{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:17:45Z","timestamp":1782973065246,"version":"3.54.5"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Marmara University Scientific Research Projects Coordination Unit","award":["TDH-2022-10808"],"award-info":[{"award-number":["TDH-2022-10808"]}]},{"name":"Marmara University Scientific Research Projects Coordination Unit","award":["TDH-2022-10808"],"award-info":[{"award-number":["TDH-2022-10808"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Med Ther"],"DOI":"10.1186\/s12906-025-04828-8","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T06:55:36Z","timestamp":1740639336000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["In-vitro evaluation of the effect of okra (Abelmoschus esculentus L.) extract on periodontal cells: a comprehensive study of cellular and molecular impacts"],"prefix":"10.1186","volume":"25","author":[{"given":"Umut Ula\u015f","family":"Tosun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema Tu\u011f\u00e7e","family":"Ayd\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015feg\u00fcl","family":"Tiryaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilruba","family":"Baykara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleyna","family":"Yakut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkan","family":"Rayaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turgut","family":"Ta\u015fk\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"Ekinci Do\u011fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O\u011fuzhan","family":"G\u00fcnd\u00fcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer Birkan","family":"A\u011fral\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"4828_CR1","doi-asserted-by":"publisher","first-page":"585917","DOI":"10.3389\/fcimb.2020.585917","volume":"10","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Liu D, Liu S, Zhang S, Pan Y. The role of Porphyromonas gingivalis outer membrane vesicles in periodontal disease and related systemic diseases. Front Cell Infect Microbiol. 2020;10:585917.","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"4828_CR2","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jobcr.2018.01.002","volume":"8","author":"H Jakhu","year":"2018","unstructured":"Jakhu H, Gill G, Singh A. Role of integrins in wound repair and its periodontal implications. J Oral Biol Craniofac Res. 2018;8(2):122\u20135.","journal-title":"J Oral Biol Craniofac Res"},{"key":"4828_CR3","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3389\/fphys.2019.00270","volume":"10","author":"PC Smith","year":"2019","unstructured":"Smith PC, Mart\u00ednez C, Mart\u00ednez J, McCulloch CA. Role of fibroblast populations in periodontal wound healing and tissue remodeling. Front Physiol. 2019;10:270.","journal-title":"Front Physiol"},{"issue":"11","key":"4828_CR4","doi-asserted-by":"publisher","first-page":"6010","DOI":"10.1111\/jocd.15075","volume":"21","author":"HAS Bazid","year":"2022","unstructured":"Bazid HAS, Samaka RM, Mousa MEA, Seleit I. Immunohistochemical expression of Axin-2, as an implication of the role of stem cell in scar pathogenesis and prognosis. J Cosmet Dermatol. 2022;21(11):6010\u201320.","journal-title":"J Cosmet Dermatol"},{"issue":"1","key":"4828_CR5","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13041-019-0525-5","volume":"12","author":"L Jia","year":"2019","unstructured":"Jia L, Pi\u00f1a-Crespo J, Li Y. Restoring Wnt\/\u03b2-catenin signaling is a promising therapeutic strategy for Alzheimer\u2019s disease. Mol Brain. 2019;12(1):104.","journal-title":"Mol Brain"},{"key":"4828_CR6","doi-asserted-by":"publisher","first-page":"110935","DOI":"10.1016\/j.biopha.2020.110935","volume":"133","author":"J Bao","year":"2021","unstructured":"Bao J, Yang Y, Xia M, Sun W, Chen L. Wnt signaling: an attractive target for periodontitis treatment. Biomed Pharmacother. 