{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:44:05Z","timestamp":1790286245066,"version":"4.1.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Complement Med Ther"],"DOI":"10.1186\/s12906-025-04835-9","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T15:09:34Z","timestamp":1741705774000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Phytochemical analysis, antioxidant activity, and cytotoxic effects of Caulerpa lentillifera extracts inducing cell apoptosis and sub-G\/G0-G1 cell cycle arrest in KON oral cancer cells"],"prefix":"10.1186","volume":"25","author":[{"given":"Suwisit","family":"Manmuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanchanok","family":"Sirirak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukannika","family":"Tubtimsri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpa","family":"Petchsomrit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiraniti","family":"Chuenbarn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"issue":"1","key":"4835_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41368-023-00249-w","volume":"15","author":"Y Tan","year":"2023","unstructured":"Tan Y, Wang Z, Xu M, Li B, Huang Z, Qin S, Nice EC, Tang J, Huang C. Oral squamous cell carcinomas: state of the field and emerging directions. Int J Oral Sci. 2023;15(1):44.","journal-title":"Int J Oral Sci"},{"issue":"12","key":"4835_CR2","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.3390\/cancers13122864","volume":"13","author":"A Romano","year":"2021","unstructured":"Romano A, Di Stasio D, Petruzzi M, Fiori F, Lajolo C, Santarelli A, Lucchese A, Serpico R, Contaldo M. Noninvasive Imaging Methods to Improve the Diagnosis of Oral Carcinoma and Its Precursors: State of the Art and Proposal of a Three-Step Diagnostic Process. Cancers (Basel). 2021;13(12):2864.","journal-title":"Cancers (Basel)"},{"issue":"1","key":"4835_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3390\/pharmaceutics16010007","volume":"16","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Wu Y, Du H, Li Z, Bai X, Wu Y, Li H, Zhou M, Cao Y, Chen X. Nano-Drug Delivery Systems in Oral Cancer Therapy: Recent Developments and Prospective. Pharmaceutics. 2023;16(1):7.","journal-title":"Pharmaceutics"},{"issue":"1","key":"4835_CR4","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s12935-023-02943-5","volume":"23","author":"HS Budi","year":"2023","unstructured":"Budi HS, Farhood B. Targeting oral tumor microenvironment for effective therapy. Cancer Cell Int. 2023;23(1):101.","journal-title":"Cancer Cell Int"},{"issue":"7","key":"4835_CR5","doi-asserted-by":"publisher","first-page":"E2266","DOI":"10.1002\/lary.29394","volume":"131","author":"A Gangopadhyay","year":"2021","unstructured":"Gangopadhyay A, Bhatt S, Nandy K, Rai S, Rathod P, Puj KS. Survival Impact of Surgical Resection in Locally Advanced T4b Oral Squamous Cell Carcinoma. Laryngoscope. 2021;131(7):E2266\u201374.","journal-title":"Laryngoscope"},{"issue":"9","key":"4835_CR6","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1007\/s00432-022-04028-8","volume":"148","author":"H Li","year":"2022","unstructured":"Li H, Zhang Y, Xu M, Yang D. Current trends of targeted therapy for oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2022;148(9):2169\u201386.","journal-title":"J Cancer Res Clin Oncol"},{"issue":"3","key":"4835_CR7","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","volume":"20","author":"AG Atanasov","year":"2021","unstructured":"Atanasov AG, Zotchev SB, Dirsch VM. International Natural Product Sciences T, Supuran CT: Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov. 2021;20(3):200\u201316.","journal-title":"Nat Rev Drug Discov"},{"issue":"11","key":"4835_CR8","first-page":"1655","volume":"9","author":"J Khazir","year":"2014","unstructured":"Khazir J, Riley DL, Pilcher LA, De-Maayer P, Mir BA. Anticancer agents from diverse natural sources. Nat Prod Commun. 