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The experimental animal protocol received ethical approval from the Laboratory Animal Ethics Committee of Guizhou Medical University (No. 201345). The study is reported in accordance with ARRIVE guidelines. All methods were carried out in accordance with relevant guidelines and regulations in the declarations section.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"No applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"334"}}