{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:20:53Z","timestamp":1791969653711,"version":"4.3.4"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Scientific Research Projects of Medical and Health Institutions of Longhua District, Shenzhen","award":["2023077"],"award-info":[{"award-number":["2023077"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2022A1515010833"],"award-info":[{"award-number":["2022A1515010833"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2021A1515010567"],"award-info":[{"award-number":["2021A1515010567"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82003988"],"award-info":[{"award-number":["82003988"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82074078"],"award-info":[{"award-number":["82074078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Key Laboratory of Chinese Medicine Active substance screening and Translational Research","award":["ZDSYS20220606100801003"],"award-info":[{"award-number":["ZDSYS20220606100801003"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Med Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Endoplasmic reticulum (ER) stress, promoting lipid metabolism disorders and steatohepatitis, contributes significantly to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Hugan Qingzhi tablets (HQT) has a definite effect in the clinical treatment of NAFLD patients, but its mechanism is still unclear. This study aims to investigate the effects of HQT on ER stress in the liver tissues of NAFLD rats and explore the underlying mechanism.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The NAFLD rat model was managed with high-fat diet (HFD) for 12weeks. HQT was administrated in a daily basis to the HFD groups. Biochemical markers, pro-inflammatory cytokines, liver histology were assayed to evaluate HQT effects in HFD-induced NAFLD rats. Furthermore, the expression of ER stress-related signal molecules including glucose regulating protein 78 (GRP78), protein kinase RNA-like endoplasmic reticulum kinase (PERK), p-PERK, eukaryotic translation initiation factor 2\u03b1 (EIF2\u03b1), p-EIF2\u03b1, activating transcription factor 4 (ATF4), acetyl-coenzyme A-carboxylase (ACC), activating transcription factor (ATF6), and nuclear factor-kappa B-p65 (NF-\u03baB-p65) were detected by western blot and\/or qRT-PCR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The histopathological characteristics and biochemical data indicated that HQT exhibited protective effects on HFD-induced NAFLD rats. Furthermore, it caused significant reduction in the expression of ERS markers, such as GRP78, PERK, p-PERK, and ATF6, and subsequently downregulated the expression of EIF2\u03b1, p-EIF2\u03b1 ATF4, ACC, and NF-\u03baB-p65.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The results suggested that HQT has protective effect against hepatic steatosis and inflammation in NAFLD rats by attenuating ER stress, and the potential mechanism is through inhibition of PERK and ATF6 pathways.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12906-024-04336-1","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T12:02:54Z","timestamp":1705060974000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hugan Qingzhi tablets attenuates endoplasmic reticulum stress in nonalcoholic fatty liver disease rats by regulating PERK and ATF6 pathways"],"prefix":"10.1186","volume":"24","author":[{"given":"Miaoting","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorui","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijian","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waijiao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"4336_CR1","doi-asserted-by":"publisher","first-page":"597648","DOI":"10.3389\/fendo.2020.597648","volume":"11","author":"C Luci","year":"2020","unstructured":"Luci C, Bourinet M, Leclere PS, Anty R, Gual P. Chronic inflammation in non-alcoholic steatohepatitis: molecular mechanisms and therapeutic strategies. Front Endocrinol (Lausanne). 2020;11:597648.