2014;9(11):1655\u201369.","journal-title":"Nat Prod Commun"},{"issue":"1","key":"4835_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.59566\/IJBS.2009.5001","volume":"5","author":"A Amin","year":"2009","unstructured":"Amin A, Gali-Muhtasib H, Ocker M, Schneider-Stock R. Overview of major classes of plant-derived anticancer drugs. Int J Biomed Sci. 2009;5(1):1\u201311.","journal-title":"Int J Biomed Sci"},{"issue":"Suppl 1","key":"4835_CR10","doi-asserted-by":"publisher","first-page":"S181","DOI":"10.4103\/0975-7406.155895","volume":"7","author":"E Rajesh","year":"2015","unstructured":"Rajesh E, Sankari LS, Malathi L, Krupaa JR. Naturally occurring products in cancer therapy. J Pharm Bioallied Sci. 2015;7(Suppl 1):S181-183.","journal-title":"J Pharm Bioallied Sci"},{"issue":"16","key":"4835_CR11","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1200\/JCO.2008.20.6235","volume":"27","author":"AR Amin","year":"2009","unstructured":"Amin AR, Kucuk O, Khuri FR, Shin DM. Perspectives for cancer prevention with natural compounds. J Clin Oncol. 2009;27(16):2712\u201325.","journal-title":"J Clin Oncol"},{"issue":"1","key":"4835_CR12","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3390\/cancers15010268","volume":"15","author":"A Sachdeva","year":"2022","unstructured":"Sachdeva A, Dhawan D, Jain GK, Yerer MB, Collignon TE, Tewari D, Bishayee A. Novel Strategies for the Bioavailability Augmentation and Efficacy Improvement of Natural Products in Oral Cancer. Cancers (Basel). 2022;15(1):268.","journal-title":"Cancers (Basel)"},{"issue":"6","key":"4835_CR13","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1002\/med.21969","volume":"43","author":"JT Burcher","year":"2023","unstructured":"Burcher JT, DeLiberto LK, Allen AM, Kilpatrick KL, Bishayee A. Bioactive phytocompounds for oral cancer prevention and treatment: A comprehensive and critical evaluation. Med Res Rev. 2023;43(6):2025\u201385.","journal-title":"Med Res Rev"},{"issue":"5","key":"4835_CR14","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.ejso.2023.01.013","volume":"49","author":"K Kannan","year":"2023","unstructured":"Kannan K, Pitchiah S. E D, Ramasamy P: Novel therapeutic inhibitors for oral squamous cell cancer (OSCC) from seaweeds. Eur J Surg Oncol. 2023;49(5):1048\u20139.","journal-title":"Eur J Surg Oncol"},{"issue":"6","key":"4835_CR15","first-page":"332","volume":"14","author":"S Sundaramoorthy","year":"2022","unstructured":"Sundaramoorthy S, Dakshinamoorthi A. K C: Evaluation of anti-oxidant and anticancer effect of marine algae Cladophora glomerata in HT29 colon cancer cell lines- an in-vitro study. Int J Physiol Pathophysiol Pharmacol. 2022;14(6):332\u20139.","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"issue":"9","key":"4835_CR16","doi-asserted-by":"publisher","first-page":"484","DOI":"10.3390\/md19090484","volume":"19","author":"F Menaa","year":"2021","unstructured":"Menaa F, Wijesinghe U, Thiripuranathar G, Althobaiti NA, Albalawi AE, Khan BA, Menaa B. Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs? Mar Drugs. 