volume":"9","author":"JP Jacobs","year":"2021","unstructured":"Jacobs JP, Gupta A, Bhatt RR, et al. Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvement. Microbiome. 2021;9(1):236.","journal-title":"Microbiome"},{"issue":"40","key":"4019_CR22","doi-asserted-by":"publisher","first-page":"6141","DOI":"10.3748\/wjg.v26.i40.6141","volume":"26","author":"J Ding","year":"2020","unstructured":"Ding J, Jin Z, Yang X, et al. Role of gut microbiota via the gut-liver-brain axis in digestive diseases. World J Gastroenterol. 2020;26(40):6141\u201362.","journal-title":"World J Gastroenterol"},{"issue":"40","key":"4019_CR23","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.3748\/wjg.v26.i40.6141","volume":"26","author":"G De Palma","year":"2020","unstructured":"De Palma G, Stephen M, Collins, et al. The microbiota-gut-brain axis in gastrointestinal disorders stressed bugs, stressed brain or both. World J Gastroenterol. 2020;26(40):6141\u201362.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"4019_CR24","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.gtc.2016.09.007","volume":"46","author":"G Timothy","year":"2017","unstructured":"Timothy G, Dinan JF. Cryan. The Microbiome-Gut-Brain Axis in Health and Disease. Gastroenterology clinics of North America. Gastroenterol Clin North Am. 2017;46(1):77\u201389.","journal-title":"Gastroenterol Clin North Am"},{"issue":"6","key":"4019_CR25","first-page":"520","volume":"37","author":"F Gao","year":"2018","unstructured":"Gao F, Liu TG. Research progress on the correlation between brain-gut axis and gastrointestinal dynamics. J Tianjin Univ Traditional Chin Med. 2018;37(6):520\u20134.","journal-title":"J Tianjin Univ Traditional Chin Med"},{"issue":"4","key":"4019_CR26","first-page":"253","volume":"25","author":"JN Li","year":"2005","unstructured":"Li JN, Qian JM. Gastrointestinal hormones and digestive diseases. Chin Gastroenterol J Gastroenterol. 2005;25(4):253\u20134.","journal-title":"Chin Gastroenterol J Gastroenterol"},{"issue":"21","key":"4019_CR27","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.11569\/wcjd.v21.i23.2300","volume":"23","author":"CH Bao","year":"2013","unstructured":"Bao CH, Dou CZ. Brain-gut interactions and inflammatory bowel disease implications for acupuncture and moxibustion treatment. World J Chin Digestion. 2013;23(21):2300\u20137.","journal-title":"World J Chin Digestion"},{"issue":"6","key":"4019_CR28","first-page":"951","volume":"21","author":"M Liu Wa, Liu","year":"2018","unstructured":"Liu Wa, Liu M. Research on brain and intestinal peptides in functional gastrointestinal diseases Progress. Chin Med Emerg. 2018;21(6):951\u20133.","journal-title":"Chin Med Emerg"},{"issue":"2","key":"4019_CR29","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/j.1469-7793.1998.551bw.x","volume":"506","author":"K Hillsley","year":"1998","unstructured":"Hillsley K, Kirkup AJ, Grundy D. Direct and indirect actions of 5-hydroxytryptamine on the discharge of mesenteric afferent fibres innervating the rat jejunum. J Physiol. 1998;506(2):551\u201361.","journal-title":"J Physiol"},{"key":"4019_CR30","doi-asserted-by":"crossref","unstructured":"Degen L, Matzinger D, Merz M, et al. Tegaserod, a 5-HT4 receptor partial agonist, accelerates gastric emptying and gastrointestinal transit in healthy male subjects. Volume 15. Alimentary pharmacology & therapeutics; 2001. pp. 1745\u201351. 11.","DOI":"10.1046\/j.1365-2036.2001.01103.x"},{"key":"4019_CR31","doi-asserted-by":"crossref","unstructured":"HOUGHTON L A, FOSTER J M, WHORWELL PJ, Alosetron. A 5-HT3 receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers. Volume 14. Alimentary pharmacology & therapeutics; 2000. pp. 775\u201382. 