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"7","key":"4336_CR2","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","volume":"24","author":"SL Friedman","year":"2018","unstructured":"Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ. Mechanisms of NAFLD development and therapeutic strategies. NAT MED. 2018;24(7):908\u201322.","journal-title":"NAT MED"},{"issue":"5","key":"4336_CR3","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1002\/hep.31150","volume":"71","author":"J Zhou","year":"2020","unstructured":"Zhou J, Zhou F, Wang W, Zhang XJ, Ji YX, Zhang P, She ZG, Zhu L, Cai J, Li H. Epidemiological features of NAFLD From 1999 to 2018 in China. Hepatology. 2020;71(5):1851\u201364.","journal-title":"Hepatology"},{"issue":"8","key":"4336_CR4","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","volume":"65","author":"E Buzzetti","year":"2016","unstructured":"Buzzetti E, Pinzani M, Tsochatzis EA. The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism. 2016;65(8):1038\u201348.","journal-title":"Metabolism"},{"issue":"2","key":"4336_CR5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1051\/medsci\/2020008","volume":"36","author":"D Vallee","year":"2020","unstructured":"Vallee D, Blanc M, Lebeaupin C, Bailly-Maitre B. [Endoplasmic reticulum stress response and pathogenesis of non-alcoholic steatohepatitis]. Med Sci (Paris). 2020;36(2):119\u201329.","journal-title":"Med Sci (Paris)"},{"issue":"4","key":"4336_CR6","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.jhep.2018.06.008","volume":"69","author":"C Lebeaupin","year":"2018","unstructured":"Lebeaupin C, Vallee D, Hazari Y, Hetz C, Chevet E, Bailly-Maitre B. Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease. J Hepatol. 2018;69(4):927\u201347.","journal-title":"J Hepatol"},{"issue":"12","key":"4336_CR7","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.3109\/10715762.2015.1078461","volume":"49","author":"NU Ashraf","year":"2015","unstructured":"Ashraf NU, Sheikh TA. Endoplasmic reticulum stress and oxidative stress in the pathogenesis of non-alcoholic fatty liver disease. Free Radic Res. 2015;49(12):1405\u201318.","journal-title":"Free Radic Res"},{"issue":"7","key":"4336_CR8","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.3748\/wjg.v20.i7.1768","volume":"20","author":"XQ Zhang","year":"2014","unstructured":"Zhang XQ, Xu CF, Yu CH, Chen WX, Li YM. Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol. 2014;20(7):1768\u201376.","journal-title":"World J Gastroenterol"},{"issue":"35","key":"4336_CR9","doi-asserted-by":"publisher","first-page":"25350","DOI":"10.1074\/jbc.M113.470526","volume":"288","author":"G Xiao","year":"2013","unstructured":"Xiao G, Zhang T, Yu S, Lee S, Calabuig-Navarro V, Yamauchi J, Ringquist S, Dong HH. ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice. J Biol chem. 2013;288(35):25350\u201361.","journal-title":"J Biol chem"},{"key":"4336_CR10","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.intimp.2018.10.013","volume":"65","author":"D Wang","year":"2018","unstructured":"Wang D, Lao L, Pang X, Qiao Q, Pang L, Feng Z, Bai F, Sun X, Lin X, Wei J. Asiatic acid from potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism. Int Immunopharmacol. 2018;65:256\u201367.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"4336_CR11","doi-asserted-by":"publisher","first-page":"16362","DOI":"10.1038\/s41598-017-16587-9","volume":"7","author":"KY Yeh","year":"2017","unstructured":"Yeh KY, Lai CY, Lin CY, Hsu CC, Lo CP, Her GM. ATF4 overexpression induces early onset of hyperlipidaemia and hepatic steatosis and enhances adipogenesis in zebrafish. Sci Rep. 2017;7(1):16362.","journal-title":"Sci Rep"},{"issue":"2","key":"4336_CR12","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.4049\/jimmunol.0900017","volume":"183","author":"H Yamazaki","year":"2009","unstructured":"Yamazaki H, Hiramatsu N, Hayakawa K, Tagawa Y, Okamura M, Ogata R, Huang T, Nakajima S, Yao J, Paton AW, et al. Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response. J Immunol. 