2021;19(9):484.","journal-title":"Mar Drugs"},{"key":"4835_CR17","doi-asserted-by":"publisher","first-page":"5243","DOI":"10.2147\/IJN.S423412","volume":"18","author":"Z Xin","year":"2023","unstructured":"Xin Z, Zhang M, Cui H, Ding X, Zhang T, Wu L, Cui H, Xue Q, Chen C, Gao J. Algae: A Robust Living Material Against Cancer. Int J Nanomedicine. 2023;18:5243\u201364.","journal-title":"Int J Nanomedicine"},{"issue":"18","key":"4835_CR18","doi-asserted-by":"publisher","first-page":"2832","DOI":"10.3390\/foods11182832","volume":"11","author":"N Syakilla","year":"2022","unstructured":"Syakilla N, George R, Chye FY, Pindi W, Mantihal S, Wahab NA, Fadzwi FM, Gu PH, Matanjun P. A Review on Nutrients, Phytochemicals, and Health Benefits of Green Seaweed, Caulerpa lentillifera. Foods. 2022;11(18):2832.","journal-title":"Foods"},{"issue":"7","key":"4835_CR19","doi-asserted-by":"publisher","first-page":"575","DOI":"10.12980\/APJTB.4.2014APJTB-2014-0091","volume":"4","author":"BR Sharma","year":"2014","unstructured":"Sharma BR, Rhyu DY. Anti-diabetic effects of Caulerpa lentillifera: stimulation of insulin secretion in pancreatic beta-cells and enhancement of glucose uptake in adipocytes. Asian Pac J Trop Biomed. 2014;4(7):575\u201380.","journal-title":"Asian Pac J Trop Biomed"},{"key":"4835_CR20","doi-asserted-by":"publisher","first-page":"1010867","DOI":"10.3389\/fnut.2022.1010867","volume":"9","author":"JIC Manoppo","year":"2022","unstructured":"Manoppo JIC, Nurkolis F, Pramono A, Ardiaria M, Murbawani EA, Yusuf M, Qhabibi FR, Yusuf VM, Amar N, Karim MRA, et al. Amelioration of obesity-related metabolic disorders via supplementation of Caulerpa lentillifera in rats fed with a high-fat and high-cholesterol diet. Front Nutr. 2022;9:1010867.","journal-title":"Front Nutr"},{"issue":"3","key":"4835_CR21","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.3390\/molecules28031365","volume":"28","author":"F Nurkolis","year":"2023","unstructured":"Nurkolis F, Taslim NA, Qhabibi FR, Kang S, Moon M, Choi J, Choi M, Park MN, Mayulu N, Kim B. Ulvophyte Green Algae Caulerpa lentillifera: Metabolites Profile and Antioxidant, Anticancer, Anti-Obesity, and In Vitro Cytotoxicity Properties. Molecules. 2023;28(3):1365.","journal-title":"Molecules"},{"issue":"3","key":"4835_CR22","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1271\/bbb.110813","volume":"76","author":"R Maeda","year":"2012","unstructured":"Maeda R, Ida T, Ihara H, Sakamoto T. Immunostimulatory activity of polysaccharides isolated from Caulerpa lentillifera on macrophage cells. Biosci Biotechnol Biochem. 2012;76(3):501\u20135.","journal-title":"Biosci Biotechnol Biochem"},{"key":"4835_CR23","first-page":"128","volume":"26","author":"V Tanawoot","year":"2021","unstructured":"Tanawoot V, Vivithanaporn P, Siangcham T, Meemon K, Niamnont N, Sobhon P, Tamtin M, Sangpairoj K. Hexane extract of seaweed Caulerpa lentillifera inhibits cell proliferation and induces apoptosis of human glioblastoma cells. Sci Technol Asia. 2021;26:128\u201337.","journal-title":"Sci Technol Asia"},{"key":"4835_CR24","doi-asserted-by":"publisher","first-page":"100883","DOI":"10.1016\/j.scp.2022.100883","volume":"30","author":"A Petchsomrit","year":"2022","unstructured":"Petchsomrit A, Chanthathamrongsiri N, Manmuan S, Leelakanok N, Wangpradit N, Vongsak B, Sirirak T. Green extraction of Buchanania siamensis and water-based formulations. Sustain Chem Pharm. 2022;30:100883.","journal-title":"Sustain Chem Pharm"},{"issue":"1","key":"4835_CR25","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3390\/fermentation5010029","volume":"5","author":"M Haile","year":"2019","unstructured":"Haile M. Kang WH\u202f: Antioxidant Activity, Total Polyphenol, Flavonoid and Tannin Contents of Fermented Green Coffee Beans with Selected Yeasts. Fermentation. 