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In this study, we evaluated the phytochemical groups present in seven plants from the Brazilian Cerrado even as their antioxidant, antiproliferative and antimicrobial activities.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The extracts were obtained by the maceration technique and secondary metabolites were determined by phytochemical analysis. The antioxidant activity was assessed by the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging method. The antiproliferative activity of the extracts was assessed using human breast, kidney, and liver neoplastic cells. Cytotoxicity was evaluated in a non-neoplastic cell line \u2014 NIH\/3T3. The antimicrobial activity of the plant extracts against resistant bacteria and yeasts was determined using disk diffusion assays, and the minimum inhibitory concentration (MIC) was determined by the broth microdilution technique.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Phytochemical analysis revealed the presence of phenolic compounds, flavonoids, steroids, tannins, and saponins in all of the extracts, with <jats:italic>Smilax fluminensis<\/jats:italic> showing the highest levels of phenolic compounds and flavonoids. All tested extracts exhibited antioxidant activity above 50%, notably <jats:italic>Tapiria obtusa<\/jats:italic> (82.36\u2009\u00b1\u20090.44). The <jats:italic>T. obtusa<\/jats:italic> extract showed potent antiproliferative activity against the 786-0 cell line (GI<jats:sub>50<\/jats:sub> 10.16\u2009\u00b1\u20092.33\u00a0\u00b5g\/mL) and a significantly greater SI (SI\u2009=\u200924.61) than the control (SI\u2009=\u20093.23, doxorubicin), indicating its selective cytotoxicity against cancer cells and its potential as a therapeutic agent against renal cancer. No cytotoxicity was observed in non-tumor cells. Extracts of <jats:italic>S. fluminensis<\/jats:italic> leaves showed fungicidal effects on <jats:italic>Candida glabrata<\/jats:italic> (MIC\u2009=\u2009500\u00a0\u00b5g\/mL). This study is the first to demonstrate the antibacterial activity of <jats:italic>T. obtusa<\/jats:italic> leaf ethanolic extract against MRSA (MIC\u2009=\u20091,000\u00a0\u00b5g\/mL).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The ethanolic extract of <jats:italic>T. obtusa<\/jats:italic> demonstrated antioxidant activity, antiproliferative effects against the 786-0 cell line, and antibacterial activity against MRSA. The ethanolic extract of <jats:italic>S. fluminensis<\/jats:italic> leaves exhibited a fungicidal effect against <jats:italic>C. glabrata<\/jats:italic>. These findings may pave the way for more effective and safer treatments for managing oncological and infectious diseases.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12906-025-04787-0","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:02:45Z","timestamp":1741712565000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bioactives derived from Brazilian native flora with antimicrobial and anticancer activity"],"prefix":"10.1186","volume":"25","author":[{"given":"Daniele Cristina","family":"Vitorelli-Venancio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Matias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Rodrigues","family":"Ganassin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Antonio","family":"Venancio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Trentin","family":"Perdomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana Bicudo","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Kwiatkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o V\u00edctor","family":"de Andrade dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3402-4740","authenticated-orcid":false,"given":"Marilene Rodrigues","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"issue":"3","key":"4787_CR1","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","volume":"20","author":"AG Atanasov","year":"2021","unstructured":"Atanasov AG, Zotchev SB, Dirsch VM, International Natural Product Sciences Taskforce, Supuran CT. 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