2009;183(2):1480\u20137.","journal-title":"J Immunol"},{"key":"4336_CR13","first-page":"1277","volume":"38","author":"M Yang","year":"2018","unstructured":"Yang M, Chen Z, Xiao C, Tang W, Zhou B. Effects of sera of rats fed with Huganqingzhi tablets on endoplasmic reticulum stress in a HepG2 cell model of nonalcoholic fatty liver disease. Nan Fang Yi Ke Da Xue Xue Bao. 2018;38:1277\u201387.","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"4336_CR14","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/810369","volume":"2015","author":"W Tang","year":"2015","unstructured":"Tang W, Zeng L, Yin J, Yao Y, Feng L, Yao X, Sun X, Zhou B. Hugan Qingzhi exerts anti-inflammatory effects in a rat model of nonalcoholic fatty liver disease. Evid Based Complement Alternat Med. 2015;2015: 810369.","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"4336_CR15","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.jep.2014.04.011","volume":"154","author":"J Yin","year":"2014","unstructured":"Yin J, Luo Y, Deng H, Qin S, Tang W, Zeng L, Zhou B. Hugan Qingzhi medication ameliorates hepatic steatosis by activating AMPK and PPARalpha pathways in L02 cells and HepG2 cells. J Ethnopharmacol. 2014;154(1):229\u201339.","journal-title":"J Ethnopharmacol"},{"key":"4336_CR16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3389\/fphar.2017.00099","volume":"8","author":"F Xia","year":"2017","unstructured":"Xia F, Yao X, Tang W, Xiao C, Yang M, Zhou B. Isobaric tags for relative and absolute quantitation (iTRAQ)-Based proteomic analysis of Hugan Qingzhi and its Protective properties against free fatty Acid-Induced L02 hepatocyte Injury. Front Pharmacol. 2017;8:99.","journal-title":"Front Pharmacol"},{"key":"4336_CR17","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jep.2017.09.016","volume":"212","author":"X Yao","year":"2018","unstructured":"Yao X, Xia F, Tang W, Xiao C, Yang M, Zhou B. Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics for the investigation of the effect of Hugan Qingzhi on non-alcoholic fatty liver disease in rats. J Ethnopharmacol. 2018;212:208\u201315.","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"4336_CR18","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1186\/s12906-020-03164-3","volume":"20","author":"M Yang","year":"2020","unstructured":"Yang M, Chen Z, Xiang S, Xia F, Tang W, Yao X, Zhou B. Hugan Qingzhi medication ameliorates free fatty acid-induced L02 hepatocyte endoplasmic reticulum stress by regulating the activation of PKC-delta. BMC Complement Med Ther. 2020;20(1):377.","journal-title":"BMC Complement Med Ther"},{"issue":"\u2013","key":"4336_CR19","first-page":"644","volume":"35","author":"Z Bj","year":"2012","unstructured":"Bj Z, Ym Y, Sx H, Yf Y, Sy Z. The quality standard study on Hugan Qingzhi tablets. Zhong Yao Cai. 2012;35:644\u20137.","journal-title":"Zhong Yao Cai"},{"key":"4336_CR20","doi-asserted-by":"publisher","first-page":"7261619","DOI":"10.1155\/2018\/7261619","volume":"2018","author":"W Tang","year":"2018","unstructured":"Tang W, Yao X, Xia F, Yang M, Chen Z, Zhou B, Liu Q. Modulation of the gut microbiota in rats by Hugan Qingzhi tablets during the treatment of high-fat-diet-induced nonalcoholic fatty liver disease. Oxid Med Cell Longev. 2018;2018:7261619.","journal-title":"Oxid Med Cell Longev"},{"issue":"58","key":"4336_CR21","doi-asserted-by":"publisher","first-page":"597","DOI":"10.4103\/pm.pm_614_17","volume":"14","author":"C Xiao","year":"2018","unstructured":"Xiao C, He F, Yang M, Zhou H. Ultra-high performance liquid chromatography\/triple quadrupole mass spectrometry study of the stabilities and transformations of four alisols in Alismatis Rhizoma and proprietary traditional Chinese medicine prescriptions. Pharmacog Mag. 2018;14(58):597\u2013603. https:\/\/phcog.com\/article\/view\/2018\/14\/58\/597-603.","journal-title":"Pharmacog Mag"},{"issue":"3","key":"4336_CR22","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1177\/1091581814526890","volume":"33","author":"A Mohammadi","year":"2014","unstructured":"Mohammadi A, Mehrzad J, Mahmoudi M, Schneider M. Environmentally relevant level of aflatoxin B1 dysregulates human dendritic cells through signaling on key toll-like receptors. Int J Toxicol. 