2021;133:110935.","journal-title":"Biomed Pharmacother"},{"issue":"15","key":"4828_CR7","doi-asserted-by":"publisher","first-page":"7331","DOI":"10.1002\/jsfa.12099","volume":"102","author":"NA Tashim","year":"2022","unstructured":"Tashim NA, Lim SA, Basri AM. Synergistic antioxidant activity of selected medicinal plants in Brunei Darussalam and its application in developing fortified pasta. J Sci Food Agric. 2022;102(15):7331\u201342.","journal-title":"J Sci Food Agric"},{"key":"4828_CR8","doi-asserted-by":"crossref","unstructured":"Toplan GG, Ta\u015fk\u0131n T, \u0130\u015fcan G, G\u00f6ger F, K\u00fcrk\u00e7\u00fco\u011flu M, Civa\u015f A, Ecevit-Gen\u00e7 G, Mat A, Ba\u015fer KHC. Comparative studies on essential oil and phenolic content with in vitro antioxidant, anticholinesterase, antimicrobial activities of Achillea biebersteinii Afan. and A. millefolium subsp. millefolium Afan. L. Growing in Eastern Turkey. Molecules 2022;27(6).","DOI":"10.3390\/molecules27061956"},{"issue":"1","key":"4828_CR9","first-page":"8","volume":"4","author":"HB Shao","year":"2007","unstructured":"Shao HB, Chu LY, Lu ZH, Kang CM. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Int J Biol Sci. 2007;4(1):8\u201314.","journal-title":"Int J Biol Sci"},{"issue":"13","key":"4828_CR10","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.1021\/acs.jafc.7b04975","volume":"66","author":"H Chen","year":"2018","unstructured":"Chen H. RH Liu 2018 Potential mechanisms of action of Dietary Phytochemicals for Cancer Prevention by Targeting Cellular Signaling Transduction pathways. J Agric Food Chem 66 13 3260\u201376.","journal-title":"J Agric Food Chem"},{"issue":"4","key":"4828_CR11","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1002\/ptr.7341","volume":"36","author":"A Saatchi","year":"2022","unstructured":"Saatchi A, Aghamohammadzadeh N, Beheshtirouy S, Javadzadeh Y, Afshar FH, Ghaffary S. Anti-hyperglycemic effect of Abelmoschus Culentesus (Okra) on patients with diabetes type 2: a randomized clinical trial. Phytother Res. 2022;36(4):1644\u201351.","journal-title":"Phytother Res"},{"key":"4828_CR12","doi-asserted-by":"publisher","first-page":"114843","DOI":"10.1016\/j.jep.2021.114843","volume":"287","author":"H Sipahi","year":"2022","unstructured":"Sipahi H, Orak D, Reis R, Yalman K, \u015eenol O, Palabiyik-Y\u00fccelik SS, Deniz \u0130, Alg\u00fcl D, Guzelmeric E, \u00c7elep ME, et al. A comprehensive study to evaluate the wound healing potential of okra (Abelmoschus esculentus) fruit. J Ethnopharmacol. 2022;287:114843.","journal-title":"J Ethnopharmacol"},{"issue":"38","key":"4828_CR13","doi-asserted-by":"publisher","first-page":"34448","DOI":"10.1021\/acsomega.3c02560","volume":"8","author":"TM Rababah","year":"2023","unstructured":"Rababah TM, Al-U\u2019datt M H, Angor M, Gammoh S, Abweni F, Magableh G, Almajwal A, Y\u00fccel S, Al-Rayyan Y, Al-Rayyan N. Effect of drying and freezing on the phytochemical properties of okra during storage. ACS Omega. 2023;8(38):34448\u201357.","journal-title":"ACS Omega"},{"issue":"22","key":"4828_CR14","doi-asserted-by":"publisher","first-page":"15280","DOI":"10.1039\/D3RA01367G","volume":"13","author":"MAM Abdel-Razek","year":"2023","unstructured":"Abdel-Razek MAM, Abdelwahab MF, Abdelmohsen UR, Hamed ANE. A review: pharmacological activity and phytochemical profile of Abelmoschus esculentus (2010\u20132022). RSC Adv. 2023;13(22):15280\u201394.","journal-title":"RSC Adv"},{"key":"4828_CR15","doi-asserted-by":"crossref","unstructured":"Choi HK, Kim GJ, Yoo HS, Song DH, Chung KH, Lee KJ, Koo YT, An JH. Vitamin C activates osteoblastogenesis and inhibits osteoclastogenesis via Wnt\/\u03b2-catenin\/ATF4 signaling pathways. Nutrients. 