2019;5(1):29.","journal-title":"Fermentation"},{"issue":"5","key":"4835_CR26","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1042\/bst0110591","volume":"11","author":"HK Lichtenthaler","year":"1983","unstructured":"Lichtenthaler HK. Wellburn AR\u202f: Determinations of total carotenoids and chlorophylls a and b of leaf extracts in different solvents. Biochem Soc Trans. 1983;11(5):591\u20132.","journal-title":"Biochem Soc Trans"},{"issue":"2","key":"4835_CR27","doi-asserted-by":"publisher","first-page":"121","DOI":"10.4103\/RPS.RPS_81_23","volume":"19","author":"S Manmuan","year":"2024","unstructured":"Manmuan S, Tubtimsri S, Chaothanaphat N, Issaro N, Tantisira MH, Manmuan P. Determination of the anticancer activity of standardized extract of Centella asiatica (ECa 233) on cell growth and metastatic behavior in oral cancer cells. Res Pharm Sci. 2024;19(2):121\u201347.","journal-title":"Res Pharm Sci"},{"key":"4835_CR28","volume-title":"Statistics for the behavioral sciences","author":"FJ Gravetter","year":"2013","unstructured":"Gravetter FJ, Wallnau LB. Statistics for the behavioral sciences. 9th ed. Belmont, CA: Wadsworth Cengage Learning; 2013.","edition":"9"},{"issue":"9","key":"4835_CR29","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.3390\/cancers12092425","volume":"12","author":"L Koklesova","year":"2020","unstructured":"Koklesova L, Liskova A, Samec M, Buhrmann C, Samuel SM, Varghese E, Ashrafizadeh M, Najafi M, Shakibaei M, Busselberg D, et al. Carotenoids in Cancer Apoptosis-The Road from Bench to Bedside and Back. Cancers (Basel). 2020;12(9):2425.","journal-title":"Cancers (Basel)"},{"issue":"12","key":"4835_CR30","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3390\/md21120607","volume":"21","author":"H Kim","year":"2023","unstructured":"Kim H, Kim HT, Jung SH, Han JW, Jo S, Kim IG, Kim RK, Kahm YJ, Choi TI, Kim CH, et al. A Novel Anticancer Peptide Derived from Bryopsis plumosa Regulates Proliferation and Invasion in Non-Small Cell Lung Cancer Cells. Mar Drugs. 2023;21(12):607.","journal-title":"Mar Drugs"},{"key":"4835_CR31","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13020-018-0177-x","volume":"13","author":"QW Zhang","year":"2018","unstructured":"Zhang QW, Lin LG, Ye WC. Techniques for extraction and isolation of natural products: a comprehensive review. Chin Med. 2018;13:20.","journal-title":"Chin Med"},{"issue":"3","key":"4835_CR32","first-page":"e201065","volume":"20","author":"S Osotprasit","year":"2021","unstructured":"Osotprasit S, Samrit T, Chaiwichien A, Changklungmoa N, Meemon K, Niamnont N, Manohong P, Noonong K, Tamtin M, Sobhon P, et al. Toxicity and Anti-Oxidation Capacity of The Extracts from Caulerpa lentillifera: CMUJ. Nat Sci. 2021;20(3):e201065.","journal-title":"Nat Sci"},{"issue":"24","key":"4835_CR33","doi-asserted-by":"publisher","first-page":"7454","DOI":"10.3390\/molecules26247454","volume":"26","author":"AM Salih","year":"2021","unstructured":"Salih AM, Al-Qurainy F, Nadeem M, Tarroum M, Khan S, Shaikhaldein HO, Al-Hashimi A, Alfagham A, Alkahtani J. Optimization Method for Phenolic Compounds Extraction from Medicinal Plant (Juniperus procera) and Phytochemicals Screening. Molecules. 2021;26(24):7454.","journal-title":"Molecules"},{"issue":"5","key":"4835_CR34","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.3390\/molecules28052041","volume":"28","author":"S Alhayyani","year":"2023","unstructured":"Alhayyani S, Akhdhar A, Asseri AH, Mohammed AMA, Hussien MA, Roselin LS, Hosawi S, AlAbbasi F, Alharbi KH, Baty RS, et al. Potential Anticancer Activity of Juniperus procera and Molecular Docking Models of Active Proteins in Cancer Cells. Molecules. 