{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:14:06Z","timestamp":1783523646608,"version":"3.55.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Med Ther"],"DOI":"10.1186\/s12906-024-04685-x","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T08:00:42Z","timestamp":1731052842000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Herbo-vitamin medicine Livogrit Vital ameliorates isoniazid induced liver injury (IILI) in human liver (HepG2) cells by decreasing isoniazid accumulation and oxidative stress driven hepatotoxicity"],"prefix":"10.1186","volume":"24","author":[{"given":"Acharya","family":"Balkrishna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Gohel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenu","family":"Tomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishabh","family":"Dev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Varshney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"issue":"6","key":"4685_CR1","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S2213-2600(22)00184-9","volume":"10","author":"R Houben","year":"2022","unstructured":"Houben R, Esmail H, Cobelens F, et al. Tuberculosis prevalence: beyond the tip of the iceberg. Lancet Respir Med. 2022;10(6):537\u20139.","journal-title":"Lancet Respir Med"},{"issue":"5","key":"4685_CR2","first-page":"4289","volume":"17","author":"G Zheng","year":"2019","unstructured":"Zheng G, Wang M, Ren Q, et al. Experimental observation of mitochondrial oxidative damage of liver cells induced by isonicotinic acid hydrazide. Exp Ther Med. 2019;17(5):4289\u201393.","journal-title":"Exp Ther Med"},{"issue":"8","key":"4685_CR3","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1177\/0960327111433901","volume":"31","author":"M Singh","year":"2012","unstructured":"Singh M, Sasi P, Gupta VH, et al. Protective effect of curcumin, silymarin and N-acetylcysteine on antitubercular drug-induced hepatotoxicity assessed in an in vitro model. Hum Exp Toxicol. 2012;31(8):788\u201397.","journal-title":"Hum Exp Toxicol"},{"issue":"2","key":"4685_CR4","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1080\/01480545.2020.1778021","volume":"45","author":"NV Bhilare","year":"2022","unstructured":"Bhilare NV, Dhaneshwar SS, Mahadik KR, et al. Co-drug of isoniazid and sulfur containing antioxidant for attenuation of hepatotoxicity and treatment of tuberculosis. Drug Chem Toxicol. 2022;45(2):850\u201360.","journal-title":"Drug Chem Toxicol"},{"key":"4685_CR5","doi-asserted-by":"publisher","first-page":"S66","DOI":"10.1016\/j.tube.2019.04.012","volume":"116S","author":"ER Erwin","year":"2019","unstructured":"Erwin ER, Addison AP, John SF, et al. Pharmacokinetics of isoniazid: the good, the bad, and the alternatives. Tuberculosis (Edinb). 2019;116S:S66-70.","journal-title":"Tuberculosis (Edinb)"},{"issue":"23","key":"4685_CR6","doi-asserted-by":"publisher","first-page":"13135","DOI":"10.3390\/ijms222313135","volume":"22","author":"VA Arzumanian","year":"2021","unstructured":"Arzumanian VA, Kiseleva OI, Poverennaya EV. The curious case of the HepG2 cell line: 40 years of expertise. Int J Mol Sci. 2021;22(23):13135.","journal-title":"Int J Mol Sci."},{"issue":"5","key":"4685_CR7","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3109\/15376511003793325","volume":"20","author":"S Bhadauria","year":"2010","unstructured":"Bhadauria S, Mishra R, Kanchan R, et al. Isoniazid-induced apoptosis in HepG2 cells: generation of oxidative stress and Bcl-2 down-regulation. Toxicol Mech Methods. 2010;20(5):242\u201351.","journal-title":"Toxicol Mech Methods"},{"issue":"12\/01","key":"4685_CR8","first-page":"1611","volume":"2011","author":"M Singh","year":"2010","unstructured":"Singh M, Sasi P, Rai G, et al. Studies on toxicity of antitubercular drugs namely isoniazid, rifampicin, and pyrazinamide in an in vitro model of HepG2 cell line. Med Chem Res. 2010;2011(12\/01):1611\u20135.","journal-title":"Med Chem Res"},{"key":"4685_CR9","doi-asserted-by":"publisher","first-page":"116387","DOI":"10.1016\/j.jep.2023.116387","volume":"310","author":"Y Sun","year":"2023","unstructured":"Sun Y, Zhang Y, Ma N, et al. Rhus chinensis Mill. Fruits alleviate liver injury induced by isoniazid and rifampicin through regulating oxidative stress, apoptosis, and bile acid transport. J Ethnopharmacol. 