6.","DOI":"10.1046\/j.1365-2036.2000.00762.x"},{"issue":"3","key":"4019_CR32","first-page":"463","volume":"118","author":"CM Prather","year":"2000","unstructured":"Prather CM, Camilleri M, Zinsmeister AR, et al. Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome. Gastroenterol (New York N Y 1943). 2000;118(3):463\u20138.","journal-title":"Gastroenterol (New York N Y 1943)"},{"issue":"1","key":"4019_CR33","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13030-016-0070-8","volume":"10","author":"M Kanazawa","year":"2016","unstructured":"Kanazawa M, Miwa H, Nakagawa A, et al. Abdominal bloating is the most bothersome symptom in irritable bowel syndrome with constipation (IBS-C): a large population-based internet survey in Japan. Biopsychosoc Med. 2016;10(1):19.","journal-title":"Biopsychosoc Med"},{"key":"4019_CR34","doi-asserted-by":"crossref","unstructured":"Mearin F, Lacy BE, Chang L et al. Bowel Disorders. Gastroenterology (New York, N.Y. 1943), 2016,150(6):1393\u20131407.","DOI":"10.1053\/j.gastro.2016.02.031"},{"issue":"5","key":"4019_CR35","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/ajg.2017.41","volume":"112","author":"WD Chey","year":"2017","unstructured":"Chey WD, Lembo AJ, Rosenbaum DP. Tenapanor treatment of patients with constipation-predominant irritable bowel syndrome: a phase 2, Randomized, Placebo-Controlled efficacy and safety Trial. Am J Gastroenterol. 2017;112(5):763\u201374.","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"4019_CR36","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13030-018-0137-9","volume":"12","author":"M Kosako","year":"2018","unstructured":"Kosako M, Akiho H, Miwa H, et al. Influence of the requirement for abdominal pain in the diagnosis of irritable bowel syndrome with constipation (IBS-C) under the Rome IV criteria using data from a large japanese population-based internet survey. Biopsychosoc Med. 2018;12(1):18.","journal-title":"Biopsychosoc Med"},{"key":"4019_CR37","doi-asserted-by":"crossref","unstructured":"Hungin APS, Chang L, Locke GR, et al. Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact. Volume 21. Alimentary pharmacology & therapeutics; 2005. pp. 1365\u201375. 11.","DOI":"10.1111\/j.1365-2036.2005.02463.x"},{"issue":"8","key":"4019_CR38","first-page":"1910","volume":"97","author":"A Yuri","year":"2002","unstructured":"Yuri A, Saito, Philip Schoenfeld. The epidemiology of irritable bowel syndrome in North America a systematic review. Am J Gastroenterol. 2002;97(8):1910\u20135.","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"4019_CR39","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1023\/A:1018831127942","volume":"43","author":"DONALDL PATRICK","year":"1998","unstructured":"PATRICK DONALDL, MSPH DOUGLASA, DROSSMAN, et al. Quality of life in persons with irritable bowel syndrome: development and validation of a new measure. Dig Dis Sci. 1998;43(2):400\u201311.","journal-title":"Dig Dis Sci"},{"issue":"1","key":"4019_CR40","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1751-0759-1-6","volume":"1","author":"M Kanazawa","year":"2007","unstructured":"Kanazawa M, Drossman DA, Shinozaki M, et al. Translation and validation of a japanese version of the irritable bowel syndrome-quality of life measure (IBS-QOL-J). Biopsychosoc Med. 2007;1(1):6.","journal-title":"Biopsychosoc Med"},{"issue":"8","key":"4019_CR41","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1001\/archinte.163.8.929","volume":"163","author":"A Stephanie","year":"2003","unstructured":"Stephanie A, Leong VB, et al. The economic consequences of irritable bowel syndrome: a US employer perspective. Arch Intern Med. 2003;163(8):929\u201335.","journal-title":"Arch Intern Med"},{"key":"4019_CR42","doi-asserted-by":"crossref","unstructured":"REILLY MC, MCBURNEY C BARGHOUTV. R, et al. Effect of tegaserod on work and daily activity in irritable bowel syndrome with constipation. Volume 22. Alimentary pharmacology & therapeutics; 2005. pp. 373\u201380. 