2023;28(5):2041.","journal-title":"Molecules"},{"issue":"6","key":"4835_CR35","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.3390\/foods12061310","volume":"12","author":"N Goutzourelas","year":"2023","unstructured":"Goutzourelas N, Kevrekidis DP, Barda S, Malea P, Trachana V, Savvidi S, Kevrekidou A, Assimopoulou AN, Goutas A, Liu M, et al. Antioxidant Activity and Inhibition of Liver Cancer Cells\u2019 Growth of Extracts from 14 Marine Macroalgae Species of the Mediterranean Sea. Foods. 2023;12(6):1310.","journal-title":"Foods"},{"issue":"1","key":"4835_CR36","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s10886-005-0984-2","volume":"31","author":"R Koivikko","year":"2005","unstructured":"Koivikko R, Loponen J, Honkanen T, Jormalainen V. Contents of soluble, cell-wall-bound and exuded phlorotannins in the brown alga Fucus vesiculosus, with implications on their ecological functions. J Chem Ecol. 2005;31(1):195\u2013212.","journal-title":"J Chem Ecol"},{"issue":"6","key":"4835_CR37","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3390\/md18060331","volume":"18","author":"B Zhong","year":"2020","unstructured":"Zhong B, Robinson NA, Warner RD, Barrow CJ, Dunshea FR. Suleria HAR\u202f: LC-ESI-QTOF-MS\/MS Characterization of Seaweed Phenolics and Their Antioxidant Potential. Mar Drugs. 2020;18(6):331.","journal-title":"Mar Drugs"},{"issue":"1","key":"4835_CR38","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4103\/0974-8490.91044","volume":"4","author":"K Jana","year":"2012","unstructured":"Jana K, Chatterjee K, Ali KM, De D, Bera TK, Ghosh D. Antihyperglycemic and antioxidative effects of the hydro-methanolic extract of the seeds of Caesalpinia bonduc on streptozotocin-induced diabetes in male albino rats. Pharmacognosy Res. 2012;4(1):57\u201362.","journal-title":"Pharmacognosy Res"},{"issue":"2","key":"4835_CR39","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3390\/md10020403","volume":"10","author":"D Kelman","year":"2012","unstructured":"Kelman D, Posner EK, McDermid KJ, Tabandera NK, Wright PR, Wright AD. Antioxidant activity of Hawaiian marine algae. Mar Drugs. 2012;10(2):403\u201316.","journal-title":"Mar Drugs"},{"key":"4835_CR40","first-page":"101139","volume":"28","author":"E Tajvidi","year":"2021","unstructured":"Tajvidi E, Nahavandizadeh N, Pournaderi M, Pourrashid AZ, Bossaghzadeh F, Khoshnood Z. Study the antioxidant effects of blue-green algae Spirulina extract on ROS and MDA production in human lung cancer cells. Biochem Biophys Rep. 2021;28:101139.","journal-title":"Biochem Biophys Rep"},{"issue":"9","key":"4835_CR41","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.3390\/ijms20092272","volume":"20","author":"B Medeiros","year":"2019","unstructured":"Medeiros B, Allan AL. Molecular Mechanisms of Breast Cancer Metastasis to the Lung: Clinical and Experimental Perspectives. Int J Mol Sci. 2019;20(9):2272.