2019;11(3):506.","DOI":"10.3390\/nu11030506"},{"issue":"4","key":"4828_CR16","doi-asserted-by":"publisher","first-page":"354","DOI":"10.4062\/biomolther.2019.206","volume":"28","author":"JI Kang","year":"2020","unstructured":"Kang JI, Choi YK, Koh YS, Hyun JW, Kang JH, Lee KS, Lee CM, Yoo ES, Kang HK. Vanillic acid stimulates anagen signaling via the PI3K\/Akt\/ \u03b2-catenin pathway in dermal papilla cells. Biomol Ther (Seoul). 2020;28(4):354\u201360.","journal-title":"Biomol Ther (Seoul)"},{"key":"4828_CR17","doi-asserted-by":"crossref","unstructured":"Ta\u015fk\u0131n D, Y\u0131lmaz B, Taskin T, Omurtag G. The influence of different extraction methods\/solvents on composition, biological activities and ADMET predictions of phenolics in Tribulus terrestris. Braz Arch Biol Technol 2021, 64.","DOI":"10.1590\/1678-4324-2021210249"},{"key":"4828_CR18","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.sajb.2022.03.021","volume":"147","author":"G G\u00fclsoy Toplan","year":"2022","unstructured":"G\u00fclsoy Toplan G, K\u00fcrk\u00e7\u00fco\u011flu M, G\u00f6ger F, Ta\u015fk\u0131n T, Civa\u015f A, \u0130\u015fcan G, Ecevit-Gen\u00e7 G, Mat A, Ba\u015fer KHC. Phytochemical screening and biological evaluation of Salvia Hydrangea DC. Ex Benth. Growing in eastern Anatolia. S Afr J Bot. 2022;147:799\u2013807.","journal-title":"S Afr J Bot"},{"key":"4828_CR19","volume-title":"Performance standards for antimicrobial disc susceptibility tests; approved standard\u2014twelfth edition. CLSI document M02-A12","author":"CLSI","year":"2015","unstructured":"CLSI. Performance standards for antimicrobial disc susceptibility tests; approved standard\u2014twelfth edition. CLSI document M02-A12. Wayne, PA: Clinical and Laboratory Standards Institute; 2015."},{"key":"4828_CR20","first-page":"113","volume":"15","author":"C Perez","year":"1990","unstructured":"Perez C, Pauli M, Bazerque P. An antibiotic assay by the agar well diffusion method. Acta Biologiae et Medicinae Exp. 1990;15:113\u20135.","journal-title":"Acta Biologiae et Medicinae Exp"},{"key":"4828_CR21","volume-title":"Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Approved standard. NCCLS Document M38-A","author":"National Committee for Clinical Laboratory Standards","year":"2002","unstructured":"National Committee for Clinical Laboratory Standards. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Approved standard. NCCLS Document M38-A. Wayne: National Committee for Clinical Laboratory Standards; 2002."},{"key":"4828_CR22","doi-asserted-by":"crossref","unstructured":"Fawzy El-Sayed KM, Cosgarea R, Sculean A, Doerfer C. Can vitamins improve periodontal wound healing\/regeneration? Periodontol 2000 2024, 94(1):539\u2013602.","DOI":"10.1111\/prd.12513"},{"issue":"Suppl 1","key":"4828_CR23","doi-asserted-by":"publisher","first-page":"764","DOI":"10.4103\/jpbs.jpbs_175_23","volume":"15","author":"SD Venkadassalapathy","year":"2023","unstructured":"Venkadassalapathy SD, Ramasamy M, Balashanmugam, Victor DJ, Subramanian S, Praveen JAA, Akbar MAR. In vitro antibacterial, cytotoxicity and wound healing activities of methanol and aqueous extracts from Achyranthes aspera. J Pharm Bioallied Sci. 2023;15(Suppl 1):764\u201370.","journal-title":"J Pharm Bioallied Sci"},{"issue":"9","key":"4828_CR24","doi-asserted-by":"publisher","first-page":"7856","DOI":"10.1039\/D0FO00867B","volume":"11","author":"G D\u2019Urso","year":"2020","unstructured":"D\u2019Urso G, Napolitano A, Cannavacciuolo C, Masullo M, Piacente S. Okra fruit: LC-ESI\/LTQOrbitrap\/MS\/MS(n) based deep insight on polar lipids and specialized metabolites with evaluation of anti-oxidant and anti-hyperglycemic activity. Food Funct. 