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Its chemodiversity and bioactivities, however, have not been thoroughly investigated. In this work, several extracts from various parts of<jats:italic>T. falconeri<\/jats:italic>were assessed for their chemical profile, antioxidant activity, and potential for enzyme inhibition. The total phenolic contents of<jats:italic>T. falconeri<\/jats:italic>varied from 40.28\u2009\u00b1\u20090.47\u00a0mg GAE\/g to 11.92\u2009\u00b1\u20090.22\u00a0mg GAE\/g in various extracts, while flavonoid contents were found highest in TFFM (36.79\u2009\u00b1\u20090.36\u00a0mg QE\/g extract) and lowest (11.08\u2009\u00b1\u20090.22\u00a0mg QE\/g extract) in TFSC (chloroform extract of stem) in similar pattern as found in total phenolic contents. Highest DPPH inhibition was observed for TFFC (49.58\u2009\u00b1\u20090.11\u00a0mg TE\/g extract) and TFSM (46.33\u2009\u00b1\u20090.10\u00a0mg TE\/g extract), whereas, TFSM was also potentially active against (98.95\u2009\u00b1\u20090.57\u00a0mg TE\/g) ABTS radical. In addition, TFSM was also most active in metal reducing assays: CUPRAC (151.76\u2009\u00b1\u20091.59\u00a0mg TE\/g extract) and FRAP (101.30\u2009\u00b1\u20090.32\u00a0mg TE\/g extract). In phosphomolybdenum assay, the highest activity was found for TFFE (1.71\u2009\u00b1\u20090.03\u00a0mg TE\/g extract), TFSM (1.64\u2009\u00b1\u20090.035\u00a0mg TE\/g extract), TFSH (1.60\u2009\u00b1\u20090.033\u00a0mg TE\/g extract) and TFFH (1.58\u2009\u00b1\u20090.08\u00a0mg TE\/g extract), while highest metal chelating activity was recorded for TFSH (25.93\u2009\u00b1\u20090.79\u00a0mg EDTAE\/g extract), TFSE (22.90\u2009\u00b1\u20091.12\u00a0mg EDTAE\/g extract) and TFSC (19.31\u2009\u00b1\u20090.50\u00a0mg EDTAE\/g extract). In biological screening, all extracts had stronger inhibitory capacity against AChE while in case of BChE the chloroform extract of flower (TFFC) and stem (TFSC) showed the highest activities with inhibitory values of 2.57\u2009\u00b1\u20090.24 and 2.10\u2009\u00b1\u20090.18 respectively. Similarly, TFFC and TFSC had stronger inhibitory capacity (1.09\u2009\u00b1\u20090.015 and 1.08\u2009\u00b1\u20090.002\u00a0mmol ACAE\/g extract) against \u03b1-Amylase and (0.50\u2009\u00b1\u20090.02 and 0.55\u2009\u00b1\u20090.02\u00a0mmol ACAE\/g extract) \u03b1-Glucosidase. UHPLC-MS study of methanolic extract revealed the presence of 133 components including sterols, triterpenes, flavonoids, alkaloids, and coumarins. The total phenolic contents were substantially linked with all antioxidant assays in multivariate analysis. These findings were validated by docking investigations, which revealed that the selected compounds exhibited high binding free energy with the enzymes tested. Finally, it was found that<jats:italic>T. falconeri<\/jats:italic>is a viable industrial crop with potential use in the production of functional goods and nutraceuticals.<\/jats:p>","DOI":"10.1186\/s12906-024-04459-5","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T07:02:21Z","timestamp":1713769341000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Secondary metabolic profiling, antioxidant potential, enzyme inhibitory activities and in silico and ADME studies: a multifunctional approach to reveal medicinal and industrial potential of Tanacetum falconeri"],"prefix":"10.1186","volume":"24","author":[{"given":"Muhammad Imran","family":"Tousif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaheer","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamona","family":"Nazir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Tauseef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areeba","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajid","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maqsood","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jallat","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer","family":"Hashem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid F.","family":"Almutairi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela Dolores","family":"Avila-Quezada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsayed Fathi","family":"Abd-Allah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"issue":"5","key":"4459_CR1","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s11745-003-1498-6","volume":"38","author":"N Tsevegsuren","year":"2003","unstructured":"Tsevegsuren N, Fujimoto K, Christie WW, Endo Y. 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