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4835_CR42","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1080\/07315724.2020.1735572","volume":"40","author":"D Barhoi","year":"2021","unstructured":"Barhoi D, Upadhaya P, Barbhuiya SN, Giri A, Giri S. Aqueous Extract of Moringa oleifera Exhibit Potential Anticancer Activity and can be Used as a Possible Cancer Therapeutic Agent: A Study Involving In Vitro and In Vivo Approach. J Am Coll Nutr. 2021;40(1):70\u201385.","journal-title":"J Am Coll Nutr"},{"issue":"6","key":"4835_CR43","doi-asserted-by":"publisher","first-page":"e0252820","DOI":"10.1371\/journal.pone.0252820","volume":"16","author":"KY Orabi","year":"2021","unstructured":"Orabi KY, Abaza MS, Luqmani YA, Al-Attiyah R. Psiadin and plectranthone selectively inhibit colorectal carcinoma cells proliferation via modulating cyclins signaling and apoptotic pathways. PLoS ONE. 2021;16(6):e0252820.","journal-title":"PLoS ONE"},{"issue":"1","key":"4835_CR44","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3892\/ijo.2016.3794","volume":"50","author":"H Yu","year":"2017","unstructured":"Yu H, Zhang H, Dong M, Wu Z, Shen Z, Xie Y, Kong Z, Dai X, Xu B. Metabolic reprogramming and AMPKalpha1 pathway activation by caulerpin in colorectal cancer cells. Int J Oncol. 2017;50(1):161\u201372.","journal-title":"Int J Oncol"},{"key":"4835_CR45","doi-asserted-by":"publisher","first-page":"964816","DOI":"10.3389\/fonc.2022.964816","volume":"12","author":"HK Permatasari","year":"2022","unstructured":"Permatasari HK, Wewengkang DS, Tertiana NI, Muslim FZ, Yusuf M, Baliulina SO, Daud VPA, Setiawan AA, Nurkolis F. Anti-cancer properties of Caulerpa racemosa by altering expression of Bcl-2, BAX, cleaved caspase 3 and apoptosis in HeLa cancer cell culture. Front Oncol. 2022;12:964816.","journal-title":"Front Oncol"},{"key":"4835_CR46","doi-asserted-by":"publisher","first-page":"300","DOI":"10.2741\/1798","volume":"11","author":"RH Engel","year":"2006","unstructured":"Engel RH, Evens AM. Oxidative stress and apoptosis: a new treatment paradigm in cancer. Front Biosci. 2006;11:300\u201312.","journal-title":"Front Biosci"},{"issue":"5","key":"4835_CR47","doi-asserted-by":"publisher","first-page":"e20151","DOI":"10.1371\/journal.pone.0020151","volume":"6","author":"KC Pramanik","year":"2011","unstructured":"Pramanik KC, Boreddy SR, Srivastava SK. Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells. PLoS ONE. 2011;6(5):e20151.","journal-title":"PLoS ONE"},{"issue":"9","key":"4835_CR48","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.3390\/antiox11091714","volume":"11","author":"W Lee","year":"2022","unstructured":"Lee W, Song G, Bae H. Laminarin Attenuates ROS-Mediated Cell Migration and Invasiveness through Mitochondrial Dysfunction in Pancreatic Cancer Cells. Antioxidants (Basel). 2022;11(9):1714.","journal-title":"Antioxidants (Basel)"},{"issue":"5","key":"4835_CR49","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s10495-007-0720-1","volume":"12","author":"L Galluzzi","year":"2007","unstructured":"Galluzzi L, Zamzami N, de La Motte RT, Lemaire C, Brenner C, Kroemer G. Methods for the assessment of mitochondrial membrane permeabilization in apoptosis. Apoptosis. 2007;12(5):803\u201313.","journal-title":"Apoptosis"},{"issue":"7\u20138","key":"4835_CR50","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1007\/s10495-022-01735-y","volume":"27","author":"S Kari","year":"2022","unstructured":"Kari S, Subramanian K, Altomonte IA, Murugesan A, Yli-Harja O, Kandhavelu M. Programmed cell death detection methods: a systematic review and a categorical comparison. Apoptosis. 2022;27(7\u20138):482\u2013508.","journal-title":"Apoptosis"},{"issue":"2","key":"4835_CR51","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1023\/A:1022945107762","volume":"8","author":"JD Ly","year":"2003","unstructured":"Ly JD, Grubb DR, Lawen A. The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update. Apoptosis. 