5.","DOI":"10.1111\/j.1365-2036.2005.02577.x"},{"key":"4019_CR43","doi-asserted-by":"crossref","unstructured":"Sandler RS, Everhart JE, Donowitz M et al. The burden of selected digestive diseases in the United States. Gastroenterology (New York, N.Y. 1943), 2002,122(5):1500\u20131511.","DOI":"10.1053\/gast.2002.32978"},{"issue":"4","key":"4019_CR44","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1517\/14728214.2015.1105215","volume":"20","author":"S Nusrat","year":"2015","unstructured":"Nusrat S, Miner PB. New pharmacological treatment options for irritable bowel syndrome with constipation. Expert Opin Emerg Drugs. 2015;20(4):625\u201336.","journal-title":"Expert Opin Emerg Drugs"},{"issue":"2","key":"4019_CR45","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1080\/14656566.2018.1427733","volume":"19","author":"PB Miner","year":"2018","unstructured":"Miner PB. Efficacy and safety of plecanatide in treating constipation predominant irritable bowel syndrome. Expert Opin Pharmacother. 2018;19(2):177\u201383.","journal-title":"Expert Opin Pharmacother"},{"issue":"2","key":"4019_CR46","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/00004650-200001000-00009","volume":"14","author":"A Mitzel-Wilkinson","year":"2000","unstructured":"Mitzel-Wilkinson A. Massage therapy as a nursing practice. Holist Nurs Pract. 2000;14(2):48\u201356.","journal-title":"Holist Nurs Pract"},{"key":"4019_CR47","doi-asserted-by":"crossref","unstructured":"Underdown A, Barlow J, Chung V et al. Massage intervention for promoting mental and physical health in infants aged under six months. Cochrane database of systematic reviews, 2006(4):D5038.","DOI":"10.1002\/14651858.CD005038.pub2"},{"issue":"8","key":"4019_CR48","first-page":"1331","volume":"36","author":"HK Lee","year":"2006","unstructured":"Lee HK. The effects of infant massage on weight, height, and mother-infant interaction. Taehan Kanho Hakhoe chi. 2006;36(8):1331.","journal-title":"Taehan Kanho Hakhoe chi"},{"issue":"2","key":"4019_CR49","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1097\/SGA.0b013e31824c235a","volume":"35","author":"NU Uysal","year":"2012","unstructured":"Uysal NU, E\u015fer \u0130E, Akpinar HA. The effect of abdominal massage on gastric residual volume: a randomized controlled trial. Gastroenterol Nurs. 2012;35(2):117\u201323.","journal-title":"Gastroenterol Nurs"},{"issue":"2","key":"4019_CR50","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1093\/ageing\/afw005","volume":"45","author":"D McClurg","year":"2016","unstructured":"McClurg D, Hagen S, Jamieson K, et al. Abdominal massage for the alleviation of symptoms of constipation in people with Parkinson\u2019s: a randomised controlled pilot study. Age Ageing. 2016;45(2):299\u2013303.","journal-title":"Age Ageing"},{"issue":"4","key":"4019_CR51","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.jbmt.2010.07.007","volume":"15","author":"ML Sinclair","year":"2011","unstructured":"Sinclair ML. The use of abdominal massage to treat chronic constipation. J Bodyw Mov Ther. 2011;15(4):436\u201345.","journal-title":"J Bodyw Mov Ther"},{"issue":"6","key":"4019_CR52","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.ijnurstu.2009.01.007","volume":"46","author":"K L\u00e4m\u00e5s","year":"2009","unstructured":"L\u00e4m\u00e5s K, Lindholm L, Stenlund H, et al. Effects of abdominal massage in management of constipation\u2014A randomized controlled trial. Int J Nurs Stud. 2009;46(6):759\u201367.","journal-title":"Int J Nurs Stud"},{"issue":"12","key":"4019_CR53","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1097\/01.phm.0000247649.00219.c0","volume":"85","author":"S Aya\u015f","year":"2006","unstructured":"Aya\u015f S, Leblebici B, S\u00f6zay S, et al. The effect of abdominal massage on bowel function in patients with spinal cord injury. Am J Phys Med Rehabil. 