2020;11(9):7856\u201365.","journal-title":"Food Funct"},{"key":"4828_CR25","doi-asserted-by":"crossref","unstructured":"Wu DT, Nie XR, Shen DD, Li HY, Zhao L, Zhang Q, Lin DR, Qin W. Phenolic compounds, antioxidant activities, and inhibitory effects on digestive enzymes of different cultivars of okra (Abelmoschus esculentus). Molecules 2020, 25(6).","DOI":"10.3390\/molecules25061276"},{"key":"4828_CR26","doi-asserted-by":"crossref","unstructured":"Ganeshpurkar A, Saluja AK. The pharmacological potential of rutin. Saudi Pharm J 2017, 25(2):149\u201364.","DOI":"10.1016\/j.jsps.2016.04.025"},{"key":"4828_CR27","doi-asserted-by":"crossref","unstructured":"Syarifah-Noratiqah SB, Zulfarina MS, Ahmad SU, Fairus S, Naina-Mohamed I. The pharmacological potential of oil palm phenolics (OPP) individual components. Int J Med Sci 2019, 16(5):711\u20139.","DOI":"10.7150\/ijms.29934"},{"key":"4828_CR28","doi-asserted-by":"crossref","unstructured":"Wahyuningsih SPA, Savira NII, Anggraini DW, Winarni D, Suhargo L, Kusuma BWA, Nindyasari F, Setianingsih N, Mwendolwa AA. Antioxidant and nephroprotective effects of okra pods extract (Abelmoschus esculentus L.) against lead acetate-induced toxicity in mice. Scientifica (Cairo) 2020, 2020:4237205.","DOI":"10.1155\/2020\/4237205"},{"key":"4828_CR29","first-page":"100126","volume":"5","author":"G Panighel","year":"2022","unstructured":"Panighel G, Ferrarese I, Lupo MG, Sut S, Dall\u2019Acqua S, Ferri N. Investigating the in vitro mode of action of okra (Abelmoschus esculentus) as hypocholesterolemic, anti-inflammatory, and antioxidant food. Food Chem (Oxf). 2022;5:100126.","journal-title":"Food Chem (Oxf)"},{"issue":"8","key":"4828_CR30","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.2174\/1871527313666141023141545","volume":"13","author":"G Mushtaq","year":"2014","unstructured":"Mushtaq G, Greig NH, Khan JA, Kamal MA. Status of acetylcholinesterase and butyrylcholinesterase in Alzheimer\u2019s disease and type 2 diabetes mellitus. CNS Neurol Disord Drug Targets. 2014;13(8):1432\u20139.","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"10","key":"4828_CR31","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1111\/jcpe.12989","volume":"45","author":"DA Apatzidou","year":"2018","unstructured":"Apatzidou DA, Iskas A, Konstantinidis A, Alghamdi AM, Tumelty M, Lappin DF, Nile CJ. Clinical associations between acetylcholine levels and cholinesterase activity in saliva and gingival crevicular fluid and periodontal diseases. J Clin Periodontol. 2018;45(10):1173\u201383.","journal-title":"J Clin Periodontol"},{"issue":"12","key":"4828_CR32","first-page":"2382","volume":"12","author":"HT Bakhsh","year":"2023","unstructured":"Bakhsh HT, Mokhtar FA, Elmaidomy AH, Aly HF, Younis EA, Alzubaidi MA, Altemani FH, Algehainy NA, Majrashi MAA, Alsenani F, et al. AbelmoEculentuslentus seed extract exhibits in vitro and inanti-alzheimerheimer\u2019s potential supported by metabolomic and computational investigation. Plants (Basel). 2023;12(12):2382.","journal-title":"Plants (Basel)"},{"key":"4828_CR33","doi-asserted-by":"publisher","first-page":"3343","DOI":"10.2147\/IJN.S307676","volume":"16","author":"S Devanesan","year":"2021","unstructured":"Devanesan S, AlSalhi MS. Green synthesis of silver nanoparticles using the flower extract of Abelmoschus esculentus for cytotoxicity and antimicrobial studies. Int J Nanomed. 2021;16:3343\u201356.","journal-title":"Int J Nanomed"},{"key":"4828_CR34","doi-asserted-by":"crossref","unstructured":"Weinreb M, Nemcovsky CE. In vitro models for evaluation of periodontal wound healing\/regeneration. Periodontol 2000 2015, 68(1):41\u201354.","DOI":"10.1111\/prd.12079"},{"issue":"3","key":"4828_CR35","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jep.2005.06.038","volume":"102","author":"AM Deters","year":"2005","unstructured":"Deters AM, Lengsfeld C, Hensel A. Oligo- and polysaccharides exhibit a structure-dependent bioactivity on human keratinocytes in vitro. J Ethnopharmacol. 