2003;8(2):115\u201328.","journal-title":"Apoptosis"},{"key":"4835_CR52","doi-asserted-by":"publisher","first-page":"154854","DOI":"10.1016\/j.prp.2023.154854","volume":"251","author":"SG Almalki","year":"2023","unstructured":"Almalki SG. The pathophysiology of the cell cycle in cancer and treatment strategies using various cell cycle checkpoint inhibitors. Pathol Res Pract. 2023;251:154854.","journal-title":"Pathol Res Pract"},{"key":"4835_CR53","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/bs.apcsb.2022.11.011","volume":"135","author":"D Patra","year":"2023","unstructured":"Patra D, Bhavya K, Ramprasad P, Kalia M, Pal D. Anti-cancer drug molecules targeting cancer cell cycle and proliferation. Adv Protein Chem Struct Biol. 2023;135:343\u201395.","journal-title":"Adv Protein Chem Struct Biol"},{"issue":"7","key":"4835_CR54","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3390\/cells7070081","volume":"7","author":"E Smith","year":"2018","unstructured":"Smith E, Palethorpe HM, Tomita Y, Pei JV, Townsend AR, Price TJ, Young JP, Yool AJ, Hardingham JE. The Purified Extract from the Medicinal Plant Bacopa monnieri, Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis. Cells. 2018;7(7):81.","journal-title":"Cells"},{"issue":"1","key":"4835_CR55","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/s43856-023-00304-x","volume":"3","author":"NL Hudock","year":"2023","unstructured":"Hudock NL, Mani K, Khunsriraksakul C, Walter V, Nekhlyudov L, Wang M, Lehrer EJ, Hudock MR, Liu DJ, Spratt DE, et al. Future trends in incidence and long-term survival of metastatic cancer in the United States. Commun Med (Lond). 2023;3(1):76.","journal-title":"Commun Med (Lond)"},{"key":"4835_CR56","doi-asserted-by":"publisher","first-page":"108522","DOI":"10.1016\/j.pharmthera.2023.108522","volume":"250","author":"SU Khan","year":"2023","unstructured":"Khan SU, Fatima K, Malik F, Kalkavan H, Wani A. Cancer metastasis: Molecular mechanisms and clinical perspectives. Pharmacol Ther. 2023;250:108522.","journal-title":"Pharmacol Ther"},{"key":"4835_CR57","first-page":"21","volume":"110","author":"A Munshi","year":"2005","unstructured":"Munshi A, Hobbs M, Meyn RE. Clonogenic cell survival assay. Methods Mol Med. 2005;110:21\u20138.","journal-title":"Methods Mol Med"},{"issue":"5","key":"4835_CR58","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1038\/nprot.2006.339","volume":"1","author":"NA Franken","year":"2006","unstructured":"Franken NA, Rodermond HM, Stap J, Haveman J, van Bree C. Clonogenic assay of cells in vitro. Nat Protoc. 2006;1(5):2315\u20139.","journal-title":"Nat Protoc"},{"issue":"11","key":"4835_CR59","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.3390\/ph14111154","volume":"14","author":"TL Gunathilaka","year":"2021","unstructured":"Gunathilaka TL, Dilrangi KH, Ranasinghe P, Samarakoon KW. Peiris LDC\u202f: Mechanistic Insight into Apoptotic Induction in Human Rhabdomyosarcoma and Breast Adenocarcinoma Cells by Chnoospora minima: A Sri Lankan Brown Seaweed. Pharmaceuticals (Basel). 2021;14(11):1154.","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"4835_CR60","doi-asserted-by":"publisher","first-page":"bpab014","DOI":"10.1093\/biomethods\/bpab014","volume":"6","author":"M Aslan","year":"2021","unstructured":"Aslan M, Hsu EC, Liu S, Stoyanova T. Quantifying the invasion and migration ability of cancer cells with a 3D Matrigel drop invasion assay. Biol Methods Protoc. 2021;6(1):bpab014.","journal-title":"Biol Methods Protoc"},{"issue":"1","key":"4835_CR61","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","volume":"12","author":"D Hanahan","year":"2022","unstructured":"Hanahan D. Hallmarks of Cancer: New Dimensions. Cancer Discov. 