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Rob. belongs to the<jats:italic>Litsea<\/jats:italic>genus and is categorized under the family of<jats:italic>Lauraceae<\/jats:italic>. The study aimed to investigate the phytoconstituents and pharmacological properties of methanol extract of leaves of\u00a0<jats:italic>Litsea glutinosa<\/jats:italic>, focusing on antidiabetic activity via in vivo and in silico techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Extensive chromatographic and spectroscopic techniques were applied to isolate and characterize the constituents from the<jats:italic>L. glutinosa<\/jats:italic>plant species. The antidiabetic activity was studied in streptozotocin-induced diabetes mice, and the computational study of the isolated compounds was carried out by utilizing AutoDock Vina programs. In addition, the pharmacokinetic properties in terms of absorption, distribution, metabolism and excretion (ADME) and toxicological profiles of the isolated compounds were examined via in silico techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the present study, two flavonoid glycosides 4\u0384-<jats:italic>O<\/jats:italic>-methyl (2 \u030b,4 \u030b-di-<jats:italic>E<\/jats:italic>-p-coumaroyl) afzelin (1) and quercetin 3-<jats:italic>O<\/jats:italic>-(2 \u030b,4 \u030b-di-<jats:italic>E<\/jats:italic>-p-coumaroyl)-\u03b1-L-rhamnopyranoside (2) were isolated from the leaves of\u00a0<jats:italic>L. glutinosa<\/jats:italic>\u00a0and characterized by<jats:sup>1<\/jats:sup>H and<jats:sup>13<\/jats:sup>C NMR, COSY, HSQC, HMBC, and mass spectral data. Although compounds\u00a01\u00a0and\u00a02\u00a0have been reported twice from\u00a0<jats:italic>Machilis litseifolia<\/jats:italic>\u00a0and\u00a0<jats:italic>Lindera akoensis<\/jats:italic>, and\u00a0<jats:italic>Machilis litseifolia<\/jats:italic>\u00a0and\u00a0<jats:italic>Mammea longifolia<\/jats:italic>, respectively, this is the first report of this isolation from a\u00a0<jats:italic>Litsea<\/jats:italic>\u00a0species. Administering the methanolic extract of<jats:italic>L. glutinosa<\/jats:italic>at doses of 300 and 500\u00a0mg\/kg\/day to mice with diabetes induced by streptozotocin led to a significant decrease in fasting blood glucose levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) starting from the 7th day of treatment. Besides, the computational study and PASS analysis endorsed the current in vivo findings that\u00a0the both isolated compounds exerted higher binding affinities to human pancreatic \u03b1-amylase and aldose reductase than the conventional drugs. The in silico ADMET analysis revealed that\u00a0the both isolated compounds have a favorable pharmacokinetic and safety profile suitable for human consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to the current outcomes obtained from in vivo and in silico techniques, the leaf extract of\u00a0<jats:italic>L. glutinosa<\/jats:italic>\u00a0could be a natural remedy for treating diabetes, and the isolated phytoconstituents could be applied against various illnesses, mainly hyperglycemia. However, more investigations are required for extensive phytochemical isolation and pharmacological activities of these phytoconstituents against broader targets with exact mechanisms of action.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12906-024-04337-0","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T06:02:37Z","timestamp":1706767357000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Two rare flavonoid glycosides from Litsea glutinosa (Lour.) C. B. Rob.: experimental and computational approaches endorse antidiabetic potentiality"],"prefix":"10.1186","volume":"24","author":[{"given":"Israt Jahan","family":"Bulbul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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The animal study was performed in accordance with relevant guidelines and regulations of Declaration of Helsinki. The protocols for handling animals and the experimental model were thoroughly reviewed and approved by the Committee on Ethical Compliance in Research of Southeast University, Dhaka, Bangladesh (approval number: SEU\/Pharm\/CECR\/109\/2021). In addition, this work was also carried out in accordance with the updated Animal Research: Reporting of\u00a0In Vivo\u00a0Experiments (ARRIVE) guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None declared.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"69"}}