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In this study a polyphenol-rich <jats:italic>Rosa multiflora<\/jats:italic> (var. platyphylala) petal extract (RoseFit\u2122) was investigated for weight loss in humans.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In a randomized, placebo-controlled, parallel-group, double-blind clinical trial seventy overweight male and female subjects (20\u201350 years) with body mass index (BMI) 25\u201330\u00a0kg\/m<jats:sup>2<\/jats:sup> were randomly allocated to the active treatment group (RoseFit) and placebo group in a 1:1 ratio. The subjects received 300\u00a0mg capsules twice daily for 12 weeks. The primary efficacy outcome measures included body weight, BMI, and body composition, as determined using Dual-energy X-ray absorptiometry (DEXA). Secondary measures consisted of serum lipid profile and appetite marker (leptin and ghrelin) analyses. Safety analyses included biochemical and hematological assessments.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>At the end of the study, a marked reduction in body weight (-1.20\u2009\u00b1\u20092.62\u00a0kg, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and BMI from baseline was observed in the RoseFit group. In addition, the body fat % (RoseFit = -1.69\u2009\u00b1\u20092.59%, placebo\u2009=\u20090.96\u2009\u00b1\u20093.21%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and fat mass (RoseFit = -1.75\u2009\u00b1\u20091.80\u00a0kg, placebo\u2009=\u20091.61\u2009\u00b1\u20093.82\u00a0kg; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were significantly abated in RoseFit group. Importantly, the lean mass was maintained during the intervention. RoseFit ingestion significantly increased the serum leptin levels compared to the placebo (4.85%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Further, RoseFit group showed reduction in the hunger hormone ghrelin level (2.27%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) from baseline to the end of study, compared to the placebo. The subjective evaluation of appetite using visual analog scale (VAS) questionnaires further confirmed the appetite-suppression effects of RoseFit. The lipid profile significantly improved in RoseFit-treated subjects. No serious adverse events were observed during the study, indicating the tolerability of RoseFit.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Supplementation with RoseFit significantly impacts body weight management and can thus be a potential nutraceutical ingredient for sustainable weight loss.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>CTRI\/2019\/10\/021584 dated 09\/10\/2019<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12906-024-04487-1","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T14:01:38Z","timestamp":1716300098000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A polyphenol fraction from Rosa multiflora var. platyphylala reduces body fat in overweight humans through appetite suppression \u2013 a randomized, double-blind, placebo-controlled trial"],"prefix":"10.1186","volume":"24","author":[{"given":"Heggar Venkataramana","family":"Sudeep","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puwar","family":"Prithviraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas V","family":"Jestin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kodimule","family":"Shyamprasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"4487_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.metabol.2018.09.005","volume":"92","author":"YC Chooi","year":"2019","unstructured":"Chooi YC, Ding C, Magkos F. 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The trial was prospectively registered in the Clinical Trial Registry, India (CTRI\/2019\/10\/021584 dated 09\/102019). Subjects meeting all inclusion and no exclusion criteria signed a written informed consent and enrolled in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"RoseFit is a product from Vidya Herbs Pvt. Ltd., manufactured for commercial purposes. The authors Heggar Venkataramana Sudeep and Kodimule Shyamprasad are employed at Vidya Herbs Pvt. Ltd. Author Puwar Prithviraj is employed at Anand Multispeciality Hospital, Gujarat, India. Thomas V Jestin is employed at Leads Clinical Research and Bioservices Pvt Ltd., Bangalore, India. Hence, we declare potential competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"197"}}