2023;310:116387.","journal-title":"J Ethnopharmacol"},{"key":"4685_CR10","doi-asserted-by":"publisher","unstructured":"Kantharia C, Kumar M, Jain MK, et al. Hepatoprotective effects of Liv.52 in Chronic Liver Disease Preclinical, Clinical, and Safety evidence: a review. Gastroenterol Insights. 2023;293\u2013308. https:\/\/doi.org\/10.3390\/gastroent14030021.","DOI":"10.3390\/gastroent14030021"},{"issue":"3","key":"4685_CR11","doi-asserted-by":"publisher","first-page":"197","DOI":"10.22146\/mot.45762","volume":"24","author":"E Kosasih","year":"2019","unstructured":"Kosasih E, Chiuman L, Lister INE, et al. Hepatoprotective Effect of Citrus Sinensis Peel Extract against Isoniazid and Rifampicin-induced Liver Injury in Wistar rats. Majalah Obat Tradisional. 2019;24(3):197\u2013203.","journal-title":"Majalah Obat Tradisional."},{"issue":"4","key":"4685_CR12","doi-asserted-by":"publisher","first-page":"516","DOI":"10.3109\/13880209.2013.864682","volume":"52","author":"A Ahmad","year":"2014","unstructured":"Ahmad A, Afroz N, Gupta UD, et al. Vitamin B(12) supplement alleviates N\u2019-nitrosodimethylamine-induced hepatic fibrosis in rats. Pharm Biol. 2014;52(4):516\u201323.","journal-title":"Pharm Biol"},{"issue":"7","key":"4685_CR13","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1177\/0960327116661022","volume":"36","author":"H Khaldoun Oularbi","year":"2017","unstructured":"Khaldoun Oularbi H, Richeval C, Lebaili N, et al. Ameliorative effect of vitamin C against hepatotoxicity induced by emamectin benzoate in rats. Hum Exp Toxicol. 2017;36(7):709\u201317.","journal-title":"Hum Exp Toxicol"},{"key":"4685_CR14","doi-asserted-by":"publisher","first-page":"989311","DOI":"10.3389\/fnut.2022.989311","volume":"9","author":"H Zhang","year":"2022","unstructured":"Zhang H, Zuo Y, Zhao H, et al. Folic acid ameliorates alcohol-induced liver injury via gut-liver axis homeostasis. Front Nutr. 2022;9:989311.","journal-title":"Front Nutr"},{"issue":"20","key":"4685_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25204849","volume":"25","author":"A Balkrishna","year":"2020","unstructured":"Balkrishna A, Gohel V, Singh R, et al. Tri-herbal medicine Divya Sarva-Kalp-Kwath (Livogrit) regulates fatty acid-induced steatosis in human HepG2 cells through inhibition of intracellular triglycerides and extracellular glycerol levels. Molecules. 2020;25(20): 4849.","journal-title":"Molecules"},{"issue":"3","key":"4685_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2021.100067","volume":"1","author":"A Balkrishna","year":"2021","unstructured":"Balkrishna A, Gohel V, Singh R, et al. Livogrit ameliorates acetaldehyde-induced steatosis in HepG2 cells through modulation of lipogenesis and \u03b2-oxidation pathways. Phytomedicine Plus. 2021;1(3): 100067.","journal-title":"Phytomedicine Plus"},{"issue":"4","key":"4685_CR17","doi-asserted-by":"publisher","first-page":"10811","DOI":"10.1080\/21655979.2022.2065789","volume":"13","author":"A Balkrishna","year":"2022","unstructured":"Balkrishna A, Gohel V, Kumari P, et al. Livogrit prevents methionine-Cystine Deficiency Induced Nonalcoholic Steatohepatitis by Modulation of steatosis and oxidative stress in human hepatocyte-derived spheroid and in primary rat hepatocytes. Bioengineered. 2022;13(4):10811\u201326.","journal-title":"Bioengineered"},{"key":"4685_CR18","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.toxrep.2022.03.053","volume":"9","author":"A Balkrishna","year":"2022","unstructured":"Balkrishna A, Lochab S, Varshney A. Livogrit, a herbal formulation of Boerhavia diffusa, Phyllanthus niruri and Solanum nigrum reverses the thioacetamide induced hepatocellular toxicity in zebrafish model. Toxicol Rep. 2022;9:1056\u201364.","journal-title":"Toxicol Rep"},{"issue":"1","key":"4685_CR19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3746\/pnf.2014.19.1.019","volume":"19","author":"SH Ko","year":"2014","unstructured":"Ko SH, Park JH, Kim SY, et al. Antioxidant effects of Spinach (Spinacia oleracea L.) supplementation in hyperlipidemic rats. Prev Nutr food Sci. 2014;19(1):19\u201326.","journal-title":"Prev Nutr food Sci"},{"issue":"7","key":"4685_CR20","doi-asserted-by":"publisher","first-page":"e202200158","DOI":"10.1002\/cbdv.202200158","volume":"19","author":"C Dubois","year":"2022","unstructured":"Dubois C, Plainfosse H, Delcroix M, et al. Anti-aging potential of a Rosa centifolia Stem Extract with Focus on Phytochemical Composition by Bioguided Fractionation. Chem Biodivers. 