2022;12(1):31\u201346.","journal-title":"Cancer Discov"},{"key":"4835_CR62","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.3389\/fimmu.2019.01713","volume":"10","author":"M Schulz","year":"2019","unstructured":"Schulz M, Salamero-Boix A, Niesel K, Alekseeva T, Sevenich L. Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis. Front Immunol. 2019;10:1713.","journal-title":"Front Immunol"},{"issue":"11","key":"4835_CR63","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1038\/nm.3394","volume":"19","author":"DF Quail","year":"2013","unstructured":"Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013;19(11):1423\u201337.","journal-title":"Nat Med"},{"issue":"2","key":"4835_CR64","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1177\/2211068214561025","volume":"20","author":"B Srinivasan","year":"2015","unstructured":"Srinivasan B, Kolli AR, Esch MB, Abaci HE, Shuler ML, Hickman JJ. TEER measurement techniques for in vitro barrier model systems. J Lab Autom. 2015;20(2):107\u201326.","journal-title":"J Lab Autom"},{"key":"4835_CR65","doi-asserted-by":"publisher","first-page":"106511","DOI":"10.1016\/j.ejps.2023.106511","volume":"188","author":"BB Karakocak","year":"2023","unstructured":"Karakocak BB, Keshavan S, Gunasingam G, Angeloni S, Auderset A, Petri-Fink A, Rothen-Rutishauser B. Rethinking of TEER measurement reporting for epithelial cells grown on permeable inserts. Eur J Pharm Sci. 2023;188:106511.","journal-title":"Eur J Pharm Sci"},{"issue":"1","key":"4835_CR66","doi-asserted-by":"publisher","first-page":"100116","DOI":"10.1016\/j.slast.2023.10.008","volume":"29","author":"J Schimetz","year":"2024","unstructured":"Schimetz J, Shah P, Keese C, Dehnert C, Detweiler M, Michael S, Toniatti-Yanulavich C, Xu X, Padilha EC. Automated measurement of transepithelial electrical resistance (TEER) in 96-well transwells using ECIS TEER96: Single and multiple time point assessments. SLAS Technol. 2024;29(1):100116.","journal-title":"SLAS Technol"},{"issue":"11","key":"4835_CR67","doi-asserted-by":"publisher","first-page":"6135","DOI":"10.21873\/anticanres.13821","volume":"39","author":"CC Wu","year":"2019","unstructured":"Wu CC, Lai PY, Hsieh S, Cheng CC, Hsieh SL. Suppression of Carnosine on Adhesion and Extravasation of Human Colorectal Cancer Cells. Anticancer Res. 2019;39(11):6135\u201344.","journal-title":"Anticancer Res"},{"issue":"5","key":"4835_CR68","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1248\/bpb.20.541","volume":"20","author":"H Harada","year":"1997","unstructured":"Harada H, Noro T, Kamei Y. Selective antitumor activity in vitro from marine algae from Japan coasts. Biol Pharm Bull. 1997;20(5):541\u20136.","journal-title":"Biol Pharm Bull"}],"container-title":["BMC Complementary Medicine and Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-025-04835-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12906-025-04835-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12906-025-04835-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T15:59:25Z","timestamp":1741708765000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-025-04835-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,11]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4835"],"URL":"https:\/\/doi.org\/10.1186\/s12906-025-04835-9","relation":{},"ISSN":["2662-7671"],"issn-type":[{"value":"2662-7671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,11]]},"assertion":[{"value":"8 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"101"}}