2014;33(3):175\u201386.","journal-title":"Int J Toxicol"},{"issue":"9\u201310","key":"4336_CR23","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s12012-023-09804-7","volume":"23","author":"S Iqbal","year":"2023","unstructured":"Iqbal S, Jabeen F, Kahwa I, Omara T. Suberosin alleviates thiazolidinedione-induced cardiomyopathy in diabetic rats by inhibiting ferroptosis via modulation of ACSL4-LPCAT3 and PI3K-AKT signaling pathways. Cardiovasc Toxicol. 2023;23(9\u201310):295\u2013304.","journal-title":"Cardiovasc Toxicol"},{"issue":"1","key":"4336_CR24","doi-asserted-by":"publisher","first-page":"20742","DOI":"10.1038\/s41598-023-47097-6","volume":"13","author":"Y Watanabe","year":"2023","unstructured":"Watanabe Y, Watanabe H, Kogure S, Tanioka Y, Yamauchi J, Furusho T. Essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet-induced NASH model rats. Sci Rep. 2023;13(1):20742.","journal-title":"Sci Rep"},{"issue":"7","key":"4336_CR25","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1080\/10495398.2022.2077743","volume":"34","author":"A Rassouli","year":"2023","unstructured":"Rassouli A, Shihmani B, Mehrzad J, Shokrpoor S. The immunomodulatory effect of minocycline on gene expression of inflammation related cytokines in lipopolysaccharide-treated human peripheral blood mononuclear cells. Anim Biotechnol. 2023;34(7):2159\u201365.","journal-title":"Anim Biotechnol"},{"issue":"3","key":"4336_CR26","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.18632\/aging.203817","volume":"14","author":"Q Xie","year":"2022","unstructured":"Xie Q, Gao S, Lei M, Li Z. Hesperidin suppresses ERS-induced inflammation in the pathogenesis of non-alcoholic fatty liver disease. Aging. 2022;14(3):1265\u201379.","journal-title":"Aging"},{"issue":"36","key":"4336_CR27","doi-asserted-by":"publisher","first-page":"8078","DOI":"10.3748\/wjg.v22.i36.8078","volume":"22","author":"MG Clemente","year":"2016","unstructured":"Clemente MG, Mandato C, Poeta M, Vajro P. Pediatric non-alcoholic fatty liver disease: recent solutions, unresolved issues, and future research directions. World J Gastroenterol. 2016;22(36):8078\u201393.","journal-title":"World J Gastroenterol"},{"issue":"13","key":"4336_CR28","doi-asserted-by":"publisher","first-page":"270","DOI":"10.21037\/atm.2017.04.41","volume":"5","author":"A Mantovani","year":"2017","unstructured":"Mantovani A, Targher G. Type 2 diabetes mellitus and risk of hepatocellular carcinoma: spotlight on nonalcoholic fatty liver disease. Ann Transl Med. 2017;5(13):270.","journal-title":"Ann Transl Med"},{"issue":"10","key":"4336_CR29","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1007\/s00018-019-03263-6","volume":"77","author":"T Zhao","year":"2020","unstructured":"Zhao T, Wu K, Hogstrand C, Xu YH, Chen GH, Wei CC, Luo Z. Lipophagy mediated carbohydrate-induced changes of lipid metabolism via oxidative stress, endoplasmic reticulum (ER) stress and ChREBP\/PPARgamma pathways. Cell Mol Life Sci. 2020;77(10):1987\u20132003.","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"4336_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4331\/wjbc.v9.i1.1","volume":"9","author":"J Fujii","year":"2018","unstructured":"Fujii J, Homma T, Kobayashi S, Seo HG. Mutual interaction between oxidative stress and endoplasmic reticulum stress in the pathogenesis of diseases specifically focusing on non-alcoholic fatty liver disease. World J Biol Chem. 2018;9(1):1\u201315.","journal-title":"World J Biol Chem"},{"issue":"8","key":"4336_CR31","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1194\/jlr.R067595","volume":"57","author":"J Han","year":"2016","unstructured":"Han J, Kaufman RJ. The role of ER stress in lipid metabolism and lipotoxicity. J Lipid Res. 2016;57(8):1329\u201338.","journal-title":"J Lipid Res"},{"key":"4336_CR32","doi-asserted-by":"crossref","unstructured":"Preissler S, Ron D. Early events in the endoplasmic Reticulum unfolded protein response. Cold Spring Harb Perspect Biol. 2019;11(4):a033894. https:\/\/cshperspectives.cshlp.org\/content\/11\/4\/a033894.long.","DOI":"10.1101\/cshperspect.a033894"},{"key":"4336_CR33","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jnutbio.2018.09.007","volume":"62","author":"K Flister","year":"2018","unstructured":"Flister K, Pinto B, Franca LM, Coelho C, Dos SP, Vale CC, Kajihara D, Debbas V, Laurindo F, Paes A. Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned male mice. J Nutr Biochem. 2018;62:155\u201366.","journal-title":"J Nutr Biochem"},{"issue":"1","key":"4336_CR34","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13046-018-1012-z","volume":"38","author":"Z Li","year":"2019","unstructured":"Li Z, Zhang L, Gao M, Han M, Liu K, Zhang Z, Gong Z, Xing L, Shi X, Lu K, et al. Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK\/c-Jun Axis in hepatocellular carcinoma. J Exp Clin Cancer Res. 2019;38(1):8.","journal-title":"J Exp Clin Cancer Res"},{"issue":"6","key":"4336_CR35","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.cmet.2008.04.011","volume":"7","author":"S Oyadomari","year":"2008","unstructured":"Oyadomari S, Harding HP, Zhang Y, Oyadomari M, Ron D. Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab. 2008;7(6):520\u201332.","journal-title":"Cell Metab"},{"issue":"1","key":"4336_CR36","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1186\/s12967-018-1685-2","volume":"16","author":"X Gao","year":"2018","unstructured":"Gao X, Guo S, Zhang S, Liu A, Shi L, Zhang Y. Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway. J Transl Med. 2018;16(1):319.","journal-title":"J Transl Med"},{"issue":"6","key":"4336_CR37","doi-asserted-by":"publisher","first-page":"533","DOI":"10.2174\/1566524016666160523143937","volume":"16","author":"W Rozpedek","year":"2016","unstructured":"Rozpedek W, Pytel D, Mucha B, Leszczynska H, Diehl JA, Majsterek I. The role of the PERK\/eIF2alpha\/ATF4\/CHOP signaling pathway in Tumor Progression during endoplasmic reticulum stress. Curr Mol Med. 2016;16(6):533\u201344.","journal-title":"Curr Mol Med"},{"issue":"5","key":"4336_CR38","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1172\/JCI23621","volume":"115","author":"KL Donnelly","year":"2005","unstructured":"Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J clin Invest. 2005;115(5):1343\u201351.","journal-title":"J clin Invest"},{"issue":"24","key":"4336_CR39","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.3748\/wjg.v25.i24.3009","volume":"25","author":"JM Mato","year":"2019","unstructured":"Mato JM, Alonso C, Noureddin M, Lu SC. Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease. World J Gastroenterol. 2019;25(24):3009\u201320.","journal-title":"World J Gastroenterol"},{"issue":"42","key":"4336_CR40","doi-asserted-by":"publisher","first-page":"16314","DOI":"10.1073\/pnas.0808517105","volume":"105","author":"E Bobrovnikova-Marjon","year":"2008","unstructured":"Bobrovnikova-Marjon E, Hatzivassiliou G, Grigoriadou C, Romero M, Cavener DR, Thompson CB, Diehl JA. PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation. Proc Natl Acad Sci U S A. 2008;105(42):16314\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"4336_CR41","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.2337\/db09-0335","volume":"58","author":"J Seo","year":"2009","unstructured":"Seo J, Fortuno ER, Suh JM, Stenesen D, Tang W, Parks EJ, Adams CM, Townes T, Graff JM. Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes. 2009;58(11):2565\u201373.","journal-title":"Diabetes"},{"issue":"2","key":"4336_CR42","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/cr.2010.4","volume":"20","author":"C Wang","year":"2010","unstructured":"Wang C, Huang Z, Du Y, Cheng Y, Chen S, Guo F. ATF4 regulates lipid metabolism and thermogenesis. CELL RES. 2010;20(2):174\u201384.","journal-title":"CELL RES"},{"issue":"5","key":"4336_CR43","doi-asserted-by":"publisher","first-page":"e01639","DOI":"10.1128\/AAC.01639-18","volume":"63","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Cen J, Jia Z, Hsiao CD, Xia Q, Wang X, Chen X, Wang R, Jiang Z, Zhang L, et al. Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through endoplasmic reticulum stress, Autophagy, and apoptosis pathways in zebrafish. Antimicrob Agents Chemother. 2019;63(5):e01639-18.","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"4336_CR44","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1247\/csf.07044","volume":"33","author":"Y Adachi","year":"2008","unstructured":"Adachi Y, Yamamoto K, Okada T, Yoshida H, Harada A, Mori K. ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. Cell Struct Funct. 2008;33(1):75\u201389.","journal-title":"Cell Struct Funct"},{"key":"4336_CR45","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.imlet.2020.03.003","volume":"222","author":"Z Chen","year":"2020","unstructured":"Chen Z, Liu Y, Yang L, Liu P, Zhang Y, Wang X. MiR-149 attenuates endoplasmic reticulum stress-induced inflammation and apoptosis in nonalcoholic fatty liver disease by negatively targeting ATF6 pathway. Immunol Lett. 2020;222:40\u20138.","journal-title":"Immunol Lett"},{"key":"4336_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2023.108883","volume":"139","author":"X Li","year":"2023","unstructured":"Li X, Bai Y, Bi Y, Wu Q, Xu S. Baicalin suppressed necroptosis and inflammation against chlorpyrifos toxicity; involving in ER stress and oxidative stress in carp gills. Fish Shellfish Immunol. 2023;139: 108883.","journal-title":"Fish Shellfish Immunol"},{"issue":"19","key":"4336_CR47","doi-asserted-by":"publisher","first-page":"9347","DOI":"10.1039\/D1FO01517F","volume":"12","author":"Y Yang","year":"2021","unstructured":"Yang Y, Qu Y, Lv X, Zhao R, Yu J, Hu S, Kang J, Zhang Y, Gong Y, Cui T, et al. Sesamol supplementation alleviates nonalcoholic steatohepatitis and atherosclerosis in high-fat, high carbohydrate and high-cholesterol diet-fed rats. Food Funct. 2021;12(19):9347\u201359.","journal-title":"Food Funct"},{"issue":"3","key":"4336_CR48","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3390\/cells9030695","volume":"9","author":"G Di Conza","year":"2020","unstructured":"Di Conza G, Ho PC. ER stress responses: an emerging modulator for innate immunity. Cells Basel. 2020;9(3):695.","journal-title":"Cells Basel"},{"key":"4336_CR49","doi-asserted-by":"publisher","first-page":"109806","DOI":"10.1016\/j.cbpc.2023.109806","volume":"276","author":"W Wang","year":"2023","unstructured":"Wang W, Zhang Y, Geng X, Li H, Wang X, Zhang Y, Zhao H. Zinc attenuates arsenic overdose-induced brain damage via PERK\/ATF6 and TLR\/MyD88\/NF-kappaB pathways. Comp Biochem Physiol C Toxicol Pharmacol. 2023;276:109806.","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"}],"container-title":["BMC Complementary Medicine and Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-024-04336-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12906-024-04336-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-024-04336-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T13:02:41Z","timestamp":1705064561000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-024-04336-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,12]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4336"],"URL":"https:\/\/doi.org\/10.1186\/s12906-024-04336-1","relation":{},"ISSN":["2662-7671"],"issn-type":[{"value":"2662-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,12]]},"assertion":[{"value":"9 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Southern Medical University Animal Ethics Committee (Animal Welfare Assurance L2016133) and carried out in compliance with the institutional guidelines. All methods are reported in accordance with ARRIVE guidelines for the reporting of animal experiments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"36"}}