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This vice-chancellor has an ethics committee that fully supervises all the ethical aspects of the conducted research (including ethical discussions of working with laboratory animals and ethics in publishing research) with the help of a grant from Tabriz University of Medical Sciences. Additionally, all animal work was performed under the standards of the Iran National Committee for Ethics in Biomedical. All animal experiments comply with the ARRIVE guidelines and carried out in accordance with the U.K. Animals (Scientific Procedures) Act, 1986 and associated guidelines, EU Directive 2010\/63\/EU for animal experiments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"427"}}