2005;102(3):391\u20139.","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"4828_CR36","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.jcms.2015.04.012","volume":"43","author":"FJ Rodr\u00edguez-Lozano","year":"2015","unstructured":"Rodr\u00edguez-Lozano FJ, Garc\u00eda-Bernal D, Ros-Roca Mde L, Alguer\u00f3 Mdel C, O\u00f1ate-S\u00e1nchez RE, Camacho-Alonso F, Moraleda JM. Cytoprotective effects of melatonin on zoledronic acid-treated human mesenchymal stem cells in vitro. J Craniomaxillofac Surg. 2015;43(6):855\u201362.","journal-title":"J Craniomaxillofac Surg"},{"issue":"11","key":"4828_CR37","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.3109\/13880209.2014.1001402","volume":"53","author":"A Manosroi","year":"2015","unstructured":"Manosroi A, Pattamapun K, Khositsuntiwong N, Kietthanakorn BO, Issarangporn W, Chankhampan C, Manosroi W, Manosroi J. Physicochemical properties and biological activities of Thai plant mucilages for artificial saliva preparation. Pharm Biol. 2015;53(11):1653\u201360.","journal-title":"Pharm Biol"},{"key":"4828_CR38","doi-asserted-by":"crossref","unstructured":"Sanz JL, L\u00f3pez-Garc\u00eda S, Forner L, Rodr\u00edguez-Lozano FJ, Garc\u00eda-Bernal D, S\u00e1nchez-Bautista S, Puig-Herreros C, Rosell-Clari V. O\u00f1ate-S\u00e1nchez RE: Are Endodontic Solvents Cytotoxic? An In Vitro Study on Human Periodontal Ligament Stem Cells. Pharmaceutics. 2022;14(11).","DOI":"10.3390\/pharmaceutics14112415"},{"issue":"8","key":"4828_CR39","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1111\/odi.12938","volume":"24","author":"K Gawron","year":"2018","unstructured":"Gawron K, Ocha\u0142a-K\u0142os A, Nowakowska Z, Bereta G, \u0141azarz-Bartyzel K, Grabiec AM, Plakwicz P, G\u00f3rska R, Fertala A, Chomyszyn-Gajewska M, et al. TIMP-1 association with collagen type I overproduction in hereditary gingival fibromatosis. Oral Dis. 2018;24(8):1581\u201390.","journal-title":"Oral Dis"},{"issue":"1","key":"4828_CR40","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1177\/0022034513511640","volume":"93","author":"M Yanagita","year":"2014","unstructured":"Yanagita M, Kojima Y, Kubota M, Mori K, Yamashita M, Yamada S, Kitamura M, Murakami S. Cooperative effects of FGF-2 and VEGF-A in periodontal ligament cells. J Dent Res. 2014;93(1):89\u201395.","journal-title":"J Dent Res"},{"issue":"8","key":"4828_CR41","doi-asserted-by":"publisher","first-page":"393","DOI":"10.3390\/pharmaceutics11080393","volume":"11","author":"SY Park","year":"2019","unstructured":"Park SY, Kim KH, Kim S, Lee YM, Seol YJ. BMP-2 gene delivery-based bone regeneration in dentistry. Pharmaceutics. 2019;11(8):393.","journal-title":"Pharmaceutics"},{"issue":"2","key":"4828_CR42","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s10689-014-9775-7","volume":"14","author":"S Li","year":"2015","unstructured":"Li S, Wang C, Liu X, Hua S, Liu X. The roles of AXIN2 in tumorigenesis and epigenetic regulation. Fam Cancer. 2015;14(2):325\u201331.","journal-title":"Fam Cancer"},{"key":"4828_CR43","doi-asserted-by":"crossref","unstructured":"Bisevac J, Katta K, Petrovski G, Moe MC, Noer A. Wnt\/\u03b2-catenin signaling activation induces differentiation in human limbal epithelial stem cells cultured ex vivo. Biomedicines. 2023;11(7):1829.","DOI":"10.3390\/biomedicines11071829"},{"issue":"1","key":"4828_CR44","doi-asserted-by":"publisher","first-page":"19673","DOI":"10.1038\/s41598-021-99231-x","volume":"11","author":"H Naruse","year":"2021","unstructured":"Naruse H, Itoh S, Itoh Y, Kagioka T, Abe M, Hayashi M. The Wnt\/\u03b2-catenin signaling pathway has a healing ability for periapical periodontitis. Sci Rep. 2021;11(1):19673.","journal-title":"Sci Rep"},{"issue":"1\u20132","key":"4828_CR45","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s11010-015-2329-y","volume":"402","author":"SH Kook","year":"2015","unstructured":"Kook SH, Heo JS, Lee JC. Crucial roles of canonical Runx2-dependent pathway on Wnt1-induced osteoblastic differentiation of human periodontal ligament fibroblasts. Mol Cell Biochem. 