2022;19(7):e202200158.","journal-title":"Chem Biodivers"},{"issue":"11","key":"4685_CR21","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1080\/13880209.2016.1178307","volume":"54","author":"S Saheed","year":"2016","unstructured":"Saheed S, Frans Hendrik O, Tom AA. Zea mays, Stigma Maydis prevents and extenuates acetaminophen-perturbed oxidative onslaughts in rat hepatocytes. Pharm Biol. 2016;54(11):2664\u201373.","journal-title":"Pharm Biol"},{"key":"4685_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114309","volume":"160","author":"A Balkrishna","year":"2023","unstructured":"Balkrishna A, Gohel V, Pathak N, et al. Anti-oxidant response of lipidom modulates lipid metabolism in Caenorhabditis elegans and in OxLDL-induced human macrophages by tuning inflammatory mediators. Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie. 2023;160: 114309.","journal-title":"Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie"},{"issue":"4","key":"4685_CR23","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1093\/jpp\/rgaa048","volume":"73","author":"S Sanjay","year":"2021","unstructured":"Sanjay S, Girish C, Toi PC, et al. Gallic acid attenuates isoniazid and rifampicin-induced liver injury by improving hepatic redox homeostasis through influence on Nrf2 and NF-\u03baB signalling cascades in Wistar rats. J Pharm Pharmacol. 2021;73(4):473\u201386.","journal-title":"J Pharm Pharmacol"},{"issue":"3","key":"4685_CR24","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1002\/hep.27060","volume":"60","author":"D Ye","year":"2014","unstructured":"Ye D, Wang Y, Li H, et al. Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1alpha-mediated antioxidant capacity in mice. Hepatology (Baltimore MD). 2014;60(3):977\u201389.","journal-title":"Hepatology (Baltimore MD)"},{"key":"4685_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1037814","volume":"13","author":"X Zhuang","year":"2022","unstructured":"Zhuang X, Li L, Liu T, et al. Mechanisms of isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: a review. Front Pharmacol. 2022;13: 1037814.","journal-title":"Front Pharmacol"},{"issue":"7","key":"4685_CR26","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3390\/toxins15070455","volume":"15","author":"SB Park","year":"2023","unstructured":"Park SB, Cho GH, Park YE, et al. Emodin, an Emerging Mycotoxin, Induces Endoplasmic Reticulum Stress-Related Hepatotoxicity through IRE1\u03b1\u2013XBP1 Axis in HepG2 Cells. Toxins. 2023;15(7):455.","journal-title":"Toxins."},{"key":"4685_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119583","volume":"278","author":"A Dogra","year":"2021","unstructured":"Dogra A, Gupta D, Bag S, et al. Glabridin ameliorates methotrexate-induced liver injury via attenuation of oxidative stress, inflammation, and apoptosis. Life Sci. 2021;278: 119583.","journal-title":"Life Sci"},{"issue":"3","key":"4685_CR28","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1039\/C5TX00470E","volume":"5","author":"TG Zhang","year":"2016","unstructured":"Zhang TG, Wang YM, Zhao J, et al. Induction of protective autophagy against apoptosis in HepG2 cells by isoniazid independent of the p38 signaling pathway. Toxicol Res (Camb). 2016;5(3):963\u201372.","journal-title":"Toxicol Res (Camb)"},{"issue":"9","key":"4685_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22369","volume":"33","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Zhang W, Tao L, et al. Quercetin protected against isoniazide-induced HepG2 cell apoptosis by activating the SIRT1\/ERK pathway. J Biochem Mol Toxicol. 