2006;85(12):951\u20135.","journal-title":"Am J Phys Med Rehabil"},{"issue":"5","key":"4019_CR54","doi-asserted-by":"publisher","first-page":"e250","DOI":"10.1111\/codi.12160","volume":"15","author":"CAG Silva","year":"2013","unstructured":"Silva CAG, Motta MEFA. The use of abdominal muscle training, breathing exercises and abdominal massage to treat paediatric chronic functional constipation. Colorectal Dis. 2013;15(5):e250\u20135.","journal-title":"Colorectal Dis"},{"issue":"3","key":"4019_CR55","doi-asserted-by":"publisher","first-page":"200","DOI":"10.7326\/0003-4819-158-3-201302050-00583","volume":"158","author":"J CHAN A, TETZLAFF J M, DORE C","year":"2013","unstructured":"CHAN A, TETZLAFF J M, DORE C J, et al. SPIRIT 2013 Statement: defining standard protocol items for clinical Trials. Ann Intern Med. 2013;158(3):200\u20137.","journal-title":"Ann Intern Med"},{"issue":"11","key":"4019_CR56","first-page":"705","volume":"6","author":"W JC J C Y","year":"2010","unstructured":"JC J C Y W. Complementary and alternative Medicine Modalities for the treatment of irritable bowel syndrome facts or Myths. Gastroenterol Hepatol (N Y). 2010;6(11):705\u201311.","journal-title":"Gastroenterol Hepatol (N Y)"},{"issue":"Suppl 1","key":"4019_CR57","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0399-8320(09)71528-3","volume":"33","author":"H Hag\u00e8ge","year":"2009","unstructured":"Hag\u00e8ge H. Alternative treatments in irritable bowel syndrome. Gastroent\u00e9rologie clinique et biologique. 2009;33(Suppl 1):79\u2013S83.","journal-title":"Gastroent\u00e9rologie clinique et biologique"},{"issue":"3","key":"4019_CR58","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1001\/archinte.163.3.265","volume":"163","author":"A Jennifer","year":"2003","unstructured":"Jennifer A, Spanier, Colin W. Howden. A systematic review of alternative therapies in the irritable bowel syndrome. Arch Intern Med. 2003;163(3):265\u201374.","journal-title":"Arch Intern Med"},{"issue":"7","key":"4019_CR59","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s11655-016-2275-x","volume":"24","author":"L Fang","year":"2018","unstructured":"Fang L, Fang M, Guo M. Study on force mechanism for therapeutic effect of pushing manipulation with one-finger meditation base on similarity analysis of force and Waveform. Chin J Integr Med. 2018;24(7):531\u20136.","journal-title":"Chin J Integr Med"}],"container-title":["BMC Complementary Medicine and Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-023-04019-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12906-023-04019-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-023-04019-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T23:23:51Z","timestamp":1686093831000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-023-04019-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,6]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["4019"],"URL":"https:\/\/doi.org\/10.1186\/s12906-023-04019-3","relation":{},"ISSN":["2662-7671"],"issn-type":[{"value":"2662-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,6]]},"assertion":[{"value":"5 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Human trials are subject to review and approval by the Zhejiang Hospital Medical Ethics Committee. The license number is No. 2021 Pro-Audit No. 15\u00a0K. Written informed consent to participate in this study were obtained from the patients\/participants. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare they have no commercial or financial interests that might constitute a potential conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"185"}}