2015;402(1\u20132):213\u201323.","journal-title":"Mol Cell Biochem"},{"key":"4828_CR46","doi-asserted-by":"crossref","unstructured":"Ge L, Cui Y, Liu B, Yin X, Pang J, Han J. ER\u03b1 and Wnt\/\u03b2\u2013catenin signaling pathways are involved in angelicin\u2013dependent promotion of osteogenesis. Mol Med Rep 2019, 19(5):3469\u201376.","DOI":"10.3892\/mmr.2019.9999"},{"key":"4828_CR47","doi-asserted-by":"publisher","first-page":"108746","DOI":"10.1016\/j.biopha.2019.108746","volume":"112","author":"XJ Chen","year":"2019","unstructured":"Chen XJ, Shen YS, He MC, Yang F, Yang P, Pang FX, He W, Cao YM, Wei QS. Polydatin promotes the osteogenic differentiation of human bone mesenchymal stem cells by activating the BMP2-Wnt\/\u03b2-catenin signaling pathway. Biomed Pharmacother. 2019;112:108746.","journal-title":"Biomed Pharmacother"},{"key":"4828_CR48","doi-asserted-by":"publisher","first-page":"153","DOI":"10.33808\/clinexphealthsci.709924","volume":"10","author":"B \u00d6nc\u00fc","year":"2020","unstructured":"\u00d6nc\u00fc B, Yilmaz AM, Yilmaz B, Keles E, Kuru L, A\u011fral\u0131 \u00d6. Cytotoxicity and collagen expression effects of tideglusib administration on human periodontal cells: an in-vitro study. Clin Experimental Health Sci. 2020;10:153\u201362.","journal-title":"Clin Experimental Health Sci"},{"key":"4828_CR49","doi-asserted-by":"crossref","unstructured":"Kornsuthisopon C, Tompkins KA, Osathanon T. Tideglusib enhances odontogenic differentiation in human dental pulp stem cells in vitro. Int Endod J 2023, 56(3):369\u201384.","DOI":"10.1111\/iej.13877"},{"key":"4828_CR50","doi-asserted-by":"publisher","first-page":"104693","DOI":"10.1016\/j.archoralbio.2020.104693","volume":"113","author":"Y Bian","year":"2020","unstructured":"Bian Y, Xiang J. Salvianolic acid B promotes the osteogenic differentiation of human periodontal ligament cells through Wnt\/\u03b2-catenin signaling pathway. Arch Oral Biol. 2020;113:104693.","journal-title":"Arch Oral Biol"},{"issue":"12","key":"4828_CR51","doi-asserted-by":"publisher","first-page":"3762","DOI":"10.1002\/jcp.25856","volume":"232","author":"M Chang","year":"2017","unstructured":"Chang M, Lin H, Fu H, Wang B, Han G, Fan M. MicroRNA-195-5p regulates osteogenic differentiation of periodontal ligament cells under mechanical loading. J Cell Physiol. 2017;232(12):3762\u201374.","journal-title":"J Cell Physiol"},{"issue":"2","key":"4828_CR52","first-page":"195","volume":"29","author":"KA Hwang","year":"2012","unstructured":"Hwang KA, Hwang YL, Lee MH, Kim NR, Roh SS, Lee Y, Kim CD, Lee JH, Choi KC. Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles. Int J Mol Med. 2012;29(2):195\u2013201.","journal-title":"Int J Mol Med"}],"container-title":["BMC Complementary Medicine and Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-025-04828-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12906-025-04828-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-025-04828-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T06:55:47Z","timestamp":1740639347000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-025-04828-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,27]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4828"],"URL":"https:\/\/doi.org\/10.1186\/s12906-025-04828-8","relation":{},"ISSN":["2662-7671"],"issn-type":[{"value":"2662-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,27]]},"assertion":[{"value":"27 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"84"}}