2019;33(9): e22369.","journal-title":"J Biochem Mol Toxicol"},{"key":"4685_CR30","doi-asserted-by":"publisher","first-page":"204209862211275","DOI":"10.1177\/20420986221127503","volume":"13","author":"K Shen","year":"2022","unstructured":"Shen K, Gu Y, Wang Y, et al. Therapeutic drug monitoring and safety evaluation of voriconazole in the treatment of pulmonary fungal diseases. Ther Adv Drug Saf. 2022;13:20420986221127504.","journal-title":"Ther Adv Drug Saf"},{"issue":"1","key":"4685_CR31","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1016\/S2666-5247(22)00359-7","volume":"4","author":"S Bagcchi","year":"2023","unstructured":"Bagcchi S. WHO\u2019s Global Tuberculosis Report 2022. Lancet Microbe. 2023;4(1):e20.","journal-title":"Lancet Microbe"},{"issue":"12","key":"4685_CR32","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1002\/jat.3175","volume":"35","author":"HM Hassan","year":"2015","unstructured":"Hassan HM, Guo HL, Yousef BA, et al. Hepatotoxicity mechanisms of isoniazid: a mini-review. J Appl Toxicol. 2015;35(12):1427\u201332.","journal-title":"J Appl Toxicol"},{"issue":"2","key":"4685_CR33","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.livres.2021.02.001","volume":"5","author":"S Lei","year":"2021","unstructured":"Lei S, Gu R, Ma X. Clinical perspectives of isoniazid-induced liver injury. Liver Res. 2021;5(2):45\u201352.","journal-title":"Liver Res"},{"key":"4685_CR34","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3389\/fphar.2020.00288","volume":"11","author":"A Balkrishna","year":"2020","unstructured":"Balkrishna A, Sakat SS, Ranjan R, et al. Polyherbal medicine Divya Sarva-Kalp-Kwath ameliorates persistent Carbon Tetrachloride Induced biochemical and pathological liver impairments in Wistar rats and in HepG2 cells [Original Research]. Front Pharmacol. 2020;11:288 Accessed date: 2020-March-25.","journal-title":"Front Pharmacol"},{"issue":"1","key":"4685_CR35","doi-asserted-by":"publisher","first-page":"63","DOI":"10.4103\/0976-9668.107262","volume":"4","author":"S Soujanya","year":"2013","unstructured":"Soujanya S, Lakshman M, Kumar AA, et al. Evaluation of the protective role of vitamin C in imidacloprid-induced hepatotoxicity in male albino rats. J Nat Sci Biology Med. 2013;4(1):63\u20137.","journal-title":"J Nat Sci Biology Med"},{"key":"4685_CR36","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.2147\/DDDT.S172487","volume":"12","author":"FM Abdulkhaleq","year":"2018","unstructured":"Abdulkhaleq FM, Alhussainy TM, Badr MM, et al. Antioxidative stress effects of vitamins C, E, and B(12), and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats. Drug Des Devel Ther. 2018;12:3525\u201333.","journal-title":"Drug Des Devel Ther."},{"issue":"12","key":"4685_CR37","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1007\/s00210-020-01992-1","volume":"393","author":"D Karabulut","year":"2020","unstructured":"Karabulut D, Ozturk E, Kuloglu N, et al. Effects of vitamin B12 on methotrexate hepatotoxicity: evaluation of receptor-interacting protein (RIP) kinase. Naunyn Schmiedebergs Arch Pharmacol. 2020;393(12):2473\u201380.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"4685_CR38","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1538\/expanim.20-0075","volume":"70","author":"E Akgun","year":"2021","unstructured":"Akgun E, Boyacioglu M, Kum S. The potential protective role of folic acid against acetaminophen-induced hepatotoxicity and nephrotoxicity in rats. Exp Anim. 2021;70(1):54\u201362.","journal-title":"Exp Anim"},{"issue":"8","key":"4685_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072058","volume":"8","author":"Y Lian","year":"2013","unstructured":"Lian Y, Zhao J, Xu P, et al. Protective effects of metallothionein on isoniazid and rifampicin-induced hepatotoxicity in mice. PLoS ONE. 2013;8(8): e72058.","journal-title":"PLoS ONE"},{"issue":"0121","key":"4685_CR40","doi-asserted-by":"publisher","first-page":"100098","DOI":"10.1016\/j.afres.2022.100098","volume":"2022\/06","author":"V Poli","year":"2022","unstructured":"Poli V, Aparna Y, Madduru R, et al. Protective effect of vitamin C and E on enzymatic and antioxidant system in liver and kidney toxicity of Cadmium in rats. Appl Food Res. 2022;2022\/06(0121):100098.","journal-title":"Appl Food Res"},{"key":"4685_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/separations9070177","author":"KY Thajudeen","year":"2022","unstructured":"Thajudeen KY, Alsayari A, Najib Ullah SN, et al. Validation, Optimization and Hepatoprotective Effects of Boeravinone B and Caffeic Acid Compounds from Boerhavia diffusa Linn. Separations. 2022. https:\/\/doi.org\/10.3390\/separations9070177.","journal-title":"Separations."},{"issue":"7","key":"4685_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e07465","volume":"7","author":"E Babaeenezhad","year":"2021","unstructured":"Babaeenezhad E, Nouryazdan N, Nasri M, et al. Cinnamic acid ameliorate gentamicin-induced liver dysfunctions and nephrotoxicity in rats through induction of antioxidant activities. Heliyon. 2021;7(7): e07465.","journal-title":"Heliyon"},{"key":"4685_CR43","doi-asserted-by":"publisher","unstructured":"Goh ZH, Tee JK, Ho HK. An evaluation of the in vitro roles and mechanisms of silibinin in reducing pyrazinamide- and isoniazid-induced hepatocellular damage. Int J Mol Sci. 2020. https:\/\/doi.org\/10.3390\/ijms21103714.","DOI":"10.3390\/ijms21103714"},{"issue":"4","key":"4685_CR44","first-page":"478","volume":"26","author":"A Moslehi","year":"2023","unstructured":"Moslehi A, Komeili-Movahhed T, Ahmadian M, et al. Chlorogenic acid attenuates liver apoptosis and inflammation in endoplasmic reticulum stress-induced mice. Iran J Basic Med Sci. 2023;26(4):478\u201385.","journal-title":"Iran J Basic Med Sci"},{"issue":"91","key":"4685_CR45","doi-asserted-by":"publisher","first-page":"14183","DOI":"10.1039\/D0CC05330A","volume":"56","author":"Z Guo","year":"2020","unstructured":"Guo Z, Wang M, Li X, et al. A hepatocyte-targeting fluorescent probe for imaging isoniazid-induced hydrazine in HepG2 cells and zebrafish. Chem Commun (Camb). 2020;56(91):14183\u20136.","journal-title":"Chem Commun (Camb)"},{"issue":"12","key":"4685_CR46","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1177\/0960327115627688","volume":"35","author":"SS Palabiyik","year":"2016","unstructured":"Palabiyik SS, Karakus E, Halici Z, et al. The protective effects of carvacrol and thymol against Paracetamol-induced toxicity on human hepatocellular carcinoma cell lines (HepG2). Hum Exp Toxicol. 2016;35(12):1252\u201363.","journal-title":"Hum Exp Toxicol"},{"key":"4685_CR47","first-page":"8494076","volume":"2022\/06\/06;2022","author":"C Bai","year":"2022","unstructured":"Bai C, Zhang M, Zhang Y, et al. Gamma-Glutamyltransferase activity (GGT) is a long-sought biomarker of Redox Status in blood circulation: a retrospective clinical study of 44 types of Human diseases. Oxid Med Cell Longev. 2022;2022\/06\/06;2022:8494076.","journal-title":"Oxid Med Cell Longev."}],"container-title":["BMC Complementary Medicine and Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-024-04685-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12906-024-04685-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-024-04685-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T09:04:01Z","timestamp":1731056641000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-024-04685-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4685"],"URL":"https:\/\/doi.org\/10.1186\/s12906-024-04685-x","relation":{},"ISSN":["2662-7671"],"issn-type":[{"value":"2662-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]},"assertion":[{"value":"12 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The test formulation (Livogrit Vital) was sourced from Divya Pharmacy, Haridwar, Uttarakhand, India. Livogrit Vital is a marketed medicinal product of Divya Pharmacy, Haridwar, India. Acharya Balkrishna is an honorary trustee in Divya Yog Mandir, Trust, which governs, Divya Pharmacy, Haridwar, India.\u00a0In addition, he holds an honorary managerial position in Patanjali Ayurved Ltd., Haridwar, India. Divya Pharmacy, Haridwar and Patanjali Ayurved Ltd., Haridwar manufacture and sell many herbal medicinal products. Other than providing the test formulation (Livogrit Vital), Divya Pharmacy was not involved in any aspect of the research reported in this study. All other authors have declared no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"386"}}